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The American Heart Association requests that this document be cited as follows: Brooks SC, Anderson ML, Bruder E, Daya MR, Gaffney A, Otto CW, Singer
AJ, Thiagarajan RR, Travers AH. Part 6: alternative techniques and ancillary devices for cardiopulmonary resuscitation: 2015 American Heart Association
Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015;132(suppl 2):S436–S443.
(Circulation. 2015;132[suppl 2]:S436–S443. DOI: 10.1161/CIR.0000000000000260.)
© 2015 American Heart Association, Inc.
Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIR.0000000000000260
S436
Brooks et al Part 6: Alternative Techniques and Ancillary Devices for CPR S437
during the decompression phase of CPR, enhancing the nega- negative intrathoracic pressure (vacuum) generated by chest
tive intrathoracic pressure generated during chest wall recoil, recoil, thereby increasing venous return (preload) to the heart
thereby improving venous return to the heart and cardiac out-put and cardiac output during the next chest compression. ACD-
during CPR. It does so without impeding positive-pressure CPR is believed to act synergistically with the ITD to
ventilation or passive exhalation. The ITD is removed after enhance venous return during chest decompression and
return of spontaneous circulation (ROSC) is achieved. The ITD improves blood flow to vital organs during CPR.
has been used alone as a circulatory adjunct as well as in Commercially avail-able ACD-CPR devices have a gauge
conjunction with active compression-decompression CPR meter to guide compres-sion and decompression forces and a
(ACD-CPR) devices. The ITD and ACD-CPR are thought to act metronome to guide duty cycle and chest compression rate.
synergistically to enhance venous return and improve car-diac The use of ACD-CPR in comparison with conventional CPR
output during CPR.8,9 Although initially used as part of a circuit was last reviewed for the 2010 Guidelines. Since the 2010
with a cuffed ETT during bag-tube ventilation, the ITD can also Guidelines, new evidence is available regarding the use of
be used with a face mask, provided that a tight seal is ACD-CPR in combination with the ITD.
maintained between the face and mask.
2015 Evidence Summary
2015 Evidence Summary The combination of ACD-CPR with an ITD has been studied
Three randomized controlled trials (RCTs) in humans have in 4 RCTs reported in 5 publications.9,13–16 Two of these trials
examined the benefits of incorporating the ITD as an adjunct to evaluated ACD-CPR with the ITD in comparison with ACD-
conventional CPR in out-of-hospital cardiac arrest (OHCA). CPR alone.9,13 The first of these used femoral artery catheters
One small single-site RCT of 22 patients with femoral artery to measure improved hemodynamic parameters but found no
catheters demonstrated that a functioning ITD applied to an ETT difference in ROSC, 24-hour survival, or survival to hospital
significantly increased systolic blood pressures as com-pared discharge.9 In a follow-up RCT of 400 patients, the ACD-
with a sham device, although there was no difference in ROSC CPR with a functioning ITD increased 24-hour survival, but
rates.10 The second RCT examined the safety and sur-vival to again there was no difference in survival to hospital
intensive care unit admission of a functioning versus sham ITD discharge or survival with good neurologic function as
in 230 patients.11 The ITD was initially placed on a face mask compared with the ACD-CPR with sham ITD group.13
and was relocated to the ETT after intubation. This study found The remaining 2 RCTs compared ACD-CPR with the ITD
no difference in ROSC, intensive care unit admis-sion, or 24- versus conventional CPR. The first was a single-cen-ter RCT in
hour survival between the 2 groups. The third and largest RCT which 210 patients were randomly assigned to ACD-CPR+ITD
examined the impact of a functioning ITD ver-sus a sham device
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out to 1 year. For survival to hospital discharge with favorable of these studies did any patient survive to hospital discharge.
neurologic function, this translates into a number needed to treat Time-motion analysis of manual versus mechanical chest
of 45 with very wide confidence limits (95% confidence compressions showed that it took considerable time to
interval, 25–333), making interpretation of the true clinical deploy the mechanical piston device, prolonging the no-chest
effect challenging. There was no difference in the overall inci- com-pression interval during CPR.23
dence of adverse events, although pulmonary edema was more
2015 Recommendations—New
common with ACD-CPR+ITD as compared with conventional
The evidence does not demonstrate a benefit with the use of
CPR (11.3% versus 7.9%; P=0.002). The ResQ Trial had a
mechanical piston devices for chest compressions versus man-
number of important limitations, including lack of blinding,
ual chest compressions in patients with cardiac arrest. Manual
different CPR feedback elements between the study arms (ie, co-
chest compressions remain the standard of care for the treat-
intervention), lack of CPR quality assessment, and early
ment of cardiac arrest, but mechanical piston devices may be a
termination. Although improved neurologic function was noted
reasonable alternative for use by properly trained personnel
with the use of the ACD-CPR+ITD combination at both hospital
(Class IIb, LOE B-R). The use of mechanical piston devices
discharge and 1-year follow-up, additional trials are needed to
may be considered in specific settings where the delivery of
confirm these findings.
high-quality manual compressions may be challenging or dan-
2015 Recommendation—New gerous for the provider (eg, limited rescuers available, pro-
The existing evidence, primarily from 1 large RCT of low longed CPR, during hypothermic cardiac arrest, in a moving
quality, does not support the routine use of ACD-CPR+ITD as ambulance, in the angiography suite, during preparation for
an alternative to conventional CPR. The combination may be a extracorporeal CPR [ECPR]), provided that rescuers strictly
reasonable alternative in settings with available equipment and limit interruptions in CPR during deployment and removal of
properly trained personnel (Class IIb, LOE C-LD). the devices (Class IIb, LOE C-EO).
during preparation for ECPR), provided that rescuers strictly 30-day, and 1-year follow-up with the use of ECPR. However,
limit interruptions in CPR during deployment and removal of this study showed no difference in neurologic outcomes.37 A
the devices (Class IIb, LOE C-EO). retrospective observational study including 120 IHCA patients
with historic control reported a modest benefit in both survival
Extracorporeal Techniques and and neurologic outcome at discharge and 6-month follow-up
Invasive Perfusion Devices with the use of ECPR versus conventional CPR.38 A propen-sity-
Extracorporeal CPRALS 723 matched retrospective observational study enrolling 118 IHCA
For the purpose of this Guidelines Update, the term ECPR is patients showed no survival or neurologic benefit with ECPR at
used to describe the initiation of cardiopulmonary bypass during the time of hospital discharge, 30-day, or 1-year follow-up.36
the resuscitation of a patient in cardiac arrest. This involves the One post hoc analysis of data from a prospec-tive, observational
emergency cannulation of a large vein and artery (eg, femoral cohort of 162 OHCA patients, including propensity score
vessels) and initiation of venoarterial extracor-poreal circulation matching, showed that ECPR was associated with a higher rate
and oxygenation. The goal of ECPR is to support patients of neurologically intact survival at 3-month follow-up.39 A
between cardiac arrest and restoration of spontaneous circulation prospective observational study enrolling 454 OHCA patients
while potentially reversible condi-tions are addressed. ECPR is a
demonstrated improved neurologic outcomes with the use of
complex process that requires a highly trained team, specialized
ECPR at 1-month and 6-month follow-up after arrest.40
equipment, and multidisci-plinary support within the local
healthcare system. 2015 Recommendation—New
2015 Evidence Summary There is insufficient evidence to recommend the routine use
There are no data on the use of ECPR from RCTs. Early obser- of ECPR for patients with cardiac arrest. In settings where it
vational studies in small numbers of witnessed in-hospital car- can be rapidly implemented, ECPR may be considered for
diac arrest (IHCA) and OHCA patients younger than 75 years select patients for whom the suspected etiology of the cardiac
with potentially reversible conditions suggested improved arrest is potentially reversible during a limited period of
survival when compared with conventional CPR.32–36 Patients mechanical cardiorespiratory support (Class IIb, LOE C-
receiving ECPR in these studies tended to be younger, with LD). Published series have used rigorous inclusion and
more witnessed arrests and bystander CPR.
exclusion criteria to select patients for ECPR. Although these
The 2015 ILCOR ALS Task Force reviewed several obser-
inclusion criteria are highly variable, most included only
vational studies, some of which used propensity matching. The
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results of the studies are mixed. One propensity-matched patients aged 18 to 75 years, with arrest of cardiac origin,
prospective observational study enrolling 172 IHCA patients after conventional CPR for more than 10 minutes without
reported greater likelihood of return of spontaneous beating in ROSC. Such inclusion criteria should be considered in a
the ECPR group (compared with ROSC in the conventional provider’s selection of potential can-didates for ECPR.
CPR group) and improved survival at hospital discharge,
S440 Circulation November 3, 2015
Disclosures
Part 6: Alternative Techniques and Ancillary Devices for Cardiopulmonary Resuscitation: 2015 Guidelines Update Writing Group Disclosures
Other Speakers’
Writing Group Research Bureau/ Expert Ownership Consultant/
Member Employment Research Grant Support Honoraria Witness Interest Advisory Board Other
Steven C. Brooks Queen’s University Heart and Stroke None None None None None South Eastern
Foundation†; South Ontario Academic
Eastern Ontario Medicine
Academic Medical Organization†
Organization†;
Canadian Institutes
of Health Research†;
National Institutes of
Health Research†;
Department of Defense,
Canada†; US Military†;
Heart and Stroke
Foundation of Canada†
Monique L. Duke Clinical None None None None None None None
Anderson Research Institute
Eric Bruder Emergency None None None None None None None
Medicine
Mohamud R. Daya Oregon Health NIH-NHLBI†; NIH*; None None None None Philips None
and Science NIH-NINR* Health Care
University –Uncompensated*
Alan Gaffney Columbia None None None None None None None
University Medical
Center; University
of Arizona
Downloaded from http://ahajournals.org by on November 3, 2019
Charles W. Otto University of None None None None None None None
Arizona College of
Medicine
Adam J. Singer Stony Brook AHA*; NY State* None None None None None None
University
Ravi R. Children’s NHLBI* None None None None None None
Thiagarajan Hospital, Boston
Consultant
Andrew H. Travers Emergency Health None None None None None American Heart None
Services, Nova Association†
Scotia
This table represents the relationships of writing group members that may be perceived as actual or reasonably perceived conflicts of
interest as reported on the Disclosure Questionnaire, which all members of the writing group are required to complete and submit. A
relationship is considered to be “significant” if (a) the person receives $10 000 or more during any 12-month period, or 5% or more of the
person’s gross income; or (b) the person owns 5% or more of the voting stock or share of the entity, or owns $10 000 or more of the fair
market value of the entity. A relationship is considered to be “modest” if it is less than “significant” under the preceding definition.
*Modest.
†Significant.
Brooks et al Part 6: Alternative Techniques and Ancillary Devices for CPR S441
Appendix
2015 Guidelines Update: Part 6 Recommendations
Year Last
Reviewed Topic Recommendation Comments
2015 Devices to Support Circulation: Impedance The routine use of the ITD as an adjunct during conventional CPR is not new for 2015
Threshold Device recommended (Class III: No Benefit, LOE A).
2015 Devices to Support Circulation: Active The existing evidence, primarily from 1 large RCT of low quality, does not new for 2015
Compression-Decompression CPR and support the routine use of ACD-CPR+ITD as an alternative to conventional
Impedance Threshold Device CPR. The combination may be a reasonable alternative in settings with
available equipment and properly trained personnel (Class IIb, LOE C-LD).
2015 Devices to Support Circulation: Mechanical The evidence does not demonstrate a benefit with the use of mechanical new for 2015
Chest Compression Devices: Piston Device piston devices for chest compressions versus manual chest compressions
in patients with cardiac arrest. Manual chest compressions remain the
standard of care for the treatment of cardiac arrest, but mechanical chest
compressions using a piston device may be a reasonable alternative for use
by properly trained personnel (Class IIb, LOE B-R).
2015 Devices to Support Circulation: Mechanical The use of piston devices for CPR may be considered in specific settings new for 2015
Chest Compression Devices: Piston Device where the delivery of high-quality manual compressions may be challenging
or dangerous for the provider (eg, limited rescuers available, prolonged
CPR, during hypothermic cardiac arrest, in a moving ambulance, in the
angiography suite, during preparation for extracorporeal CPR [ECPR]),
provided that rescuers strictly limit interruptions in CPR during deployment
and removal of the device (Class IIb, LOE C-EO).
2015 Devices to Support Circulation: Load- The evidence does not demonstrate a benefit with the use of LDB-CPR for new for 2015
Distributing Band Devices chest compressions versus manual chest compressions in patients with
cardiac arrest. Manual chest compressions remain the standard of care for
the treatment of cardiac arrest, but LDB-CPR may be a reasonable alternative
for use by properly trained personnel (Class IIb, LOE B-R).
2015 Devices to Support Circulation: Load- The use of LDB-CPR may be considered in specific settings where the new for 2015
Distributing Band Devices delivery of high-quality manual compressions may be challenging or
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2010 Open-Chest CPR Open-chest CPR can be useful if cardiac arrest develops during surgery when not reviewed in 2015
the chest or abdomen is already open, or in the early postoperative period
after cardiothoracic surgery (Class IIa, LOE C).
2010 Open-Chest CPR A resuscitative thoracotomy to facilitate open-chest CPR may be considered not reviewed in 2015
in very select circumstances of adults and children with out-of-hospital
cardiac arrest from penetrating trauma with short transport times to a trauma
facility (Class IIb, LOE C).
2010 Interposed Abdominal Compression-CPR IAC-CPR may be considered during in-hospital resuscitation when sufficient not reviewed in 2015
personnel trained in its use are available (Class IIb, LOE B).
2010 “Cough” CPR “Cough” CPR may be considered in settings such as the cardiac not reviewed in 2015
catheterization laboratory for conscious, supine, and monitored patients if
the patient can be instructed and coached to cough forcefully every 1 to 3
seconds during the initial seconds of an arrhythmic cardiac arrest. It should
not delay definitive treatment (Class IIb, LOE C).
2010 Prone CPR When the patient cannot be placed in the supine position, it may be not reviewed in 2015
reasonable for rescuers to provide CPR with the patient in the prone position,
particularly in hospitalized patients with an advanced airway in place (Class
IIb, LOE C).
2010 Precordial Thump The precordial thump should not be used for unwitnessed out-of-hospital not reviewed in 2015
cardiac arrest (Class III, LOE C).
(Continued )
S442 Circulation November 3, 2015
2010 Precordial Thump The precordial thump may be considered for patients with witnessed, not reviewed in 2015
monitored, unstable ventricular tachycardia including pulseless VT if a
defibrillator is not immediately ready for use (Class IIb, LOE C), but it should
not delay CPR and shock delivery.
2010 Automatic Transport Ventilators During prolonged resuscitation efforts, the use of an ATV (pneumatically not reviewed in 2015
powered and time- or pressure-cycled) may provide ventilation and
oxygenation similar to that possible with the use of a manual resuscitation
bag, while allowing the Emergency Medical Services (EMS) team to perform
other tasks (Class IIb, LOE C).
2010 Manually Triggered, Oxygen-Powered, Manually triggered, oxygen-powered, flow-limited resuscitators may be not reviewed in 2015
Flow-Limited Resuscitators considered for the management of patients who do not have an advanced
airway in place and for whom a mask is being used for ventilation during
CPR (Class IIb, LOE C).
2010 Manually Triggered, Oxygen-Powered, Rescuers should avoid using the automatic mode of the oxygen-powered, not reviewed in 2015
Flow-Limited Resuscitators flow-limited resuscitator during CPR because it may generate high positive
end-expiratory pressure (PEEP) that may impede venous return during chest
compressions and compromise forward blood flow (Class III, LOE C).
2010 Active Compression-Decompression CPR There is insufficient evidence to recommend for or against the routine not reviewed in 2015
use of ACD-CPR. ACD-CPR may be considered for use when providers are
adequately trained and monitored (Class IIb, LOE B).
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