27/03/2020 Pressure Support and Flow-Cycled, Assisted Mechanical Ventilation in Acute Lung Injury - ScienceDirect

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Chest
Volume 98, Issue 2, August 1990, Pages 458-462

laboratory and animal investigations

Pressure Support and Flow-Cycled, Assisted Mechanical

Ventilation in Acute Lung Injury
Edward K. McGough M.D. † , Michael J. Banner R.R.T., Ph.D. ‡, Philip G. Boysen M.D., F.C.C.P. §
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https://doi.org/10.1378/chest.98.2.458 Get rights and content

Pressure support is a ventilatory mode, available with many microprocessor ventilators, which
is patient-triggered, pressure-limited, and flow-cycled. This study compared the respiratory
and hemodynamic effects of PS used as a stand-alone mode of ventilation with those of
conventional patient-triggered, flow-cycled, assisted mechanical ventilation. Instruments for
hemodynamic and respiratory measurements were placed in ten spontaneously breathing,
anesthetized sheep. In each animal, baseline measurements were made during PS and flow-
cycled AMV. Acute lung injury was then instituted by instilling hydrochloric acid in the
endotracheal tube, and after 60 minutes, measurements were repeated. No hemodynamic or
respiratory variables differed, either before or after ALI, between PS and AMV. This study
demonstrates that PS, when used as a stand-alone mode of ventilation, has similar
hemodynamic and respiratory effects as flow-cycled AMV.

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ALI: acute lung injury; AMV: assisted mechanical ventilation; CLT: lung-thorax
compliance; CPAP: continuous positive airway pressure; ET: endotracheal tube;
PCWP: pulmonary capillary wedge pressure; PIP: peak inflation pressure; PS:
https://www.sciencedirect.com/science/article/abs/pii/S0012369216316713 1/2
27/03/2020 Pressure Support and Flow-Cycled, Assisted Mechanical Ventilation in Acute Lung Injury - ScienceDirect

pressure support; PSmax: maximum pressure support; Qsp/Qt: intrapulmonary

shunt; VT: tidal volume

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Presented in part at the 54th Annual Scientific Assembly, American College of Chest Physicians, Anaheim, CA,
October 3-7, 1988.

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Copyright © 1990 The American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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