Drug Information: Ketoconazole

(kee toe kon' na zole)

IMPORTANT WARNING:

Ketoconazole may cause liver damage. Tell your doctor if you drink or have ever drunk large amounts
of alcohol and if you have or have ever had liver disease. Tell your doctor and pharmacist if you are
taking acetaminophen (Tylenol, others); cholesterol-lowering medications (statins) such as atorvastatin
(Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), or simvastatin (Zocor);
isoniazid (INH, Nydrazid); methotrexate (Rheumatrex); niacin (nicotinic acid); or rifampin. If you
experience any of the following symptoms, call your doctor immediately: extreme tiredness, loss of
appetite, upset stomach, vomiting, yellowing of the skin or eyes, dark yellow urine, pale stools, pain in
the upper right part of the stomach, or flu-like symptoms.Keep all appointments with your doctor and the
laboratory. Your doctor will order certain tests to check your body's response to ketoconazole.Do not
take astemizole (Hismanal) (not available in the United States), cisapride (Propulsid), or terfenadine
(Seldane) (not available in the United States) while you are taking ketoconazole.

Why is this medication prescribed?

Ketoconazole is used to treat fungal infections. Ketoconazole is most often used to treat fungal
infections that can spread to different parts of the body through the bloodstream such as yeast
infections of the mouth, skin, urinary tract, and blood, and certain fungal infections that begin on the
skin or in the lungs and can spread through the body. Ketoconazole is also used to treat fungal
infections of the skin or nails that cannot be treated with other medications. Ketoconazole is in a class
of antifungals called imidazoles. It works by slowing the growth of fungi that cause infection.

How should this medicine be used?

Ketoconazole comes as a tablet to take by mouth. It is usually taken once a day. To help you
remember to take ketoconazole, take it at around the same time every day. Follow the directions on
your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not
understand. Take ketoconazole exactly as directed. Do not take more or less of it or take it more often
than prescribed by your doctor.

If you have certain medical conditions, your doctor will tell you to take ketoconazole tablets dissolved
in an acid solution. Your doctor will tell you exactly how to do this. Follow these directions carefully.

Your doctor will probably start you on an average dose of ketoconazole. Your doctor may increase
your dose if your infection is very serious or your condition does not improve.

You may need to take ketoconazole for several weeks or months to cure your infection completely.
Your doctor will probably order laboratory tests to be sure your infection has been treated. Continue to
take ketoconazole until your doctor tells you that you should stop, even if you feel better. Do not stop
taking ketoconazole without talking to your doctor. If you stop taking ketoconazole too soon, your
infection may come back after a short time.

Other uses for this medicine

Ketoconazole is also sometimes used to treat vaginal yeast infections, tinea versicolor (spots on skin
caused by yeast), eumycetoma (a severe fungal skin infection that often affects the foot),
leishmaniasis (a disease caused by the bite of an infected sand fly), prostate cancer (cancer that
begins in a male reproductive organ), high blood levels of calcium in patients with certain conditions,
Cushing's syndrome (high blood levels of a natural substance called cortisol), and excessive hair
growth in women. Talk to your doctor about the possible risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?

Before taking ketoconazole,

 tell your doctor and pharmacist if you are allergic to ketoconazole, other antifungal
medications such as fluconazole (Diflucan), itraconazole (Sporonox), or voriconazole (Vfend);
any other medications; or corn.
 do not take ketoconazole if you are taking any of the medications listed in the IMPORTANT
WARNING section or triazolam (Halcion).
 tell your doctor and pharmacist what other prescription and nonprescription medications,
vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention the
medications listed in the IMPORTANT WARNING section and any of the following: alprazolam
(Xanax); anticoagulants ('blood thinners') such as warfarin (Coumadin); buspirone (Buspar);
calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac),
felodipine (Plendil), nifedipine (Adalat, Procardia), nisoldipine (Sular),and verapamil (Calan,
Covera, Isoptin, Verelan);clarithromycin (Biaxin); cyclosporine (Neoral, Sandimmune);
diazepam (Valium); digoxin (Lanoxin); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV
protease inhibitors such as indinavir (Crixivan), ritonavir (Norvir), and saquinavir (Invirase,
Fortovase); loratadine (Claritin); medications for diabetes; medications for erectile dysfunction
such as sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra); methadone (Dolophine);
methylprednisolone (Medrol); midazolam (Versed); phenytoin (Dilantin); pimozide (Orap);
quinidine (Quinidex, Quinaglute); quinine; tacrolimus (Prograf); tamoxifen (Nolvadex);
telithromycin (Ketek); trazodone (Desyrel); and vincristine (Vincasar). Your doctor may need to
change the doses of your medications or monitor you carefully for side effects.
 if you are taking antacids; antihistamines; medications for heartburn or ulcers such as
cimetidine (Tagamet), famotidine (Pepcid), nizatadine (Axid), or ranitidine (Zantac); or
medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or
urinary problems, take them 2 hours after you take ketoconazole.
 tell your doctor if you have or have ever had the conditions mentioned in the IMPORTANT
WARNING section or any condition that decreases the amount of acid in your stomach.
 tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you
become pregnant while taking ketoconazole, call your doctor. Do not breastfeed while you are
taking ketoconazole.
 ask your doctor about the safe use of alcoholic beverages while you are taking ketoconazole.
You may experience unpleasant symptoms such as flushing, rash, upset stomach, headache,
and swelling of the hands, feet, ankles, or lower legs if you drink alcohol while you are taking
ketoconazole.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip
the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for
a missed one.

What side effects can this medication cause?

Ketoconazole may cause side effects. Tell your doctor if either of these symptoms is severe or does
not go away:

 stomach pain
 depression

Some side effects can be serious. The following symptoms are uncommon, but if you experience any
of them or those listed in the IMPORTANT WARNING section, call your doctor immediately:

 rash
 hives
 itching
 difficulty breathing or swallowing
 thinking about harming or killing yourself or planning or trying to do so
A small number of patients who were taking high doses of ketoconazole for prostate cancer died soon
after they began taking the medication. It is not known whether they died because of their disease or
their treatment with ketoconazole or for other reasons. Talk to your doctor about the risks of taking
ketoconazole.

Ketoconazole may cause a decrease in the number of sperm (male reproductive cells) produced,
especially if it is taken at high doses. Talk to your doctor about the risks of taking this medication if you
are a man and would like to have children.

Ketoconazole may cause other side effects. Call your doctor if you have any unusual problems while
taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug
Administration's (FDA) MedWatch Adverse Event Reporting program online [at
http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at
room temperature and away from excess heat and moisture (not in the bathroom). Throw away any
medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of
your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has
collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking
ketoconazole.

Do not let anyone else take your medication. Ask your pharmacist if you have any questions about
refilling your prescription. If you still have symptoms of infection after you finish the ketoconazole, call
your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-
counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary
supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a
hospital. It is also important information to carry with you in case of emergencies.

Brand name(s):

 Nizoral®

Last Revised - 04/01/2005

Last Reviewed - 08/01/2007

Drug Information: Ketoprofen

(kee toe proe' fen)

IMPORTANT WARNING:

People who take nonsteroidal anti-inflammatory medications (NSAIDs) other than aspirin, such as
ketoprofen, may have a higher risk of having a heart attack or a stroke than people who do not take
these medications. These events may happen without warning and may cause death. This risk may be
higher for people who take NSAIDs for a long time. Tell your doctor if you or anyone in your family has
or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever
had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you
experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or
side of the body, or slurred speech.If you will be undergoing a coronary artery bypass graft (CABG; a
type of heart surgery), you should not take ketoprofen right before or right after the surgery.NSAIDs
such as ketoprofen may cause ulcers, bleeding, or holes in the stomach or intestine. These problems
may develop at any time during treatment, may happen without warning symptoms, and may cause
death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor
health, or drink more than three alcoholic drinks per day while taking ketoprofen. Tell your doctor if you
drink large amounts of alcohol or if you take any of the following medications: anticoagulants ('blood
thinners') such as warfarin (Coumadin); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) or
naproxen (Aleve, Naprosyn); or oral steroids such as dexamethasone (Decadron, Dexone),
methylprednisolone (Medrol), and prednisone (Deltasone). Also tell your doctor if you have or have ever
had ulcers or bleeding in your stomach or intestines or other bleeding disorders. If you experience any
of the following symptoms, stop taking ketoprofen and call your doctor: stomach pain, heartburn,
vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry
stools.Keep all appointments with your doctor and the laboratory. Your doctor will monitor your
symptoms carefully and will probably order certain tests to check your body's response to ketoprofen.
Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of
medication to treat your condition with the lowest risk of serious side effects.Your doctor or pharmacist
will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment
with prescription ketoprofen and each time you refill your prescription. Read the information carefully
and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug
Administration (FDA) website (http://www.fda.gov/cder) to obtain the Medication Guide.

Why is this medication prescribed?

Prescription ketoprofen is used to relieve pain, tenderness, swelling, and stiffness caused by
osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis
(arthritis caused by swelling of the lining of the joints). Prescription ketoprofen capsules are also used
to relieve pain, including menstrual pain (pain that occurs before or during a menstrual period).
Nonprescription ketoprofen is used to relieve minor aches and pain from headaches, menstrual
periods, toothaches, the common cold, muscle aches, and backaches, and to reduce fever.
Ketoprofen is in a class of medications called NSAIDs. It works by stopping the body's production of a
substance that causes pain, fever, and inflammation.

How should this medicine be used?

Prescription ketoprofen comes as a capsule and extended-release (long-acting) capsule to take by

mouth. The capsules are usually taken three or four times a day for arthritis or every 6-8 hours as
needed for pain. The extended-release capsules are usually taken once daily. If you take ketoprofen
regularly, take it at around the same times every day.

Nonprescription ketoprofen comes as a tablet to take by mouth. It is usually taken with a full glass of
water or other liquid every 4-6 hours as needed.

Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist
to explain any part you do not understand. Take ketoprofen exactly as directed. Do not take more or
less of it or take it more often than prescribed by your doctor or written on the label.

Ketoprofen may be taken with food or milk to prevent upset stomach. Your doctor may also
recommend that you take ketoprofen with an antacid to reduce stomach upset.

Your doctor may start you on an average dose of prescription ketoprofen and may increase or
decrease on your dose depending on how well you respond to the medication and the side effects you
experience. Follow these directions carefully.
Stop taking nonprescription ketoprofen and call your doctor if your symptoms get worse, you develop
new or unexpected symptoms, the part of your body that was painful becomes red or swollen, your
pain lasts for more than 10 days or your fever lasts for more than 3 days.

Other uses for this medicine

Ketoprofen is also sometimes used to treat juvenile rheumatoid arthritis (a type of arthritis that affects
children), ankylosing spondylitis (arthritis that mainly affects the spine), Reiter's syndrome (condition in
which many parts of the body including the joints, eyes, genitals, bladder, and digestive system
become swollen), shoulder pain caused by bursitis (inflammation of a fluid-filled sac in the shoulder
joint) and tendinitis (inflammation of the tissue that connects muscle to bone), and gouty arthritis
(attacks of joint pain caused by a build-up of certain substances in the joints). Talk to your doctor about
the risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more
information.

What special precautions should I follow?

Before taking ketoprofen,

 tell your doctor and pharmacist if you are allergic to ketoprofen, aspirin or other NSAIDs such
as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), any other medications, or any of
the inactive ingredients in ketoprofen capsules or extended release capsules. Ask your
pharmacist for a list of the inactive ingredients.
 tell your doctor and pharmacist what prescription and nonprescription medications, vitamins,
nutritional supplements, and herbal products you are taking, or plan to take. Be sure to
mention the medications listed in the IMPORTANT WARNING section and any of the
following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin),
captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril),
moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril
(Mavik); diuretics ('water pills'); lithium (Eskalith, Lithobid); medications for diabetes;
methotrexate (Rheumatrex); phenytoin (Dilantin); probenecid (Benemid); and sulfa antibiotics
such as sulfisoxazole (Gantrisin) and sulfamethoxazole (in Bactrim, in Septra). Your doctor
may need to change the doses of your medications or monitor you more carefully for side
effects.
 tell your doctor if you have or have ever had any of the conditions mentioned in the
IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or
runny nose or nasal polyps (swelling of the lining of the nose); swelling of the hands, arms,
feet, ankles, or lower legs; or liver or kidney disease.
 tell your doctor if you are pregnant especially if you are in the last few months of your
pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant
while taking ketoprofen, call your doctor.
 if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking
ketoprofen.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip
the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for
a missed one.

What side effects can this medication cause?

Ketoprofen may cause side effects. Tell your doctor if any of these symptoms are severe or do not go
away:
  constipation
 diarrhea
 sores in the mouth
 headache
 dizziness
 nervousness
 drowsiness
 difficulty falling asleep or staying asleep
 ringing in the ears

Some side effects may be serious. If you experience any of the following symptoms or those
mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more
ketoprofen until you speak to your doctor.

 changes in vision
 unexplained weight gain
 fever
 blisters
 rash
 itching
 hives
 swelling of the eyes, face, lips, tongue, throat, arms, hands, feet, ankles, or lower legs
 hoarseness
 difficulty breathing or swallowing
 excessive tiredness
 unusual bleeding or bruising
 lack of energy
 loss of appetite
 upset stomach
 pain in the upper right part of the stomach
 flu-like symptoms
 yellowing of the skin or eyes
 pale skin
 fast heartbeat
 cloudy, discolored, or bloody urine
 back pain
 difficult or painful urination

Ketoprofen may cause other side effects. Call your doctor if you have any unusual problems while
taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug
Administration's (FDA) MedWatch Adverse Event Reporting program online [at
http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at
room temperature and away from excess heat and moisture (not in the bathroom). Throw away any
medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of
your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has
collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

 lack of energy
 drowsiness
 upset stomach
  vomiting
 stomach pain
 shallow breathing
 seizures
 coma

What other information should I know?

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking
ketoprofen.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about
refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-
counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary
supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a
hospital. It is also important information to carry with you in case of emergencies.

Brand name(s):

 Actron®

Last Revised - 01/01/2006

Last Reviewed - 08/01/2007

Drug Information: Ketorolac

(kee toe role' ak)
IMPORTANT WARNING:

Ketorolac is used for the short-term relief of moderately severe pain and should not be used for longer
than 5 days, for mild pain, or for pain from chronic (long-term) conditions. You will receive your first
doses of ketorolac by intravenous (into a vein) or intramuscular (into a muscle) injection in a hospital or
medical office. After that, your doctor may choose to continue your treatment with oral ketorolac. You
must stop taking oral ketorolac on the fifth day after you received your first ketorolac injection. Talk to
your doctor if you still have pain after 5 days or if your pain is not controlled with this medication.
Ketorolac may cause serious side effects, especially when taken improperly. Take ketorolac exactly as
directed. Do not take more of it or take it more often than prescribed by your doctor.People who take
nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as ketorolac may have a
higher risk of having a heart attack or a stroke than people who do not take these medications. These
events may happen without warning and may cause death. This risk may be higher for people who take
NSAIDs for a long time. Tell your doctor if you or anyone in your family has or has ever had heart
disease, a heart attack, or a stroke or 'mini-stroke' if you smoke,and if you have or have ever had high
cholesterol, high blood pressure, bleeding or clotting problems, or diabetes. Get emergency medical
help right away if you experience any of the following symptoms: chest pain, shortness of breath,
weakness in one part or side of the body, or slurred speech.If you are having surgery, including dental
surgery, tell the doctor or dentist that you are taking ketorolac. If you will be undergoing a coronary
artery bypass graft (CABG; a type of heart surgery), you should not take ketorolac right before or right
after the surgery.NSAIDs such as ketorolac may cause ulcers, bleeding, or holes in the stomach or
intestine. These problems may develop at any time during treatment, may happen without warning
symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time,
are older in age, have poor health, or drink large amounts of alcohol while taking ketorolac. Tell your
doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin
(Coumadin); aspirin; or oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone
(Medrol), and prednisone (Deltasone). Do not take aspirin or other NSAIDs such as ibuprofen (Advil,
Motrin) and naproxen (Aleve, Naprosyn) while you are taking ketorolac. Also tell your doctor if you have
or have ever had ulcers or bleeding in your stomach or intestines. If you experience any of the following
symptoms, stop taking ketorolac and call your doctor: stomach pain, heartburn, vomiting a substance
that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.Ketorolac may
cause kidney failure. Tell your doctor if you have kidney or liver disease, if you have had severe
vomiting or diarrhea or think you may be dehydrated, and if you are taking angiotensin-converting
enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec),
fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril
(Accupril), ramipril (Altace), and trandolapril (Mavik); or diuretics ('water pills'). If you experience any of
the following symptoms, stop taking ketorolac and call your doctor: swelling of the hands, arms, feet,
ankles, or lower legs; unexplained weight gain; confusion; or seizures.Some people have severe
allergic reactions to ketorolac. Tell your doctor if you are allergic to ketorolac, aspirin or other NSAIDs
such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn), or any other medications. Also tell
your doctor if you have or have ever had asthma, especially if you also have frequent stuffed or runny
nose or nasal polyps (swelling of the lining of the nose). If you experience any of the following
symptoms, stop taking ketorolac and call your doctor right away: rash; hives; itching; swelling of the
eyes, face, throat, tongue, arms, hands, ankles, or lower legs; difficulty breathing or swallowing; or
hoarseness.Do not breastfeed while you are taking ketorolac.Keep all appointments with your doctor
and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain
tests to check your body's response to ketorolac. Be sure to tell your doctor how you are feeling so that
your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of
serious side effects.Your doctor or pharmacist will give you the manufacturer's patient information sheet
(Medication Guide) when you begin treatment with ketorolac and each time you refill your prescription.
Read the information carefully and ask your doctor or pharmacist if you have any questions. You can
also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/cder) to obtain the
Medication Guide.

Why is this medication prescribed?

Ketorolac is used to relieve moderately severe pain, usually after surgery. Ketorolac is in a class of
medications called NSAIDs. It works by stopping the body's production of a substance that causes
pain, fever, and inflammation.

How should this medicine be used?

Ketorolac comes as a tablet to take by mouth. It is usually taken every 4-6 hours on a schedule or as
needed for pain. If you are taking ketorolac on a schedule, take it at around the same times every day.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain
any part you do not understand.

Other uses for this medicine

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more
information.

What special precautions should I follow?

Before taking ketorolac,

 do not take ketorolac if you are taking probenecid.

 tell your doctor and pharmacist what prescription and nonprescription medications, vitamins,
nutritional supplements, and herbal products you are taking or plan to take. Be sure to
mention the medications listed in the IMPORTANT WARNING section and any of the
following: antidepressants; medications for anxietyor mental illness; medications for seizures
such as phenytoin (Dilantin) or carbamazepine (Tegretol); methotrexate (Rheumatrex);
sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your
medications or monitor you more carefully for side effects.
 tell your doctor if you have or have ever had the conditions mentioned in the IMPORTANT
WARNING section or swelling of the hands, feet, ankles, or lower legs.
 tell your doctor if you are pregnant, especially if you are in the last few months of your
pregnancy, or you plan to become pregnant. If you become pregnant while taking ketorolac,
call your doctor.
 you should know that this medication may make you drowsy or dizzy. Do not drive a car or
operate machinery until you know how this medication affects you.
 remember that alcohol can add to the drowsiness caused by this medication. Talk to your
doctor about the safe use of alcohol while taking this medication.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

If your doctor has told you to take ketorolac regularly, take the missed dose as soon as you remember
it. However, if it is almost time for the next dose, skip the missed dose and continue your regular
dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Ketorolac may cause side effects. Tell your doctor if any of these symptoms are severe or do not go
away:

 headache
 dizziness
 drowsiness
 diarrhea
 constipation
 gas
 sores in the mouth
 sweating

Some side effects can be serious. If you experience any of the following symptoms, or those
mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more
ketorolac until you speak to your doctor.
  fever
 blisters
 yellowing of the skin or eyes
 excessive tiredness
 unusual bleeding or bruising
 lack of energy
 upset stomach
 loss of appetite
 pain in the upper right part of the stomach
 flu-like symptoms
 pale skin
 fast hearbeat
 cloudy, discolored, or bloody urine
 back pain
 difficult or painful urination

Ketorolac may cause other side effects. Call your doctor if you have any unusual problems while
taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug
Administration's (FDA) MedWatch Adverse Event Reporting program online [at
http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at
room temperature and away from excess heat and moisture (not in the bathroom). Throw away any
medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of
your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has
collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

 upset stomach
 vomiting
 stomach pain
 bloody, black, or tarry stools
 vomiting a substance that is bloody or looks like coffee grounds
 drowsiness
 slowed breathing or fast, shallow breathing
 coma (loss of consciousness for a period of time)

What other information should I know?

Do not let anyone else take your medication. Ask your pharmacist any questions you have about
refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-
counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary
supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a
hospital. It is also important information to carry with you in case of emergencies.

Brand name(s):

 Toradol®
Last Revised - 01/01/2006
Last Reviewed - 08/01/2007