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Original Article
International Journal of Health & Allied Sciences • Vol. 4 • Issue 2 • Apr-Jun 2015 83
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Gurjar, et al.: Conversion of room for Ir‑192 HDR unit to room for Co‑60 HDR unit
In brachytherapy, radiation dose is delivered to the activities of both the sources (370 GBq for Ir‑192 and
treatment volume either by implant (permanent or 74 GBq for Co‑60). [4] So, Co‑60 radioisotope based
temporary) of radionuclide in tumor volume or by HDR remote after loading brachytherapy unit (HDR
placement of radionuclide after catheters has been unit) is the alternate solution of the above problem
put in treatment volume. On the basis of dose rate which provides the optimized service considering
and its radiobiological consequences brachytherapy clinical benefits, half‑life, cost, and repeated processing
has been categorized in three categories viz. low dose documentation and administrative workouts. The chief
rate (LDR; 0.4–2 Gy/h), medium dose rate (MDR; advantage is fairly long half‑life of Co‑60 (5.26 years),[2]
2–12 Gy/h), and high dose rate (HDR; >12 Gy/h) thus source replacement becomes infrequent, although
brachytherapy. [1] Nowadays, HDR afterloading mean energy of this radioisotope is higher (1.25 MeV)
brachytherapy is commonly used amongst the above than that of Ir‑192 (0.38 MeV). This will demand larger
three, where Ir‑192 radionuclide is popularly used thick concrete walls of brachytherapy housing compared
isotope with source strength of 10 Ci or less. [2] to Ir‑192 source.[5]
Interstitial brachytherapy (for the treatment of head
and neck tumors, breast, soft tissue sarcoma, and skin Our institute had prepared room for I‑192 HDR unit,
tumors), intracavitary brachytherapy (for the treatment but later on decided to install Co‑60 HDR remote after
of cervical cancer), intraluminal brachytherapy (for the loading brachytherapy unit. The existing room had been
treatment of esophagus, uterus, trachea, bronchus, and converted to conform to radiological safety requirements
rectum), and topical brachytherapy (for the treatment of Co‑60 brachytherapy room by doing some necessary
of molds of the body part) are the main applications alterations. This study presents complete details about
of brachytherapy.[3] design and modifications of Ir‑192 housing to converted to
suit Co‑60 room and evaluation of radiation safety around
Very high conformal dose to target volume sparing the converted room with Co‑60 HDR unit.
the organs at risk (OARs) can be delivered by IMRT
technique. Recent publications suggest that several MATERIALS AND METHODS
brachytherapy procedures have been replaced by these
highly precision external beam techniques. However, Ir‑192 (max activity 10Ci) HDR unit housing was built
brachytherapy continues to be the most conformal at our institution as per room layout plan approved by
treatment modality with very high dose delivery to the regulatory body “Atomic Energy Regulatory Body (AERB),
core of target volume and excellent dose fall to spare Mumbai” as shown in Figure 1 (i). The wall thicknesses
the OARs with least integral dose. It continues to enjoy were as follows;
radiobiological superiority and it has the ability to
boost the target volume with judicious choice of target Wall A = 30 cm, wall A' = 40 cm, wall B = 140 cm, maze
volume to achieve better outcome. However, some of the wall = 30 cm, wall B' = 35 and 23 cm (back to maze wall),
practices have been shifted to external modality because and roof C = 47 cm.
of ease of the procedure. This has resulted in reduction
of number of brachytherapy procedures; hence, many After the decision to convert the abovementioned
radiotherapy centers have very low number of cases. Ir‑192 room to house the HDR unit (Bebig GyneSource
Since half‑life (T1/2) of Ir‑192 radioisotope is low, that HDR, Eckert and Zeigler Bebig GmbH, Germany) loaded
is, 73.8 days,[2] it requires replacement of source every with Co‑60 radioisotope (model Co0. A86, Eckert and
3–4 months which work outs economical expenses as Ziegler Bebig GmbH, Germany) with initial nominal
well as a generation and coordination with statutory activity of 74 GBq and apparent activity of 66.96 GBq,
authorities for source procurement, loading transporting, room layout plan as shown in Figure 1 (ii) was sent to
and disposal with multiple documentation procedures AERB for approval. After getting official approval, all
with regulatory body’s rules. the walls (except wall B) and roof was added with 15 cm
uniform thickness of concrete. Since the tenth value
In last few years, Co‑60 with enhanced specific activity layer (TVL) of concrete for Ir‑192 is 14 cm, whereas, for
made possible to design miniaturized sources which Co‑60 it is 21 cm; so for the walls (wall A and maze wall)
are equal to Ir‑192 sources. Applicators are same in with 30 cm thickness prepared for Ir‑192 must be added
shape and diameter, application techniques are also 15 cm more for housing Co‑60. Although the calculated
same in both, and the irradiation time on average is thicknesses for other walls (wall A', wall B', and roof C)
only 1.7 times longer for Co‑60 with initial nominal came different than 15 cm, but by seeing the surrounding
84 International Journal of Health & Allied Sciences • Vol. 4 • Issue 2 • Apr-Jun 2015
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Gurjar, et al.: Conversion of room for Ir‑192 HDR unit to room for Co‑60 HDR unit
Figure 1: Approved room Layout plan for (i) Ir-192 (walls sketched with dots) and (ii) Co-60 (walls sketched with dots + fully
black color) high dose rate (HDR) remote afterloading Brachytherapy
of room and uniformity of wall thicknesses, management in console so that the instantaneous dose rate (IDR) inside
decided to add 15 cm additional thickness on all the walls room can be seen in console.
and roof. Also since the old room was with height of
485 cm which was more than required height, a second Co‑60 source was loaded with due observance of statutory
15 cm concrete had to be added which was tough just in procedures and all necessary quality assurance (QA)
touch with old ceiling. So, the new ceiling with 15 cm tests were performed as per performa “RP and AD/
thickness was constructed at 300 cm height. Thus hollow Remote QA/01”provided by Radiological Physics and
space of 170 cm got created which is totally empty and Advisory Division, Bhabha Atomic Research Centre.[7]
packed from all sides. The thicknesses of all walls and To check the unit leakage, radiation survey around the
roof after modification are as follows: HDR unit (in source OFF condition) was done at
5 cm from the unit surface and 1 m from center of the
Wall A = 45 cm, wall A' = 55 cm, wall B = 140 cm, maze source storage in all direction as shown in Figure 2,
wall = 45 cm, wall B' = 50 and 23 cm (back to maze wall), and then radiation survey was done all around the
roof C = 15 cm + 170 cm air space + 47 cm.
room using digital contamination monitor (Micro)
Type: CM710P (Pancake) (Nucleonix Systems Pvt Ltd,
Our designing consideration envisages erection of maze
to bolster the radiation safety, thus there is no need of Hyderabad, India) capable of measuring β and γ rays and
a heavy lead door to stop the scatter reaching to door.[6] having measuring range of 0–200 mR/h. The calibration
Simple wooden door with door interlock was put at the accuracy of the contamination monitor is ± 15%. All the
treatment room entrance. data were taken in doserate mode. The detector type in
this instrument is halogen quenched GM detector. After
After requisite furnishing and electric fitting, Bebig commissioning approval from AERB, the unit has been
GyneSource HDR unit was installed inside the room in commissioned for patient treatment.
such a way that the patient bed is placed in center of the
room as shown in Figure 1. Gamma area monitor, type Since above alterations were done by in‑house expertise of
no. ‑ GA720H (Nucleonix Systems Pvt Ltd, Hyderabad, the institution with the help of architect after documented
India) having range 0–100 mR/h was installed on approval from regulatory body, unit installation, and
maze wall towards inner maze entrance and the digital commissioning with the help of service engineer was
display (connected with gamma area monitor) was installed accomplished. Since this was the case of modified room,
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Gurjar, et al.: Conversion of room for Ir‑192 HDR unit to room for Co‑60 HDR unit
so to analyze the above modified room design calculations consider 100% occupancy in public passage back to wall
were done as follows: at position A’ as shown in Figure 1].
The barrier attenuation to give the acceptable external Calculation for wall thickness
annual dose is given as:[6,8,9]
Walls facing public area
B = (Da × d2)/(Tw × 50 × Γ × A × U × T) (1) B = 0 . 3 m S v × ( 3 . 0 5 m ) 2/ ( 1 h × 5 0 × 3 0 6
µGym2h−1GBq−1 × 66.96 GBq × 1 × 1).
Where
B (The barrier attenuation required to achieve Da). = 2.72 × 10−3
Da (The annual dose constraint) =0.3 mSv annually (design n (number of tenth value layer (TVL)) = −log10B = 2.57
limit for public area).[6,10] TVL (TVL for concrete is 0.21 m).[5]
=6 mSv annually (design limit for occupational Required wall thickness = 0.54 m concrete
exposure).[6,10]
d [The distance from the source (in the patient) to the far Wall facing control console
side of the barrier) ≥3.05 m (3.05 is nearest distance for B = 6 mSv × (2.8 m) 2/(1h × 50 × 306 µGym2h−1GBq−1 × 66.96
far side of walls facing to public area, see Figure 1] and GBq × 1 × 1).
2.8 m (distance of far side of console wall).
= 4.59 × 10−2
Tw (The average source exposure time per week (hours)
covering all procedures) = 1 hour (our center has maximum n = −log10B = 1.34 TVL (TVL for concrete is 0.21 m)[5]
four patients/week, and the maximum treatment time for
one patient is 15 min with initial activity). Required wall thickness = 0.28 m concrete
Γ (The air kerma rate constant for the radionuclide in Calculation for IDR
the source (µGy/GBq.h@1m)) = 306 µGym2h−1GBq−1 The IDRis calculated as follows:[6,8,9]
(as mentioned in source certificate).
IDR = Γ× A × B/d2(2)
A (The maximum activity (GBq) of the source (at renewal))
= 66.96 GBq
For public area
U (The use factor) = 1 IDR = 306 µGym 2h −1GBq −1 × 66.96 GBq × 2.72 ×
10−3/(3.05 m) 2
T (The occupancy factor in the area adjacent to the barrier)
= 1 [the control area with 100% occupancy and let we = 5.99 µSv/h
86 International Journal of Health & Allied Sciences • Vol. 4 • Issue 2 • Apr-Jun 2015
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Gurjar, et al.: Conversion of room for Ir‑192 HDR unit to room for Co‑60 HDR unit
Table 1: Radiation survey around Co‑60 HDRafterloading brachytherapy unit (with initial maximum activity 66.96 GBq)
Measuring direction as in figure 2 1 2 3 4 5 6 7 8 9
Measured dose rate (mR/h) at 5 cm 4.21 2.67 4.16 7.74 8.49 0.21 0.19 0.22 0.25
from the surface of the source storage
Measured dose rate (mR/h) at 1 m 0.21 0.14 0.10 0.18 0.16 0.11 0.10 0.10 0.11
from the center of the source storage
Table 2: Radiation survey around Co‑60 HDR afterloading brachytherapy room (with initial maximum activity 66.96 GBq)
Measuring point A A’ B B C C’ D E F
Radiation level (mR/h) 0.55* 2.37# 0.35 0.02 0.06 0.05 0.19 1.12 0.09 0.15
*When position of HDR unit in the room is between the source ON position and console wall, we maintain this position while doing actual patient treatment
also, #on direct facing the console wall to source like other walls. This arrangement was done for taking this data only. Note: The radiation level in
brachytherapy room is negligible when the 15 MV beam live ON in adjoining linear accelerator room. HDR: High dose rate
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Gurjar, et al.: Conversion of room for Ir‑192 HDR unit to room for Co‑60 HDR unit
there while source is ON. Measured IDR values at all other ACKNOWLEDGEMENT
positions in public area are well within tolerance limit. To
bring the IDR in console less than 7.5 µSv/h, the required We thank to Dr. Virendra Bhandari, HOD, Roentgen‑SAIMS
wall thickness of console can be calculated using formula Radiation Oncology Centre, SAIMS, Indore for his positive
2 and IDR design dose limit 7.5 µSv/h as follows: support in conducting this study.
Design dose limits should also be considered while planning How to cite this article: Gurjar OP, Kaushik S, Mishra SP, Punia R. A
room layout for radiation facility and regulatory body may study on room design and radiation safety around room for Co-60 after
loading HDR brachytherapy unit converted from room for Ir-192 after
incorporate these constraints in radiation safety code. This loading HDR brachytherapy unit. Int J Health Allied Sci 2015;4:83-8.
study has direct practical application for such institutions, Source of Support: Equipment support of Roentgen Oncologic
which are at the cusp of moving from Ir‑192 to Co‑60 based Solutions Pvt. Ltd. and Sri Aurobindo Institute of Medical Sciences,
Indore (India), Conflict of Interest: None declared.
brachytherapy in the light of new developments.
88 International Journal of Health & Allied Sciences • Vol. 4 • Issue 2 • Apr-Jun 2015