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Abstract
Ameloblastoma is the second most common intraosseous benign odontogenic tumor usually affecting the
posterior region of mandible, is slowly growing, locally invasive, epithelial odontogenic of the jaw with a high rate to recurrence. This is a lesion
whose clinical and radiographical features are similar to all the variants, and a definitive diagnosis is achieved by histopathology only.
Ameloblastoma has histologicall patterns, these pattern are follicular, plexiform, acanthomatous and granular cell. other less common
histological variants are clear cell and desmoplastic cells. Variants with more than one histological pattern for the same ameloblastoma could show,
depending on the direction and degree of differentiation of tumor cells. Here we present a serial case with with more than one type of histologic
variants of conventional ameloblastoma seen.
buccal, mentale, and labial region. Enlarged of inferior alveolar nerve canal was displaced
regional lymp nodes 1 cm in size, firm in downward, and mandibular bone destruction with
consistence, mobile with no pain. inferior border of mandible in region 46 to 47 was
ballooning out and not intact. CT scan review
revealed solid lesion 8,5 x 5 x 5 cm in mentale to
ramus mandible dextra with destruction that area.
Intraorally, a diffused swelling was present in Figure 6. Preoperative panoramic photo of the
the buccal aspect of teeth 33, 36, 37, 38, and mandibular mass, shows multilocular radiolucency,
extending to lingual area. diffuse borders, hiperemi root resorption and mandibular bone destruction
to surrounding tissue, no fistula, no ulcer. On with inferior border of mandible was not intact
palpation, swelling was non tender, clear borders,
7x5x2.5 cm in size , firm to hard in consistency Fine needle aspiration biopsy was carried out
with few soft spots in mandible posterior region 44- and the puncture were taken from the nodul in the
46.Uneven surface, same temperature as the ramus mandible dextra, benign cystic degeneration
surrounding tissue. Clinically teeth 42, 43, 48 were tissue was found. Then an incisional biopsy was
mobile. carried out, and tissue samples were taken from 3
sites. Ameloblastoma (follicular and plexiform type)
was obtained in the all tissue. Right
hemimandibulectomy was done with Costochondral
Graft and Stabilize with reconstruction plate.
4 DISCUSSION
The ameloblastoma is a histologically almost
always benign odontogenic tumour of the jaw bones.
In 2017, the classification of these lesions underwent
modifications in terminology with the introduction
of prospective views based on updates in current
genetic studies. WHO 2017 classification divided
ameloblastoma based on clinical and radiographic
characteristics, histopathology, behavioral and
subtypes or variants into four categories;
conventional, unicystic, extraosseous / peripheral,
and metastasizing ameloblastoma. The solid/
multicystic term was discarded, as it could be
confused withthe unicystic type. Desmoplastic
ameloblastoma was also reclassified as a histological
subtype and not as aclinical-pathological entity. 1
Conventional ameloblastoma is the most common,
representing 85% of all ameloblastomas, It can be
divided into follicular, plexiform, acanthomatous
and granular cell morphological patterns. other less
common histological variants are clear cell and
desmoplastic cells.In general, one-third of the
conventional type has a plexiform pattern, one-third
a follicular pattern, and the remaining third
corresponds to the other variants. Its biological Figure 9. The presence of more than one histological
behavior is considered more aggressive due to its subtype conventional ameloblastoma. It presenting
higher incidence of recurrence.11 multiple patterns, follicular, acantomathous, and
Ameloblastoma consists of a proliferation of plexiform.
solid strands, cords and islands of odontogenic (1)Follicular type of islands with Peripheral palisade
epithelium supported by connective tissue stroma, and central reticulum stellate pattern. Squamous
This proliferating epithelium can undergo cystic metaplasia formation.
changes. the histopathological features of
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(2) Central squamous metaplasia with fibrous stroma and safety margins, it was found that the
surrounding suggestive of acanthomatous conventional type of ameloblastoma was more
transformation. aggressive when compared to the unicystic type. 14
(3) Appear stranded basal cell image of Plexiform The postoperative histopathological of unicystic type
type Ameloblastoma showed infiltration up to 0.2 cm. Postoperative
histopathological type Acanthomatous type showed
The case showed histological picture with more infiltration of up to 0.5 cm. Postoperative Follicular
than one histological subtype conventional type histopathological analysis showed infiltration of
ameloblastoma. It presenting multiple patterns, up to 0.75 cm Postoperative Plexiform type
follicular, acantomathous, and plexiform. In the histopathological analysis showed infiltration of up
study conducted by Fulco GM et al14, 75.5% of the to 0.75 cm.15 For large ameloblastomas, in order to
solid lesions ameloblastomas ( now it means ensure the removal of micro-cyst and
conventional ameloblastoma) included were made daughter cyst, resection of jaw should be done
up by more than one histological pattern. Similiarly, approximately 1.5–2 cm beyond the radiological
in the study carried out by Adeline et al.15, 68.6% of limit.18 In our case, marginal clearance of 2 cm was
the solid revealed more than one histological pattern. also achieved.
Nonetheless, only 16.1% and 19.7% of the solid
lesions evaluated by Reichart, et al. and Kim and 5 CONCLUSION
Jang16, respectively, showed more than one
histological type. According to Adebiyi et al., and Ameloblastoma can be divided into several types
Waldron and El-Mofty, ameloblastomas, especially based on the histopathological features. In one case
the large ones, are made up of numerous histological of Ameloblastoma could show more than one
9
Although there are various histopathological types histological patterns of various types of
of Ameloblastoma, it is known that they do not Ameloblastoma. Although is not uncommon, a
affect the biological behavior of the neoplasm. It is surgeon is expected to be more careful and
currently accepted that there is no relationship understand the histological pattern of
between histological pattern and tumor prognosis. In Ameloblastoma, starting from the results of a biopsy
addition, it is not uncommon for the same until definitive treatment of the case. It is currently
ameloblastoma to present different histological accepted that there is no relationship between
patterns.19 histological pattern and tumor behavior or prognosis.
The treatment of ameloblastoma remains
controversial because it is a benign, locally
aggressive tumor with a high recurrence rate. In References
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