Professional Documents
Culture Documents
Dyonne L. M. Broers1,2 ,
Do patients benefit from orthognathic Geert J. M. G. van der Heijden2 ,
Frederik R. Rozema3,4 ,
surgery? A systematic review on the Ad de Jongh1,2,5,6
1
Centre for Special Care Dentistry,
Orthognathic surgery aims to improve function and self-esteem. Although plastic surgeons report high levels
physical appearance and therefore can also partly be of satisfaction among their patients after cosmetic sur-
considered as cosmetic surgery. It has been estimated gery in general (almost 90%) (8–10), it is unknown
that approximately 5% of the current UK and US pop- how frequently patients who seek orthognathic surgery
ulation suffers from dentofacial deformities that are not for cosmetic reasons are dissatisfied with their appear-
receptive to orthodontic treatment, whereby orthog- ance following surgery.
nathic surgery can be considered (1, 2). It has been There is a lack of information regarding whether
reported that 2,718 orthognathic surgical procedures orthognathic surgery will indeed make people happier
were performed in the UK in 2012 compared with and more satisfied with their appearance, and whether
10,345 in the USA in 2008 (3, 4). This represents orthognathic surgery improves their well-being and qual-
0.004% of the current UK population and 0.003% of ity of life. This may hold true particularly for individuals
the current US population. suffering from psychological difficulties (such as a low
While the reasons for orthognathic surgery may vary, self-esteem) and mental health conditions. For example,
the most prevalent indications (approximately 70%) Body Dysmorphic Disorder (BDD) has been identified
seem to be functional limitations, problems with as an important driver for seeking surgical treatment and
appearance, and temporomandibular joint dysfunction has been found to be associated with a tendency to be
(5–7). In cases where one has good reasons to be dissatisfied with the result of cosmetic treatment (11, 12).
dissatisfied about oneself or one’s appearance, it is This may also hold true for other mental health condi-
likely that surgery will lead to a positive change in tions or symptoms of psychopathology.
esthetic appearance and consequently may result in To the best of our knowledge, until now only two
improved psychosocial well-being, self-confidence, and systematic reviews have been published regarding the
2 Broers et al.
Fig. 1. Flow of information through the different phases of the systematic literature search.
in Embase, and 872 in PsycInfo. After excluding dupli- considerably in their approach to the outcome
cates and subsequent title and abstract screening, 245 measure. Remarkably, the response rate was not
publications remained. Of these, 163 were excluded fol- reported in four studies (16, 17–19); in one study
lowing full-text reading, leaving 82 studies for inclusion the reported response rate was low (34%) (20); in
After screening of reference lists another four studies another study the reported response rate was rather
were identified. Moreover, KIYAK (16) reported two high (89% of the surgery patients, 96% of the
separate studies in her paper. Hence, 87 studies fulfilled orthodontic patients, 93% in the no-treatment
all eligibility criteria for further assessment of methods group) (21). Furthermore, the sample size was small
and outcomes. The reference lists of these studies were (n = 15) in one study (17), the follow-up period was
also checked for relevant articles and unpublished unknown in one study (18), and no exclusion criteria
manuscripts. During assessment of the methods, 39 were mentioned in one study (16). All studies were
studies were excluded because they reported on retro- prospective follow-up studies.
spective data from hospital charts or failed to include a
prospective parallel-control group. Another 39 studies
Directness of Evidence
were excluded owing to inappropriate outcome mea-
sures (nine for no psychosocial functioning measure Studies failed to satisfy DoE criteria when they
and another 30 for no validated measure). Therefore, included syndromal patients, patients ≤16 yr of age,
we eventually report the DoE and the RoB for nine or reported on orthognathic surgery for defects result-
studies. ing from trauma or cancer. Studies satisfied DoE cri-
teria when the Peer Assessment Rating Index (PAR),
the index of orthodontic treatment need (IOTN), the
Study characteristics
index of orthognathic functional treatment need
A summary of the characteristics of the trials (IOFTN), or the index of complexity, outcome and
included is provided in Table 2. These trials differed need (ICON) were reported as the outcome measure
4 Broers et al.
Table 1
Characteristics of the nine studies analyzed with respect to their fulfillment of the criteria for Directness of Evidence (DoE)* and
their Risk of Bias (RoB)†
ALVES E SILVA ? L H
et al. (17)
BAHERIMOGHADDAM + L H
et al. (33)
KIYAK et al. (21) + L H
KIYAK (Study II) (16) ? L H
LOVIUS et al. (18) + L + H
ØLAND et al. (20) + + M + H
RUSTEMEYER & + L NA H
GREGERSEN (19)
SCOTT et al. (30) + L H
SILVOLA et al. (32) + + M H
*Directness of Evidence is assessed by evaluation of: (i) Patients: are all patients with orthognathic surgery 17 yr of age or older, excluding
syndromal patients or patients treated with orthognathic surgery as a result of trauma or because of oncological defects? (ii) Intervention:
is orthognathic surgery carried out according to the Peer Assessment Rating Index (PAR Index), the index of orthodontic treatment need
(IOTN), the index of orthognathic functional treatment need (IOFTN), or the index of complexity, outcome and need (ICON)? (iii) Out-
come: is patient satisfaction measured with PSPSQ or PSQ?
†
Risk of Bias is assessed by evaluation of: (i) selection bias (randomization, concealment); (ii) information bias (blinding); and (iii) com-
pleteness of data (complete description of data of all patients included).
+, satisfied; , not satisfied; ?, insufficient information/unclear; H, high; L, low; M, moderate; NA, not available.
for orthognathic surgery. The PAR is a suitable and definition, impossible to satisfy the item of blinded out-
validated clinical outcome measure for the deviation come measurement. For all nine studies the RoB was
of a normal occlusion and alignment for the combined found to be high (Table 1).
orthodontic treatment and orthognathic surgery (22,
23). The IOFTN is a reliable tool for measuring
Relationship between psychiatric conditions and
patient need for orthognathic surgery (2, 24) and has
(dis)satisfaction with treatment outcome
good content validity, and good inter-rater and mod-
erate-to-good intra-rater reliability (25). The ICON is Given that no evidence was found for the effect of elec-
also a valid index for measuring orthodontic treatment tive orthognathic surgery on patient satisfaction and
need and complexity (26) and may be used instead of psychosocial functioning, we were not able to evaluate
PAR or IOTN (27). The IOTN is a valid and reliable the effects of orthognathic surgery in patients with psy-
index also for measuring the severity of malocclusion chiatric disorders and mental health conditions.
(28).
Furthermore, studies satisfied DoE when the following
validated outcome measures for measuring patient satis-
Discussion
faction were used: the Post-Surgical Patient Satisfaction
Questionnaire (PSPSQ) and the Patient Satisfaction The purpose of this systematic review was to examine
Questionnaire (PSQ) (29–31). Except for the studies by the benefits of elective orthognathic surgery for adults,
ØLAND et al. (20) and SILVOLA et al. (32), which had a in terms of patient satisfaction and psychosocial func-
moderate DoE, the DoE was found to be low for the tioning. There appear to be no valid studies to support
remaining seven studies (Table 1). claims for such an effect. Among the rather limited
number of studies available, only a few qualified for
inclusion in this systematic review when rigorous crite-
Risk of bias
ria were applied. At best, the available evidence consists
All studies failed randomized and concealed allocation of a few cohort studies with rather small sample sizes,
of treatment, making them vulnerable to selection bias. a low DoE, and a particularly high RoB. In other
Outcomes of orthognathic surgery were compared with words, the evidence for a benefit of elective orthog-
outcomes in one or two control groups undergoing dif- nathic surgery for adults in terms of having a positive
ferent treatments, sometimes non-surgical treatment. impact on patients’ psychosocial functioning or their
Most studies reported the completeness of data poorly. satisfaction with treatment (irrespective of their mental
Because patients were involved in evaluating the effect condition) is lacking.
of orthognathic surgery, in which placebo surgery is Based on the many articles and meta-analyses (13,
not feasible, they could not be blinded for the nature 14) that have been published on this topic it is tempting
of treatment. For all studies included it is therefore, by to conclude that there is some evidence to suggest that
Table 2
Characteristics of the nine studies analyzed
Results concerning patient
Measure points/follow-up satisfaction and psychosocial
Authors Design Participants Measures period Response rate impact
ALVES E SILVA Prospective N = 15 11 multiple-choice and/or Follow up: 6 months ? Self-esteem improvement was
et al. (17) Age: mean SD = 25 5.70 open-ended questions (i.e. 13.3%, especially in relation to
yr; range = 17–35 yr appearance satisfaction, and appearance satisfaction
M/F (%): ? social relationships); Improvements were also noted
WHO QoL-Bref (postsurgical regarding social, occupational,
only) and family relationships
Note: the questionnaire did not
contain answer options capable
of identifying possible worsening
of symptoms
BAHERIMOGHADDAM Prospective N = 58 OHIP-14 T0: after referral 77.3% Although the results suggest an
et al. (33) (28 Class II, T1: at the presurgical increase in QoL score from T1 to
30 Class III) stageT2: postsurgery (at T2, in their analyses the authors
Age: least 6 months after did not tease out the effects of
Class II, mean SD = 25.1 3.4 yr surgery) orthodontic and surgical
Class III, mean SD = 21.3 2.7 yr T3, post-treatment treatments
M/F (%): Class II, 42.9/57.1 (12 months after removal
Class III, 63.3/36.7 of orthodontic
appliances)
KIYAK (16) Prospective Study I (N = 74) Open-ended questions to Follow up: 3 yr ? 3 wk following surgery, body
(two studies) Age: mean SD = 22 7.5 yr determine patients’ attitude to image, including facial image,
M/F (%): 39.2/60.8 measures developed in an improved over the 24-month
Study II earlier pilot study; TSCS; follow-up period
(N = 188: 122 S, 33 OT, 33 NT) body image with an Neuroticism did not affect
Age: S: mean SD = 26 8.5 yr instrument modified from the satisfaction with outcome in the
OT mean SD = 24.5 5.2 yr, work of SECORD & JOURARD long term (9–24 months)
NT: mean SD = 30 4.3 yr (34);
KIYAK et al. (21) Prospective, N = 156 EPI POMS; T1: 6–12 months before S T1: 100% Tension and fatigue increased
case–control N = 90 (S patients) EPI; T2: 5–10 d before S T2: 79% significantly among surgical
Age: mean = 26 yr TSCS; questionnaire with T3: 1 d after S T3: 89% (S), patients from before surgery to
M/F (%): 35.4/64.6 satisfaction questions T4: 4–6 wk after S 96% (OT), 93% immediately after surgery, and
N = 33 (OT patients) T5: 6 months after S (NT) dropped to presurgical levels
Age: mean = 24.5 yr Follow-up: 3 yr T4: 89% (S) when fixation was removed.
M/F (%): 33.3/66.7 T5: 90% (S), Anger-hostility increased at
N = 33 (NT patients) 90% (OT), 88% fixation removal but declined
Age: mean = 30.3 yr; (NT) within 5 months
range = 14–43 yr Postsurgical discomfort, pain and
M/F (%): 28.0/72.0 paresthesia, and oral function
problems were correlated with
postsurgical emotional state
Effects of orthognathic surgery
5
Table 2 Continued 6
Results concerning patient
Measure points/follow-up satisfaction and psychosocial
Authors Design Participants Measures period Response rate impact
LOVIUS et al. Prospective, N = 41 (longitudinal sample) BSS, SAD, FNE, GHQ ? ? In the longitudinal sample
(18) cross-sectional Age: mean SD = following surgery body
Broers et al.
AD-1, ‘Have you felt discomfort during chewing?’; AD-2, ‘Have you been dissatisfied with your facial aesthetics?’; AD-3, ‘Do you have a loss of sensitivity in your lips, tongue or other facial area?’; BSS, Body Satisfac-
tion Scale; EPI, Eysenck Personality Inventory; FNE, Fear of Negative Evaluation; GHQ, General Health Questionnaire; M/F, male:female ratio; NT, no treatment; OHIP-14 (OH-1 – OH-14: OHIP items 1-14), Oral
Health Impact Profile; OHSQ, Oral Health Status Questionnaire; OT, Orthodontic Treatment; PAR index, Peer Assessment Rating Index; POMS, Profile of Mood States; PSPSQ, Post-Surgical Patient Satisfaction Ques-
tionnaire; QoL, Quality of Life; S, Surgery; SAD, Social Avoidance and Distress; SCL-90-R, Revised Symptom Checklist-90; SIP, Sickness Impact Profile; TSCS, Tennessee Self-Concept Scale; WHOQoL-Bref, abbrevi-
ated version of WHOQoL-100, World Health Organization Quality of Life.
some form of functional improvement (i.e. occlusion) is need to be performed. In other words, there is an
likely to enhance peoples’ oral health-related quality of urgent need for new consistent knowledge on this
life and make them satisfied with the results. However, topic.
when applying more rigorous criteria, the available
Acknowledgements – This work was not funded.
study findings do not allow for valid inference on the
size, direction, and consistency of an effect of orthog-
nathic surgery. The poor quality of the evidence avail- Conflicts of interest – The authors declare no potential conflicts of
interest with respect to the authorship and/or publication of this
able means that we need to be cautious about article.
developing recommendations for delivering care to cer-
tain target groups that are considered to be vulnerable
to invasive procedures. For example, in an earlier study
we found evidence that patients with characteristics of References
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strings used for each database.