Biological Activities of Piri-Piri (Cyperus articulatus)

Plan t Part - Origin Activity Tested For Type Extract Test Mod el Dosage Re sult Notes/Organism tested Ref #

Rhizome - Cam eroon Anti-epileptic Activity H2O ext Rat cortex 0.5 m g/m l Active J19348

Rhizome - Cam eroon Anti-epileptic Activity H2O ext Rat B rain 0.5 m g/m l Active Reduced spontaneous L23992
epileptiform discharges and
NMD A-induced epolarisations

Rhizome - Cam eroon Receptor Inhibition H20 ext Rat B rain 0.3 m g/m l Active Inhibited n-m ethyl-d-a spa rtate L23992
(for an ti-epileptic activity) (NMD) receptor binding.

Rhizome - Cam eroon Receptor Inhibition H2O ext Rat B rain ED 50: 1.3 Active Inhibited 50 % of glutam ate T06340
(for an ti-epileptic activity) m icrom ols induced inward current
through hNMDAR 1A/2A
receptors.

Rhizome - Cam eroon Receptor Inhibition H2O ext Rat B rain ED50: 30 Active Decrease excitation (NMDA T06340
(for an ti-epileptic activity) m icrom ols receptor antagonists) and
increase inhibition (GABA(B)
receptor agonists) in the
central nervous system.

Rhizome - Cam eroon Binding Activity H2O ext Rat cortex 178 m cg/m l Active Glycine receptor binding. J19348
ETO AC ext 36.0 m cg/m l Active

Rhizome - Cam eroon Anticonv ulsant Ac tivity MEO H ext IP Mouse ED50: 306 mg/kg Active vs. maximal electroshock- and L15103
pentylenetetrazol-induced
seizures.

Rhizome - Cam eroon Anticonv ulsant Ac tivity MEO H ext IP Mouse 50 mg/kg Active vs. strychnine-, bicucu lline-, & PP1007
n-methyl-d-aspartate- induced
convulsions and excitation.

Rhizome - Cam eroon Anticonv ulsant Ac tivity MEO H ext IP Mouse Not stated Active vs. maximal electroshock- and PP1010
pentylenetetrazol-induced
seizures.

Rhizome - Cam eroon Loc om otor A ctivity Decoction IP Mouse 0.02 gm/kg Active Decreased locom oto r ac tivity. L14930

GI = G astric Intu bation IG = Intragastric IP = Intraperitoneally IV = Intravenously SC = Subcutan eously PO = O rally

Plan t Part - Origin Activity Tested For Type Extract Test Mod el Dosage Re sult Notes/Organism tested Ref #

Rhizome - Cam eroon Sedative Activity Decoction IP Mouse 2.0 gm/kg Active vs. sodium thiopental-induced L14930
and diazepam-induced sleep
time.

Rhizome - Cam eroon Analgesic Activity Not stated Mouse 2 gm/kg Inactive vs. uphold tail in hot water. L14930

Rhizome - Cam eroon Sm ooth Muscle Relaxant Decoction IP Mouse 2.0 gm/kg Inactive L14930
Activity

Rhizom e - Peru Anticrustace an A ctivity MEO H ext In vitro E D50: 69 m cg/m l Active Assay system is intend ed to K28202
CH2CL2 ext D E50: 33 m cg/m l Active predict for antitum or activity.

Rhizo m e - N igeria Antimalarial Activity ETO H-H20 ext Not stated Not stated Active Plasmodium falciparum J16227

Rhizom e - Peru Antioxidant Ac tivity MEO H ext In vitro IC50: Active Measured by quenching of L03868
171.8 m g/m l Luminol-enhanced
chemiluminenscence.

Rhizom e - Peru Antibacte rial Activity Decoction Broth 25/m g/m l Active Staphylococcus aureus K28202
culture Active Pseudomonas aeruginosa
Inactive Mycobacterium gordonae
Inactive Es cherichia coli
Inactive Klebsiella pneumoniae
Inactive Salmonella gallinarum

Rhizom e - Peru Antibacte rial Activity Decoction Agar plate Not stated Active Staphylococcus aureus J15343
Active Pseudomonas aeruginosa
Inactive Mycobacterium gordonae
Inactive Es cherichia coli
Inactive Klebsiella pneumoniae
Inactive Salmonella gallinarum

Rhizom e - Peru Anti-yeast A ctivity Decoction Broth 25/m g/m l Inactive Candida albicans K28202
culture

Rhizo m e - B razil Anti-yeast A ctivity ETO H ext Agar plate Not stated Active Candida albicans PP1008

Rhizom e - Peru DNA Binding Effect MEO H ext In vitro 1.0 m g/m l Inactive DNA-Meth yl gre en assay. K28202

GI = G astric Intu bation IG = Intragastric IP = Intraperitoneally IV = Intravenously SC = Subcutan eously PO = O rally

Plan t Part - Origin Activity Tested For Type Extract Test Mod el Dosage Re sult Notes/Organism tested Ref #

Rhizo m e - N igeria Inse cticide Activity Powder In vivo 1% Active Tribolium confusum adult L09384
Petroleum ext
MEO H Ext

Rhizo m e - N igeria Antifeedant A ctivity Petroleum ext In vivo Not stated Active Tribolium confusum adult L09384
MEO H Ext

Biological Activities of Compounds in Piri-Piri (Cyperus articulatus)

Compound Activity Tested For Test Mod el Dosage Re sult Notes/Organism tested Ref #

Alpha-cyperone An tim alarial Activity In vitro 5.5 m cg/m l Active PP1006

Cyperotundone Nitric Oxide Synth esis Cell culture IC50: 7.8 m cg/m l Active Macrophage cell line vs. LPS- L15243
Inhibition Activity induced nitric oxide production

Cyperotundone Prostaglandin Synthetase In vitro IC50: 520 Active Rabbit microsomes T08539
Inhibition m icrom ols

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GI = G astric Intu bation IG = Intragastric IP = Intraperitoneally IV = Intravenously SC = Subcutan eously PO = O rally