Empiric Antibiotic Therapy Evaluation of Clinical Outcome in Patients Against

Children With Bacterial Meningitis in Ward Inpatient Hospital Dr. Sardjito

20102015

Evaluation of empirical Antibiotic Therapy Toward Clinical Outcome in Children with

Bacterial Meningitis Patients in Dr. Sardjito General Hospital in Yogyakarta 2010-2015

Wihda Yanuar 1, Ika Puspita Sari 2 *, point Nuryastuti 3

1. Master of Clinical Pharmacy, Faculty of Pharmacy, UGM
2. Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, UGM
3. Department of Microbiology, Faculty of Medicine, Public Health and Nursing, UGM

Corresponding author: Ika Puspita Sari: Email: ika.puspitasari@gmail.com

ABSTRACT

Cases of bacterial meningitis in Indonesia reached 158 / 100,000. Bacterial

meningitis affects children aged less than 2 years. Patients with bacterial meningitis who
survive are at risk for complications such as brain damage. Therefore, patients with
bacterial meningitis, especially in children need to get the optimal therapy. This study
aims to determine the empirical antibiotic use against

cinical outcome pediatric patients with bacterial meningitis at the Hospital inpatient
ward Dr. Sardjito. Research carried out by the draft descriptive observational
retrospective data collection of medical records of patients who met the inclusion
criteria. Obtained as many as 25 patients with appropriate inclusion criteria. The results
showed that 26% of empirical antibiotic use in accordance with the guideline treatment
of bacterial meningitis. Clinical outcomes empiric antibiotic use that has improved by
40%.

Keywords : empiric antibiotic, clinical outcome, bacterial meningitis

ABSTRACT

Cases of bacterial meningitis in Indonesia reach 158 / 100,000. Bacterial

meningitis attacks of children less than 2 years old. Patients with bacterial meningitis
who survive are at risk for complications such as brain damage. Therefore, Patients
with bacterial meningitis, especially in children, need to get optimal therapy. This
study aims to Determine the pattern of empirical antibiotic use on clinical outcomes of
pediatric Patients with bacterial meningitis in the inpatient ward of Sardjito General
Hospital. The study was conducted in an observational descriptive design by
collecting the data retrospectively on the medical records of Patients who met the
inclusion criteria. There were 25 Patients who met the inclusion criteria. The results
Showed that 26% use of empiric antibiotics was in accordance with the guidelines for
the treatment of bacterial meningitis. Increased empiric therapy clinical outcomes of
40% Patients.

keyword: empiric therapy, clinical outcome, bacterial meningitis

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descriptively
Cases of bacterial meningitis in Indonesia reached 158 / 100,000 cases per year, with the etiology Haemophilus

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influenza type b ( H. influenzae) 16 / 100,000 and other
bacteria 67 / 100,000
(Natural, 2011). patient particularly bacterial meningitis in children needs to obtain
the optimal therapeutic remember patients may experience
complications such as damage to the brain (Prasad

et al., 2007). Availability

current antibiotics has been assured, yet still have a bacterial meningitis morbidity and mortality.
The mortality rate in patients treated is about 10% of the total cases reported. The mortality rate in
untreated

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