NEOPLASIA

Tim Dosen Patologi

 Introduction ...
• Neoplasm  “new growth”
but how to distinguish from reactive hyperplasia?

a. Tumor : Swelling
b. Hyperplasia : Excessive rate of cell division,
leading to larger than usual but the structure and
arrangement remain normal (reversibel process)
c. Dysplasia : Excessive cells proliferation
characterized by loss of normal tissue arrangement
and structure. Potential for becoming malignant
d. Metastasis : secondary growth of a malignant
neoplasm at a site distant from primary neoplasm
Carcinoma in situ
Proliferation on neoplasia
• Tumor : swelling
• Dysplasia : alteration in size, shape, and staining
characteristic of cells in nonneoplastic neoplastic
tissue
• Anaplasia : lack of differentiation (tdk ada
perubahan pd sel??)
• Metastasis : secondary growth of a malignant
neoplasm at a site distant from primary
neoplasm (dit4 jauh dr tmpt aslinya)
Site of human cancer associated with chronic exposure
 4 types of genetic
mutations that
contribute to cancer
1

2 3 4
 1). Failure of DNA repair

•
2). Activation Growth-Promoting Oncogenes
3). Inactivation Tumor-Suppressor Genes
4). Alteration in apoptosis genes
TUGAS
• TOPIK : GANGGUAN NUTRISI
• Meliputi : definisi, jenis (klasifikasi), mekanisme
penyakit, dampak (akibat) gangguan tersebut terhadap
tubuh
• Tugas dikerjakan secara kelompok @ 7 – 8 mahasiswa
• Tugas paling lambat dikumpulkan tanggal 10
Desember 2014 ke email farmasi_ndaru@yahoo.co.id
• Paper terlengkap dan terbaik akan dipresentasikan
• Jika nilai tugas masih dianggap belum optimal, maka
tugas selanjutnya akan diberikan kepada mahasiswa
• Referensi untuk mengerjakan tugas : Basic Pahology
(softfile bisa meminta ke saya)