Quinoxaline der activity adv ref

2-acetyl and 2-
benzoyl anti-Mycobacterium tuberculosisagents European Journal of
quinoxaline
1,4-di-N-oxide Medicinal Chemistry
derivatives Volume 38, Issue
9, September 2003,
Pages 791-800

4- antiplasmodial agents
trichloromethy European Journal of
lpyrrolo[1,2-
a]quinoxalines Medicinal Chemistry
Volume 83, 18 August
2014, Pages 26-35

N-substituted tubulin polymerization inhibitors

3-oxo-1,2,3,4- European Journal of
tetrahydro-
quinoxaline-6- Medicinal Chemistry
carboxylic Volume 143, 1
acid January 2018, Pages 8-
20

4- anticonvulsants
styryltetrazolo panelShivanandaWagleaAirody European Journal of
[1,5- VasudevaAdhikaribNalilu SuchethaKu
a]quinoxaline Medicinal Chemistry
and 1- Volume 44, Issue
substituted-4- 3, March 2009, Pages
styryl[1,2,4]tri 1135-1143
azolo[4,3-
a]quinoxaline
steroidal in vitro antibacterial activitySalman
thiazolo AhmadKhanKishwarSaleemZaheerKhan
quinoxalines
European Journal of

Medicinal Chemistry
Volume 42, Issue
1, January 2007, Pages
103-108

quinoxaline-2- antimycobacterial activity

carboxamide panelElsaMorenoSaioaAncizuSilviaPérez- European Journal of
1,4-di-N-oxide SilanesEnriqueTorresIgnacioAldanaAntonio
Monge Medicinal Chemistry
Volume 45, Issue
10, October 2010,
Pages 4418-4426

pyrrolo[1,2- non-peptide glucagon receptor

a]quinoxalines European Journal of
antagonistsJeanGuillonaPatrickDallemagnea
BrunoPfeifferbPierreRenardbDominiqueMan Medicinal Chemistry
Volume 33, Issue
echezcAlainKervrandSylvainRaulta
4, April 1998, Pages
293-308

Anti TB activities

 monoresistant M. tuberculosis and some nontuberculous Mycobacterium (NTM) strains.

Inhibitory Assay-DNA gyrases from M. tuberculosis(inhibitory effect quinoxaline der on M. tuberculosis
gyrase supercoiling)

 Std drug- Rifampicin, isoniazid

 Antituberculosis activity testing against drug monoresistant strains (ATCC35822, ATCC35838,
ATCC35837, and ATCC35820) or NTM clinical isolates was performed as described earlier by
Luna-Herrera et al.
 Antitubercular Screening by Microplate Alamar Blue Assay (MABA) Method.Antibactrial
 In Vitro Antibacterial Screening by Microdilution Method. Compounds were tested against
bacterial pathogens,namely, Staphylococcus aureus ATCC 25923, Escherichia coliATCC 25922,
Proteus vulgaris ATCC 29905, Pseudomonas aeroginosa ATCC 27853, and Salmonella typhi
ATCC 14028