Biobench

series

Kbiotech
swiss
 Overview of laboratory Biobench

SMART DESIGN
BIOBENCH series is modularity and
flexibility. the homogeneity of our
BIOBENCH HMI
control unit and software depends on
the vessel’s concept, There are more
possibilities to work with several
The HMI-PC 15.6" or 21" large screen size
types of cells, lines and micro-
(human interface touch-screen) represents the local interface to fully
organisms without need to modify
manage, control and record process parameters in a bioreactor.
any instrument design.

Functionalities:
• set-points configuration and modification in running cultivation
• P.I.D. settings in recipe
• probes and pumps calibration and storage for review
• dose monitoring
• level of alarms and user access up to password
• Possibility to upgrade configuration system
• sequences batches programming
• batches and feeding profiles formulations
Every unit is composed of:
• cascade and polygonal control
• Bioflex software &
• Online recording on Pc - Ethernet output connections
Panel pc touch screen (option)
• Data Visualization with graphic, curves and profiles displays
• Control Unit based on Compact RIO
systems with high-performance
BIOBENCH series is work either in Desktop computer nor Human
processing capabilities and specific
Interface Touch screen which is mounted on control unit panel. Each unit
sensor conditioned of I/O ideal for
is equipped with:
monitoring, and control applications.
• Batch
It also includes gasmixing system
• Feed-batch
which is controlled by manually (rotor
• Continuous modes of operation.
meter) or alternatively (MFC).
Peristaltic Pump is an another
component which is mounted on
Slave module and the entire unit
developed inside by Thermostatic
circuit which are build-in fluidics and
actuators to control the accurate
temperature.
Each module can be replaced or
exchanged at any time without the
need of an expert technician.
 SPECIFICATIONS
•Agitation System :
Direct drive, mechanical
or magnetically coupled drive.
•Stirrer speed (rpm) :
Standard range is 5 – 1200 rpm
selectable 1 rpm.
•Impellers:
Rushton, Marine, Pitched
Blade, adjustable and
removable type impellers.
Special impellers available
•Gas sparger :
Porous sparger , L-type sparger ,
Sinterized sparger , fixed or
Removable type.
•Gas overlay: Included as standard
feature.
•Gas mixing :
Standard set-up for Air,O2,CO2,N2 in
gas mixing station and it can hold up to 8
gases and also standard setup for flow
meters with on/off automatic solenoid
valve to control gas flow regulation or MFC
(mass flow controller).
•Exhaust gas : Water cooled
exhaust gas Condenser
•Sampling : Sanitary sampling
system of pipe height is Fixed or
adjustable and it also available
sample bottles with different
volumes.
•Harvesting : Sanitary Drain pipe or
Dip tube, both height of tube and
pipe are fixed or adjustable.
•Liquid additions : Triple or single
inlet ports for chemicals additions
(optional micro liquid injectors)
 SENSORS – PROBES - ACCESSORIES
•pH probe : Potenziometric pH sensor, 12mm, connectors, (various length). Bioflex data management are acid pump or
CO2 gas (flow meter or MFC) in combination with alkali pump and/or other actuators and feed loop cascade.

•DO probe: Optical or Amperometric DO sensor, 12mm, connectors, (various length). Bioflex data management are
combination with N2, Air, O2 (flow meter or automation MFC) and agitation ,nutrient addition pump or other actuators and
feed loop cascade.

•Foam sensor: It is height adjustable conductivity sensor, when the foam is contact to the sensor and its regulate by
Bioflex data management , Anti foam reagent addition pump or other actuators and feed loop cascade.

•Temperature sensor: Pt-100 sensor insert in vessel and measure the temperature by Bioflex data management , cooling -
heating jacket vessel by internal heat system and cooling by tap water or chilled water and feed loop cascade.

•Biomass NIR probe. length 120mm, 220mm, 320mm , 420mm are data integration and visualization by Bioflex
data management and feed loop cascade.

•CO2/O2 Gas Analyser. Working range O2 = 0-25% resolution 0.1% , CO2 = 0-10% resol. 0.01% are data integration and
visualization by Bioflex data management and feed loop cascade.

•Scale Platform stainless steel 304L - 400x440 mm range 0- 30.000 gram , div. 1 gram are data integration and
visualization by Bioflex data management and feed loop cascade.
CULTIVATION

Bioflex Parameter setting access:

1 Preparation
2 Condition and Pre-inoculum
3 Inoculum start switch
4 Cultivation (fermentation) batch
5 Alarm setting
6 Pump control
7 Probe and storage data of calibration
8 Memory data record of batch
9 Start the” new batch” wizard
10 Standby batch to modify the recipe
11 Stop batch switch

Kbiotech R&D team is now working on :

• New Disposable Bioreactors for microbial and cell cultivation
• New Concept of Micro-Bioreactors for products optimization
• Laboratory stainless steel 316L vessel from 5L up to 30L
for Biofuel and Biomass fermentation.
PARALLEL BIOREACTORS

• TWIN-BENCH 1 tower, 2 vessel • QUAD-BENCH 1 tower, 4 vessel

Kbiotech as new generation of parallel bioreactors,it offers advanced functionalities to designed for meeting
demanding requirements in research and process development as well as for media optimization and screening
studies.

BIOBENCH Parallel Bioreactor Systems can be used for microbial and cell cultivation applications in research and
development, It allow full information on screening of bacteria, yeasts, fungi, Cell Culture, Stem Cell, Biofuels and
Phototrophic organisms. Kbiotech systems guarantee high precision , monitoring and control for each bioreactor with a
trusted parallel hardware and Bioflex data management. cRio FPGA based on which result in high information output
and easy comparative analysis.

KBiotech is proud to announce its innovative modular bioreactors for cell culture and fermentation.
We manufacture from entry level compact bioreactors (Biobook) to sophisticated parallel
solutions, STR and SUB systems for laboratory, pilot and industrial applications, designed by experienced, leading-
edge engineers to achieve the highest standard of flexibility, performance and reliability for your bioprocess. We offer
complete bioreactor solutions, from cell line development through to industrial manufacturing with a unique automation
and software platform to simplifying your scale-down and up-scaling operations and enabling.To obtain optimal results
for batch, fed-batch and continuous cultures.
Next generation compact , modular bioreactors and fermenters: The innovative, modular bioconsole enables to select
over 40 types of re-usable, interchangeable glass, single-use disposable and stainless steel vessel.
Bioflex™ software ensures simple, reliable data management and control across all platforms. Integrated solutions for
online automated analyzers are also available to boost your data analysis, simplify the application of Design of
Experiments (DoE) and enhance your Quality by Design.
Kbiotech gmbh

Street: Castausio, 19
City – 6900 – Lugano (TI)
Switzerland

+41 798111795

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Kbiotech
swiss