Aberrant placental development and function Polymorphism of

FasL and receptor

(mechanism still under investigation)
gene

Abnormal maternal immune tolerance of

placentation in early pregnancy

Levels of placental
FasL in maternal
Lesions in membrane Release of inflammatory circulation
separating maternal and products from placenta into
fatal circulation maternal circulation

Systemic maternal inflammatory response (activation of

coagulation and complement pathways)

Microvascular endothetial activation, dysfunction,

and damage

Widespread platelet
aggregation and agglutination Microthrombin in
RBC`s shared as they flow decrease amount of platelets hepatic circulation
through damaged vessels measurable on complete
blood count

Microangiophatic
hemolytic anemia
(MAHA)
Damage to
hepatocytes
Low platelets
Lab findings indicative of
hemolysis; normocytic
anemia, high LDH & Elevated liver
bilirubin, low haptoglobin enzymes

HELLP Syndrome
Hemolysis Elevated Liver Enzymes Low Platelets