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United States Patent (19) 11) Patent Number: 5,173,288

Everhart et al. 45 Date of Patent: Dec. 22, 1992
54 NAIL POLISH REMOVER COMPRISING 56) References Cited
ACETONE AND HYDROLYZED KERATIN U.S. PATENT DOCUMENTS
75 Inventors: Nelson S. Everhart, Unionville; Peter 3,124,825 3/1964 lovenko .............................. 424/401
Gallagher, Richmond Hill; Ellen J. 3,729,569 4/1973 Charle. ... 424/401
M. Watts, North York, all of Canada 4,445,521 5/1984 Grollier ................................. 424/47
4,485,037 1/1984 Curtis ....... ... 424/40
73) Assignee: Chesebrough-Pond's USA Co., 4,824,662 4/1989 Hofmann .............................. 424/61
Greenwich, Conn.
Primary Examiner-Thurman K. Page
(21) Appl. No.: 700,656 Assistant Examiner-Raj Bawa
22 Filed; May 15, 1991 Attorney, Agent, or Firn-Milton L. Honig
30) Foreign Application Priority Data 57 ABSTRACT
May 15, 1990 (GB) United Kingdom................. 90.10853 An aqueous acetone-based nail polish remover com
prises:
51 Int. Cl. ........................ A61K 7/047; C11D 1/94 i. from 40 to 90% by weight acetone, and
52 U.S. Cl. ...................................... 424/61; 424/401; ii. from 0.001 to 10% by weight of hydrolyzed keratin.
252/546; 252/364; 134/38
58 Field of Search .................................. 424/401, 61 8 Claims, No Drawings
 5,173,288 2
1.
The nail polish remover of the invention also com
NAL POLISH REMOVER COMPRISING prises hydrolysed keratin, whose function is to reduce
ACETONE AND HYDROLYZED KERATIN the amount of moisture loss from the nail following
application of the remover, the water loss being due
FIELD OF INVENTION essentially to the presence of acetone in the nail polish
renover.
The invention relates to an improved aqueous ace The amount of hydrolysed keratin present in the nail
tone-based nail polish remover. polish remover of the invention is from 0.001 to 10%,
BACKGROUND TO THE INVENTION preferably from 0.005 to 1% by weight of the nail polish
Nail polish is readily removed with pure acetone. O renover.
The nail polish remover according to the invention
However, acetone alone has a severe dehydrating effect preferably also comprises lanolin or a derivative
upon skin, finger and toe nails, which is irritating to the thereof, whose function is further to reduce moisture
former and renders the latter susceptible to cracking loss from the nail following topical application of the
and breaking. Therefore, acetone-based commercial 15
nail polish remover to nails from which polish is to be
nail polish removers all contain other ingredients, e.g., renoved.
water and/or oils, which lower this dehydrating effect
but with the inevitable consequence that the efficacy of A preferred lanolin derivative for use in accordance
the polish remover is lowered. For example, Cutex with the invention is PPG-12-PEG-50 lanolin, avail
(registered Trade Mark), a well known acetone-based 20 able, for example, as Lanexol AWS (ex Croda).
polish remover, has about 80% of the polish removal The amount of lanolin or derivative thereof when
efficacy of pure acetone. Several other commercial present in the nail polish remover of the invention is up
brands, e.g., Quickie Instant (registered Trade Mark), to 20%, preferably from 1 to 20%, and most preferably
Unpolish (registered Trade Mark), and Dip. It (regis from 2 to 10% by weight of the nail polish remover.
tered Trade Mark), have substantially less. 25 Other Ingredients
It would be desirable if the nail water removal activ
ity of aqueous acetone based polish removers which The nail polish remover of the invention can option
have high polish removal efficacy, e.g., those contain ally also comprise a cosmetically acceptable water-solu
ing at least about 80% acetone and which have at least ble amine salt of a fatty acid amide of a hydrolysed
half the water removal activity of pure acetone, could 30 collagen having the structure (1):
be substantially lowered without adversely affecting
their polish removal efficacy. To date, no such polish R R (1)
remover formulation is known to exist. It is an object of R'---CO---NH---(CH-CONH)-CH-COOH
this invention to provide an aqueous acetone-based nail
polish remover having high polish remover efficacy but 35 wherein R is the side chain of a primary or a-amino acid
less nail water removal activity than corresponding
conventional polish removers. It is another object to polymer unit of the hydrolysed collagen, x is the integer
provide a method of removing nail polish employing from 20 to 40, and R'-CO- is acyl radical of the ami
dizing fatty acid of from 5 to 18 carbon atoms.
the novel polish removers of this invention. Preferably the nail polish remover of the invention
40
SUMMARY OF THE INVENTION comprises up to 0.15%, preferably from 0.01 to 0.15%
The invention concerns an aqueous acetone-based by weight of water-soluble amine salt of the fatty acid
amide of a hydrolysed collagen.
nail polish remover comprising an effective amount of The nail polish remover of the invention can also
hydrolysed keratin, preferably together with an effec optionally comprise a cosmetically acceptable acid ad
tive amount of lanolin or a derivative thereof, particu 45 dition salt of a mono-fatty acid-amido substituted-trialk
larly an ethoxylated lanolin derivative. The hydrolysed
keratin functions to reduce substantially the nail water ylamine cationic surfactant.
removal activity of the polish remover; this benefit is Preferably the nail polish remover comprises from 0.1
further improved when the lanolin, or a derivative to 0.8% by weight of the acid addition salts of a mono
thereof, is also present. 50 fatty acid-amido substituted-trialkylamine cationic sur
The invention also relates to a method of removing factant.
nail polish by employing a polish remover of the inven optionally The nail polish remover of the invention can also
tlOn. comprise other ingredients conventionally
employed in nail polish removers. These include sol
DEFINITION OF THE INVENTION Accordingly, 55 vents in addition to acetone, for example, isopropylal
the invention provides an aqueous acetone-based nail cohol, colouring agents, perfumes, viscosity raising
polish remover which comprises: agents, other emollients, moisture impermeable film
i. from 40 to 90% by weight acetone, and formers such as nitrocellulose.
i. from 0.001 to 10% by weight of hydrolysed keratin. Evidence to Demonstrate Superiority of the Nail
60 Varnish Remover of the Invention
DISCLOSURE OF THE INVENTION
The nail polish remover of the invention comprises A panel of 13 women who conventially use nail var
an amount of acetone sufficient at least partially to re nish was selected.
move nail polish from nails to which a polish has been All panellists removed their original nail varnish and
applied. 65 then reapplied to the finger nails of each hand fresh
The amount of acetone present in the nail polish re varnish supplied to them. The fresh varnish was pro
mover of the invention is from 40 to 90%, preferably vided from the Cutex range, each panellist being given
from 50 to 80% by weight of the nail polish remover. a bottle from the same batch.
 3
5,173,288
20 minutes after application, when the varnish had -continued
thoroughly dried, the nail varnish was removed using Ingredient % w/w
either of the following two formulations, the "Test PPG-12-PEG-50 Lanolin 2.5
formulation being applied to the nails of one hand and 5 Cocamidopropyl dimethylamine 0.5
the "control to the nails of the other. propionate(?)
Aminomethylpropanol salt of 0.
isostearic hydrolysed collagen(3)
% w/w Fragrance and colour 0.8
Ingredient TEST (#1) CONTROL (#2) (Crotein ASK 10-15% solution in alcohol (ex Croda)
10 (EMCOL 655 (ex Emery)
Acetone 54.0 54.0 (3)CROTEIN AD (ex Croda)
Isopropyl alcohol 33.0 33.0
Water 9.0 9. What is claimed is:
Hydrolysed animal keratin) 0.1 -
PPG-12-PEG-50 Lanoin 2.5 2.5 1. An aqueous acetone-based nail polish remover
Cocamidopropyl dimethylamine 0.5 0.5 15
which comprises:
propionate(?) i. from 40 to 90% by weight acetone, and
Aminomethylpropanol salt of O. 0.1 i. from 0.001 to 10% by weight of hydrolysed kera
isostearic hydrolysed collagen tin.
Fragrance and colour 0.8 0.8 2. The nail polish remover according to claim 1,
(Crotein ASK: 10-15% solution in alcohol (ex Croda)
(EMCOL 1655 (ex Emery) 20
which comprises from 50 to 80% by weight acetone.
(CROTEIN AD (ex Croda) 3. The nail polish remover according to claim 1,
which comprises from 0.005 to 1% by weight of hydro
lysed keratin.
Each panellist was asked to complete a questionnaire 4. The nail polish remover according to claim 1,
indicating preferences against a list of attributes. The which further comprises from 1 to 20% by weight of
cumulative results are set out in Table 1 below: 25 lanolin or a derivative thereof.
TABLE 1. 5. The nail polish remover according to claim 4, in
Nail Polish Remover Test
which the lanolin derivative is PPG-12-PEG-50 lanolin.
"Please remove the nail polish from the nails of your left 6. The nail polish remover according to claim 1,
hand with sample #1 and the nail polish from the nails of 30
which further comprises a cosmetically acceptable
your right hand with #2". water-soluble amine salt of a fatty acid amide of a hy
#1 h2 No drolysed collagen having the structure (1)
Compare #1 with #2 preferred preferred preference
effectiveness at 6 3 4. R R (1)
removing nail polish 35
feel of nail after use 9 2 2 R"-COrNH-(CH-CONH)-CH-COOH
(smoothness, softness)
"fragrance 8 4. 1 wherein R is the side chain of a primary or a-amino acid
'whitening of nail 6 3 4. polymer unit of the hydrolysed collagen, x is an integer
Do you have any overall 9 3 1 of from 20 to 40, and R'-CO- is acyl radical of the
preference? amidizing fatty acid having from 5 to 18 carbon atoms.
Note: the less whitening the better the product. 7. The nail polish remover according to claim 1,
which further comprises a cosmetically acceptable acid
From these results, it was concluded that there was addition salt of a mono-fatty acid-amido substituted
an overwhelming preference for the Test product #1 trialkylamine cationic surfactant.
which contained hydrolysed animal keratin. Of the 45 8. The nail polish remover according to claim 1,
individual attributes reported on, the preference for feel which comprises:
of nail after use was most marked, this being perhaps the i. from 0 to 80% by weight of acetone,
most important consumer perceivable attribute. Also, ii. from 0.001 to 1% by weight of hydrolysed keratin,
the after use fragrance was clearly superior with the iii. from 1 to 5% by weight of PPG-12-PEG-50 lano
50 lin,
Test product, indicating a more pronounced delivery
and substantivity to the nail of the fragrance carried by iv. from 0.01 to 0.15% by weight of a cosmetically
the Test nail varnish remover. acceptable water-soluble amine salt of a fatty acid
amide of hydrolysed collagen having the structure
EXAMPLES (1)
55
The invention is further illustrated with reference to R R
the following example. (1)

EXAMPLE 1.
R"-CO-NH-(CH-CONH)-CH-COOH
A nail polish remover in accordance with the inven 60 wherein R is the side chain of a primary or a-amino
tion contained the following ingredients: acid polymer unit of the hydrolysed collagen, x is
the integer from 20 to 40, and R'-CO- is acyl
radical of the amidizing fatty acid having from 5 to
Ingredient % w/w 18 carbon atoms, and
Acetone 54.0 65 v. from 0.1 to 0.8% by weight of cosmetically accept
Isopropyl alcohol 33.0 able acid addition salt of a mono-fatty acid-amido
water 9.0 substituted-trialkylamine cationic surfactant.
Hydrolysed animal keratin() 0. x k r k r