SOLID ORAL MODIFIED-RELEASE DOSAGE FORMS and DRUG DELIVERY SYSTEMS

 DEFINITION
 Differentiate the following dosage forms:
a) extended-release c) repeat action
b) delayed-release d) targeted release
 Advantages and disadvantages.of extended release dosage forms over conventional
forms?
 Characteristics of drugs best suited for incorporation into an extended release product?
 Mechanisms by which extended drug action are achieved.
 Explanation of 3 ways by which the rate of drug release from the solid dosage forms be
modified

 Explanation of the different technologies employed in the modification of drug release

rate. Give the products (examples) employing these modifications:
a) coated beads, pellets, granules, microspheres
b) multitablet system
c) microencapsulated drugs
d) embedding drug in slowly eroding/hydrophilic matrix system
e) embedding drug in inert plastic matrix
f) complex formation
g) ion-exchange resins
h) osmotic pump

 Reasons why drugs must remain intact until it reaches the intestines? How are these be
achieved?
 Development of an IVIVC model
 Clinical considerations in the use of oral modified-release dosage forms?
 How extended drug action is achieved by routes other than oral administration
(Chapter 20 – Novel and Advanced Dosage Forms, Delivery Systems & Devices pp 737-750)
a) in ocular drug products
b) parenteral system
c) vaginal inserts
d) subdermal implants

 Table 9.2 – Modified Release Tablets &

Capsules Official in the USP
 Table 9.3 – Proprietary Modified Oral
Dosage Forms