CALCA Gene

Calcitonin gene–related peptide (CGRP; official name CALCA) is important for variety of
functions ranging from formation of new blood vessels to anti-inflammatory properties.It has
shown anti-ulcer properties in various mouse model studies and its release by S
Thermophilus contributes to the cytoprotective properties of CALCA in acute and chronic
inflammation of gut.
CCL3
S.Thermophilus increases Chemokine (C-C motif) ligand 3 (CCL3) also known
as macrophage inflammatory protein 1-alpha (MIP-1-alpha) that causes increases migration
of leucocytes to the site of infection and those it helps to clear the pathogenic infections.
Monocytes and macrophages are cellular components of the innate immune system that prevent
the invasion of pathogens by releasing cytotoxic molecules such as reactive oxygen species (ROS)
and by secreting proinflammatory cytokines such as TNF-α and IL-8

CD3D
CD3D is the T cell associated genes which along with NK cells defends against pathogenic
bacteria and plays the important role in cell mediated immunity(8).