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Defense Against Biological Attacks, vol. II

Book · May 2019

DOI: 10.1007/978-3-030-03071-1

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Sunit Kumar Singh Jens H. Kuhn

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Sunit K. Singh
Jens H. Kuhn Editors

Defense Against
Biological Attacks
Volume II
Editors
Sunit K. Singh Jens H. Kuhn
Molecular Biology Unit Integrated Research Facility at Fort Detrick
Institute of Medical Sciences, Banaras NIH/NIAID, Division of Clinical Research
Hindu University Frederick, MD, USA
Varanasi, India

ISBN 978-3-030-03070-4 ISBN 978-3-030-03071-1 (eBook)

https://doi.org/10.1007/978-3-030-03071-1

# Springer Nature Switzerland AG 2019

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Contents

1 Neurotropic Viruses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Michael R. Holbrook
2 Overview of Human Viral Hemorrhagic Fevers . . . . . . . . . . . . . . . 21
James Logue, Martin Richter, Reed F. Johnson, Jens H. Kuhn,
and Wade Weaver
3 Variola Virus: Clinical, Molecular, and Bioterrorism
Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
Shane D. Falcinelli, Justine Ciric, and Jason Kindrachuk
4 Viral Therapeutics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 103
Martin Richter
5 Challenges Associated with Bacillus anthracis as a Bio-threat
Agent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115
Haim Levy, Itai Glinert, Assa Sittner, Amir Ben-Shmuel,
Elad Bar-David, David Kobiler, and Shay Weiss
6 Brucella: Potential Biothreat Agent . . . . . . . . . . . . . . . . . . . . . . . . . 139
Mehmet Doganay, Gizem Dinler-Doganay, Aysegul Ulu-Kilic,
and Rebecca J. Ingram
7 Burkholderia mallei and Glanders . . . . . . . . . . . . . . . . . . . . . . . . . . 161
Nittaya Khakhum, Daniel Tapia, and Alfredo G. Torres
8 Burkholderia pseudomallei . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185
Kathryn J. Pflughoeft, Derrick Hau, Peter Thorkildson,
and David P. AuCoin
9 Coxiella burnetii: Hiding in Plain Sight . . . . . . . . . . . . . . . . . . . . . . 213
Patrice Newton, Miku Kuba, Bhavna Padmanabhan,
Eleanor A. Latomanski, and Hayley J. Newton
10 Francisella tularensis: Causative Agent of Tularemia
and Biothreat Agent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 239
Monique Barel and Alain Charbit

ix
 x Contents

11 Yersinia pestis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251

Minoarisora Rajerison and Thomas Kratz
12 Bacterial Therapeutics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
Martin Richter
13 Advances in Molecular Diagnostic Approaches for Biothreat
Agents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
Meghana Rastogi and Sunit K. Singh
14 Next Generation Sequencing for the Detection of Foodborne
Microbial Pathogens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311
Travis G. Wentz, Lijun Hu, Thomas S. Hammack, Eric W. Brown,
Shashi K. Sharma, and Marc W. Allard
15 Overview on the Systematics of Biotoxins as Threat Agents . . . . . . 339
Harald Striegl
16 Agrobioterrorism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 359
Lawrence F. Roberge

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