SYSTEMIC LUPUS ERYTHEMATOSUS PATHOPSHYSIOLOGY

Modifiable Non-Modifiable
 Environmental Factors  Genetics
1. Medications (antidepressants/ antibiotics) 1. Gender
2. Extreme stress 2. Age
3. Exposure to sunlight/UV radiation 3. Race
4. Infections
5. Hormonal changes
Increases in self & non self antigen

Hyperactivity of B cells

Immune complex deposition,

Antineurral, antibody activity
 Production of abnormal antibodies by B cells (hallmark sign),
(antidouble stranded DNA & anti smith)

Few tingible body macrophage (engulf B cells that have

undergone apoptosis after somatic hypomutation)

Dec./ missing/ deficient CRP & glycoproteins

(complement factors for efficiently operating phagocytes)

Abnormal reaction of body against its own cells and serum protein

Increased level of anti ds DNA antibodies

Results to engulfed LE bodies in the LE cells

Increased disease activity in client w/ SLE

ANA and nuclear antigen found in serum, small blood vessels,

skin & glomelular basement membrane

Immune complexes initiate the complement reaction & serum

complement level are decreased during attacks of SLE

Degeneration of connective tissues, glomeruli, blood vessels