DEPARTMENT OF PHARMACEUTICAL SCIENCES AND DRUG RESEARCH

PUNJABI UNIVERSITY, PATIALA

M. Pharm II year
(2018-19 & 2019-20)

Course of study for M. Pharm. (Semester III)

(Common for all specializations)
Course Course Credit Credit
Code Hours Points
MRM 301T Research Methodology and 4 4
Biostatistics*
- Journal Club 1 1
- Discussion/Presentation 2 2
(Proposal Presentation)
- Research Work 28 14*
Total 35 07
*To be evaluated at the end of Semester IV.

Table – 8: Course of study for M. Pharm. (Semester IV)

(Common for all specializations)
Course Course Credit Credit
Code Hours Points
- Journal Club 1 1
- Research Work 31 16+14*
- Progress Presentation 3 3
Total 35 34
*Carried from Semester III.

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 M. Pharm. (Semester III)
MRM 301T - Research Methodology & Biostatistics
Max Marks: 75 Max Time: 3h
Internal Assessment: 25 Marks 4hrs/Week
Total Marks 100 Credits: 4

INSTRUCTIONS FOR THE PAPER SETTERS

The question paper will consist of three sections A, B and C. Section A will consist of 20
Multiple Choice Questions (MCQ) of 1 mark each or 10 very short answer type questions of 2
marks each. Section B will have three questions of 10 marks each. Section C will consist of nine
questions of 5 marks each
INSTRUCTIONS FOR THE CANDIDATES
Section A is compulsory. Candidates are required to attempt two questions from section B
and seven questions from Section C.

UNIT – I
General Research Methodology: Research, objective, requirements, practical difficulties, review
of literature, study design, types of studies, strategies to eliminate errors/bias, controls,
randomization, crossover design, placebo, blinding techniques.
UNIT – II
Biostatistics: Definition, application, sample size, importance of sample size, factors influencing
sample size, dropouts, statistical tests of significance, type of significance tests, parametric
tests(students “t” test, ANOVA, Correlation coefficient, regression), non-parametric tests
(wilcoxan rank tests, analysis of variance, correlation, chi square test), null hypothesis, P values,
degree of freedom, interpretation of P values.
UNIT – III
Medical Research: History, values in medical ethics, autonomy, beneficence, non-maleficence,
double effect, conflicts between autonomy and beneficence/non-maleficence, euthanasia,
informed consent, confidentiality, criticisms of orthodox medical ethics, importance of
communication, control resolution, guidelines, ethics committees, cultural concerns, truth telling,
online business practices, conflicts of interest, referral, vendor relationships, treatmentof family
members, sexual relationships, fatality.
UNIT – IV
CPCSEA guidelines for laboratory animal facility: Goals, veterinary care, quarantine,
surveillance, diagnosis, treatment and control of disease, personal hygiene, location of animal

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facilities to laboratories, anesthesia, euthanasia, physical facilities, environment, animal
husbandry, record keeping, SOPs, personnel and training, transport of lab animals.
UNIT – V
Declaration of Helsinki: History, introduction, basic principles for all medical research, and
additional principles for medical research combined with medical care.

Journal Club
Maximum Marks 25 1h/week
Credits 1

Discussion/Presentation of proposal
Maximum Marks 50 2h/week
Credits 2

Research work
The research work will be evaluated and credits will be added in semester IV

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 M. Pharm Semester IV
Journal Club
Maximum Marks 25 1h/week
Credits 1

Discussion/Progress presentation
Maximum Marks 75 3 h/week
Credits 3

Research work
Maximum Marks 750 31h/week
Credits 30
The research work carried out in Semester III and IV will be evaluated for total credits of 30.