DIURETICS

Drugs Bendroflume Furosemide Aceta Amiloride Glycerin

Chloro Bumetanide Meta Spirolonactone Isosorbide
Hydrochloro Ethacrynic Acid Triamterene Mannitol
Hydroflume Torsemide Urea
Methyclo

Therapeutic Act to block chloride pump to -same mechanism with thiazide Blocks the effect of the Causes loss of Na and K Pull water into the renal
Action keep chloride and sodium in enzyme carbonic anhydrase retention tubule
the renal tubule to be (catalyst for NaHCO3 form.)
excreted in the urine

Indications For hypertension For Acute HF, Acute PE, HPN For glaucoma For Hyper-aldosteronism For IICP, Acute Glaucoma,
and ARF

Contra- CI: CI: CI: CI: CI:

indications &  Allergy to • Severe renal failure • Allergy to thiazides • Hyperkalemia • Renal disease
Cautions sulfonamides • Hepatic coma • Pregnancy • Renal Disease • Pulmonary
• F&E imbalance CAUTIONS: CAUTIONS: • Pregnancy congestion
• Severe renal disease • SLE • COPD • Intracranial
CAUTIONS: • DM bleeding
• SLE • DHN
• DM • HF
• Bipolar disorder • Pregnancy
Adverse Effects • GI upset • Hypotension • Hypokalemia • Hyperkalemia • SUDDEN DROP in
• F&E imbalance • Hypokalemia • Paresthesia • Androgen effects fluid levels (most
• Hypotension • Hyperglycemia • LOC Changes common)
(most common) • Hypocalcemia • Metabolic acidosis • N/V
• Hypokalemia • Ototoxicity • Hypotension
• Hyperglycemia • Confusion
• Hypercalcemia • Headache
• Hyperuricemia

Drug-to-Drug • Cholestyramine • Aminoglycosides • ASA; Lithium • ASA

Interactions • Digoxin • Anticoagulants
• Lithium • NSAIDs

NOTE! DOC when rapid diuresis is Spironolactone, aldosterone

needed antagonist