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a State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's
Republic of China
b Yunnan Institute of Endemic Diseases Control and Prevention, Dali, People's Republic of China
c Commonwealth Scientific and Industrial Research Organisation Livestock Industries, Geelong, Victoria,
Australia
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Received 16 November 2009, Revised 20 February 2010, Accepted 30 March 2010, Available online 7 April 2010.
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https://doi.org/10.1016/j.meegid.2010.03.015 Get rights and content
Abstract
An outbreak of hemorrhagic fever with renal syndrome occurred among students in a college
(College A) in Kunming, Yunnan province, China in 2003. Subsequent investigations revealed the
presence of hantavirus antibodies and antigens in laboratory rats at College A and two other
institutions. Hantavirus antibodies were detected in 15 additional individuals other than the
index case in these three locations. Epidemiologic data indicated that the human infections were
a result of zoonotic transmission of the virus from laboratory rats. A virus was isolated from rats
in College A and the full-length genome sequence revealed that this was a new Hantaan virus
https://www.sciencedirect.com/science/article/abs/pii/S1567134810000766?via%3Dihub 1/2
4/12/2020 Hantavirus outbreak associated with laboratory rats in Yunnan, China - ScienceDirect
isolate, designated strain KY. Sequence analysis of the three genome segments indicated that this
new isolate is a reassortant derived from human and rat Hantaan viruses. Further sequence
analysis of the medium (M) genome segment revealed that it originated from a recombination
event between two rat Hantaan virus lineages.
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Keywords
Hemorrhagic fever with renal syndrome; Hantavirus; Laboratory rats; Recombination
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