Antimicrobial DOC

Dr. Ranjan Kumar Patel

Acinetobacter Carbapenems
ESBL organisms
Serratia
Enterobacter
Actinomycosis Penicillin G
Gas gangrene
Leptospira
Rat Bite Fever
Streptococcus
Syphilis
Yaws
Amebiasis 1. Extraintestinal/Intestinal symptomatic -
Metronidazole
2. Intestinal asymptomatic - Paromomycin
Anaerobes 1. Supradiaphragmatic Infections e.g.
Prevotella - Clindamycin
2. Infradiaphragmatic infections e.g.
Bacteroides – Metronidazole
Aspergillus Voriconazole
Scedosporium
Trichosporon
Amebiasis Metronidazole
(Extraintestinal/Intestinal
Symptomatic)
Bacterial Vaginosis
Bacteroides
Tetanus
Trichomoniasis
Antimicrobial DOC
Dr. Ranjan Kumar Patel
Babesiosis Atovaquone + Azithromycin

Chancroid Azithromycin
Legionella
Mycoplasma pneumoniae
Mycoplasma genitalium
Ureaplasma urealyticum
Ureaplasma parvum
Chlamydia and cholera in
pregnancy
Campylobacter
Borrelia Doxycycline
Brucella (+Rifampin)
Bartonella
Chlamydia
Cholera
Granuloma inguinale
Lymphogranuloma
venerum
Mycoplasma hominis
Inflammatory acne
Rickettsia
Pleurodesis
Pericardiodesis
Burn Infection Silver Sulfadiazine
Diphtheria Erythromycin
Pertussis
Candida Coccidioidal Fluconazole
Meningitis
1. Albendazole
Cestodes • T. Solium (NCC)
• Echinococcus

2. Praziquantel
• T. Saginata
• H. Nana
Antimicrobial DOC
Dr. Ranjan Kumar Patel
• D. Latum
• T. Solium (Intestinal)
Chagas’s disease (American Benznidazole
Trypanosomiasis)
Clostridium difficile Oral Vancomycin
Cryptococcus Amphotericin B
Kala Azar
Mucormycosis
Primary amebic
meningoencephalitis
Systemic fungal infections
Cryptosporidium Nitazoxanide
Resistant giardiasis
Dermatophytes 1. Terbinafine except for T.
Capitis/Cruris/Corporis

(T. Capitis – Griseofulvin, T. Cruris/Corporis –

Itraconazole)
Diarrhoea (Empirical Fluoroquinolones
Therapy)
E. Coli Ceftriaxone
Gonococcus
HACEK organisms
H. Influenza Meningitis
Meningococcal meningitis
case
Empirical treatment of
meningitis
Klebsiella
Providencia
Typhoid
Brain abscess
Subdural empyema
Endemic Mycoses Itraconazole
Sporotrichosis
T. Cruris/Corporis
Antimicrobial DOC
Dr. Ranjan Kumar Patel
Enterococcus 1. Enterococcus faecalis – Ampicillin +
Aminoglycoside
2. Enterococcus faecium – Vancomycin +
Aminoglycoside
3. Aminoglycoside toxicity – Ampicillin or
Vancomycin + Ceftriaxone
4. Vancomycin or Ampicillin resistance –
Linezolid
Gonococcus 1. Ceftriaxone
2. Spectinomycin for beta lactam resistance
Hepatitis B Tenofovir
Hepatitis C Direct Acting Antiviral Agents
1. HSV and VZV – Valacyclovir > Acyclovir
Herpes Virus 2. CMV – Valganciclovir > Ganciclovir
3. Resistant herpes – Foscarnet
H. Influenza Treatment 1. Meningitis – Ceftriaxone
2. Pneumonia or Otitis – Ampicillin +
Sulbactam
H. Influenza Prophylaxis Rifampicin
Influenza A 1. Oseltamivir
Influenza B 2. Oseltamivir resistance – Zanamivir
Bird flu

Legionella 1. Azithromycin
2. Transplant recipients – Fluoroquinolones
(Macrolides can interact with calcineurin
inhibitors)
Leishmania 1. Cutaneous – Sodium Stibogluconate
2. Visceral (Kala Azar) – Amphotericin B
Listeria Monocytogenes Ampicillin
(Cotrimoxazole in case of penicillin allergy)
Melioidosis Ceftazidime
Pseudomonas
Febrile neutropenia
Meningococcus 1. Case –Ceftriaxone
2. Contact – Ciprofloxacin
Antimicrobial DOC
Dr. Ranjan Kumar Patel
3. Mass chemoprophylaxis – Ciprofloxacin
Nocardia Cotrimoxazole
Pneumocystis
Burkholderia cepacia
Isosporiasis
Cyclosporiasis
Sarcocystosis
Cystitis
Nematodes 1. Albendazole
• Soil Transmitted Helminths
• Round Worm (Ascaris Lumbricoides)
• Whip Worm (Trichuris Trichiura)
• Hook Worm (Necator Americanus,
Ancylostoma Duodenale)
• Trichinella Spiralis
• Enterobius Vermicularis
• Dracunculus Medinensis

2. Ivermectin
• Thread Worm (Strongyloides
Stercoralis)
• Onchocerca Volvulus
(Also includes Scabies, cutaneous larva
migrans and Streptocerciasis)

3. Diethyl Carbamazine (DEC)

• Loa Loa
• Lymphatic Filariasis
Plague Gentamicin/Streptomycin
Tularemia
RSV 1. Treatment – Ribavirin
2.Prophylaxis – Palivizumab
Sleeping Sickness (African 1. East African
Trypanosomiasis) • Early – Suramin
• Late – Melarsoprol
Antimicrobial DOC
Dr. Ranjan Kumar Patel
2. West African
• Early – Pentamidine
• Late – Eflornithine
Scabies Permethrin cream (5%)
Staphylococcus 1. Non-Penicillinase Producing – Penicillin G
2. Penicillinase Producing – Penicillinase
Resistant Penicillin
3. MRSA – Vancomycin
4. VRSA – Daptomycin
Syphilis 1. All stages (Except CNS involvement) -
Benzathine Penicillin G
2. CNS involvement – Aqueous Penicillin G
Toxoplasma 1. Sulfadiazine + Pyrimethamine
2. Pregnancy – Spiramycin
Trematodes 1. Triclabendazole
• Liver Fluke (Fasciola Hepatica)
2. Praziquantel
• Lung Fluke (Paragonimus)
• Schistosoma
Typhoid 1. Ceftriaxone
2. Oral DOC – Cefixime
Whipple disease Ceftriaxone or Carbapenems
(Tropheyma whippelii)