Exam ID: 54286 Roll No.

______________
RIPHAH INTERNATIONAL UNIVERSITY
Riphah College of Rehabilitation Sciences
             3  Semester DPT Terminal Fall 2013 Examinations (January 2014)
rd

Biochemistry & Genetics-I

Total marks: 100 (MCQs) Time Allowed: 120 Mins
Instructions: Attempt all questions. Select one best answer in each question. Please fill your Roll No. and
answers on response sheet carefully only with pencil provided.
Note: Please return the question book, response sheet at the end of this session

1. When ATP forms AMP 8. Humans most easily tolerate a lack of the
a. Inorganic pyrophosphate is produced nutrient:
b. Inorganic phosphorous is produced a. Protein
c. Phsophagen is produced b. Lipid
d. No energy is produced c. Iodine
d. Carbohydrate
2. The number of ATP produced in the
oxidation of 1 molecule of NADPH in 9. The major calcium salt in bones is
oxidative phosphorylation is a. Calcium carbonate
a. Zero b. Calcium chloride
b. 2 c. Calcium hydroxide
c. 3 d. Calcium phosphate
3. Calcium is excreted by 10. Cholesterol is a precursor in the biogenesis of
a. Kidney a. Vitamin A
b. Kidney and intestine b. Vitamin D
c. Kidney and liver c. Vitamin E
d. Kidney and pancreas d. None of these
4. A rise in blood calcium may indicate 11. In retinal rickets, the following hydroxylation of
a. Paget’s disease Vitamin D3 does not take place:
b. Rickets a. 25
c. Osteomalacia b. 1
d. Hypervitaminosis D c. 24
d. 7
5. Iron is a component of
a. Hemoglobin 12. The following does not have phosphorous:
b. Ceruloplasmin a. Riboflavin
c. Transferase b. TPP
d. Transaminase c. NAD+
d. COASH
6. One gram of fat on complete oxidation in
the body yields about 13. Rice polishings contain this vitamin:
a. 4 Kcal a. Riboflavin
b. 6 Kcal b. Niacin
c. 9 Kcal c. Thiamine
d. 12 Kcal d. Vitamin B12
7. Proteins have the SDA: 14. Symptoms of pellagra are
a. 5% a. Dermatitis and diarrhea only
b. 10% b. Dermatitis and dementia only
c. 20% c. Diarrhea, dermatitis and dementia
d. 30% d. Diarrhea and elements only

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15. Pyridoxine deficiency leads to 24. 25-hydroxylation of Vitamin D3 takes place in
a. Megaloblastic anemia a. Liver
b. Aplastic anemia b. Kidneys
c. Hypochromic microcytic anemia c. Intestines
d. Permicious anemia d. Pancreas
16. Antisterility vitamin is 25. Hydroxylation of 25-hydroxy cholecalciferol
a. Vitamin B1 is promoted by
b. Vitamin B2 a. Cytochrome A
c. Vitamin E b. Panthyroid hormone
d. Vitamin K c. Cytochrome b
d. cAMP
17. A deficiency of vitamin B12 causes
a. Cheliosis 26. The human species can biosynthesize
b. Beriberi a. Vitamin C
c. Pernicious anemia b. Vitamin B12
d. Scurvy c. Thiamine
d. Niacin
18. In adults a severe deficiency of vitamin D
e. None of the above
causes
a. Night blindness 27. Retina contains this photo sensitive pigment.
b. Osteomalacia a. Rhodopsin
c. Rickets b. Opsin
d. Skin cancer c. Retinol
d. Malanin
19. Which of the following statements
regarding Vitamin A is true? 28. Choline is not required for the formation of
a. It is not an essential Vitamin a. Lecithins
b. It is related to tocopherol b. Acetyl choline
c. It is a component of rhodopsin c. Sphingomyelin
d. It is also known as Opsin d. Cholic acid
20. Megaloblastic anemia is caused by the 29. Steroidal prohormone is
deficiency of a. Vitamin A
a. Folic acid b. Vitamin C
b. Vitamin B6 c. Vitamin D
c. Iron d. None of these
d. Protein 30. A deficiency of folate leads to
21. This vitamin acts as anti oxidant. a. Megaloblastic anemia
a. Vitamin A b. Aplastic anemia
b. Vitamin D c. Pernicious anemia
c. Vitamin E d. Hypochromic microcytic anemia
d. Vitamin K 31. Deficiency of Iron leads to
22. Calcitriol is a. Megaloblastic anemia
a. 1-hydroxy cholecalciferol b. Aplastic anemia
b. 25-hydroxy cholecalciferol c. Pernicious anemia
c. 24, 25-dihydroxy cholecalciferol d. Hypochromic microcytic anemia
d. 1, 25-dihydroxy cholecalciferol 32. Antixerophthalmic vitamin is
23. 1-hydroxylation of 25-hydroxy Vitamin D3 a. Vitamin B1
takes place in b. Vitamin B2
a. Liver c. Vitamin B6
b. Kidneys d. Vitamin A
c. Intestine
d. Pancreas
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33. Antirachitic vitamin is 40. Which of the following contains an ether
a. Vitamin A bond and an unsaturated alkyl group:
b. Vitamin D a. Platelet-activating factor.
c. Vitamin E b. Plasmalogens.
d. Vitamin K c. Cephalin.
d. Lecithin.
34. One of the main functions of Vitamin K is
e. Cardiolipin.
the cofactor for
a. Carboxylase for the formation of -- 41. Which of the following contains an ether
carboxy glutamate bond and an acetyl residue rather than a
b. Methylation by S-adenosyl methionine fatty acid on carbon 2:
c. Carboxylation by biotin a. Platelet-activating factor.
d. One carbon transfer by tetra hydrofolate b. Plasalogens.
c. Cephalin.
35. Vitamin used in the treatment of
d. Lecithin.
homocystinuria is
e. Cardiolipin.
a. B1
b. B5 42. Sphingomyelin of gray matter of the brain
c. B12 primarily contains:
d. B6 a. Nervonic acid.
b. Stearic acid.
36. Cephalin is a compound containing:
c. Lignoceric acid.
a. Glycerol + phosphatidic acid (PA).
d. Archidonic acid.
b. Serine + PA.
e. Linoleic acid.
c. Choline + PA.
d. Inositol + PA. 43. Arachidonic acid becomes essential in the
e. Ethanolamine + PA. diet when there is a deficiency in:
a. Butyric acid.
37. Lecithin is a compound containing:
b. Capric acid.
a. Ethanolamine + PA.
c. Linolenic acid.
b. Choline + PA.
d. Stearic acid.
c. Inositol + PA.
e. Linoleic acid.
d. Serine + PA.
e. Glycerol + PA. 44. Regarding triacylglycerols:
a. The fatty acid on carbon 1 is typically
38. The plasminogen similar in structure to
unsaturated.
cephalin is:
b. They can form stable micelles by
a. Phosphatidylcholine.
themselves.
b. Phosphatidylserine.
c. The fatty acid on carbon 2 is typically saturated.
c. Phosphatidalethanolamine.
d. Are highly soluble in water.
d. Phosphatidalcholine.
e. Form lipid droplets that serve as the
e. Phosphatidylinositol.
major energy reserve of the body.
39. Triacylglycerol synthesis occurs in all of the
45. The yield from complete oxidation of fatty
following except:
acids to CO2 and H2O is:
a. Liver.
a. 4 kcal/g.
b. Erythrocytes.
b. 7 kcal/g.
c. Lactating mammary glands.
c. 9 kcal/g.
d. Adipose tissues.
d. 11 kcal/g.
e. Intestinal mucosal cells.
e. 12 kcal/g.
46. Serotonin is synthesized from
a. Tyrosin
b. Tryptophan
c. phenylalanine
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47. Which of these is not a characteristic of 55. Arachidonic acid contains the number of
enzymes? double bonds:
a. Shifting the Equilibrium constant forward a. 2
b. Optimising the substrates orientation for b. 3
reaction c. 4
c. Providing catalytically competent groups d. 5
for a specific reaction mechanisms 56. The Iodine number of essential fatty acids of
d. Preferentially binding and stabilising vegetable oils:
transition states of substrates a. High
48. Which of these enzymes is involved in fat b. Very high
digestion? c. Very low
a. Maltase d. Low
b. Amylase 57. Which of the following are classified as
c. Protease essential fatty acids?
d. Lipase a. Arachidonic acid
49. The following form of vitamin A is used in b. Oleic acid
the visual cycle: c. Acetic acid
a. Retinol d. Butyric acid
b. Retinoic acid 58. All the following saturated fatty acids are
c. Retinaldehyde present in buffer except
d. Retinyl acetate a. Butyric acid
50. Lecithins are soluble in ordinary solvents b. Capryllic acid
except c. Caproic acid
a. Benzene d. Capric acid
b. Ethyl alcohol 59. Saponification number is
c. Methyl alcohol a. mg of KOH required to saponify one gm
d. Acetone of fat or oil
51. The alkyl radical in plasmalogen is an b. mg of KOH required to neutralize free
alcohol: fatty acids of one gms of fat
a. Saturated c. mg of KOH required to neutralize the
b. Unsaturated acetic acid obtained by saponification of
c. Both (A) and (B) one gm of fat after it has been acetylated
d. None of these d. None of these
52. Glycolipids contain an amino alcohol: 60. Saponification number indicates
a. Sphingosine a. Unsaturation in fat
b. Iso-sphingosine b. Average M.W of fatty acid
c. Both (A) and (B) c. Acetyl number
d. None of these d. Acid number
53. Cerebrosides may also be classified as 61. Lecithins are composed of
a. Sphingolipids a. Glycerol + Fatty acids + Phosphoric acid +
b. Sulpholipids Choline
c. Aminolipids b. Glycerol + Fatty acids + Phosphoric acid +
d. Glycolipids Ethanolamine
c. Glycerol + Fatty acids + Phosphoric acid +
54. The number of carbon atoms in decanoic
Serine
acid present in butter:
d. Glycerol + Fatty acids + Phosphoric acid +
a. 6
Beaine
b. 8
c. 10
d. 12
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62. Sphingomyelins are composed of fatty acids, 69. Phosphatidic acid on hydrolysis yields
phosphoric acid and a. Glycerol, fatty acids, phosphoric acid,
a. Sphingosine and choline choline
b. Glycerol and sphingosine b. Glycerol, fatty acids, phosphoric acid
c. Glycerol and Serine c. Glycerol, fatty acids, phosphoric acid,
d. Glycerol and Choline Glucose
d. Sphingol, fatty acids, phosphoric acid
63. When choline of lecithine is replaced by
ethanolamine the product is 70. A fatty acid not synthesized in man is
a. Sphingomyelin a. Oleic
b. Cephalin b. Palmitic
c. Plasmalogens c. Linoleic
d. Lysolecithine d. Stearic
64. The smell of fat turned rancid is due to 71. Phospholipase A2 is an enzyme which removes
a. Presence of vit E a fatty acid residue from lecithin to form
b. Presence of quinines a. Lecithin fragments
c. Phenols b. Phosphotidic acid
d. Volatile fatty acids c. Glyceryl phosphate
d. Lysolecithin
65. Phospholipids are important cell membrane
components because 72. Prosthetic group in cone cell
a. They have glycerol phototreceptors is
b. They can form bilayers in water a. Iodine
c. They have both polar and non polar b. Opsin
potions c. 11-cis-retinal
d. They combine covalently with proteins d. all-trans-retinal
66. A fatty acid which is not synthesized in 73. An early effect of vitamin a deficiency is
human body and has to be supplied in the a. Xerophthalmia
diet: b. Keratomalacia
a. Palmitic acid c. Prolonged dark adaptation time
b. Oleic acid d. Follicular hyperkeratosis
c. Linoleic acid 74. Daily requirement of vitamin A in an adult
d. Stearic acid man can be expressed as
67. Rancidity of butter is prevented by the a. 400 IU
addition of b. 1,000 IU
a. Vitamin D c. 5,000 IU
b. Tocopherols d. 10,000 IU
c. Presence of priotin 75. Vitamin A is stored in the body in
d. Presence of ‘Cu’ a. Liver
68. Sphingomyelins on hydrolysis yields b. Adipose tissue
a. Glycerol, fatty acids, phosphoric acid and c. Reticuloendothelial cells
choline d. All of these
b. Glycerol, sphingosine, choline and fatty 76. All the following conditions produce a real
acids or functional deficiency of vitamin K except
c. Sphingosine, phosphoric acid, Glycerol a. Prolonged oral, broad spectrum antibiotic
and Inositol therapy
d. Sphingosine, fatty acids, phosphoric acid b. Total lack of red meat in the diet
and choline c. The total lack of green leafy vegetables in
the diet
d. Being a new born infant

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77. Deficiency of vitamin D causes 86. In human beings, vitamin E prevents
a. Ricket and osteomalacia a. Sterility
b. Tuberculosis of bone b. Hepatic necrosis
c. Hypthyroidism c. Muscular dystrophy
d. Skin cancer d. None of these
78. Tocopherols prevent the oxidation of 87. Vitamin E protects
a. Vitamin A a. Polyunsaturated fatty acids against
b. Vitamin D Aperoxidation
c. Vitamin K b. Vitamin A and carotenes against
d. Vitamin C oxidation
c. Lung tissue against atmospheric
79. Vitamin A is required for the formation of a
pollutants
light receptor protein known as
d. All of these
a. Globulin
b. Lypoprotein 88. Parathormone is required for the conversion
c. Chomoprotein of
d. Rhodospin a. Cholecalciferol into 1-
hydroxycholecalciferol
80. Vitamin A over dosage causes injury to
b. Cholecalciferol into 25-
a. Mitochondria
hydroxycholecalciferol
b. Microtubules
c. 25-Hydroxycholecalciferol into calcitriol
c. Lysosomes
d. Cholesterol into 7-dehydrocholesterol
d. E.R
89. Bowlegs and knock-knees can occur in
81. Which is a pro vitamin or vitamin that has
a. Rickets
antioxidant properties?
b. Osteomalacia
a. Beta carotene
c. Both A and B
b. Vitamin E
d. Hypervitaminosis D
c. Vitamin C
d. Vitamin D 90. A provitamin D synthesized in human beings is
a. Ergosterol
82. Deficiency of Vitamin D leads to
b. 7-Dehydrocholesterol
a. Rickets
c. Cholecalciferol
b. Osteomalacia
d. 25-Hydroxycholecalciferol
c. Xeropthalmia
d. Both a and b 91. Vitamin E protects the polyunsaturated
fatty acids from oxidation by molecular
83. Dictary deficiency of this vitamin leads to
oxygen in the formation of
night blindness:
a. Superoxide
a. Retinol
B Peroxide
b. Tocopherol
b. Trioxide
c. Ascorbic acid
c. All of these
d. Cholecalciferol
92. The symptoms of scurvy are
84. The poor sources of vitamin D:
a. Poor healing of wounds
a. Eggs
b. Loosening of teeth
b. Butter
c. Anaemia
c. Milk
d. All of these
d. Liver
85. Requirement of vitamin E increases with the 93. Which among the following fatty acids is an
increasing intake of essential fatty acid for man?
a. Calories a. Palmitic acid
b. Proteins b. Oleic acid
c. PUFA c. Linoleic acid
d. Cholesterol d. None of these
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94. Fibre in the diet is beneficial in
a. Hyper glycemia
b. Hyper cholseteremia
c. Colon cancer
d. All of these
95. The vitamin in leafy vegetables:
a. D
b. K
c. A
d. Both b and c
96. When light falls on rod cells
a. All-cis-retinal is converted into all-trans-
retinal
b. 11-cis-retinal is converted into 11-trans-
retinal
c. 11-trans-retinal is converted into all-
transretinal
d. 11-cis-retinal is converted into all-trans-
retinal
97. Anti-oxidant activity is present in
a. -Carotene
b. Retinol
c. Retinoic acid
d. All of these
98. Daily requirement of vitamin A in an adult
man can be expressed as
a. 400 IU
b. 1,000 IU
c. 5,000 IU
d. 10,000 IU
99. Vitamin B6 includes
a. Pyridoxal
b. Pyridoxamine
c. Pyridoxine
d. All of these
100.Ergosterol is found in
a. Animals
b. Plants
c. Bacteria
d. All of these

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