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Radhika Banka
Oxford University Hospitals NHS Trust
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Each of us should strive “to rise above the routines of the daily ward round and to see in every patient an
opportunity not only to serve mankind in the best tradition of medical excellence, but to add to the store
of medical knowledge”
–A McGehee Harvey
ABSTRACT
Cough is one of the most common symptoms of respiratory tract infections. A wide range of disease
processes may present with cough and definitive treatment depends on identifying the cause and
diagnosis. Specific treatment of the cause should control the cough, but this may not occur in all cases
and in a sizable proportion of patients, no associated cause can be found. This chapter reviews the
causes, presentation and management of dry cough.
CHAPTER 76
Dry Cough: Presentation, Causes and Management Algorithm
In its simplest form, clinical cough is a reflex event The clinical presentation of patients with UACS,
beginning with activation of vagal afferent sensory in addition to cough, commonly involves complaints
nerves located in pulmonary and extrapulmonary (or at least an affirmative response to questioning) of
sites that project the “signal” centrally, where it a sensation of something draining into the throat, a
undergoes modulation, resulting in the generation of need to clear the throat, a tickle in the throat, nasal
the appropriate efferent motor response. congestion, or a nasal discharge with a cobblestone
Although the anatomic and neurophysiologic appearance of the oropharyngeal mucosa or mucus in
processes responsible for the initiation and regulation the oropharynx on examination. Patients sometimes
of cough are complex, knowledge about the mechanism complain of hoarseness of voice, wheeze and a history of
of cough can help the clinician understand how and upper respiratory illness. In patients with an atypical
why his/her patient coughs and provide rationale for a clinical presentation, the diagnosis is often established
targeted and systematic approach to treatment. only after the response to empirical treatment with oral
first-generation antihistamines/decongestants, which
CAUSES OF DRY COUGH are preferred over newer agents. Use of intranasal
Chronic cough can be caused by a myriad of different corticosteroids for 2–8 weeks or oral antihistamines
respiratory or nonrespiratory conditions. The common or nasal ipratropium bromide is also recommended in
causes of chronic cough in an immunocompetent selected patients with rhinitis.6,7
nonsmoking adult with normal chest radiograph
are angiotensin-converting enzyme (ACE) inhibitor Asthma
medication, upper airway cough syndrome (UACS), Asthma is the second leading cause of persistent cough
also known as postnasal drip syndrome, asthma, or in adults, and the most common cause in children.
gastroesophageal reflux disease (GERD), alone or in Cough due to asthma is commonly accompanied
combination. Chronic cough has two or more causes by episodic wheezing and dyspnea; with symptoms
in 18–62% of patients, and three causes in up to 42% typically worse at night; however, it can also be
of patients. It has been reported that causes of cough the sole manifestation of a form of asthma called
cannot be identified in up to 42% of the patients “cough variant asthma”. Mechanism of cough in
presenting at a specialized clinic.4 asthma includes (1) sensitization of cough receptors
by inflammatory mediators such as bradykinin,
Upper Airway Cough Syndrome tachykinins, or prostaglandins; (2) bronchial smooth
The American College of Chest Physicians (ACCP) 2006 muscle constriction.
guidelines has suggested the term ‘UACS’ instead of Spirometry is the most reliable test for establishing
the previously described ‘postnasal drip syndrome’.5 the diagnosis of asthma which reveals reversible
This is because UACS more effectively addresses the airflow obstruction. Use of objective tests, such as raised
possibility that cough in these patients occurs not only sputum eosinophil count or increased exhaled nitric
because of postnasal drip, but can occur as a result oxide (NO) concentration are important for establishing
of irritation or inflammation of the upper airway diagnosis of cough-variant asthma. Treatment
structures that directly stimulate the cough receptors involves use of inhaled long-acting bronchodilators and 373
independently or in addition to the postnasal drip. corticosteroids with theophylline and antileukotrienes.8
through three major mechanisms: (1) intraesophageal thickening of the posterior pharynx. Treatment options
reflux (stimulation of the esophageal tracheobronchial are limited and a trial of PPIs is warranted.
30
CHAPTER 76
Dry Cough: Presentation, Causes and Management Algorithm
Abbreviations: ACE-I, angiotensin-converting enzyme inhibitor; Rx, Treatment.
a patient with chronic dry cough is illustrated in Other centrally acting antitussives include
Flow chart 2. chlophedianol, levopropoxyphene, and noscapine in the
nonnarcotic group and hydrocodone, hydromorphone,
Other drugs used for treatment of dry cough include:
methadone, and morphine in the narcotic group.
Antitussives: Antitussive therapies should be
considered in patients with chronic dry cough when the
Peripherally Acting Antitussives
cause of the increased cough reflex is unexplained and
Peripherally acting antitussives may act on either the
treatment against the potential aggravating factors
afferent or the efferent side of the cough reflex. They
is not satisfactory. These drugs may be centrally or
are grouped as demulcents, local anesthetics, and
peripherally acting.
humidifying aerosols.
Demulcents are useful for coughs originating above
Centrally Acting Antitussives the larynx. They form a protective coating over the
Centrally acting antitussives inhibit or suppress the irritated pharyngeal mucosa. They are usually given as
cough reflex by depressing the medullary cough center syrups or lozenges and include acacia, licorice, glycerin,
or associated higher centers. The most commonly used honey, and wild cherry syrups.
drugs in this group are dextromethorphan and codeine.17 Benzonatate is a peripherally acting antitussive
Dextromethorphan, a congener of the narcotic agent that presumably acts by anesthetizing stretch
analgesic levorphanol, has no significant analgesic receptors in the lungs and pleura. There are case
or sedative properties, does not depress respiration reports of effective use of benzonatate in the palliative
in usual doses, and is nonaddictive. No evidence of treatment of cough in advanced cancer.
tolerance has been found during long-term use. Thalidomide has been evaluated as an antitussive
Codeine, which has antitussive, analgesic, and agent, due to its anti-inflammatory and antifibrotic
slight sedative effects, is especially useful in relieving properties for patients with cough due to idiopathic
painful cough and is considered the gold standard for pulmonary fibrosis (IPF). Although it was useful
treatment of dry cough. There is a linear relationship additional studies are needed due to serious side effects
between a codeine dosage of 7.5–60 mg/d and a decrease including teratogenicity.
in the frequency of chronic cough.17 Codeine (60 mg) Nebulized lidocaine may be helpful in a minority of
significantly reduced the cough frequency compared patients with refractory chronic cough.
to placebo (p < 0.001), and also produced a greater
reduction in cough intensity than placebo and lower Combinations
doses of codeine (20 and 30 mg; p < 0.001). It also exerts Single agents may not be effective, combination may
a drying action on the respiratory mucosa that may be be essential for better control. Many antitussive
useful (e.g. in bronchorrhea) or deleterious (e.g. when preparations are available including combinations of
bronchial secretions are already viscous). Nausea, codeine or dextromethorphan with antihistamines,
vomiting, constipation, tolerance to antitussive as well decongestants, expectorants, and/or antipyretics. In
as analgesic effects, and physical dependence can occur, India, several such cough mixtures containing an
375
but potential for abuse is low. antihistaminic and an opioid derivative claiming