CHAPTER 7

CAPSULES

1. Why are tablets and capsules preferred over other pharmaceutical dosage forms?
2. Give instances when capsules should be kept intact and swallowed whole.
3. Define capsules.
4. Give the composition of gelatin ? What happens to gelatin capsules in the presence of excess
humidity? In extreme dryness?
5. Give examples of:
a) dessicant d) opaquant g) lubricant
b) diluent e) colorant
c) surfactant f) disintegrant
6. What is gamma scintigraphy? Give its use.
7. What are the uses of Heidelberg capsule?
8. Name the steps of preparing hard gelatin capsule shells.
9. What are the different capsule shell designs?
10. How would you minimize capsule splitting (telescoping)?
11. What are the different capsule sizes? What weight range of powdered materials can be
placed in capsules?
12. What are the 4 steps of filled hard gelatin capsules?
13. Give the goal for the product formulation of capsules?
14. What particle size range are obtained through:
a) milling
b) micronization
15. When are the following used for fill in hard gelatin capsules?
a) pellet mixture b) paste
c) capsule d) tablet
16. How will the retail pharmacist ensure that she has enough fill in materials for compounding
small number of capsules?
17. What is the “punch” method as fill in hard gelatin capsule?
18. What are the different ways of capsule sealing?
19. What are the soft gelatin capsules?
20. Differentiate hard gelatin from soft gelatin capsules
21. Give the 2 methods of preparing soft gelatin capsules?
22. Enumerate the different liquids which can be encapsulated?
23. Give the characteristics of materials which can be added to active ingredients.
24. What kinds of container should be used for dispensing capsules?
25. Explain briefly the ff. tests for capsules?
a) disintegration test d) weight variation for hard and soft capsules
b) dissolution test e) moisture permeation test
c) content uniformity
26. What are the advantages of unit dose and strip packaging?
27. Name some of drug substances commercially prepared into soft gelatin capsules.