NEUROLOGY MULTIPLE-CHOICE QUESTIONS

Directions: Each question below contains four suggested responses. Select the one best response
to each question.

1) Cerebral palsy is associated with each of the following EXCEPT

A. gastro-oesophageal reflux

B. increased sensitivity to non-depolarising muscle relaxants

C. malnutrition

D. recurrent aspiration

2) Common complications of spinal cord injury include each of the following EXCEPT

A. deep vein thrombosis

B. diarrhoea

C. heterotopic calcification

D. pressure sores

3) The respiratory pattern of a patient sustaining an acute C5 spinal cord injury is characterised
by

A. a rapid respiratory rate

B. arterial hypoxaemia

C. chest wall immobility

D. preservation of the cough

E. preservation of the inspiratory force

4) Von Hippel-Lindau disease is associated with

A. increased risk of malignant hyperthermia

B. meningiomas

C. peripheral neuropathy

D. pheochromocytomas

5) The incidence of an intra-cranial aneurysm is increased by each of the following EXCEPT

A. Ehlers-Danlos syndrome

B. hypertension

C. neurofibromatosis

D. type 2 diabetes mellitus

6 hyperkalemic periodic paralysis is caused by mutation in the following gene

a SCN1A
b SCN2A
c SCN3A
d SCN4A

7 muscle not involved in inflammatory myopathy

a ocular muscles
b quadriceps muscles
c pharyngeal muscles
d neck flexor muscle

8 polymyositis includes

a skin rash
b involvement of extraocular and facial muscles
c endocrinopathy
d none of the above

9 acute painless weakness with myoglobinuria may occur with

A hypokalemia
b hypophosphatemia
c hypomagnesemia
d all of the above

10 characteristic of polymyositis

a CD4/MHC-I complex
b CD8/MHC-I complex
c CD20/MHC-I complex
d CD28/MHC-I complex

11 antibody directed against histidyl transfer RNA synthetase is called as

a anti-Jo-1 antibody
b anti-Ro antibody
c anti-Hu antibody
d anti-Zic antibody

12 glucocorticoid posing a high risk for myopathy

a triamcinolone
b betamethasone
c dexamethasone
d all of the above

13 tumors associated with dermatomyositis include all except

a ovarian cancer
b breast cancer
c colon cancer
d hodgkins lymphoma

14 Long QT syndrome is a feature of

a Thomsen`s disease
b Becker`s disease
c Paramyotonia congenita
d Andersen-Tawil syndrome

15 inflammatory myopathy patients with anti-Jo-1 antibodies have an increased frequency of

a interstitial lung disease

b Raynaud`s phenomenon
c nonerosive arthritis
d all of the above

16characteristic prolongation of relaxation phase of muscle stretch reflexes in hypothyroidism is

best observed in

a triceps reflex
b biceps reflex
c supinator reflex
d knee reflex

17 lipid lowering agents causing myopathy includes

a fibrates
b HMG-CoA reductase inhibitors
c niacin
d all of the above

18 extramuscular manifestations are associated with which inflammatory myopathies

a polymyositis
b dermatomyositis
c inclusion body myositis
d all of the above

19 hypokalemic periodic paralysis type 1 is caused by mutation in gene

a CALCL1A1
b CALCL1A2
c CALCL1A3
d CALCL1A4

20 onset of hypokalemic periodic paralysis is at

a childhood
b adolescence
c adulthood
d middle age

21 attacks of muscle weakness are induced by cold in

a Thomsen`s disease
b Becker`s disease
c Paramyotonia congenita
d all of the above
22 which is rare in dermatomyositis

a rheumatoid arthritis
b SLE
c Sjogren`s syndrome
d all of the above

23 inflammatory myopathy includes

a polymyositis
b dermatomyositis
c inclusion body myositis
d all of the above

24 tropical polymyositis caused by

a parasite
b bacteria
c virus
d toxin

25 parasitic polymyositis caused by

a toxoplasma
b trypanosoma
c cysticerci
d all of the above

26 patient with overlap syndrome of dermatomyositis and systemic sclerosis have which
antinuclear antibody

a anti-PM/Scl
b anti-IBM/Scl
c anti-DM/Scl
d all of the above
27 inclusion body myositis include all except

a thrice more frequent in men than women

b may have asymmetric muscle weakness pattern
c fine motor movements affected late in the course
d falling is common

28 β-amyloid deposits on muscle biopsy found in

a inclusion body myositis

b polymyositis
c dermatomyositis
d all of the above

29 drug related inflammatory or antibody mediated myopathy is caused by

a zidovudine
b D-pencillamine
c glucocorticoids
d vitamin D

30 which causes mitochondrial myopathy with ragged fibers

a zidovudine
b D-pencillamine
c glucocorticoids
d vitamin D

31 serum CK level is elevated in which endocrine myopathies

a hyperthyroidism
b hypothyroidism
c hyperparathyroidism
d diabetes mellitus

32 acute quadriplegic myopathy associated with

a glucocorticoid related myopathy
b lipid lowering agent related myopathy
c vitamin D related myopathy
d vitamin E related myopathy

33dermatomyositis feature include

a gottron rash
b V sign
c shawl sign
d all of the above

34 in hypokalemic periodic paralysis preferred vehicle for administration of iv potassium is

a normal saline
b GDW
c ringer lactate
d mannitol

35 In patients suffering from multiple sclerosis it is better to avoid the use of

A. epidural lignocaine

B. neostigmine

C. pancuronium

D. Suxamethonium

36 A 45-year-old woman presents to the emergency room with the worst headache of
her life. A lumbar puncture reveals many red blood cells, and the head CT shows a
subarachnoid hemorrhage. Intracranial CT angiography reveals a left posterior
communicating aneurysm.

Most appropriate treatment for this patient?

A. Watchful waiting
B. Craniotomy and clipping of the aneurysm
C. Endovascular coiling
D. Hypothermia

37 What is the approximate 7 day risk for stroke after TIA?

A. 0.05%
B. 1%
C. 5%
D. 20%

38 True about impulse control disorder (ICD) and parkinsons disease (PD) is

A. Patients with PD only display problems with impulse control when they are on
dopamine agonists
B. The incidence of ICD is higher in patients with PD who are not taking dopamine
agonists
C. The incidence of ICD is higher in patients with PD when they are taking dopamine
agonists
D. The problem of ICD is not typically associated with PD
15

39 Second most common type of dementia is

A. Alzheimer's dementia
B. Dementia with Lewy bodies
C. Frontotemporal dementia
D. Vascular dementia
33
40 All of the following statements about autism spectrum disorders (ASD) are
true EXCEPT:

A. Affected children usually lack social reciprocity

B. Profound language delay is universal
C. Rett syndrome is a genetic disease
D. Pervasive developmental disorder not otherwise specified (PDD-NOS) is a
commonly
diagnosed ASD
E. ASD and PDD are synonymous
39