OBSTRUCTIVE PULMONARY proteinases and anti-proteinases
DISEASES in the lung;- responsible for
Obstructive pulmonary disease airflow limitation. -describes conditions in which airflow • When activated by chronic in the lungs is obstructed. inflammation, proteinases and - Resistance to inspiration is other substances may be released, decreased, whereas resistance to damaging the parenchyma of the expiration is increased, so that the lung. expiratory phase of respiration is • The parenchymal changes may prolonged (Bullock & Henze, 2000). also be consequences of Chronic obstructive pulmonary inflammation, environmental, or disease: genetic factors. -(COPD) is an umbrella term for • Early course of COPD; the chronic lung diseases that inflammatory response causes have limited airflow in and out of the pulmonary vasculature changes lungs. that are characterized by -Symptoms include chronic cough and thickening of the vessel wall. expectoration, dyspnea, • Occur as a result of exposure to shortness of breath, wheezing, and cigarette smoke or use of tobacco impaired expiratory airflow. products or as a result of the -COPD- diseases that cause airflow release of inflammatory mediators. obstruction or a combination. • Categories of COPD: - emphysema, chronic bronchitis and • A. Emphysema- disease of the other diseases such as cystic airways characterized by fibrosis, bronchiectasis and asthma. destruction of the walls of over Pathophysiology: distended alveoli. - airflow limitation is both progressive - a pathological term that describes an and associated with an abnormal abnormal distention of the walls of inflammatory response of the lungs to alveoli. noxious particles or gases. - the End Stage- walls of the alveoli are - the inflammatory process occurs destroyed (process accelerated by throughout the airways, parenchyma recurrent infections), and pulmonary vasculature. a. the alveolar surface area in direct - the chronic inflammation and the contact with the pulmonary capillaries body’s attempts to repair it, continually decreases, causing an narrowing occurs in the small increase in dead space (no gas peripheral airways. exchange); - this injury-and-repair process causes b. impaired oxygen diffusion which scar tissue formation and narrowing leads to hypoxemia. of the lumen. Later Stage- carbon dioxide tension in - airflow obstruction may also be due arterial blood (hypercarpnia) and to parenchymal destruction, causing respiratory acidosis. (emphysema), a disease of the alveoli -As the alveolar walls continue to or gas exchange units. break down, the pulmonary bed is • In addition to inflammation; reduced. processes relating to imbalances of - Pulmonary blood flow increased, 2. irritates the goblet cells and mucus forcing the right ventricle to glands, causing an increased maintain a higher blood pressure accumulation of mucus. in the pulmonary artery. 3. carbon monoxide (byproduct of - Hypoxemia increase pulmonary smoking)- combines pressure, thus right- sided heart with hemoglobin to form failure (cor pulmonale) as a carboxyhemoglobin- cannot carry complication. oxygen efficiently. ==congestion, dependent edema, b. prolonged and intense exposure to distended neck veins, or pain in the occupational dusts and region of the liver. chemicals, indoor air pollution and • Two main types of Emphysema: outdoor air pollution. 1. Panlobar (panacinar)- there is c. deficiency of alpha, antitrypsin, an destruction of the respiratory enzyme inhibitor that bronchiole, alveolar duct and process the lung parenchyma from alveoli. injury. - all air spaces within the lobule are • Clinical manifestations: essentially enlarged, but there is little - cough, sputum production inflammatory disease. and dyspnea in exertion, weight loss, - manifestations-hyperinflated - barrel chest (chronic (hyperexpanded), chest (barrel chest), hyperinflation)- loss of lung elasticity marked dyspnea on exertion and • Assessment and Diagnostic weight loss. findings: = negative pressure during - pulmonary function studies- inspiration- to move air and out of the determine disease severity lungs. - spirometry- evaluate airflow = adequate level of positive pressure obstruction must be attained and maintained - arterial blood gas- obtained to assess during expiration. baseline oxygenation and gas 2. Centrilobular (Centroacinar)- take exchange. place mainly in the center of the - chest x-ray- secondary lobule, preserving the - alpha1 antitrypsin deficiency peripheral portions of the acinus. screening - derangement of ventilation • Complications: -perfusion ratios, producing chronic - Respiratory insufficiency and hypoxemia, hypercarpnia (increased failure, pneumonia, atelectasis, CO2 in the arterial blood), pneumothorax and cor polycythemia and episodes of right pulmonale (pulmonary heart disease). sided heart failure; leads to central • Medical management: cyanosis, peripheral edema and 1. Smoking cessation respiratory failure. 2. Pharmacologic therapy: Risk Factors: a. bronchodilators- relieve a. cigarette smoking/ passive smoking bronchospasm and reduce airway 1. depresses the activity of scavenger obstruction by allowing increased cells and affects the respiratory tract’s oxygen distribution throughout the ciliary cleansing mechanism, lungs and improving alveolar 4. Self care activities- take short walks, ventilation. resting as needed to avoid fatigue = metered-dose inhaler (MDI)- and excessive dyspnea. Fluid should pressurized device containing an always available and patient should aerosol powder of medication. begin to drink fluids without having to b. Corticosteroids- be reminded. • Management of Exacerbation: 5. Physical conditioning- breathing • Causes: tracheobronchial infection exercise and general exercises to and air pollution; pneumonia, conserve energy and increase pulmonary embolism, pulmonary ventilation. pneumothorax, rib fractures or 6. oxygen therapy at home- portable chest trauma. oxygen system; proper flow rate and • Treatment: indications for requires number of hours for oxygen hospitalization: use. 1. optimization of bronchodilator - precaution – smoking is not allowed medication-first line therapy.; (explode) 2. antibiotic agents. 7. nutritional therapy- caloric needs 3. oxygen therapy and counseling about meal planning 4. intensive respiratory intervention • Coping measures- patient and • Oxygen therapy- long-term family continuous therapy B. Chronic Bronchitis- chronic • Surgical management: inflammation of the lower respiratory 1. bullectomy- reduce dyspnea and tract characterized by excessive improve lung function. Done mucus secretion, cough and dyspnea thoracoscopically ( video associated with recurring infections of assisted thoracoscope). the lower respiratory tract. 2. lung volume reduction surgery- • Pathophysiology: removal of a portion of the diseased - smoke or other environmental lung parenchyma. Allows the pollutants irritate the airways, functional tissue to expand, resulting resulting in hyper secretion of mucus in improved elastic recoil of the lung and inflammation. and improved chest wall and - Constant irritation causes the mucus- diaphragmatic mechanism. secreting glands and goblet cells to 3. lung transplant- viable alternative increase in number, ciliary function is for definitive surgical treatment of reduced. end stage emphysema. - the bronchial walls thickened, the • Nursing management: bronchial lumen is narrowed, 1. Patient education and mucus plug the airway. 2. Breathing exercises- pursed-lip - alveoli adjacent to the bronchioles breathing helps to slow expiration, may be damaged and fibrosed prevent collapse of small airways, resulting in altered function of the helps the patient to control the alveolar macrophages. rate and depth of respiration. • Signs/symptoms: 3. Inspiratory muscle training- a. presence of cough and sputum diaphragmatic breathing; to production for at least three months strengthen the muscles in each of 2 consecutive years. b. production of thick, gelatinous 8. Enhancing coping sputum, greater amounts producing Other Classified Diseases as superimposed infections COPD: c. wheezing and dyspnea as disease A. ASTHMA: progresses Asthma is usually a reversible Diagnostic evaluation: obstructive disease of the lower 1. pulmonary function test- airway. Inflammation of the airway demonstrate airflow obstruction- and hyper responsiveness of the - reduced FEV to FVC ratio airway to internal or external stimuli - increased residual volume to total characterize asthma. lung capacity (TLC )ratio Pathophysiology and Etiology: 2. ABG’s decreased PaO2,pH and There are two types of asthma: increased O2 1. allergic asthma (extrinsic),- which 3. CXR- (late stage)- hyperinflation, occurs in response to allergens, such flattened diaphragm, increased as pollen, dust, spores, and animal retrosternal space, decreased vascular dander; and markings, possible bullae. 2. non-allergic asthma (intrinsic),- • Management: associated with factors such as upper 1. smoking cessation respiratory infections, emotional 2. bronchodilators upsets, and exercise. ***Many clients - symphathomimetics; experience mixed asthma, which has metaproterenol-to protect against characteristics of allergic and non- bronchospasm ( aerosol allergic asthma. formulations); MDIs. • Acute asthma results from - methylxanthines- theophylline increasing airway obstruction 3. Antimicrobial agents- infection caused by bronchospasm and 4. corticosteroids- acute exacerbations bronchoconstriction, inflammation for anti-inflammatory effect. and edema of the lining of the 5. Chest physical therapy bronchi and bronchioles, and 6. Low-flow oxygen production of thick mucus that can 7. Pulmonary rehabilitation- limit plug the airway. activity • The airways in people with asthma • Complications: are hyper-reactive in response to - respiratory failure stimuli. - pneumonia- overwhelming • Allergic asthma causes the respiratory infection immunoglobulin E (IgE) - right heart failure; dysrythmias inflammatory response. - depression; • These antibodies attach to mast Nursing Management: cells (granulocyte contain 1. Improving airway clearance histamine and heparin) within the 2. Improving breathing pattern lungs. 3. Controlling infection • Reexposure to the antigen causes 4. Improving gas exchange the antigen to attach to the 5. Nutrition antibody, releasing mast cell 6. Increased activity tolerance products such as histamine. 7. Improving sleep patter • Because alveoli cannot expel air, • Diagnostic Findings: they hyperinflate and trap air in 1. Chest auscultation reveals the lungs. expiratory and sometimes inspiratory • The client breathes faster, blowing wheezes and diminished breath off excess CO2. sounds. • Although the client tries to force 2. Pulmonary function studies; the air out, the narrowed airway - Forced expiratory volume makes it difficult. - abnormal • Wheezing usually is audible with - Total Lung Capacity (TLC) and expiration, resulting from air being Functional Residual Volume (FRV) forced out of the narrowed airway. increased secondary to trapped air. • Other pathophysiologic changes Forced Expiratory Volume (FEV) and include interference with gas Forced Vital Capacity (FVC) are exchange, poor perfusion, possible decreased. atelectasis, and respiratory failure 3. During acute attacks, blood gases if inadequately treated. (ABG) show hypoxemia. • Asthma may develop at any age. - The partial pressure of carbon • Significant relationship between dioxide (PaCO2) level may be elevated bronchiolitis (inflammation if the asthma becomes worse, but of the bronchioles) in the first usually the PaCO2 level is decreased year of life and development of because of the rapid respiratory rate. asthma in early childhood. - A normal PaCO2 level in the latter • Assessment Findings: part of an asthma attack may indicate • Signs and Symptoms: impending respiratory failure. =paroxysms of shortness of • Medical Management: breath, wheezing, and coughing and 1. If the history and diagnostic tests the production of thick, indicate allergy as a causative factor, tenacious sputum. treatment includes avoidance of the = Duration of acute episodes allergen, desensitization, or varies; it may be brief (less antihistamine therapy. than 1 day) or extended 2. Oxygen usually is not necessary (lasting for several weeks). during an acute attack because most =During an acute episode, the clients are actively hyperventilating. work of breathing greatly Oxygen may be necessary if cyanosis increases, and the client occurs. may suffer from a sensation of 3. Pharmacologic management: suffocation. - metered-dose inhalers (MDIs). -The client frequently - Bronchodilators are used to manage assumes a classic sitting position, acute breathing disorders with the body leaning • Nursing Management: slightly forward and the arms at 1. administers oxygen if indicated and shoulder height. puts the client in a sitting position. - This position facilitates 2. Rest and adequate fluid intake- chest expansion and more secretions less tenacious and replaces effective excursions of the fluids lost through perspiration. the diaphragm. 3. checks the intravenous (IV) site • Airway clearance is further frequently for signs of extravasation. impaired, and the purulent 4. when the client is receiving material remains, causing more epinephrine or other adrenergic dilatation, structural damage, agents, which may cause palpitations, and more infection. nervousness, trembling, pallor, and • Nursing Management for the insomnia. Elderly; 5. instructs the client in using the peak • The goals of therapy in the elderly flow meter to monitor the degree of with COPD: asthma control. • to treat and prevent chronic • Nutrition: symptoms, 1. Encourage clients with asthma to • decrease emergency room visits consume adequate calories and and hospitalizations, optimize and protein to optimize health and resist preserve activity level, infection. • optimize pulmonary function with 2. Large meals may aggravate asthma minimal adverse effect from by distending the stomach; small medications. frequent meals may be better • Management should also focus on tolerated. improving health status (quality of 3. Certain vitamins and minerals are life), which is greatly impaired by important for immune function, respiratory symptoms such as especially vitamins A, C, B6, and the breathlessness and by symptoms mineral zinc. of anxiety and depression. 4. Food allergens that may trigger • Clinical manifestations: asthma include milk, eggs, seafoods 1. persistent cough with production of and fish. copious amounts of purulent sputum. • B. Bronchiectasis- a chronic, 2. intermittent hemoptysis; irreversible dilatation of the breathlessness bronchi and bronchioles. 3. recurrent fever and bouts of • Causes: pulmonary infection - bronchial obstruction by tumor or 4. crackles and rhonchi ( foreign body, whistling/snoring) heard over - congenital abnormalities, involved lobes - exposure to toxic gases, 5. finger clubbing - chronic pulmonary infections. Diagnostic evaluation; Pathophysiology: -CXR- may reveal areas of atelectasis - damage to the bronchial wall, which with widespread dilatation of bronchi. leads to buildup of thick sputum, - sputum examination- pathogens causing obstruction. • Medical Management - severe coughing result in permanent 1. drainage of purulent material from dilatation of bronchial walls. the bronchi; antibiotics, • The structure of the wall tissue bronchodilators, and mucolytics to subsequently changes, resulting improve breathing and help raise in formation of saccular secretions; dilatations, which collect purulent 2. humidification to loosen secretions; material. 3. surgical removal if bronchiectasis is Subsequently, thick, viscous confined to a small area. secretions and protein plugs Nursing management: eventually block the ducts of the 1. instructing the client in postural exocrine glands. Eventually, ducts may drainage techniques, which help the become client mobilize and expectorate fibrotic and convert into cysts secretions. (Bullock & Henze, 2000). 2. Chest percussion and vibration may • Airflow obstruction is a key be performed during this time. feature in the presentation CF. 3. Encourage increased intake of fluid • This obstruction is due to to reduce viscosity of sputum and bronchial plugging by purulent make expectoration easier. secretions, bronchial thickening C. Cystic Fibrosis - an inherited due to inflammation resulting multisystem disorder that affects airway obstruction. infants, children, and young adults. • Chronic retained secretions in the - It obstructs the lungs, leading to airways set up an excellent major lung infections, as well as reservoir for continuous bronchial obstructing the pancreas. infection. • Pathophysiology and Etiology • Clinical manifestations: - CF results from a defective • respiratory infections, ranging autosomal recessive gene. from URIs with increased cough - A person with CF inherits a defective and purulent sputum to the copy of the CF gene from both parents. production of thick, tenacious - A person who is a carrier has one mucus. normal copy of the gene and one • Finger clubbing is common. defective copy. • Hemoptysis also may occur as - When two carriers give birth to a blood vessels are damaged in the child, the child has a 25% chance of lungs, secondary to frequent having CF, a 50% chance of being a coughing and constant efforts to carrier, and a 25% chance of not clear mucus. being a carrier. • Sinusitis and nasal polyps • The genetic defect causes • Assessment and diagnostic inadequate synthesis of a protein findings: (CF gene product) referred to • Pilocarpine iontophoresis sweat as the CF transmembrane test. Up to 20 years of age, levels conductance regulator (CFTR). higher than 60 mEq/L are • CFTR molecules are located in the diagnostic, and those between 50 cells lining the ducts of the and 60 mEq/L are highly exocrine glands, particularly the suggestive for CF. lungs, pancreas, intestine, and • Chest radiography demonstrates sweat ducts. widespread consolidation, fibrotic • Clients with CF cannot synthesize changes, and overaerated lungs. adequate CFTR to regulate the Pulmonary function tests assist in combination of water and determining current function as well electrolytes with exocrine secretions as progression of the disease. and mucus. • Radiographic studies of the GI system show fibrous abnormalities. • In 80% of those with CF, tests for pancreatic enzymes in duodenal contents fail to show evidence of trypsin. • Medical management; • promoting the removal of the thick sputum through postural drainage, • chest physical therapy with vigorous percussion and vibration, breathing exercises, • hydration to help thin secretions, • bronchodilator medications, nebulized mist treatments with saline or mucolytic • lung infections with antibiotics. • Inhaled antibiotics, such as tobramycin, are being used successfully and have the benefit of decreasing systemic absorption. • Nursing management: 1. chest physical therapy (including postural drainage, percussion, and vibration) two to four times daily, 2. deep-breathing and coughing exercises, nebulized treatments, and medications. 3. prophylactic antibiotic therapy to decrease recurrence of infection Chronic Illness/ Conditions it is a “mundane occurrence” in old Heart disease, people. Hypertension, - “only about 1/3 of elderly patients Chronic obstructive Pulmonary present with classical prolonged Disease COPD episode of chest pain”. (Kart & Kinny) Diabetes, Gerontology: Cancer and - elderly patients: more likely to Dementia, experience silent MIs have atypical Stroke symptoms- hypotension, low body A. Heart Disease temperature, vague complaints of Principle cause of death discomfort, mild perspiration, stroke- Accounts for significant morbidity, like symptoms ( dizziness, change in disablement and inactivity sensorium). Dominant factors; atherosclerosis Etiology (build-up of fatty deposits within 1. Acute Coronary thrombosis (partial arterial walls or total)– associated with 90% of Mis. Pathophysiology/Mechanism a. severe coronary artery disease Atherosclerosis buildup (greater then 70% narrowing of Narrowing of arteries supplying blood the to the heart artery) precipitates thrombus Ischemia ( inadequate blood supply) formation. Ischemic heart disease known as; b. Intramural hemorrhage into a. Coronary heart disease (CHD) atheromatous plaques causes b. Coronary artery disease (CAD) lesion to c. Myocardial infarction (heart enlarge and occlude the vessel; attack)- dissecting persistence of deficient blood hemorrhage can also occur. supply, c. plaque ruptures into the vessel tissue dies. lumen and a thrombus forms on - Dead area (Necrosis): an infarct top of the ulcerated lesion, with Heart attack may result from; resultant vessel occlusion. - cardiac arrest- some interruption 2. Other etiologic factors; of normal pattern of cardiac - coronary artery spasm, coronary contraction artery embolism, infectious disease - Coronary thrombosis- sudden causing arterial inflammation, blockage of coronary artery with a hypoxia, anemia severe exertion or blood clot, stress on the heart in the presence of - Strenuous exercises resulting in significant coronary artery disease. suddenly increased need for oxygen. 3. Degrees of Damage occur to the Mortality associated with MI heart muscle: Over 70 and 2x under the age 70 a. Zone of necrosis- death to the Symptoms of MI may differ in older heart muscle caused by extensive people than in younger ones. and complete oxygen deprivation; - complete absence of chest pain is (Irreversible damage). very rare in acute MI up to middle age, b. Zone of Injury – region of the heart muscle surrounding the area of Obesity necrosis; Sedentary lifestyle - inflamed and injured, but still Healthy people 2000 viable if adequate oxygenation can 1. Increase proportion of people be whose high B/P is under control restored. 2. reduce mean-serum cholesterol c. Zone of ischemia- region of the levels heart muscle surrounding the 3. reduce dietary fat intake and area of injury, which is ischemic and average unsaturated fat intake viable; 4. reduce prevalence rates of - not endangered unless extension obese/overweight adults of the infarction occurs. 5. increase proportion of children and 4. Layers of the layers of the heart adults engaging in regular, daily muscle physical activity at least 30min/day. involved; Classified as: 6. reduce cigarette smoking among a. Transmural (Q wave) infarction- people age 20 and older area of necrosis occurs throughout the (.http://www.health.gov/healthypeop entire thickness of the heart muscle. le). b. Subendocardial Management: (nontransmural/non-Q) infarction- A. oxygen therapy- improves area of necrosis is oxygenation confined to the innermost layer of the B. Pain Control; heart lining the chambers. i. Opiate analgesic therapy= 5. Location of damaged heart muscle - morphine- improve cardiac within the left ventricle; inferior, hemodynamics by reducing anterior, lateral and posterior; preload and afterload; provide a. left ventricle- most common and anxiety relief. dangerous location- main pumping - Meperidine (demerol)- allergic to chamber of the heart. morphine or sensitive to b. right ventricular infarctions – occur respiratory depression. in conjunction with damage to the ii. Vasodilator therapy- inferior and/or posterior wall of the - nitroglycerine (sublingual, paste) left ventricle. - myocardial oxygen demand 6. Region of the heart muscle that - persistent chest pain – IV becomes damaged- determined by the nitroglycerin coronary artery that becomes iii. Anxiolytic therapy- obstructed. - benzodiazepines- with 7. Amount of heart muscle damage analgesic. and the location of the MI- determines C. Pharmacologic therapy- prognosis. i. Thrombolytic agents- tissue Heart Disease: Modifiable Factors: plasminogen activator; steptokinase, Cigarette smoker: 2x MI rate of non- urokinase; reestablish blood flow in smokers coronary vessels by dissolving High B/p obstructing thrombus. High serum cholesterol levels ii. Anticoagulant therapy- adjunct Diabetes to thrombolytic therapy. iii. Beta-adrenergic blocking agents- Read about Hypertension, COPD and improve O2 supply and demand, Diabetes mellitus. decrease sympathetic stimulation to Hypertension: High Blood Pressure the heart, promote blood flow in the Disease of the vascular regulation in small vessels of the heart; have anti - which the mechanism that control dysrhythmic arterial pressure within normal range effects are altered. iv. Anti-dysrhythmic therapy; Mechanism control: lidocaine- decreases ventricular - CNS irritability. - renal pressure system (renin- v. Calcium channel blockers angiotensin-aldosterone system (Dilzem)- improve the balance b/w O2 - extracellular fluid volume. and demand by decreasing HR, B/P B/p elevation- increased cardiac and dilating coronary vessels. output and peripheral vascular D. Percutaneous Transluminal resistance. Coronary Angioplasty (PTCA)- Hypertension mechanical opening of the coronary Pathophysiology/Etiology: vessel can be performed during an A. Primary or Essential Hypertension evolving infarction. - approx. 90% of patients with hpn E. Surgical Revascularization- - diastolic pressure is 90mmHg or coronary artery bypass surgery (w/in higher and other causes of 6hrs of evolving infarction) hypertension are absent. - definite treatment of the stenosis - considered hpn when the average of and less scar formation of the heart. 3 or more B/p readings taken at rest Gerontology Consideration: several days apart exceeds the upper Elderly patients are extremely limits. susceptible to respiratory depression in response to narcotics. Causes: Analgesic agents with less profound Unknown effects on the respiratory center Hyperactivity of sympathetic should be used. vasoconstricting nerves Anxiolytic agents Presence of blood component Nursing care: containing a vasoconstrictor that acts Reducing pain- administer O2, on smooth muscle, sensitizing it to medication; constrictor substances Alleviating anxiety- explain Increases cardiac output, followed by equipment, procedures and need for arteriole constriction. frequent assessment Prostaglandins affect regulatory Maintaining hemodynamic stability- mechanism, which include the renin- monitor v/s. angiotensin system, renal Na and Increasing activity tolerance- promote water excretion and vascular smooth rest with early gradual increase in muscle tone. mobilization Familial (genetic) tendency. Preventing bleeding- monitor V/s; Decsription: thrombolytic agent. Labile- intermittently elevated B/P Assignment: Accelerated- sudden and severe Stimulates renin release by the escalation in arterial pressure, kidney, which increases producing many symptoms and circulating angiotensin II (AII) vascular damage and aldosterone. Resistant- hpn that is not responsive These hormones increase blood to usual treatment volume by enhancing renal Atrial natriuretic peptide (ANP) or reabsorption of sodium and water. atrial natriuretic factor (ANF) is a Increased AII also causes systemic natriuretic peptide hormone secreted vasoconstriction and enhances from the cardiac atria. sympathetic activity. cardiac hormone which gene and Chronic elevation of all promotes receptors are widely present in the cardiac and vascular hypertrophy. body. The net effect of these renal Main functions: mechanisms is an increase in blood To lower blood pressure and to volume that augments cardiac output control electrolyte homeostasis. by the Frank-Starling mechanism. Causing a reduction in expanded Therefore, hypertension caused by extracellular fluid (ECF) volume by renal artery stenosis results from both increasing renal sodium excretion. an increase in systemic vascular B. Secondary hypertension resistance and an increase in cardiac - approx. 5%-10% of patients with output. hypertension Frank–Starling law of the heart Causes: represents the relationship between 1. follows other pathology stroke volume and end diastolic 2. Renal Pathology- volume. a. congenital anomalies, - states that the stroke volume of pyelonephritis, renal artery the heart increases in response to an obstruction, acute and chronic increase in the volume of blood in the glomerulonephritis. ventricles, before contraction, when b. reduced blood flow to kidney all other factors remain constant.. (atherosclerotic plaque) release Hypertension- the leading causes of of renin. CKD due to the deleterious effects that - renin reacts with serum protein in increased BP has liver (a2- globulin) angiotensin I; on kidney vasculature. and angiotensin-converting enzyme - damage impairs the kidney's ability (ACE) to filter fluid and waste from the Angiotensin II leads to increase blood, leading to an increase of fluid B/P. volume in the blood causing an Renal artery disease can cause of increase in BP narrowing of the vessel lumen 3.Coarctation of aorta (stenosis of (stenosis). aorta)- blood flow to upper Reduced lumen diameter decreases extremities is greater than flow to the pressure at the afferent arteriole lower extremities hpn of upper in the kidney and reduces renal body part. perfusion. Coarctation (narrowing) of the aorta is a congenital defect that most commonly is found just distal to the C. Accelerated Hypertension- left subclavian artery in the arch of the Hypertensive Crisis Blood pressure aorta. elevates very rapidly, threatening one Obstruction of the aorta at this point or more of the target organs; brain, reduces distal arterial pressures and kidney heart elevates arterial pressures in the head Classification and arms. Prevalence and Risk factors The reduced systemic arterial No Symptoms- is termed as “silent pressure activates the renin- killer” angiotensin-aldosterone system, Factors; which leads to an increase in blood - age-30-70 volume. - race- african american This further increases arterial - birth control pills pressures in the upper body and may - overweight largely offset the reduction in lower - family history body arterial pressures. - smoking This condition is readily diagnosed by - sedentary lifestyle comparing arterial pressures - stress measured in the arms and legs. - diabetes mellitus 4. Endocrine disturbances – Clinical manifestation a. Pheochromocytoma- tumor of the Usually asymptomatic adrenal gland – causes release of Headache, epinephrine and norepinephrine and a dizziness, rise in b/p blurred vision when greatly elevated b. Adrenal cortex tumors- leads to Diagnostic evaluation increase in aldosterone secretion and ECG– left ventricular hypertrophy, an elevated blood pressure. ischemia Increased secretion of aldosterone Chest x-ray- cardiomegaly generally results from adrenal Proteinuria- elevated BUN, creatinine adenoma or adrenal hyperplasia. Serum K- decreased in primary Increased aldosteronism- elevated in cushing circulating aldosterone causes renal syndrome retention of sodium and water, which Urine catecholamines- increased causes blood volume and arterial pheochromocytoma pressure to increase. Nursing Management Plasma renin levels are generally Goal: to help achieve a normal blood decreased as the body attempts to pressure through independent and suppress the renin-angiotensin dependent interventions. system; there is also hypokalemia Assessment: associated with the high levels of On antihypertensive medication,- aldosterone. blood pressure is c. Cushing syndrome leads to an assessed to determine the increase in adrenocortical steroids effectiveness and detect changes in and hypertension. the blood pressure. d. Hyperthyroidism. Complete history should be obtained alcohol consumption and avoidance to assess for signs and symptoms that of tobacco. indicate target organ damage. 6. Assist the patient to develop and Pay attention to the rate, rhythm, and adhere to character of the apical and peripheral an appropriate exercise regimen. pulses. Evaluation: Major goals for a patient with Maintain blood pressure at less than hypertension are as follows: 140/90 mmHg with lifestyle Understanding of the disease process modifications, medications, or both. and its treatment. Demonstrate no symptoms of angina, Participation in a self-care program. palpitations, or visual changes. Absence of complications. Has stable BUN and serum creatinine BP within acceptable limits for levels. individual. Has palpable peripheral pulses. Cardiovascular and systemic Evaluation; complications prevented/minimized. Adheres to the dietary regimen as Disease process/prognosis and prescribed. therapeutic regimen understood. Exercises regularly. Necessary lifestyle/behavioral Takes medications as prescribed and changes initiated. reports side effects. Plan in place to meet needs after Measures blood pressure routinely. discharge. Abstains from tobacco and alcohol Nursing Priorities intake. Maintain/enhance cardiovascular Exhibits no complications. functioning. Discharge and Home care Guidelines Prevent complications. The nurse can help the patient achieve Provide information about disease blood pressure control process/prognosis and treatment through education about managing regimen. blood pressure. Support active patient control of Assist the patient in setting goal blood condition. pressures. Nursing Interventions Provide assistance with social Objective: focuses on lowering and support. controlling the blood pressure Encourage the involvement of family without adverse effects and without members in the education program to undue cost. support the patient’s efforts to control 1. Encourage the patient to consult a hypertension. dietitian to help develop a plan for Provide written information about improving nutrient intake or for expected effects and side effects. weight loss. Encourage and teach patients to 2. Encourage restriction of sodium measure their blood pressures at and fat home. 3. Emphasize increase intake of fruits Emphasize strict compliance and vegetables. of follow-up check up. 4. Implement regular physical activity. DASH Guidelines 5. Advise patient to limit • 6 to 8 servings of grains per day • 4 to 5 servings of fresh fruits per day Respiratory muscle strength and • 4 to 5 servings of fresh vegetables endurance diminish with age, per day especially above the age of 55 years. • 2 to 3 servings of low-fat dairy per The anterior-posterior diameter of the day thorax and the kyphosis of the • 6 or less servings of lean protein per thoracic spine also increase with age. day Changes in skeletal muscle and the • 4 to 5 servings of legumes or thoracic wall may affect clearing of the nuts/seeds per week airway in states where airway mucus • Limited fats and sweets hypersecretion occurs.
Physiological Changes and COPD in
the Elderly Aging affects the structure, function, and control of the respiratory system. The elastic recoil of the lungs is the major determinant of maximal expiratory flow and is diminished with aging, causing increased lung compliance at high lung volumes. Bronchiolar diameters diminish and alveolar ducts enlarge as a result of the change in lung matrix and elastic properties of lungs. These changes result in decreased expiratory flow and decreased surface area for gas exchange, respectively. Airways in dependent portions of the lung close at higher volumes with advancing age, so that more airways are closed during all or part of the respiratory cycle. Lower portions of the lung are better perfused at all ages, but higher closing volume with age increases ventilation perfusion mismatch and accounts for the declining Pao2 (oxygen pressure) with age. In contrast to the lungs, the chest wall stiffens with age and compliance decreases. Costochondral cartilages become calcified, and intercostal muscle contraction accounts for less chest expansion.