XIII.

DRUG STUDY

Generic Name Dosage/Administration Drug Indication Contraindication Mechanism of Action Nursing Responsibility

Amikacin 20mg + 1cc PNSS Treatment of serious Hypersensitivity to Inhibits protein synthesis Assess for infection (vital
infections for which amikacin, other in bacteria at the level of signs; wound
IV treatment with less toxic aminoglycosides, or the 30S ribosome. appearance; sputum,
anti-infectives is bisulfites. Resists the action of urine, and stool; WBCs
Q24⁰ contraindicated or enzymes known to at beginning and
known to be ineffective. inactivate other throughout therapy.
Brand Name aminoglycosides.
Obtain specimens for
culture and sensitivity
Amikacide before initiating therapy.
First dose may be given
before receiving results.

Monitor intake and output

and daily weight to
assess hydration status
and renal function.

Classification

Therapeutics:
Anti-infectives
 Generic Name Dosage/Administration Drug Indication Contraindication Mechanism of Action Nursing Responsibility

Aminophylline 2.5mg + 1cc PNSS Long-term control of Hypersensitivity to Inhibits Assess BP, pulse,
reversible airway aminophylline or phosphodiesterase, respiratory status (rate,
IV obstruction caused by theophylline. producing increased lung sounds, use of
asthma or COPD. tissue concentrations of accessory muscles,
Q8⁰ Increases diaphragmatic cyclic adenosine number and severity of
contractility. monophosphate (cAMP). apnea spells in infants)
Brand Name Increased levels of before and throughout
cAMP result in: therapy.
Bronchodilation, CNS
No Brand Name stimulation, Positive Monitor intake and output
Indicated inotropic and ratios for an increase in
chronotropic effects, diuresis or fluid overload.
Diuresis, Gastric acid
secretion.

Classification

Therapeutics:
Bronchodilators
 Generic Name Dosage/Administration Drug Indication Contraindication Mechanism of Action Nursing Responsibility

Moropenem 64mg + 2cc NSS X 2 Treatment of: Intra- Hypersensitivity to Binds to bacterial cell Assess for infection (vital
abdominal infections, meropenem or wall, resulting in cell signs; appearance of
IV Bacterial meningitis. imipenem; Serious death. Meropenem wound, sputum, urine,
Skin and skin structure hypersensitivity to other resists the actions of and stool; WBC) at
Q8⁰ infections beta-lactams (penicillins many enzymes that beginning of and
or cephalosporins; degrade most other throughout therapy.
Brand Name cross-sensitivity may penicillins and penicillin-
occur). like anti-infectives. Obtain a history before
initiating therapy to
Merop determine previous use
of and reactions to
penicillins. Persons with
a negative history of
penicillin sensitivity may
still have an allergic
response.

Observe for signs and

symptoms of anaphylaxis
Classification (rash, pruritus, laryngeal
edema, wheezing).

Therapeutics:
Anti-infectives
 Generic Name Dosage/Administration Drug Indication Contraindication Mechanism of Action Nursing Responsibility

Ampicillin Sulbactam 100mg The treatment of Contraindicated in Ampicillin Sulbactam is a Advise parents to report
infections due to individuals with a history combination of a beta- signs of superinfection
IV susceptible strains of the of serious lactam antibiotic and a and allergy.
designated hypersensitivity beta-lactamase inhibitor.
Q8⁰ microorganisms in the reactions to ampicillin Ampicillin works by Advise parents taking
conditions: sulbactam or to other binding to penicillin oral contraceptives to
Brand Name  Skin and skin beta-lactam antibacterial binding proteins to use an alternative or
structure drugs. inhibit bacterial cell wall additional nonhormonal
infections synthesis. This causes method of contraception
Unasyn  Intra-abdominal disruption of the while t taking
infections bacterial cell wall and ampicillin/sulbactam.
 Gynecological leads to bacterial cell
infections death. Instruct parents to notify
health care professional
if symptoms do not
improve.

Classification

Therapeutics:
anti-infectives
 Generic Name Dosage/Administration Drug Indication Contraindication Mechanism of Action Nursing Responsibility

Dibencozide 1 cap mix with breast Premature babies, low Thromboembolism Dibencozide increases Advise patient to avoid
milk birth weight, retarded the protein “efficiency products that contain
growth, poor appetite in Erythremia coefficient”, the caffeine. Tell him to
PO infant, children and percentage of “bound report evidence of
adult, adjuvant to Erythrocytosis nitrogen” for protein excessive stimulation.
OD treatment of tuberculosis build-up in the body
Brand Name and other chronic Increased sensitivity to compared to “ingested Warn patient that drug
ailments, convalescence cyanocobalamin nitrogen with food may lose its
from acute infection or intake”. The initial sign of effectiveness over time.
Heraclene surgery, faculty nutrition effectiveness is
in older people. manifested by a marked
increase in appetite.
Thus, dibencozide
facilitates optimum
utilization of dietary
protein intake,
contributes to the
formation and repair of
body tissues and
Classification stimulates appetite.

Therapeutics:
Vitamin B12
 Generic Name Dosage/Administration Drug Indication Contraindication Mechanism of Action Nursing Responsibility

Domperidone 0.5mL Management of Known hypersensitivity/ Domperidone facilitates Take this medication by
symptoms associated Intolerance gastric emptying and mouth as prescribed
30 mins prior to feeding with GI motility disorders decreases small bowel usually 30 minutes
including Concurrent use of transit time by increasing before meal and at
Q6⁰ subacute/chronic ketoconazole esophageal and gastric bedtime.
gastritis and diabetic peristalsis and by
Brand Name gastroparesis. Prolactinoma lowering esophageal Monitor for persistence of
sphincter pressure. nausea and vomiting to
Treatment of nausea Conditions where GI evaluate the
Motillium and vomiting associates hemorrhage or effectiveness of the drug.
with dopamine agonist mechanical obstruction
antiparkinson therapy. or preforation Monitor for signs of
abdominal discomfort
LACTATION: such as epigastric pain
Breastfeeding is not or abdominal fullness.
recommended unless
potential benefits Monitor vital signs to
outweigh potential risk. determine signs of
dehydration.
Classification

Therapeutics:
Gastric stimulant
 Generic Name Dosage/Administration Drug Indication Contraindication Mechanism of Action Nursing Responsibility

Fluconazole 50mg Fungal infections caused Hypersensitivity to It decrease ergosterol Culture infection before
by susceptible fluconazole or other synthesis by interfering therapy; begin treatment
PO organisms, including: azole antifungals; with cytochrome P450 before lab results are
Oropharyngeal or Concurrent use with activity. Thus inhibiting returned
Q other day esophageal candidiasis , pimozide or cell membrane formation
Serious systemic voriconazole. of susceptible fungi Decrease dosage in
Brand Name candidal infections, including B dermatitis cases of renal failure
Urinary tract infections,
Peritonitis, Cryptococcal
Diflucan meningitis. Prevention of
candidiasis in patients
who have undergone
bone marrow
transplantation

Classification

Therapeutics:
antifungals (systemic)
 Generic Name Dosage/Administration Drug Indication Contraindication Mechanism of Action Nursing Responsibility

Mupirocin ointment Apply to umbilical site Topical: Treatment of: Hypersensitivity to An RNA synthetase Watch for s/s of super
Impetigo, Secondarily mupirocin or any inhibitor antibacterial infection
TID infected traumatic skin component of the
lesions (up to 10 cm in formulation. Typical antibacterial Reevaluate drug use if
length or 100 cm2 area) produced by patient does not show
caused by fermentation of response w/in 3-5 days
Brand Name Staphylococcus aureus pseudomonas
and Streptococcus fluorescens Discontinue the drug and
pyogenes. notify the physician if
Bactroban signs of contact
dermatitis is develop

Classification

Therapeutics
Anti-infectives
 Generic Name Dosage/Administration Drug Indication Contraindication Mechanism of Action Nursing Responsibility

Glycerin suppository 1/3 per rectum Treatment of Hypersensitivity Draws water into the Instruct pattern to take
constipation. lumen of the colon. glycerin as directed. Do
BID Osmotically draws water not take more than the
from extravascular amount prescribed.
spaces, including the
eye, into intravascular
Brand Name compartment.

No Brand Name
Indicated

Classification

Therapeutics:
laxatives