Professional Documents
Culture Documents
A Research Paper
Presented to the
Biology Department
Adventist University of the Philippines
In Partial fulfillment
Of the Requirements for the Course
Microbiology and Parasitology Lecture
Measles in the 10th century was described by Muhammad ibn Zakariya ar-Razi (860-
932) or Rhazes – a Persian philosopher and physician, as a disease that is “more dreaded than
smallpox”. “The Book of Smallpox and Measles” was published by him also.
agent that is infecting the blood of the patient. In the 9th century, a Persian doctor published
one of the first written accounts of measles disease. In 1912, measles became a nationally
notifiable disease in the United States, requiring U.S. healthcare providers and laboratories to
report all diagnosed cases. In the first decade of reporting, an average of 6,000 measles-related
deaths were reported each year. In the decade before 1963 when a vaccine became available,
nearly all children got measles by the time they were 15 years of age. Is was estimated to have
3 to 4 million people in the United States that were infected by measles. Also, each year, among
reported cases, an estimated 400 to 500 people died, 48,000 were hospitalized, and 1,000
suffered encephalitis (swelling of the brain) from measles Current measles outbreak started late
2017 in Mindanao. In 2018, 20,827 cases were reported with 199 deaths. Outbreak and
the immunization activity was met with increased vaccine hesitancy due to the Dengue vaccine
coverage in recent years resulted in large immunity gaps among younger children against
In the decade before the measles vaccine was licensed in 1963, an average of 549,000
measles cases and 495 measles deaths were reported annually in the United States. However,
it is likely that, on average, 3 to 4 million people were infected with measles annually; most
cases were not reported. Of the reported cases, approximately 48,000 people were hospitalized
from measles and 1,000 people developed chronic disability from acute encephalitis caused by
measles annually. It is critical for all international travellers to be protected against measles,
From 1989 to 1991, a major resurgence occurred, affecting primarily unvaccinated pre-
schoolers; this measles resurgence resulted in 55,000 cases and 130 deaths and prompted the
recommendation that the second dose of measles vaccine be given to pre-schoolers in a mass
vaccination campaign that led to the effective elimination in the United States of endemic
parental concerns about the safety of measles, mumps, and rubella (MMR) vaccine caused
many children to go unvaccinated. As a result of this outbreak, many persons were exposed,
and at least 7 infants too young to receive MMR vaccine were infected.
From January 1 to May 23, 2014, 288 confirmed cases were reported to the CDC, a
figure that exceeds the highest reported annual total number of cases (220 cases in 2011) since
measles was declared eliminated in the United States in 2000. In developing countries, measles
affects 30 million children a year and causes 1 million deaths. Measles causes 15,000-60,000
In 1998, the cases of measles per 100,000 total population reported to the WHO was
1.6 in the Americas, 8.2 in Europe, 11.1 in the Eastern Mediterranean region, 4.2 in South East
In 2000, measles was declared eliminated from the United States. Elimination is defined
as the absence of endemic measles virus transmission in a defined geographic area, such as a
because measles is still commonly transmitted in many parts of the world, including countries
in Europe, the Middle East, Asia, the Americas, and Africa. Worldwide, an estimated 10
million measles cases and 110,000 deaths from measles are reported each year.
Since 2000, when measles was declared eliminated from the U.S., the annual number
of cases has ranged from a low of 37 in 2004 to a high of 667 in 2014. The 2019 case count
exceeded 2014 levels as of April 26, 2019 and continues to climb. Most cases have been among
people who are not vaccinated against measles. Measles cases in the United States occur as a
result of importations by people who were infected while in other countries and from
transmission that may occur from those importations. Measles is more likely to spread and
These are the countries measle have visited, including, but not limited to, the
Philippines, Ukraine, Israel, Thailand, Vietnam, England, France, Germany, and India, where
large outbreaks were reported. Outbreaks in countries to which Americans often travel can
directly contribute to an increase in measles cases in the United States. Measles importations
declared measles outbreaks in five regions in the Philippines – Metro Manila (NCR), Central
Luzon (Region 3), CALABARZON (Region 4A), Western Visayas (Region 6), and Central
Visayas (Region 7). Other regions also have rising measles cases and are at risk for possible
outbreaks if the epidemic is not contained. Last year, measles outbreaks were also declared
including in Mindanao (Davao City, Zamboanga City) Metro Manila (Taguig City), and some
by DOH with 203 deaths from 1 January to 23 February 2019. Over half of the measles cases
are under 5 years of age, with median age of 2 years old. Of the total measles cases, 63% have
not been vaccinated, 19% have unknown number of doses and 16% have unknown vaccination
status. DOH has reported rising measles since last year with 18,407 cases in 2018 compared to
RNA virus of the genus Morbillivirus within the family Paramyxoviridae. Measles virus is
mostly seen in the winter and spring. It's spread from one child to another through direct contact
with discharge from the nose and throat. Sometimes, it is spread through airborne droplets
Through sneezing and coughing via close personal contact or direct contact with
secretions, this virus spreads because it is highly contagious. It is really contagious that if one
acquires it, 90% of non-immune people will also acquire it. Humans are the only natural hosts
Risk factors for measles virus infection include immunodeficiency caused by HIV or
measles commonly occurs or contact with travelers from such an area; and the loss of passive,
Symptoms typically begin 10–14 days after exposure. The classic symptoms include a
four-day fever (the 4 D's) and the three C's—cough, coryza (head cold, fever, sneezing), and
conjunctivitis (red eyes)—along with a maculopapular rash. Fever is common and typically
lasts for about one week; the fever seen with measles is often as high as 40 °C (104 °F).
Koplik's spots seen inside the mouth are diagnostic for measles but are temporary and
therefore rarely seen. Koplik spots are small white spots that are commonly seen on the inside
of the cheeks opposite the molars. They appear as "grains of salt on a reddish background."
Recognizing these spots before a person reaches their maximum infectiousness can help reduce
maculopapular rash that begins several days after the fever starts. It starts on the back of the
ears and, after a few hours, spreads to the head and neck before spreading to cover most of the
body, often causing itching. The measles rash appears two to four days after the initial
symptoms and lasts for up to eight days. The rash is said to "stain", changing color from red to
dark brown, before disappearing. Overall, measles usually resolves after about three weeks.
Most people recover from measles, but some people develop health complications that
can be serious. Complications occur because the measles virus affects a person’s immune
Up to one-third of people with measles experience one or more complications and one
in ten people with measles will require hospital treatment. Children under five years old are
(inflammation of the voice box), Pneumonia, Encephalitis (swelling of the brain), Croup
(inflammation of the airway), Pregnancy problems., Bacterial ear infection, which can lead to
Even with treatment, one or two out of 1000 people with measles will die.
Measles occurring during pregnancy increases the risk of premature labor, miscarriage,
and low-birth-weight infants. Birth defects have not been linked to measles during pregnancy.
systems, such as people with HIV/AIDS and those receiving cancer treatment
DIAGNOSIS
If you suspect that you have measles or have been exposed to someone with measles,
contact your doctor immediately. They can evaluate you and direct you where to be seen to
Doctors can confirm measles by examining your skin rash and checking for symptoms that are
characteristic of the disease, such as white spots in the mouth, fever, cough, and sore throat.
If they suspect you may have measles based on your history and observation, your
doctor will order a blood test to check for the measles virus.
Healthcare providers should consider measles in patients presenting with febrile rash
illness and clinically compatible measles symptoms, especially if the person recently traveled
internationally or was exposed to a person with febrile rash illness. Healthcare providers should
report suspected measles cases to their local health department within 24 hours.
Laboratory confirmation is essential for all sporadic measles cases and all outbreaks.
polymerase chain reaction (RT-PCR) in a respiratory specimen are the most common methods
for confirming measles infection. Healthcare providers should obtain both a serum sample and
a throat swab (or nasopharyngeal swab) from patients suspected to have measles at first contact
with them. Urine samples may also contain virus, and when feasible to do so, collecting both
respiratory and urine samples can increase the likelihood of detecting measles virus.
Molecular analysis can also be conducted to determine the genotype of the measles
virus. Genotyping is used to map the transmission pathways of measles viruses. The genetic
data can help to link or unlink cases and can suggest a source for imported cases. Genotyping
is the only way to distinguish between wild-type measles virus infection and a rash caused by
all patients with clinical features compatible with measles. When sending specimens for testing
please contact your health department to determine where to submit specimens and how to ship
them.
To send specimens to CDC from within the US, use the CDC Specimen Submission
Form. You must provide Contact name with telephone number and email address, Type of
virus specimen and date collected, Date serum sample collected, MMR vaccination history
[date(s) if known], Clinical signs and symptoms, Patient’s date of birth or age,
Collect the first (acute-phase) serum sample as soon as possible upon suspicion of
measles disease. If the acute-phase serum sample collected ≤3 days after rash onset is negative,
and the case has a negative (or not done) result for RT-PCR, a second serum sample collected
3–10 days after symptom onset is recommended because, in some cases, the IgM response is
not detectable until 3 days after symptom onset. Store specimens at 4°C and ship on wet ice
packs.
Detection of measles RNA and measles virus isolation are most successful when
samples are collected on the first day of rash through the 3 days following onset of rash.
However, virus may still be recovered by cell culture through day 10 following rash onset.
Detection of measles RNA by RT–PCR may be successful as late as 10-14 days post rash onset.
Collect throat or nasopharyngeal swab samples as soon as measles disease is suspected. RT-
PCR has the greatest diagnostic sensitivity when samples are collected at first contact with a
suspected case.
A commercial product designed for the collection of throat specimens or a flocked
polyester fiber swab can be used. Synthetic swabs are preferred over cotton swabs, which may
contain substances that are inhibitory to enzymes used in RT-PCR. Flocked synthetic swabs
Swabs should be placed in 2 ml of standard viral transport medium (VTM) [1]. Allow
the swab to remain in VTM for at least 1 hour (4°C). Ream the swab around the rim of the tube
to retain cells and fluid in the tube. The swab can be broken off and left in the tube or discarded.
Storage and shipment: Following collection, samples should be maintained at 4°C and
shipped on cold packs (4°C) within 24 hours. If there is a delay in shipment, the sample is best
Processing the swabs within 24 hours of collection will enhance the sensitivity of both the RT-
Cell culture medium (minimal essential medium or Hanks’ balanced salt solution) or
other sterile isotonic solution (e.g. phosphate buffered saline) can be used. The presence of
protein, for example 1% bovine albumin, 0.5% gelatin, or 2% serum, stabilizes the virus.
Samples without a source of protein in the medium will lose 90%–99% infectivity within 2
hours at 4°C.
Urine specimens
resuspended in 2 ml of VTM. Storage and Shipment: Store urine sediment in VTM at 4°C and,
if possible, ship on cold packs within 24 hours. The best method for preserving measles virus
in processed (centrifuged) urine is to freeze the sample at −70°C and ship on dry ice
Reverse-transcription polymerase chain reaction (PCR). Reverse-transcription
polymerase chain reaction (PCR) evaluation is highly sensitive at visualizing measles virus
RNA in blood, throat, nasopharyngeal, or urine specimens and, where available, can be used
the frequent occurrence of measles pneumonia, even in uncomplicated cases, limits the
Antibody assays. The measles virus sandwich-capture IgM antibody assay, offered
through many local health departments and through the CDC, is the quickest method of
confirming acute measles; laboratories can confirm measles by demonstrating more than a 4-
fold rise in IgG antibodies between acute and convalescent sera, although relying solely on
Hydration. Maintenance of good hydration and replacement of fluids lost through diarrhea or
Antibiotic therapy. Secondary infections (e.g., otitis media or bacterial pneumonia) should be
treated with antibiotics; patients with severe complicating infections (eg, encephalomyelitis)
should be admitted for observation and antibiotics, as appropriate to their clinical condition.
(Ig).
Pharmacologic Therapy
Medications used in the treatment or prevention of measles include vitamin A, antivirals (eg,
Vitamin A. Vitamin A treatment for children with measles in developing countries has been
associated with a marked reduction in morbidity and mortality; thus, two doses of vitamin A
given 24 hours apart are recommended; a third age-specific dose should be given 2 to 4
weeks later to children with clinical signs and symptoms of vitamin A deficiency.
Antivirals. Measles virus is susceptible to ribavirin in vitro; although ribavirin (either IV or
aerosolized) has been used to treat severely affected and immunocompromised adults with
acute measles or SSPE (IV plus intrathecal high-dose interferon alfa), no controlled trials
have been conducted; ribavirin is not approved by the US Food and Drug Administration
(FDA) for this indication, and such use should be considered experimental.
Vaccines. The live MMR vaccine is used to induce active immunity against viruses that cause
Physical exam. Assess the child for symptoms that may indicate the presence of measles.
Knowledge of the disease. Assess the patient’s or significant other’s knowledge regarding the
disease.
Hygienic practices. Assess the family’s hygienic practices to prevent the spread of the
disease.
Isolation. Patients will need to be on isolation precautions to decrease transmission within the
community; emphasize the need for immediate isolation when early catarrhal symptoms
appear.
Skin care. Measles causes extreme pruritus; nursing interventions include keeping the
patient’s nails short, encourage long pants and sleeves to prevent scratching, keeping skin
moist with health care provider recommended lotions, and avoiding sunlight and heat.
Eye care. Treat conjunctivitis with warm saline when removing eye secretions and encourage
patient not to rub eyes; protect the eyes from the glare of strong light.
Hydration. Encourage oral hydration; medical literature encourages the use of oral
rehydration solution.
temperature greater than 100.4 Fahrenheit unless directed elsewise by a healthcare provider;
be sure to remind parents not to administer aspirin due to the risk of Reye’s syndrome.
PROGNOSIS AND TREATMENT
The outcome for most cases of measles is excellent. Once the disease passes, the person
will be protected against contracting it again. In cases where there are severe complications,
the chances of long-term problems are less certain and vary on a case-by- case basis.
Complications are rare but may be serious. This is the reason why health care
There is no specific antiviral treatment or cure for measles. Children should stay at
home and out of school until cleared to return by their health care professional. Health
researchers have noticed that some children in underdeveloped countries or those throughout
the globe who develop a severe case of measles have low vitamin A blood levels and seem to
have a reduction of their symptoms if given vitamin A supplementation. Current guidelines are
that all patients with rubeola should start a 2-day course of vitamin A at the time of diagnosis.
Contact a doctor immediately. As soon as you think that you or someone you know
may have measles, make an appointment with your doctor to receive a proper diagnosis.
Describe your symptoms and try to schedule your appointment as soon as possible. Follow any
instructions given by the doctor. Since measles can appear like chicken pox, it's important to
get a definitive diagnosis from your doctor so that proper treatment is given.
Your doctor will likely recommend you stay home and avoid contact with other people.
Measles is very contagious, so isolation is key to preventing an outbreak. Be aware that your
doctor may ask you to take special precautions when you come to the office, like wearing a
mask or using a back entrance, to prevent the spread of measles. In some cases, the doctor may
come out to your car rather than have you come into the office. This is to prevent the spread of
the infection to nurses and patients, particularly those who are pregnant.
Bring the fever down with over the counter medication. Measles is often accompanied
with a fever that can peak at 104°F (40°C). Use over the counter (OTC) pain relievers like
level. Follow the directions on the bottle for the correct dosage and timing.
As a bonus, these pain medicines will also help to relieve the aches and pains associated
with the measles virus. Note: Do not give aspirin to children unless instructed to by your doctor,
Rest. Almost everyone who gets measles will require plenty of rest to recover. Measles
is usually a serious viral infection that takes much of your body's energy and resources to fight.
On top of this, the symptoms of measles can leave you feeling more drained and fatigued than
you normally would. Be sure to allow for plenty of sleep and restrict all physical activities
People who have measles are contagious from 1-2 days before they show symptoms
until about 4 days after symptoms begin. However, the disease incubates for 14 days, so you
may be contagious for that entire time. Since the disease is spread by coughing and sneezing,
it's important you stay home during this time. Plan to rest at home for about a week. It may
take a while for the rash to heal, but you usually aren't contagious after 4 days of symptoms.
Keep the lights dim. The facial rash that causes measles can produce conjunctivitis —a
condition involving inflamed, watery eyes. This can make people with measles sensitive to
light. Use heavy curtains on windows and keep overhead lighting dim when suffering from
While you won't generally want to leave your house when you have measles, if, for
some reason, you are forced to, try using a pair of shades to protect your eyes.
Keep the eyes clean with gentle cotton swabs. As noted above, the eye condition
conjunctivitis is an increased production of discharge in the eyes. This discharge can cause the
eyes to become "crusty" or even stuck shut (especially after sleeping.) Remove the crustiness
from the eyes by dipping a cotton ball in clean, warm water and wiping from the corner of the
Conjunctivitis can be very serious, so it's best to prevent it. Maintain good hygiene to
prevent the spread of germs to the eyes. If you're caring for a child who has measles, keep their
hands washed and put gloves on their hands to decrease the likelihood that they'll scratch their
rash then put their hands to their eyes. Press very gently when you are cleaning your eyes—
since your eyes are already inflamed, they will be extra-sensitive to pain and damage.
As much as possible, you must avoid touching your genital area. Once measles spread
into your genital area, there will be a possibility that you'll have UTI. The measles infection
can spread to your genitals and cause, as well as other complications. Make sure you have
washed and cleanse your hands before wiping your genital area. If you're caring for a child
with measles, make sure they don't touch their private parts.
Run a humidifier. Humidifiers increase the amount of moisture in the air by evaporating
water to create vapor. Running a humidifier in the room with you while you are sick will keep
the air moist, which can help soothe the sore throat and cough that accompany the measles
virus.
If a humidifier is not available, just place a large bowl of water in the room to increase the
ambient humidity. Note that some humidifiers allow you to add a medicated inhalant to the
water vapor. If your humidifier lets you do this, pick a cough suppressant, like Vick's.
Hydrate. Like many illnesses, measles drains your body's supply of moisture faster than
it normally would deplete, especially if you have a fever. For this reason, it' very important to
stay well-hydrated to keep the body strong enough to fight the infection until you feel better.
As a rule, clear fluids, especially clean, clear water, are best for sick people.
Although complications are rare, one should contact a physician if symptoms worsen
breath, a cough that produces sputum, and/or chest pain may be symptoms of pneumonia.
Doctors must report all cases of rubeola and rubella to the local public health department. This
allows close monitoring, which is necessary to track new cases and enables the U.S. Centers
for Disease Control and Prevention (CDC) to have up-to-date statistics for both local regions
Measles is a highly contagious respiratory infection that's caused by a virus that infects only
humans. It is transmitted by respiratory droplets and direct contact with nasal or throat
The incubation period of measles ranges between 7 and 18 days and patients are infectious
from about 4 days before developing the rash until 4 days after rash. The illness is presented
by high fever, generalized rash, and cough, coryza (runny nose) or conjunctivitis (red eyes).
Complications of measles include viral and bacterial pneumonias and severe diarrhea. The
disease can also lead to lifelong disabilities including brain damage, blindness and deafness.
Measles kills more children than any other vaccine-preventable disease. Before the widespread
use of vaccine, 90% of children had contracted measles by the age of 10 years. An effective
vaccine has been available since the 1960s, and all countries offer measles-containing vaccine
Measles is highly transmissible; almost all non-immune children contract measles if exposed
to infection. Poorly nourished children and those whose immune systems have been weakened
by HIV/AIDS or other diseases are severely at high risk of developing measles complication
and death.
Measles occurs worldwide and it is still a significant cause of childhood morbidity and
mortality despite the existence of effective vaccine. Measles infection has its greatest incidence
Getting vaccinated is the best way to prevent measles. Two doses of the measles vaccine are
There are two vaccines available — the MMR vaccine and the MMRV vaccine. The MMR
vaccine is a three-in-one vaccination that can protect you from measles, mumps, and rubella.
The MMRV vaccine protects against the same infections as the MMR vaccine and also includes
Children can receive their first vaccination at 12 months, or sooner if traveling internationally,
and their second dose between the ages of 4 and 6. Adults who have never received an
People who’ve had a previous life-threatening reaction to the measles vaccine or its
with HIV or AIDS, people undergoing cancer treatment, or people on medications that suppress
Side effects to vaccination are typically mild and disappear in a few days. They can include
things like fever and mild rash. In rare cases, the vaccine has been linked to low platelet count
or seizures. Most children and adults who receive a measles vaccine don’t experience side
effects.
Some believe that the measles vaccine can cause autism in children. As a result, an intense
amount of study has been devoted to this topic over many years. This research has found that
when you are vaccinated, you protect people who haven’t had any vaccines. There’s a least
possibility that virus will spread within the community. To achieve herd immunity against
Not everyone can receive the measles vaccination. But there are other ways that you can help
Practice goo hand hygiene in which you wash your hand before eating your meals and after
Do not ever share any personal items to people you know who is sick. This include the common
things you have in your house like toothbrush, eating utensils, drinking glasses, etc.
You must stay away from school or any public places and just stay at home until you can say
You must stay away from people who are susceptible to being infected like the infant,
When there is an urge to cough or sneeze, cover your mouth. You have to throw away all tissues
that have been used. Dispose is properly. If there’s not tissue available, make use of the crook
of your elbow and not into your hand. Be sure to practice proper handwashing and proper way
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