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Inhibitori ai pompei de protor Protectoare cle mucoasei gastrice Terapia anti Helicobacter Pylori Antiffatulentele /Adsorbantele intestinale Corminotivele Antispasticele © Medicatia prokineticé/propuls PREPARATE UTILIZATE IN TERAPIA BILIARA $i HEPATICA, > Medicatia vericit biliare > Medicatia fcetului ‘© Medicatia hepatitelor eronice (veri medicatia antiviral} Antiemeticele (antivomitivele) Amtidisreicele Anitinflamatoare gi ant Laxativele si purgativele Produse digestive inclusiv preparate pe baz’ de enzime MEDICATIA ANTIDIABETIC > Anticiabetice orale 2) oeo00 iectioase intestinale vyvvy > ina Glucagon MEDICATIA OBEZITATI VITAMINE, MINERALE, TONICE > Vitaminele tiposolubi > Vitaminele hidrosolubil > Substantele minerale gi tonice MEDICATIA APARATULUI RESPIRATOR > Antitusivele > Expectorantele TRATAMENTUL ASTMULU! BRONSIC (AB) Bronhodllatatoare Antiinflamatoarele sterodiene Inhibitors i mastocitare icotrlenici{antileucotrienele} vey 24 24 24 25, 26 26 26 27 2 ey 28 28 28 30 30 3 3 32 33 34 34 35 36 36 36 a7 38 40 ay ay 42 a 45 46 > Alte antiastmatice pentru uz sistemic > Surfactantit puimonari MEDICATIA ANTITUBERCULOASA (TUBERCULOSTATICA) > Chimioterapice majore % Chimioterapice minore MEDICATIA APARATULU! CARDIOVASCULAR > Medicatia antiaritmics > Medicatia antiangincass > Medicatia antihipertensivi > Tonicele cardiace/cacdiotonice > Medicatia cu actiune ocitocic’ si toce MEDICATIACU ACTIUNE ANTINEOPLAZICA, > Principalele grupe de medicamente anticanceroase © Citostatice core actioneazd In principal asupra sintezei de ADN © itostotice care actioneazé osupre adr-ulul preformat © Citestatice care actioneazé Ia nivelul mitoze! © Agentiterapeuticl vlizoti In hormonoterapia cancenuioi © Alte trotamente utilizate in cancer ANTINFLAMMATOARE NESTEROIDIENE, ANALGEZICE, ANTIPIRETICE, ANTIMIGRENOASE Antiinflamatoarele nestercidiene (AINS) > Analgezicele % Antimigrenoass MEDICATIA SISTEMULUI MUSCULO-SCHELETIC > Antiinflamatoare nesteroidiene cu administrere topic& ‘© Preparate ontigutoase MEDICAMENTE PENTRU TRATAMENTUL AFECTIUNILOR OSOASE in osteoporozs MEDICATIA SiSTEMULU! NERVOS CENTRAL > Medicatia antiepilaptics > Medicatia antiparkinsonian’ Anticolivergi Agenti domominerg! 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Farmacotoxicologia - studiaz manifestdrile ce apar in urma administrSrit gresite sau eccidentale a toxicelor precum si combateres efectelor adverse 4, Farmacografia - se ocups cu regullle de prescriere a medicamentelor 5. Farmacoterapia - stabileste conditile tn care un medicament poate fi folosit pentru prevenirea, vindecarea sau ameliorarea unei 6. Farmacoepidemiofogia - are ca obiect de studi situal care enumite medicamente sunt contraindicate la subiectil cu particularitiys fiziologice sau patologice, deoarece ele ar putea fi dunatoare, precum si masurile de precautie menite si evite sau si minimalizeze eventualele efecte nedorite ale medicamentelor, SEEMS BIODISPONIBIUTATEA MEDICAMENTELOR > Biodisponibilitates medicamentului reprezinté procentul din medicament care a ajuns la locul tinté de actiune > Este un paramettu farmaceutic specific fiecarui medicament care poate fi cexprimat prin doug variabile: * Cantitatea de substantd medicementoass elikerat’ dintr-o forma farmaceutica si absorbita in circulatiasistemicd © Viteze cu care substanta medicamentoss este cliberaté si absorbits Bioechivalenta Tipuri de echivalenté: > chimic3 = echivalenta intre substantele medicamentoase care contin aceeasi substanté activ’, aceeasi daz’, cu forme Farmaceutice diferite > farmaceuticS = echivaienta intre substantele medicamentoase care contin aceeasi substantd activ, aceasi doz’, acel de forma farmaceutic’, dar substantele auxiliae $i tehrologia sunt di > farmacologic’ = ect ite lenta intre substantele medicamentoase care au acelagi afectfarmacolagic, substants activa poate s& fie diferit3 > terapeutica = medicarente cu aceeasi eficacitate terapeuticd Ie acelayi indivi, aceeasi doz’, indiferent dacé med prez numa e. chins, farm sau farmacologies % biologicé (Bioechivalenta) = echivalenta intre medicamentele echivalente chimic sfarmaceuticsiidentice ca blosispuni Tipuri de biodisponibilitate: > Biodisponibilitare absolut® ~ corespunde fractiunli de substantS activa din forma farmaceutic’ de care dup’ administrare ajunge in circulatie sengving sistemicS > Biodisponibilitateo relative ~ se exprim’ prin cantitatea de substanga activ’ dinte-un medicament care dup administrare ajunge in circulat siviteza cu care se realizeazé acest araces. > Biodisponibilitotea relatives optimaki ~ compar’ biadisponibilitatee a 2 forme farmaceutice dintre care una este forma de referins& Factoril care influenteaza biod'sponibilitatea: 1. Primut posaj metabolic hepatic: are loc atunci cind un medicament este absorbit din tractul gastrointestinal si patrunde mai int3i in cicculatie portala, apoi in circulstia sistemicd 2, Solubilitatea medicamentului: pentru ca un medicament sé fie absorbit cu Usurintd acesta trebuie si fie inalt hidrofob si s8 prezinte solubilitates in posse 3. Instobilitatea chimicd: unele medicamente, spre exemply sunt dostruse fn mediul gestric acid iar altele sunt distrusa in tractul gastrointestinal de itre enzimele de degradare 4, Noturo formuieior medicamentoase: absorbtia medicementelor poate fi alterat8 de compacta chimicd a acestora Factor! fegati de medicament © forms farmacautic’ © forma geometric’ a comprimatului * tehnologia ce fabricate si abjugati folositi substanta chimicd a substentei © marirea particuletor © tipo sau hisro-solubilitari © doza de adiministrare Foctori legat! de organism * factor care influenteazé trensferul substarte! prin membrele biologice calea de administrare| i | 1 1620] eaunifae nauad axfoso}o} 05 « yonain/2joujboannuy 23j0> 2au0d § garounue> wud quosge as jatuauieD.pou 8 ie00} euniize nauad wsnioee gzeanyiin as ‘puoyn20 Daj09 Sse0URNeHU) JeRSIUIpe ynzeD w}g>—p INIMIDa}D e pide UL INgEp UN NE 2959 jaraBunie sojeiustuea.pa ® epdes efiquosge japse pueluuiad ‘a8ues ap a.8w x 13 ‘o1ew elejezdns 0 axe seuowind ynnsal‘uoseue auapan 29 iu . 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gueiquiew ap indy ennnadsou midojoig euesquiat ap purdap 3109 pewiseyd ajauiatoud ap ease93) ‘aanse rojuersgns exfestuaauo9 i ezog gow emanas < ‘syuswed|paus ap ui 9409 03324 “T sayBojog syauosquiau und afsuon geoatuanyfuy 3302 4109304 sojaseoanuu ajauids -p ‘3}ainjao 3p 2eInjeoenU! ynyUaLa_sedwioD giedas aie giejn|so eueIqUIW “e a2Bojerg auoiquauu 2p indi, ~orgin{ucouynypau 16 2/999 S.nu! axeuLO;Uy ap jnxny 1S giuersqNs 3p alunqUyPs gzeajos}U0D a1e> ayqeauiadiwas asaiieq aimysuOd ayy od ujid ardnsesauy aujaroud xojduios Up ayeuuioy uligns syieo) tumonuS uns s2/SoIOIG slaueIqWNY SNVWGMIIW 30 Rind SNVMONEA Niwa TRUSTEE 180 YoHLINOGIUARN 3 INLLONCalea cutanatd © asigur’ o eliberare controlst® s] continua @ unui medicament de Ia tocul de dintr-un rezervor printr-o membrang semnipermeat le asociate cu cresteri rapide ale ratiel plasmatice (plasturii transdermi CAL ARTIFICIALE Colea intravenoast © nu presupune absorbtie ‘© Intreaga cantitate de medicament intré direct cefectul se realizeaz8 chiar din momentul administr3 compartimentul intravascular > compartimentat inte > compartimentul intract Intotdeauna intre aceste compartimente existé un echilibru, Distribuires in cele trei compartimente poate > uniforma - alcool > neunifornd = organe gi Sesut fierul pentru ficat) > redistribuire - ticbarbituricele-actioneaz dupa administrare, asupre creierulul, realixind © coma indusadupa care se adipos,de unde se sotatiastfel incat persoa icé pentru unele rontiu pentru oase, , doz’, viteza de izat, cu att va Medicarentele aflate tn singe, fle sub forma de traci fe legate de hepati, calea rectal 50%, calea digestivl 100%, 2 Unele medicamente nu stribat doug bariere: ‘+ bariera hematoencefs © bariera placentart ELIMINAREA MEDICAMENTELOR = _ este un proces principal care corespunde incetari acljunli medicamentelor cle se elirind prin mai multe c&i cum ar fi Eliminarea pe cale renalé: este principals cale medicamentele se pot inare 3 medicamentelor, unde lo acest ina prin trel mecanisme: rare glomerular © secretie tubular © reabsorbtie tubular iminare pe cale renal3 depinde de structura chimici 2 vel ® vitera de medicomentul jinarea medicamentelor pe cale digestiv’ © cei insolubile se vor elimina ce atare © medicamentele solubile si neabsorbabile (streptomicina, kanamicina, sul magneziu) Eliminares pe cate pulmonerd sau res} > se poate realiza fie Ie nivel az03se, eranoiul ivecielor pulmonare (substantele volatile gi in mucoasa bronsic’ (exoectorantele) Eliminarea pe cale cutanatt > se realizeard prin trensplratie sav fanere liminarea prin secretille tacrimale Eliminarea n seereti 2w auaso.e) 3108 exeuafoupses ‘ezaueS0}e103 ‘ezauaSeany say jnuusigosouUsID — wrojopua vos) sauieyxiey offaoas = Inz2> uy euqay “aierosnwenu jupiatur nso} 2] aia. sanpoud 30d 8s auargossjusjaun anjdovesoyunya na ja/couan e2ne WIC {exioype tea1yisd ‘eor2y) efupuadag eluinusiqg, syapwueUoyins ‘njdwaxe ap :f10)0}29 aypypauy) Bary . soneiguue :{euni ‘punujoane ganyowal;ajusaue eusuuiaap rod eu: nes siularsIs soxewazue sndaj eonpoid 30d eurwe} wloUL9} “2uITeWeudso;> injawiaxa ap :f2KexoR}9) 2: z81u1s ap sjauaipiounque nue :foupoyfoun) yng raaiBojounwu af rs ‘sjsondajouneu ‘ajeounyqieg —‘asnoy yuaweapaus Un e| jewioue insundsp ‘njdulaxa ap :snauad aeuarap Puy ‘sonnedeia ajezop ej ininwisiueBi0 ale aynusiqoeu noes quns - aojzeoutsoyp apifaeoy aued 22} ajediound asianpe ajapaya anuip MOTALNSWYIIGIN IV SSUIAGY SALES vt ‘un 3 9/80) iq waveyAnde eane © ap quaweripeur inun este! 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Poyiunea : forma lichid obtinuts prin dizolvarea substantei active in excipient, care este ntotdeauna apa dstllatS © pentru corectarea gustulul se adaugs tn praportie de 20% sicap ‘= nu se adeugs sirop in administrarea medicementelor contra greturilor, \rsSturlor sau pentru cresterea apetitului 2. Hidrolatul ‘2p aromatic’ care este 0 solute apoasé amestecata cu uleuri volatile este folosit in igienizarea cavitiyi bueale 3. Sivopul + este 0 solutie apoasd de zahir, la care se adaug’ substante activa gi unui produs vegetal uscat $1 . cu care este mentinut la temperatura cameret un anumit ip de 5 minute, poi se poate adauga sirop in proportie de 20% 6. Decoctul © se foloseste pentru extragerea principillor active vegetale din @ se obtine prin flerbere timp de 30 minute 7. Mucilagi + sunt solufii ccloidale, apoase formate din macror substante active, solide, foarte fin se folosese muci amestecuri dintre dowd suhstange nemiscibile iul medicamentos © are ca excipient ulet de floarea soaralut in cares 11, Tinetura este un extract alcoolic de prinaipli active, alcoalul necesitind o trie de 90" pentru ametiorarea gustulul se acministresza pe zahar cubic 12, Vinul medicamentos = este un ameste de vin vvegetele seu chimice cu r 13. Extractele + forme medicamentoase obtinute prin acjiunea unor solventi precu alcootul, apa sau eterul se obsin in doua faze: -15" in care se dizolv’ principit active in cresterea apetitulul respect + se pis at8 obligetoriu in flacoane de culoare inchisa si ermetice (MEDICAMENTE SOUDE ADMINISTRATEPER OS 1 Pulberea -doud substante amestecdri cu o substangS: amorf © se administra’ cu lingurta, i precise a pulb ‘© existd gi forme farmaceutice ambelate apé 2, Pulberile efervescente + se obtin prin adaugarea fan existind pe icursigilate unice sau duble, ce ntact eu 3. Pachetul medicanentos © ete 0 form’ doi 4. Capsule al 3 din amidon sub forms a dou sau trel c&pacele care se Ita se administrearé medicamente cu gust cou miros nepidcut sau cele care colorear: mucoasele + se dizolvé in stomac, motiv pentru care substantele admi mucoasa gasteicd 5. Capsula gelatinoas’ * este constituita din gelating sau subst + are forma ovoids, sferics sau operculat: wv| | | | | et 2agze rojuersqns aque 93 192} FOUN eavescyied suncnsesd g20p B1edY - [RHOs, ‘agnodsip ul sae ap axa2npo: 2e8 ep uoden ap leuanue asa yod a5 aunyejequy eavensimmupe nnuad + gseoquawesipaus wuuad a1 auojoyuy ap pe naquad 16 ep 1dsa1 gtudo sutuow as punyoud g. sndun ezestuejap as xO un grearasaja 3s = 2 midaup UL gzeOxy aS Imeede 8p wisjuenaus un ap nes elueysqns ares 159) elueysqns no 1swo9 ayuunu yasse ye sired inna, aieouadns yoreuidso. soe> ayundoaje UL sysoje} eseoweweripau Ninjos uns @ onéerequi yaa) Injanu e} e200) sunif>ene e Lunyn ap uo} qns gzeansiuuupe as eualSune; un-Aesds wns @ ayiexuoning -z ‘31210 JNeUAED jmjan B| DUS ISAs} as « ‘gin ap ede no ajgonqumgieds uns & yousuezie9 “y (WUVIORAI EE yoiSNOwe-OaNVaL YNVIONIEVE 7O¥O “YIVUO WSVOONIN Nid —ZLVSINIWGY: asVOINIWWIIGIIN aud exezjuaBowo najuad jnuosey e1/3e as asensijuupe avenay ap ayuIeU) + PIEINSIP nes euiey ede a: juuupe myuaLuoW Uj enjozIp as st junuupe 9p 496m yeu feBap ede no yequos uy « HMueiojoa 6 awove 3129 pine uyfuan jeu gmnze efuersqns eave] ad» stusosonsayo aja3iges “ET veinueu$ ap eBund eye as axes uj uoyie2 ap 4 wi ereajequie as « ‘uopque ‘sgyer no ayezesawe eanse elueysqns ap uoqind uijuco + ‘2013)8 nes aoupuyD ‘sqeynD}ULIBN Spey UNS ayienues “zr augniosouaiue nes aygnjosonsed aynoyiad nes guau! avaqind © no guodose sya eicoUD}xD es vieeidns + ‘2481 gluaysisuor 0 no 3119)s yadse ep gseoquswes!peus guiojoaIsa a reluersgns je snagjdou imsnd esseus @ nauad ‘gig}o9009 9p sosius $ asnB aie sep “oxaqge) alenigugwore a150 + seoqUsWEDIpoU e9eIe2019 ‘OF yroewons IM(ewu 2] gzeauorfoe ewuovodwicn © - glgnp aunize ne aie aauip ued oO + 39 s2u;}eved9e anive ausUOd\ueD ayn ew LLCS 6 ateoynens ajunafesa 6 app nse8 soqpnans eaunize 2p annpe efueisqns easefojoud nauad 1ep ‘iynsosiui nes njmsa eoveoseus nsiuad aseo}syoud Less gnop mez jnun na syLedo3e aiewsdwo> yuns 6 ayunafeia 8 {euua>y0:14) qyaews gornesewes gus0} 0 pupyneos ‘noe ja8oyoseunes Guage op oayzou.e mun e gzeof exmiereduion 21 BIA uy eaieiodend ud ullgo as (€ ORHEUdweD aleogupWiose wns « aye.0 ajanenon“L sores auausenypaui {90 eauunuap guieed sf eRvenjozp ajzvquy 39 afuersqns usuos auld Oo sewers w gpides Yeu yu eoseajozip gzestuoNey 29 as9jso.nW uIP ete2uqes une ajoun © gleanq eaReNAe> unas SeWOIE UL RAED ee» Bray’ any eneinaiine « sojainanied easeiape 325 85 ase9 aqveipa:Bul ap snepe gue} nes no a3e2sn aseonuaWesIpaus jaqjnd eaves216 uud grnuligo ‘seid “eepisip ‘gplios gu0} 0 9359 « mewiudine “3 aworsizéonse8 nes oyqnjosonsed wns + snogjdeu sous 6 35n8 no sfuersqns oun eesensiuiwpe nsiusd aja uns « azeuFORME MEDICAMENTOASE PENTRU ADMINISTRARE CONJUCTIVALA © este osolutie clara © webute se aibs pH-ul apropiat de cel al secre’ crimale 8 nu fie ritant, s8 fie impede, s8 nu contind impurity in combinati conjuctivite, glaucom, cataracte se topeste repede i difuzeazd prin mucoasa ocular # aderd la mucoasl avand o actiune prelungita © are reactie neutra, neiritants lentilelor de contact FORIVE FARMACEUTICE CU ADMINISTRARE NAZALA antiseptic, anesteric,vasocanstictar, 2. Pulverizatii nazale © solutii medicamentoase sub presiune © se utilizeazd doar 7 zile de la deschididerea flaconului * poate aves efect sistemic 3, Spalsturile nazale ser fziologic, 4, Forme solide © pulberi administrate prin inspir nazal © se absorb Is nivelul mucoasei nazale © buliuri nazale ce contin substange vo! 20 FORWIE MEDICAMENTOASE ADMINISTRATE INTRARECTAL ‘© solusii apoase sau vleioase ‘2 administrace in scop evacuator, terapeutic, diagnostic * existd si forme cu administrare unicé 2. Supotitoarele * forme sol + contin butil-cacao sau glicerina ca substanta de inglobare 3. Unguentul rectal se aplicd cu ajutoru! unei canule rectale atasate fs tub FORME MEDICAMENTOASE ADMINISTRATE VAGINAL _ FORME LICHIDE Spray-uri 2u avantajul c& p&trund in toate cutele mucoasei vaginal Crema vaginal forme farmaceutice ce se aplica cu ajutorul unui dozator vaginal FORMESOUDE Ovule vaginale © sunt solide sau semisolide ce au ca substanté de inglobare butil-cacso sau glicero-gelatine sau deriva sintetici * au forme ovoid’ seu rotundé si la temperatura corpu eliberdnd substanta activ Tablete vaginale . woide si aplatizate i se topesc, Bujiurile medicamentoase + au forms de bastonase cu capetele as Ia femelle virgine si care sunt indicate la fet€ 340 pz ap dun annze.atuersqns oun e gouuepsuen ealeuiys nes soUBzid eifaro.d $ elfoajusep nauad s1)s010; y ied « unasela y (reids suad e130) e3jaid no ynmequo reBunjapuy duun usfuod "p> mnfeyuene ne» (eoyesed) sonauis asnpoad ap nes e129 ap aequazaidas aise yraualdioxs ayeres99 “¢ (ona) ssezuatungay tunsfewzoy 20un ezossou onpoud as9Bue Ud « quifie 39 vem aojisneo a]aueora:9 “7 feos ‘eupna T ganos'sw¥os ede na y3e3U09 uy gande ejuersqns greaiaq® —« Jeupipous uinundys “9 1ex6nuw) sjeiaen yeqind uiuo> ayauseideye9 “5 aueoparoud ginayad o pIPaULUO) 3s-npugasa’azeayde gdnp axeo 1S giessadsip uy syEO ‘ajsuadsns ‘9p eWIO} gns ‘Lusgind ap sew sieinueD 0 aulfucd a> quandun ap aeyaUER @ ersed"y seyzeiedep nes 2nauis0 dovs Ul a1S9s0j0j 35 Injneteo yoquawinBe) @d jewinu gyjde as s1e> 4ep yninquan3un 2 gweLeAo asa 6 epewiog “¢ + annze raiuessqns earepunnied 2saqgi8 39 afesew ap ufosul puy juauinday ad gayle os ° w suusiedsuen yuns + 2Iuna9 7 Wdoques ‘ay 5 "ewan, (qna2ejan ‘21259 ‘ejoue} ‘arfod ap eunaun! apiyese ‘auyseu eats ‘euljesed ap 19 91806 nwaldiox= suo ednp & araunsi jmuanun “gieiuownday eres 2 eugd muericdw asopunned no» pera yu JuLap \ryanru e| pues ‘spunned annze efueisuns-sipew eveyuaunfar siapunnied no» (eurjasen’euyouey) aanaeioid nauad ausojaj eqais gewwawnde, aiopunned no ly ateod mauaidpxa (21814 2p soyyoq jmuaweres, nnuad) anes dons « (azoyewep nes aseyuawunger Junyaj onposd a9 yusayxs quade soun exutodui) soiajo.d doxs & eiequauingai nes exeueyns auenyide ae ° no afeseu op aosut 221yP nes Injrwuxapody fmwuangun *t sanoswss mos juepayuzap nes soeweyuinue doss no azeuoriauy wud goujde as ‘Injoonje alsa ymauaidioxs ase Ut aiinjos « nuts“ dave pve ap gseode atinjos 0 giujzaidas muaIdioxe sowuaunenipaus mai “E _ajn2yjad pugwiio}( JoDe1a1x01g) 2ynadeiouy dovs ul goyde as aunisaid ons aienstulwpe sseciuawenipam ysusdsns nes yinjos ap unless « nzaiosd jou puene 2 pune ‘sseowuawienjpaw \agind 2p asuadsns nes afinjos o a1s3 « eauniioy T 301H911 siw¥0s YLvNvifia SHVMISINIAGY 15 SSVOINSNVOIGI IIGOSFARMACOLOGIA SPECIALA DR. JRINA ROMAN See RO ne aurea sna a ances ANTIACIDELE. > “sunt substante chimice simple care neutralizear’ acidul clorhidrc > absorisacizitbiliari curol ulcerogen refluati in stomae > cresc sectetia alcalin’ pancreatics > cresc secretia de prostaglandine (PG) cu ro! protector > se folosese compu de: © Ca((carbonat de Ca} © Mig (hidroxid de Mg, oxid de Mg, carbonat de Mg, tisiicat de Mi) + Al fhidroxid de Al, carbonat bazic, osfat) © Na{bicarbonat de Na, citrat) > acesti compusi scad aciditates gastricd favorizind vindecares se administreaz8 oral sub forma de comprimate sau suspensie buvabllé tn monoterapie ori se asociaza intre ele > au oserie de avantaje sunt bine tolerate, sunt real > in practica medicalé actual’, sunt putin fol frecvente pe 24 de ore sia timpului indelungat Efecte sireacji adverse > compusit de Ca si Al au efect constipant, hipercalcemiant > compusil de Mg au efect laxativ, iar in cantitate crescuté poate deprima sistemului nervos y icace $i sunt foarte leftine datorits administr’ih [MEDICATIA ANTIULCEROASA _ Sey > cuprinde medicament utile pentru tratarmentul ulcerulul gastric seu duod > caurcle lerinit uleeroase sunt pe deoparte cresterea secret’ de acid clothidric, iar pe de até parte, scAderea canttaii de mucus care protejeaz3 ‘ucoase gastrcd sau duodenal de factri agresiv local > dac8 vicerul apare unde exists acid clorhidric in canttate mare, atunci inlSturarea lui datermind vindecarea A BLOGANTE ALE RECEPT ORILOR HISTAMINERGICI Hl (anti 4) % locares receptorilor histaminici Hy din mucoase gasticd impliceti tn secretia acidului clorhidric, determing scBderea se atét in fazele controlate prin mecanism nervos, cét siin cele controlate umoral 24 ‘efectul acestor medicamente este ms ine tolerate 7 ‘adverse: fenomene de diaree, pancreatité, ginecomastie, (frecventS la CIMETIDINA s} foarte rard Ja RANITIDINA si FAMOTIDINA), cafalee, astenie, ens vy LRANITIDINA * se administreazé oral, sub form’ de comprimete efervescente, capsule sau sub form’ de salut administrare porenteralé (Lm... 2. FAMOTIDINA (Quamatel") ‘© se administreazd sub forma de comprimate, oral sau parenteral, sub forms de solugie injectablla rezultata izatrsolvent 3. CIMETIDINA ‘se prezinté sub formé de capsule, comprimate cu administrare oral se foloseste rar, datorita reactilor adverse 4. NIZATIDINA - sub forma de capsule, cu administrare orale imate, comprimate injectabs ¥ aceste medicarmente sunt innibitoare ale pompel lonice, care transform ion HT cin singe th HCl, prin cuplarea cu ionll de Cl in canaliculele giandei secretoare axiverse: diaree, greturi, cefalee, erupti cutanate, rise de neoplat Reprezentanti: LOMEPRAZOL /Omeran’, Omez’) * se administreazi sub forms de copsule, oral sau parenteral, suk form de solute injectabils 2, PANTOPRAZOL (Controfoc’) tran sub pentru solutie 3. LANSOPRAZOL (Lanzu + seadminitreazd sub forma de capsule, cv ad 4, ESOMEPRAZOL (Nexium’) se prezinta sub forma de comprimat buyabila ou aden Sau sub forma de jectabilé cu administrare porenteroiS m8 de, capsule cx microdrajeuri oral sau pulbere porenteroi istrare oral pentry suspensie fat pentru solugie“ sonaunoud 3139) nOeWOYS BaiyO8 SySaQBIF awywdoT201aW . fiuequazaidey saSip Injngni je sr1Bojoypes yrenuEds ap eyfeyosa uy ‘goyised 2) ap nuouputs u) auiqns ynjmunsarey nusstyersyad 8379 ayetulicwo9 ap puLio} Gns jovo greensiuIMupE as (,uawousods) wnciwous WNINOWOy gers areuas $ ep a. arewiieuoD ap Eunos gns guurraid as « ‘sounse’ “a/eunssiutyunytoaje uy foD;puy 318 euueneded yeoap exuanys teu a1so 005-0) WNINAVLONG "E piupy anus 9 asesyns ey exeas nes asaws ap aureus oso greanstuiuipe as 2123 axeuidwioD ap gwio) gns pureed as WNRIIA3EIN 7 swupe na guqeszeful alinyos i$ ae ‘YNIWaAVaya “T uequszeidey inononip ‘auozjpuy wns “nia aadad san)n ‘au aqenese ypedojoa asienp ‘awusue ‘1.8 1 ‘eunsswronsed jaau a ap nusedsonpa in SUSvaSLINW nu “UMoUB/ayewUdwOD ap ewo} qns Jo10 sYeNSIUNUDe uamYBQLE spoUOD ojuaf ‘pluaW ‘uosDUD :a[ers¥BA sjeledaid 9p EW1Os Gns 2sasoj0] a = Inmunsaru € mynewors spsuarstp eezenuluip 99 apsefip jnan wip Jojered eaveuuia ezeoz a “HaAILVAIARVS x ey220 aie ns aaveip ‘eriewuouiss ap. Inn wuezuopozop i pind aa7e8 15 ajounoy ‘sayxoy ajersgan 16 axIUEALOUR alafuersqns aqueaspe < TWNIDIOAW STaNNSEWD —Z ASeU AeUILIdWHOD ap UOJ gns UNS xojcUIS ui insdea ap euii04 qns jov0 gzeanswiupeas » YNODIHI3WIG/YNOIIMIBINIS “T iuequazeiday _a9o}0n3 29140 ap injnwsuosjow muawere.A UL aeatpUI UNS < 40) easeutuuys pugingn sewioys 18 uRsoyur ut 58aKe UE ayeye ze ap eareQUED anpal auUSTUEDW MLE, Ud 2420 gonaIUyS nes gfeumau au!Su0 ap (atuRsqns) ayUBUIEDYpaW UNS < ‘sul Soa! 9S IUEOSPY/ TILA LING gles ajsuadsns & gos e210 aisinwa nes ‘TOZVaINOYIIW “TOZVGINUL ony ~ VNIDINOULIZY < YNIDINOMLYID < ang ap 1geIs fawaYPS wo\UOD EBNEpe as ‘sou pee Oita JaDeqoaiau hue VidvuaL WNOTOXONIEUYD 7% g]o.0 asensiutuipe na ‘$y ap eiewudwoo sp guuoy qns giuleaidas® Wauvsveons “tr jequozoidoy Luojfd saszeqo3)9} jauatveq esie2\peso niqusd waUe}eH ap eweYDs Ue 4 ‘euajau no as-npuepuryuod ‘nuBau vl ajer9; anumew ereaicio2 + ‘32121p yews 3|9z0p Je) ‘afledy3su09 onpoud jaw ajazop repiojoo 1 ‘2p sesupgns ‘emugns ‘e350 ‘ig Sp dI2eq yeuogues ap guLEs qns 2sesR2 as TASTE Sa TETEWOS SDlUiswO SYOONW aIV aVOLIALONE> se administreaz3 oral, sub form de comprimate cu o jumatate de or2 ‘nainte de mas sau dup mass CISAPRIDA se administreazd orc, sub formé de comprimate ee esa nae ued ‘COLERETICELE > sunt substante care stimuleaz’ producerea de dehidrocotic (obyinut prin semisintex3) > aceste substanfe produco secretiebiars abundent, apoasé = actiune hicrocoéreticd| si pentru ,spilarea" ciilor biliare cnd PREPARATE CU ACIZ! BILIARI 1. ACIDUL URSODEOXYCHOLIC (Ursofalk) © favorizeat’ dizolvarea cal tub forma de capsule sau com; 2, ACIDUL DEHYDROCHOLICUM (Fiot © are actiune hidrocolereticd + _seprezint8 sub forma de comprimate cu administrare oral 3. SARURI BILIRE (Colebit") ‘© sunt folosite sub forma de bils bovind uscatd + seadministreaz8 oral MEDICAYIA FtcATULUI ‘A, HEPATOPROTECTOARELE > sunt medicamente care se adi de diverse etiolo diverse intoxicat e228 in boll hegatice acute si cronice i boli biliare, tratamente cu medicamente hepatorowice, te 28 Reprezentant 1. ARGININA. + Aspartat de arginind - sub formé de comp) efervescente, solute oral -adminstrate or © Acidum aspa t narenterat sav oral se prezinti sin combinate cu: = vitamina 8; (Aspatofort’) sub forma de ficle, cu administrare parenter 8 (Hepa Mera") sub forma de pulbere (ol comprimate > combi ‘Multiglutin” sub forms de fiole cu administrare parenteralé 3. METIONINA ® este indicat tn hepatita a fore hepatic’, steatoze nge), boli degenerative ale se contraindicé in bolt hevatice grave, precom’, coma hepaticé 8.PP, pantotenat de calcu} sub form: orold no") amestee de 3 favone ( ‘al membrene! hepatoctl medicaments hepat > _ seadministreazé ora, sub form’ de compinate, pulbere, pulbere efervescents 5, FOSFOLIPIDE > sunt forme biologic active ae picetor ean se giseste Y Essentioie forte’ forma de comprimatefexWBerowayosanjn enore28 gleulwopae asuaisi e[euMuopaE Laing “ype | HEIN! NUOIOD WL EaU as gle op jupe a2od ase Binpe es se8ns 2] eynae eaavelp u, atforypyy no 2re1eyp ywequospe un 359 (,0128us5) WADaWSOIO “e ‘214d aynuu yous ur yezinip ‘240 pz/ag e| eued iequios/gue Kaqeaspe TWNIDIGIN TENNEY “¢ a2jaieyppue aye no yuean(pe e2 \sojo} 16d a5 « yuequospe 1§ z01290:d 13,9 no A/BeyIMWW UN JeuNsaIUE janyU e| {FPEOULLO} B19 ao}sID Nes ABUL UIp aserxe JehaBON apLiEyeRfod runs SIBNUDAd “% lesapoul nes eojus aienisusiui 3p 3 yexypuy Anwisig 3 vionwsans “t fiuequazasdoy syeunsoruleseoanw aje ase0}ray01d 16 auequospe fgyaiidoid neg eunsonur injmgnutfuos eaxearzorsgn 28819 a4e9 ySnduio> -do15/gjes0 9/injos nes ajnsde> ap gusi03 qns 1210 920: quawenpous 2) 39729 0 921 (gefe1owsyous9in e31}0201984 ‘uyos9 e208) ajeunsey jo9 uIp goiu0sa eaauelp nes goynadsau ginde aaueIp gleunseiu) (eas2>6)w} eaienjhiow aySunecui a1e3 auniize a1 + {,woipowy 8 aiueqospe ajafuersqns) saw) jnjunuifuan ey (122Kauyoa Jeunseiuy injnwisnjeysiied eoseonpai uud ezesuorioe a1e2 afuersgns quns THORUVIOUNY solaruasod (5 jos0 gressysiuuupe as De 4p ap atenonaid arasos ayunagsign uj s9eaya 2MHaynd aRoWeALE UN TIES ° 46402} NOWLISNWANO “y jo preansiuiupe as U3) UNIZVYAAMOTIONS "E aid exstumUpe s20d 38 sgowanue § 9naunosd 1393 912 Noaiuaawoa ‘2 yossquased ppaseso. sane soyo no ideda insino oINvado12013 "t nuns afuesgns srezyan fou 3)95 nu) gupies w luapunad aundun 9s < ns « aw wns < (jan woanuy) S0L3WRLINY (ninotoaus esteoypur e ee2Siu ap nga uip ne: ezsusa if gheau8 ap ellezuas (elesnaue eeoypoui 1204) 35/NOUD YO TLILVaSH ViLVIIGAA S jopge wisuoayaus jusueopou ‘9p a1uouD winsuod “wsyRa ‘eeIIG aIZ@UNYSID "goRedaY gz0419 ‘2DIUOID |S aynoe ayeday imuswere.n uy AnUanaLd nes queAnipe e Qpur as = soreuapanue uejwadjodly ‘on juayadeur Piypu uiind no gseu ap ewe ‘ovo gzeansiuwpe 3s * e sondadsip ueungin if ajeussaquionses nes aueyyq yO> ‘snuela aaneday luniiaaje ul wennipe aisa « tote yoforodoy BINvid'9 areusiduiea ap pussy gre foseuniBue op exe pe '@ xejdwoo ‘einsesaujod (es8 tepe “spxo}soy) 4> de asemenea, se recomands in diarei acute si cronice A. Antibiotice: © COLISTIN (Colimicina’}: comprimate - administrare oralé + SULFASALAZIN (Salazopyrin © OLSALAZIN © MESALAZIN © BALSALAZIN C. Alte antiifectioase intestinale CLORQUINALDOL (Soprosan‘) > FURAZOUIDON: comprimate > NIFUROXAZID (Ercefury!"}-capsule, suspensie SAXATIVELE 5) PURGATIVELE Sunt medicamente care favorizeaz’ eliminarea mat urgative este urmétoarea: % cu sjutorul loxativelor se eliming un scaun mole 3i format influenta purgativefor se elimina scaune numeroase de consistent’ 3 sau semilichida r fecale. Diferenta constipatie functionals Preventiv, pentru 2 evita efortul de defecatie la boinavii cu hernie, insuficienga cardiac’, boal8 coronsriand, hemoroizi afectiuni anorectale radiologic Uunele intoxicat ientare sau rarea de antihelmintice [pentru amentoase sau dup admi imindrii parazitilor intestinal Contrainaicay > lizarea indelungata poate determina boala laxativelor manifestat’ prin pierderi de aps, electralig, vitamin, fenomene de colts > Ia bolnavii eu abdomen acut (apendicté, obstructie intestinalé sou ta prezenta dureriior abdominale LAXATIVELE DE VOLUM rezentate de fibrele vege contact ev 293 stimul8nd peristaltsmu vedigerabile s de coloi mirese volus 32 * cole mat utilizate sunt: Metilceluloza, Carboximetilceluloza sodiea, Ageru! (geloza), semintele de in, Ispagulla + eliminarea scaunuiut se produce dupé 1-3 zile LAKATIVELE DE CONTACT. ‘© cresc peristaltismul intestinal prir * se administreaz’ oral sub form di intrarecta! sub form’ de supozitoare Reprezentanti: 1. BISACODYE (Dulcolox”) 2. SENNA 3. NATRI PICOSULFAS (Dulcopic’) itares mucoasei ri, comprimate, solutie oral sau PURGATIVELE OSMOTICE ‘© sunt reprezentate de séruri ale unor substante, glucozd © scaunul se efiming la 1-3 ore de fa administrare . codverse: solutiile concentrate sunt iritante producind great8/emez3 si deshidratare Reprezentantl: a) LacTULOZA 2) MACROGOLUM 3) Combinatil: Fortrans’, Endofalk” ALTE % GLICEROL — se administreaza intrarectol, sub form’ de suporitoare sau spumé rect > ULEIUL DE RICIN ~ in doze terapeutice provoacs in 1-6 ore eliminarea a 1-2 scaune semilichide > ULEIUL DE PARAFINA - administ si réméne in cea mai mare parte Lsuréindwd progresiunea ¢ eliminarea > Plante Frangula (Crusin), Senna, Aloe fnmoale scaunul, Este nedigera Intestin, pBtrunzind in bolul fecal, “PRODUSE DIGESTIVE INcLUSIY PREPARATE BE BAZA Oc ENZIME4H pideady) uewn Quins EDMOS Sane Wy SULTS S yuransy) mwarep [smquo7) auiSuey® guynsut BEUNY SURE As eu yusweres ap 3 ygns pz0a.y puysd soye © 1S jaz02N19 eayeyiqiuadsip greajonuos 6 (sueysasuE] jnsul_aje_eveq| ajeinj22) uNDopUs jMseaoULd 3p BIeiaDas Sa ‘WNNIMISNE YNIdrIOVLIS < WZOENYOY < avd YNOZVLNDISON < WNOZWINDO! < FENOZVIS 5 NIAWOsNE < NINHOaIN < ‘SSGINVADH @ ve aziano azvon9 STDUTTNOTAS Y TASS AKAAA joonj@ ap jnusnsues goipuo.aues Sojoreqaip inapauu ap aug) ‘yewdUtod ap euLio} qns guuizasd as ~ s1wanyodiy im33j3 emusaze tod aageignue nes ewecjeweyuinue sjsun ‘aueindeoonue nd grepose as BIep ~ suaBove13) 312049 aauede siwod guEies UI Je opeH ‘onsa8ip wpsnginy ‘aprasoue ye WMD assanpo a waseinda Jet ‘g/e10 earenstujpe ednp pide, \uepuadep -ouynsuy YoU ymiBqeIp Uy arer;pur a]uHad!/Body s3ay9 m aQUEWeDpaL UNS ~ vao svusavicUNT Pee OLR era Jeiusp ininfjewis earersoye nes ayeyppesadiy cunaieiap 200d « ‘pinses aampoeve nes seuss engsed madd uss uldcopulars « guisdad |S supiioyp poe autucr (sdsdopoy) vnisdid"€ 2a pin aio eeasuupe 253m ‘sieuNduan nals ap Buojens posaeung “aura ' aureus A“ puouseluy ye wD Wfeunwe> us nes andus ase 2s « peas « yavait ‘ynisatus ‘yr Z Sulupe as ave ayewsuduon/ainsceo ap uo} ns ewuaald 9s + 1v0asy) WNLW3YON' SiN ‘MewazaidayE Analogi premixati Insulin’ aspart si protamin/insulin’ aspart cristalizaté (Novornix| ispro si protamin/ insulind lispro (Humatog Mix 25; 5 Siucasonuy ae % este hormonul care creste gl in intensificarea proceselor de + principala indicetie este hipoglicemio accentuati produ prin ie sau Tn cazul gocululinsulinic + se administreazd intramuscular sav introvenos *_sepreznt3 sui fori de pulbere care se diol tn solvantlatajat Raconulu + Indoze mart injectatintravenos poate determina greayi, emezs, hizopotasemie Sse Oberitates reprezintd cresteres greutiqil corp ‘adipos, obiectivata prin calculul indicelui de mas’ corporal Etionatogenic obezitatea este determinat de factor genetic, de mediv sau de ‘alimentatie prin cresterea aportului de de hidrocarbonate g grisimi de origine animal | medicaments pe seama tesutului Sunt substante care determing diminuarea apetitului Sunt apropiate structural cu AMFETAMINA 2 supraveghere a medicului specialist ear’ oral sub forma de comprimate sav capsul rincipalele substante: L. SIBUTRAMINA 2. ORLISTAT 2Aitaminele hidrosolubile: C, Complex B VITAMINELE LIPOSOLUBILE ‘© are multiple rolurt fn organism cur ar 6 lferite procese metabolice cu contribuie le mentinerea structuri ficatuli,stimuleard crestorea in inahime § greutate, asigur’ ¢ regleaz’é adaptarea are functie antinfactoasi, ntervine ih sinteza pragesteronulul etc. © este o vitaming important mai ales la organismul in crestere © se indicd in carente specifice, compietares necesarului de vitamina A la copii, utilé in stimularea cresterii la pubertate, arsuri, afectiuni ale tegumentelor si mucoaselor, oftalmopa © se administreaz’ 0 ul trimestru de A, atunci se va ioratia galben: a & tegum - derivat din plante 512 potasiulul la nivel intest Jabsco retinopatia prem, ‘continenig urna femel na azoosparmie, involutia ovarel t adiministrarea) © NU se asociazs cu anticoagulantele orale, decarece creste nseul hemoragilor 375e (eseoniou i angsas anyona 2189 gleoq) avGojed pupuiasiarap ax TWAIAIWNILOSINT ad WNT A ‘pyo10 aseqsiuuipe no Bung ep ayeUujsdwO> sp guu0} qns EUIZaIE 3s» ‘spines e|yensiunupe sp iweviodiat /Sojaunau sojaquapioze jnasu ersixe aoaieop epeilul alsa es 204 . aiapose " ojguiaUe PUSWIEES UY AEeSO}OJOS « 5 ezaTUS joulsy e7aUls Wj auWEIUL B12> g jNxa\dWwOD LIP EUIWIELIAG aIse aTOTTaay yosaquaiod azesjsiuupe n9 ajoy nes asaqind yd ‘quansensays ayeusduio> ap guise) qns jo10 920: po as « nipey "gzosodoaso“gieneuud ap Busse “s@Unjeud ay unjo TeusuLnseuode Bed np yuan ‘SSunjaud ag ues sogibaj eluonend Ynquaas w goppu) as» eaueepunn aigeqg ojsuiaoud “Ojopidy “opHONE InusyeqeraUs Y ‘aIsoNpaLoHO {8p sjoqmaw sjesmaid ul uwlaU} ‘ienyeaiatU! huss e7SLeONG UI Ol BIE SWRTAVIN= TawOSST NGO Jo10 axestsiuiwupe no runsdw0> ap uso} ig @P GUO} Gos guuIreld as « aseorsnues ers ui paipuioquosas « dau ‘saneday 92049 ‘eonseyqojesow jad wave uj jepads wl grpuy as + 1 j20 §$ (RJEUMNUE OULU ap ajasnpoud BfesBUIUL IS BUNLIEYA anfe n> a¥TeL|AUIOD Uy gns nes Joqnasnuanur ezeasisiuupe 2% aa1uo.2 ‘use eseconu ap yejanes 2es4014 FOIE} no BuTUNKO aseSAINGaN RAYOSPPYENANEd —& soquiBue-ounau ajueinginy 6 eauised eyuze ezeasoljatue ‘s0}a;n|20 Jounany eavewLio} e yer9Ua uy O|aIseiqoNUa eo1euse) e| ‘DISPAU so} ezaTUIS e| gdHUeC “sImEa! UL jos ale ‘Re PRINGIAT OTATHVEOONETS Ipsaqwased nes aso greansuuupe es 6 1d 9/2 ONS yuntiaaye “yuraue Waipu as « noe wisy)na sizinasnuy sonsiodorewel; aue8i0 ‘son: ‘zaied nes suing ‘uniai3 eauede yod 2g e soynasnu Jonsip ¥"q ap eujweya ap cfu wusloGeyatu uy Jaulgo}SowDy & fe quaimpstios un 79 YNIWWLIN) YNIAVIORIE 12in0 H0q 40 ypeu03 Syn U ‘ye1eyeR Jaqe!p UL Uennipe inodiy ap gis: JRUoWI0Y eaxeUH0, 8 edimed jesads ujueyodu jorun aie» Ce WNIT VN FIEMOSOUGIH TANINYLA ayiqeznpiad nes ayqesrafu je n> punasdu 1291 ap 2 ‘e29| aquspnce e} gued sdejeo ‘aypue>iyer ‘grouel> ‘ssudsip ‘goneior atisusuo> ep aitezuas Jafey ensa8u0a ‘ezospiysadiy tex0noud 120d gpides gseouanenul eaxeiafui = IGeWaIUY AlinjOs n> Bloy ap eLUIO NE EyaZaId 3s 6 04) nes WSouruan 1ds96 JoUn sojuunagasn & |S wind2id soneday vjaiusrrynsul uip JomBeiowsy ey eumweLa 8p apyep wud srev0A0.d so[Se:oway aon injranoseu pluyp ar najuad gygnjosoipiy Eunos -SyeuweIA djeunsoru] ayusyreg sp prezAaWUIS -“y euWeYA > ayueyd wy =(euoipeuswosy))- ty eure, (a ‘ouUIoy EQNS Uaid as « einasnwienuy goiauasod avenstunwipe mp ajoy 2160) nes give azensatupe no gseo]2)n aiinjos ‘aseoune|as sysden/iow ainsce> guUO! qns puraid as «‘se indicd in pelagré, dermetoze, degetaturi, acnee, intoxicat}l satur barbiturice, hepati re porenterolé + fenomene secundare se citea2’ hipsremia tegumentars, senzatie de ccldurd, prurit tegumen satan are actiune troficd pentru pele, efect antiaterogen * se administreazd oral sub forma de comprimate sau topic sub forms de solutie cutanata, crem’ ® indicasii: ecrema, seboree, ulceratit atone ale piel, sterosclerozé, hepatite ‘ronice, ciroza hepatic’, steatoz’ hepatica ‘SUBSTANTELE MINERALESLTONICE PREPARATELE DIN CALCIU + caldul este uncomponent major al osu avand rolimportantia ni enzimatice, coagularea Bete © se poste admrinstre orl sub form de camprimete fimete, comprimate ofervesoete, Solutiibuvable,pulbere sau se poate achniistra parenteral su fomiide slate injects © principaiele preparate pe bazs de calciu sunt. > GLUCONAT DE CALCIU > CLORURA DE CALCIU > BROMURA DE CALCU > CALCU LaCTAT * se recomandé administarea in cure cu scheme individualizate in functie de rezultatele de laborator © pentru fixare se recomands administrarea concomitent8 cv vitamina NU se recomand’ administarea concomitent3 cu preparatele de magneziv PREPARATELE DIN MAGNEZ! + se indicé dupa determinacea magne: © se edministreazd oral sul efervescente, solutie buvab © preparate: Suifat De Magnezis, Magnerot” MlagneBs’ (in combinatie cu piridoxins) imate, comiprimate 49 + sepatadminita osu for de camgrimate, sli bebe uber sa parerterah ‘+ se recomand’ administrares in scheme individualizate la indicatia medicului © Ny se administvears in ca de alergie ia una dintre substentele medicamentoase sau excipient ESN nian neiet ANTITUSIVELE sunt indicate in tusea seacd, neproductiv’ de diverse etiologit au ca mecanism de praducere deprimarea centrulul tusei Clasificare: A. opioide B, neopioide A. 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(FENOTEROL + BROMURA DE IPRATROPIU) * Combivent” (SALBUTAMOL + BROMURA DE IPRATROPIU} METIDANTINELE TEOFLINA. este un alcaloid xantinic care produce stimutare cardiac’, sistemului nervos centraf, bronhodilatayie, stimulaaza secretia ga reste diureza se Jndi¢d in tratamentul astmului brangic, tratamentul unor forme de insuficient’ cardiac’ 5¢ administreaz3 oral sub forma de comprimate sl parenteral v aa > determind ca reactti adverse cet injectarea intravenoasd rapi hipotensiune, chiar eecidenta Nu se administreaz’ la pacier vasculare, aritmi AMINOFILINA, > este derivatul de semisintez’ al teofi % are actiune bronhoditatatoare mal slabs decét B, adrenergicele, este antiinflamatoare si imunomodulatoare, cardiostimulant® se indicé mai ales in criza de astm brongic, administrandu-se la indicatia. mediculul intravenos lent sau perfuzie endovenoass I dac& se injecteazé rapid poate determina tulburati de ritm, uneori brilatie ventricular cu stap cardio-respirator lee, rit |, palpitati,crize anginoase poate determina aritmil severe, fe cu angin’ pectoral, Infarct, accidente a ANTUNELAMATOARELE STERODIENE Pee A, CORTICOTERADIA INHALATORIE (sopied © teprezinté medicatia de electie in astmul brongic persistent * se recomand’ fm toate formele de astm bronsic, BPOC, sarcoidoza, mucoviscidoza © efecte odverse: locale: candidoza orofaringians, tuse irtativi, disfonie, bronhospasm paracioxa sl sistemice: scade reziscenta la infect, asteoporaz’ Reprezentanti BECLOMETAZONA {Becotise") FLUTICAZONA (Fifxatide) FLUNISONIDE (Bronie") BUDESONIDE (PuImicor’) TRIAMCINOLON (Azmecor®’) vVYVVY I trotamentul indelungat cu corticosteroiel poate determing dependensé si reristenté la acestea 8. CORTICOTERAPIA SISTEMICK + s6-adminstreseé doa seurts de timp Administrare: > orat- PREDNISON (co, 5 mg) —dozele se vorscides treptat > intravence ‘2° HEMISUCCINAT DE HIDROCORTIZON astmul brongie forma sever’, pentru 0 perioadd 4aieseqifa n2 yNNOaL~ anawvivar | 3G INALLEO aI Jones‘ epeiueccp = | nvLavaUL eae usqwaauy | guesanau aysamu + TWLdVBEL f SvUAWED, | YOULNOD 20 39INTIZ HLWOIORIN 3a | BAIN 1 jox}UOD ap ExINUsiGo eidesay ap Bley snjd !2uDy9N98 ap jnjonyu ap a4r2unf w PIOpUoWIOD.: sIEOIPAWY uo § assed ap oxsipa ut ydo9 Is Hiney ob NOLNATIZ “LSVANTYYZ ‘ISwIMINVEd 12191029") {SYNNTELEVE Z Fles0 ofnjos nauad eveqiod nes aygicei ep BuUiD, qo peas lunse ap ezu2 ul gzeanstuwupe as nu Joo quo1g ypu as < wpe as sansedsoyuoig Jojaela £03 sompal 4 {024 1S09nI21UOM so}nBUIS) 100s LSWAMRLNOWT shueyuaraidoy nus uy eldesayoa7u09 No eRdse ajeod as « nfesypujesyu0s ap 229 {srom 3p eevee $$ wuoyeweyur_jaonaisao ae euuavodu 20) anp01_« TEE] THENILOOAT NWT ONAINLODAN WOOL TuSWOOMING quangaty 3 quaIssiag juajouwio: wovewisg | nreadea | bate ee yerpow quarsisieg wreideasy | \ earenme | age 60-02 asaese epaeiodajeny | Jo 082 sony ad uo podgieoyciee| ‘asing gupuieyces ad wep t< | au yonewordwise re inj ad u yeuiou g3d | quasuiayLy 608 =. eae ierdeary gueuerdes adeep t>s 234 efeuen aydeou sr oys0d ausosduy SISA Nes 334 aasad sworduis a nS WNID mpIdg Bdng - waluDals | yaainse (omIeRaS DaIDsIpsOID sojesew jndwin uj ayeuiriduios ap eunioy qns eso gzeons epxeyoud “qunapoasaye ‘9518 ‘ue jew eluapya oa > yBoW0.9 PDE ‘ainsdeo ap euuoy qns javo pre: 28192 ‘eo(@soje yun “oj ap ‘suey atuersgns ap “Tj ep reuwyap aiSuo1g jnwase ‘1Bu9je aySuosq muse ul sRDe|YOId grED!Is|UNUpe as < aueojeueyuynue 1s 2318s eun ass 1G0sIa LvaNDOWOUD Buowwazaidoy 1U0}9 nes 1uaBLaje e| ea1uncxa ap aru luIUIpe en as ‘Stwiyp uoperpow ap easevaqula is elowsone eosemvedfop pug>ypalduyy Jo@porsews eueiquiow greazNaaS + rey NNYYSIO Ty WOLSIHAT “NoTONDWRL (Jo1p2W-N10S) NOLOSINGIUTTLIN +Usor ‘glucocorticosteroizi ihalati condijionata sau petsistent [ Anti-leucotriene TREAPTA. . ” wot we | eae Jucocorticosterol inhalat Gragonist ora cuetiune ung drat doz’ mare de 4 lucocartcosteroidinhalat | |/-doze medie de | slucocorticosteroidinhatat | “rmodificatorde | | teucotrione ee TREAFTA | +. dozs mare de W Blucocorticosteroizi plus B- { agonist! inhalator cu achiune sever persistent | | Le | | . | | net ares ALTE ANTIASTIMATICE PENTRU UZ SisTEMIC | + -glucocorticosteroid oral 48 endogen absent sou <34 saptamay (boala membranelor hialine} se indicd in sindromul de detresd respi © seadministrea23 endotraheat ‘Chimioterapice minore ETIONAMIDA peer ~SACLOSERINA Pas, He AMIKACINA, su administrare oral gi ian joterapice in; TBC puimonars/miliard, a tuberculoasd, meningita tuberculcasd 2.RIFAMPICINA (Sinerde!’) + se prezintS sub form: intarn sub forma de josie pentra: uz luere pentru je capsule de 150-300mg: 4.PIRAZINAMIDA de 500 me, cu adh 5, alergie la Pirazinamida, boalé 48uafixo ap jnuunsuos iS ruesasau aunul uguyypazap lip sjeynzar aopienow wvodiy reun guojep aiede gseoudUe ex < ASBoU/BUE a2]40 OU aun raliuede e51e1)N9 6 uaunp eaewicns axgoergo e2 ne pseoulBuenue auniize no ejpquoueDpew usu) e gaIUIDYS| eeog WepuEWodDss < ‘YSVONIONVLINY VILVoIGa wnigous¥ud! “YNIGOULY ‘NIZINOWN ‘NIXODIG “YNIZONSGY TGATENUE STUSHIEATPST TAY vuwvevesn < wazwutia < viuewozosdoy aieuortuslu sns sow ayuntioaye nuad U0 wauIETeL 1 yoo nes wu ap ajueznqiay uy yovazuasod gluaBin wi gz2asistupe as = gansedsosen 16 go1u0.a gyero1ad guifue ‘pleuswe sumsuduadiy :y 28 wns ane}p1e9 unsioaye oye ul 1S aveDIpUL UNS ne Jeune saving nes ayfeyuqy ut ‘piua2in uy “yesauaied ysojoy aise. annunat ‘aipseaipedg ‘prequauinda} aseiojoz9p ‘areyiqysuias0}0} ‘gevowind grosqy “eiproumuadiy no guPIOsR :asianpo yiovas er ae salsojowjeyo Soipouiad sjeosuos gpuewionay as eouowase op \f auowudsos ‘ZoReday ‘gueipiosn efouny ezuowucus ea as sjei0 wensiuulpe epeouad ad» posayuaiod #010 ereansiumupe as» ‘suginaquanedns ¥ s1ejno.nuan yun Wy BrerIpULaISa wNowvooINy ee (ajansusyedyynul yzan) squedoiqeieg ajaun apulidno ree ‘ameoyuasas ssienge sojusWwOURy EOP Lesiy 6950 35- YAINIWITS < aunisuaiody eusarap apeseoap glei03.e eounisuay ezuayour eq jepaw ymuaysise ywensiujpe epecuad 2d» souanosiu nes jovo greaysiupe as 6 YNONSIvdoud < 2326019 MuswaW < os oypou Pieorpul a} gluaBin uy exeoneiwiwpe 95 - (YNNIK) YNIWDOGH < arose vawwnivooud < vial {ovo nes nompeus efesouy eeu glued uo z2nu2700 @ . vr ase Tea auvoisisvia evs 98u na ajsgunqina e} eugd Suapou! 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NITROGLICERI * este un medicament util in criza de angina pectoral + se administreazd sublingual du efect rapid sub form’ de comprimate sau doxé puf(sproy} = Nitromint” + se poate administra cutanat sub form’ de unguent 2% cu administrare pe fat8 intern’ a bratelor, torace, abdomen sau dliscuritransdermice se poate administra si in tratament cronic sub forma de comprimate retard are efect hipotensiv (III Se poate administre in crize de hipertensiune arterials) + alte efecte adverse: cefalee, hipotensiune arterial, sincop’, dependents * Atentielll ~ valabilitates nitroglicerine’ este de 12 luni (fling ‘apid degracabis igi pierde eficienta in timp) 2, ISOSORBIDI DINITRAT (Isocinit’) "se administreaad la pacientii cu angin’ pectoral§ in tretament ronic, ora! sub forms de comprimate retard 3. ISOSORBID! MONONITRAS (Oricard") + se administreazs in tratament cronic sub formé de comprimate in prizé unica 4, PENTAERITRIL! TETRANITRAS (Witropector") = se recomands in pr: laxia de durat8 a crizelor anginoase® B. VASODILATATOARE MOISIDOMINA © este un coronarodllatator natural © este putin ui at & MEDICATIA METABOLICA TRIMETAZIDINA (Precuctol”, Moduxin") + este un modulator metabolic care are setiune citoprotectoars este un vasodilatatar coronarian, cerebral si sistemic protejeazé miocardul de ischemic scade numérul crizelor anginoase ‘+ se recomand& asocieres cu beta-blocante deoarece tmpreund potenteaz’ efectul cardioprotector © se administeazd oral subs form de comprimate Alte clase de medicamente care se administeazd in boala ischemicd cronicd sua: betabiocantele, blocontele de caleis, antiagregontele plachetare, anxioliticele MEDICATIA ANTIHIPERTENSIVA |, PREPARATELE DIURETICE * Diureticele de ansé sunt indicste in HTA, insuficient’ cardiacs acuti 5) cronic8, ciroz8 hepatica cu ascita gi contraindicate In insuficienté re cronicé asociaté cu ciroz’ decompensats + Diureticele tiazidice sunt indicate in MTA, insuficlent’ cardiac’ cronicé, si se contraindica in diabet zaharat * Diuretice econamisatoare de potasiy sunt indicate Tn insuficients cardiac’, cirora hepaticé, TA gi se contreindicd in insuficienté renalé cronic& sever’ CLASIFICARE “LDluretice thazidice ~ cel mai frecvent utilizat este HIDROCLOROTIAZIOA {Nefrix’) sub form’ de comprimate administrate ordi. Se contraingicd fa pacientil diabetic! deoarece determing hiperglicemie. 2Diureticele Ge ans - cel mei frecvent folosit este FUROSEMIDUL adiministrat oref sub forrmi3 de comprimate sau parenteraf sub formé de sol injectabil8. Este indicat sin crita de hipertensiune arterial (i.v.) 3.Diuretice economisstoare de potasiu ~ cea mai reprezentativ’ este alte preparate: INDAPAMUD (Tertensif, Rawel’) ~ sub forms de comprimate cu adiministrare oralé envima de vonversie este enzima care partici? [a reglarea presiunlarteriale > jin terapeuticS, mecicamentele inhibitoare ale enzimei de conversie sunt utllzate pentru tratarea hipertsnsivy > se recomanda'in hipertensiunea arteriala de toate t % Bxceptie HTA custen > auca efecte odverse: tusea seaci, iritativ’-supSrétoare pentru pacient (se recomanda schimbarea tratamentuit - In acest caz nerecomandéndu-ce administrares de antitush fpotensiune arterialé de prima doz, parageutleeup}Uo! wees KAA A VINE (OIQUINZAGY MMOLIBTHNE '@ eapeuens eu 1o1NaaIN3d DBILVaWIs HOLE [p03 } NYAMYSIATSL, (190203) NVLNWSON (enaudy) NYAMYSIERL (,puboory) NYLNWS3QNYD (uca0ig) NYLNWSTWA gonegelp anedazsou e1euez LUBA e atfounysip n> NU nes gieDose yLH UE ADIpUI as gouged aidoser nes aidaiszouews Uy e/pU ied as ‘sn guiuussyep nu ‘yo3 20 saueurpowisy ‘yy soquoidezes je oypads aSuodeue suns 1age1p ‘Bugis 1 ena Heojeve pugne (aay TNW LEYS = {joo ‘pusno}a) 10UaaANYD “9 ens I DHINTUY (WOLISTHINE 6 y © z 1 Suewuazeidoy iSNBLOIONY 30 NOWWOLASEW TNVIOTE ‘A anpajasaudns. yor0ws3 “s (29192N) 1070 A183N (Jo2u03)1010NaOSIa “€ (102301099) 0108dO1INZ yoionaly “+ *g ongoajes TOIOXvIIE “y TOIOWL “€ TOWLOS "7 TOIONYdOwd *T £9 +89 annsajason raueoyjsepp - fuewuazauday os ponnzu’ EaIMJeYo atinios ‘eygensal 20/1 j1B}Us0d “10 eR 105 ‘ayeuduios ap gussoy sutupeas < wumaid as relewes raqeip‘einaqsquaN-olne 9-9 UO. PNIENUIsqo auoWNeUCeYUOIG “DHSLOIG MASE UL ERAN? 3 NN 23 aureD|Biodiy ‘eauasuad auayos; r2xma}nUaA -ouje sieonpuea ap upsngim ‘alfainsuosoyuo.g :asvonpe jisoas ene < SypsRDOIU! jr2AeV edhp site OSU anp—H OWEN: wOWUOD ‘ypieoiyet asian ul jrunp gzeajonues enisusvediyaue ‘gseouduenue ‘yseomuenue ‘gseorewomey—que “grjunuenue ounroa ne THINVIOTE VG AI wazvura “2 aNWaTEIA “9 NisIOOWWN “S (oipus7) NisiainER “y (psouon) Nigiaowy “¢ NigiawvOIN °z NIgIOBAIN“T suns aseowaweaypaw atueysqas ewapo siarque® awepe gua SuIpLIdospI4Ip-UOU # auIpLIdosPIYID Y gaylse as 6 inyro,pau erfenipure|asayuavod i ovo gzeansiuupe as guofoio.enve ‘gaisusadiynue ‘eseouBuenue ‘gaunenve auniise ne» TOWNS ACTOR TWN THINVIOW Hi pipietuaied asexsswujwipe ra epqeissfu atinjos 3p guuio; qns 8 gjovo azeaastutuipe no arewiidwiod ap gusi04 ans 2417016 a5 atdoidv> aiwaonisn aWwaVIVNE (osdn290) sawnin (0320919) We37¥NIB (220) ain (yudeuoy) “id0NIsos {,vaidoo) wwavioanye, (simyoss2ig) WdOONNaE ddd euunda Hueuozesday uaSove1a) 1aJ9 ~ gupLes wip gjevaLie eaunisusyadiy ul epueUIODD! as AN ~CC. INHIB/TORI ADRENERGIC! CENTRAL SI PERIFERICI > Rererpina D. ALFA BLOCANTE © _actioneaza competitiv cu noradrenalina la nivelul a-receptoriior vascular, determingnd vasodilatatie arceriolara * DOXAZOSINUL mat este Jaaicat in hiperniazia benign’ de prostats > neselective: FENOXIBENZAMINA, FENTOLAMINA selective: PRAZOSIN, DOXAZOSIN, TERAZOSIN TONICELE CARDIACE/CARDIOTONICE * sunt substante medicamentoase care restabiliesc forja de coniractie 2 riiocardului amelior8nd dinamica circulatorie® + acest efect amelioreazécalitatea viel pacientului cardiopat + _seclasificd in tonicardiace de fond, cezervi DIGOXINUM > contractil (craste forga de contractie} siinhibs functile miocardului specific > este indicat in insvficienta cardiacs, tulburdri de ritm > se cdministreazt la indicatia mediculu: > se pretinté sub forma cle comprimate,soluye buvabil, solute injectabis % se administea2i ore! si porenterat > pe peticada administearit asistentul medical va monitoriza pulsul 51 efectele adverse > poate determina tulbursri cardiace Geces}, digestive sau neurologice fibrlatie ventricular’ pan’ la LANATOSID, se foloseste rer Alte substanje cardiotonice: AMRINONA, MILRINONA, JONI DE CALCU, TEOFILINA, CATECOLAMINELE - se folosese ca rezervis MEDICATIA CU ACTIUNE OCITOCICA $1 TOCOLITICA OXITOCINA © este opeptids neurohipofiza in terapie se foloseste oxitacins sintet 8 reflexului de ejectie al laptelui matera © deciangeazd contractile uterine fieitogice ce asigur expulzia fatulul © se india Imajore pentrumamd sau fat say inducerea aval u ro fy declansares traval fiscur pentru sarcina supramaturat 56 © se odministreazé $i in cazul rupturilor uterine, hemoragiilor uterine sau ‘atonie} uterine postpartum sau post avort se contraindicd in tahicardie, crizé de angin& pectorala, hipertonie utering © se administrea2s ia indicatia_ medicul at ginecolog parenteral, cu monitarizarea fur tale TOCOUTICELE } sunt substante care determind relaxarea musculaturil uterine diminuand contractile uterine sunt indicate in profilaxia iminentei de avort, profilaxia nasterti premature > dintre substantele medicamentoase cu actiune tocolitica se enumert Fenoterol, Salbutamol, Terbutalina, Ritodrina Sulfatul de magneziu = este utilizat ca tovolitic * indoze mari se foloseste in combaterea convulsillar din eclampsie ‘+ supradozarea provoacd deprimare cardio-respiratorie mareata atst la mama at sia Ft, bloc neuromuscular la ft si depresie respiratorie severd la mama © seadministreazs le indicat Antiinflamatoarele nesteroidiene ‘© deprima motiitates uterina probabi intezei prostaglandi + sunt indica prevenirea nasteril premature, diminuarea simptomatologielin dismenoree NEE a % auscopul de distruge celuleie canceroase gi de a opr pr % tumora malgnd este o populate celulara heterogens formats din © celule in faza de diviziune celular’ influentate de cltostatice repaus (Go) rezistente le citostatice > ctostaticele actiones:s asura rmecanisme, interfering cu cic ceiviar sieventuale distrug) UTUZARI TERAPEUTICE lelor canceroase pr Wicd oprese cel din peotferere ie de stadiul neoplaz joterapia de inductie © este utilisata Inaintea tratarnenti i loco-regional al unel tumor localizateILL BUOIEP = YOIMIVESCIOID) gxFeowsy es TREST TOOT A augSqOGUON TE -SSGUOA ‘onyso¥ip vuesngim ‘ezepunaes oajuy Ud glessayuew gieinpaw asaidns :asi94p0 9109/9 « oq “Leweus wsejdoau ‘sua! 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Aeprezententi: CICLOFOSFAMIDA > IROSFAMIDA > CLORAMBUCIL (teukeran”) > BUSULFAN (Myleran‘) > cISPLATINA > PROCARBAZINA (Natulan") III mulfi ogenti anticoncerosi ca CICLOFOSFAMIDA sunt si imunosupresiv, dor $1 mnutageni, sau carcinogeni existand posibilitatea de aparitie a une! ‘molignitét secundare survenind ca 0 complicayle téreie @ chimioterapiei 8. Agenti intercalant Antraciclinele: * sunt agenti antitumorall care determina alters ale ADN-ului prin blocarea sintezei de ADN, ARN si proteine din celulele tumorale cu crestere rapids gi generare de radical liberi dar si inhibarea topoizomerezei Ii determinand ruptuca dubls catenard in celula malign’ * se indie’ in imfoame maligne, leucemil acute, sarcoame ale pirtlor moi, neoplasm mamar, nefrobiastom, neurobiestom + au ce efecte adverse: cardiotoxicitatea, alopecia complet dar reversibilt, mielosuoresie, steritate * se administreazd iv. ta indicatia mediculuiin scheme individualizate conform protocoaleior de tratarment Reprezentanti: > DOXORUBICINA > DAUNORUBICINA > EPIRUBICINA > BLEOMICINA ‘GiTOsTaTICE CARE ACHONEAZK ta hivewuL KArrOre! (tea © impiedied formarea fusuiui neee8 in fara Mia i © seindied in leucenie acu bronhapulnonar, neuroblast + predint8 ca reactii averse: tulburari react neuromusculre, necrosd tislar # se adminisireazs iv. la indicatia medicul , miclosupee je administrare scheme individualizate 60 Reprezentanti: Aicelolai de vinea rosea - extras > VINCRISTINA (Oncovin') > VINBLASTINA (Veibe") > VINDESINA n planta "vinca rosea” AGENT TERAPEUTICI UTILIZAT IN HORMONOTERAPIA CANCERULU) “ese administreaz3 in tumorile hormonadependente TAMOXIFEN ‘© se ingicd in cancer mamar estrogeno-dependent, neoplasm de corp uterin © previntS ca reacti? adverse great’, vérsdturi, bufeuri de cakdurs, ‘trombopenie usoaré # se administreaza oral sub forma de capsule {a indicatie medicului in doze individvalizate Reprezentangi: > PREDNISON > DEXAMETAZONA ANTIINELAMATOARE NESTEROIDIENE, ANALGEZICE, ANTIPIRETICE, ANTIMIGRENOASE ANTINFLAMATOARELE NESTEROIDIENE (AINS) Caracteristici farmacologice comune amplet din tubut digestiy fe plasmatice (> 98%), traversee2é placenta, tree in + se metabolizeac8 ls nivel hepatic si se el fect antiinflamator puternic, analg ic, antipiretic, ic) afectiuni reumatice articulare inflamatorii din ORL, stomatologie, ginecologie ete, sicronice, afectiun! 61‘upies 99 uaseuu pnp apes’ i ue St > yoo e aluaru aud 2p 28) qwez|8r9)@ 35 (epnesd n aera; yeunoyew pujaniayap ru) wa8oyeray 5s ‘UsB9R|n asa mu - ad {sousne.nul} osaqvaved ‘axeoxrtodns ap eussoy ans jayzavonuy‘douts“e}e40 aisuadsas ‘gje10 afinjos ‘axeluLidwos ap gu0} qné jaro gzaDrIcIMUpE 3s < g:qa} uud areisayuew es ateapou ‘eveosn yieinp ud aresayuEW aye W gopul a soyeweyungue naa ae AN < auaudnve opadjeue ase (jowe1320,06) TANSZONTATWISY ‘SESW Bap BOMOSPOR BIC IGS Be oe ‘eto alinos nnuad araqnd ‘stewnsctuas ap guloy qs jaso 20a auiecnun ‘aqneday ‘wue Zr ap eisien qns geeaancnuwae 96 AN - 1609 ef) Ady Wicupurs "seUOWIINd tvapa 2/fainsuasoyuoug 'a|eunsauA-o.nse8 NaeuowSY '9sseR00 1>D—r aunzooun seraupe|d yueSaiSenue “nuoind soreweyuinve ‘iesopow saa8leue anauIdQUE as {,55¥ eqwioWys * wuoing “ ouidsy) SAISAYS AEDT GY TW) SSTSuIaLIN = STUN “A FUTOYY no ganze erteaxoquy uy scuanenutezeansiuiuipe 2s susiul oizaBeue aj sie ‘euysojen FUDTOW no prose exfenrxoru uy souanenuy ezeanisiuiwpe as oiadjeue ways aie -PUOKOIEN. ao TESTA sipsesoqu seu uidoany no arfeaxonus ‘Buanas aeue1p erraisaueaid (va3]) nae seuowind wap eoitejdoou elfojone ap weus 42snp SeoIpUt Innuod ‘euoyeuidsas asewudap ‘eyeunseiujonsed sworduys ‘ax@iaj2 woes casianpo ay2afa eo aie + eysosd ap euBiuag erze;diodiy “yesqaraa waps ‘2,6u0ug Usnse n> yuabed 2} ‘Jue Z > t1d02 a pojpuIasIUOD 3s « AAAAAA “sojauataun 18 sojsuazauys injnsnuoy e3s01$e49 '2 UISuOIOYLOs J2)nasencip1e9 “jeunsoyy nwars)s esdnse © wowposowiaf 2ectiens0 i109 ‘BueAfes "BjZUNSAyU) 'g1eULIN 3}B> od Dune aS Sheday jan e peoarnoqmaw as } ewaneyd greasianest ‘epides asa extrqinsip 10) Buesrsiuttupe ap ajiea ayeon ad apo DV. 210 nidowp pioerjeunasa » WEEOW nue-a2!zeBjeue) apioidoau axizagieuy “g (eonowrwo“yiou) apiode soizedieuy -y STOTT 31301239 1VNV ua9 sonau evel (apinead 2} gpuewooe 9: (worewegumnue 16 sono. 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Algozone Forte” contine paracetamol = codelna cu acgune analgezc’ si antiiretie ev indicayiin giverse durer sist febrile 2. Paracetamol Sinus" contine paracetamol + maleat de clorfeniramin’ + dorhidrat de pseudoefedriné~ cu efect ancl 3. Paracof’ = paracetamol + cofei |quactiune ant METAMIZOL SODIC faigoca > este cel mal puteric analgesic al clas, antpiretc, antspastic > se ndicé in afectiuni durercase de diverse etiology rip, str fe > recep adverse: 3 cénd este administrt intravenos) > se administreazé oro! sub form’ de comprimate,solule oral sub forms de suponitoare si parenteral (intramuscular, intravencs) ti i u min” Je Injectabi8 de metamizo! + ptofenon, cu In durer spastize cu punet de plecare oe la roma, intestin,colecst), ditmenoree, migrens, durer interventi chiurgicale minors examin instrumertare metamizol + cafeind + drotoverink cu elect analgeze , vesotonic cu indict mgrend si diverse cea! sau sfera ORL le atectiuni hepatice, renale, soc anafilactic (mat ales trarectal ANTIMIGRENOASE ¢ Se adminsteazi tn migren, fa Indicalia mediculul in scheme de watanvent indvidalizate DIHYDROERGOTAMINA (Cofedat’) este un alcaloid din ergot are efect vasoconstrictor find u vyyy v SUMATRIPTAN (Imigre: > este un agonist selectiv ai receptorilor 5 H > se indicd in criza de migren’, cefalei vas > se administreaza oral sub forma de comp RIZATRIPTAN > indicat surativ al migrenst forma de cr Alte; ELETRIPTAN, FROVATRIPTAN imate 64 MEDICATIA SISTEMULUI MUSCULO-SCHELETIC SU itingicate th tratamentul Inflamafiilor osteo-musculare de orice etiologic ‘© se prezinté sub forma de unguente, creme, geluri, plasturi, spray, emulsit cu aplicare topicé ‘Sub forma de unguent © INDOMETACINUM Sub forma de unguent = DICLOFENACUM sub forma de gel, cremé, unguent cu administrare topics i subtire aplicat de 4-5 ori pe zi * PIROXICAM, TENOXICAM, MELOXICAM Sub forma de crem’, unguet, gel cu apl + IBUPROFEN, KETOPROFEN, DEXKETOPROFEN PREPARATE TOPICE PENTRU ALGII ARTICULARE $1 MUSCULARE ‘© Se prezinté sub forma de gal, rem’, emulsie, ungueat cu administrate topicd 1 Reprozentarg Niu”, Tantum Gel®, heurnon®, adudan® Indoretacin, Fenioutsacr [ALTE PRODUSE TOPICE PENTRU DURERI ARTICULARE $1 MUSCULARE re topled > are actiune antiinflamatoare speci > se administreazd in criza de guts formé de comprimate, oral 10 posotogie indicat de medic useulul de artett fe, dup mas inp se recornand8 ingestia de peste 2 itr de ACIDUL OROTIC Uriconurice si Uri PROBENECID, SULFINPIRAZONA, BENZ@ROMARONA, URATOXIDAZA 65a Dyewudulod ap eusiOy Gns "jo10 greassIUIUBE sw ereisene eaunine elusyod enqued yaOOGATI Mo aeuiquica uj geesasaIUpe as « vaoaiau 7 pseu gdnp ‘ehewidwor ap guO} gns jo10 gzearsiMuise 2s asec ewes aluesqns aye Mm aieuquen uines aifemcuoWUEreRSULUpeSs « guiwedop uy esreuniossuen, po pzaanswuiwupe 2s vdoaonat Tt DSENMVANOGINISY wud uosuxied Bjeog UL at wasqns ap atfen ‘eWuLdw09 ap guUsO} Gns ovo gzearsUILUpe as « gousqiod 1 getuss aunyive mo 2iauyoonue un aise» Niansaais 2 gsew gdp 'syewydswo> ap guuoy gns ovo weeanswIMIpe as + atesuene ajau9s uy i@soujuewop 3ou0y nupe as» anncsjounau mo juauierea ap snpoid lepluiendesro injnusoupuys eaiersas09 wy juEYodus yuaBe UN so inpmuaped 2 gieieua8 eases § nsious pusiojause geposnus eareuplst apeas + {,voyostvoy) WaINasIXaHAL SSRNIOOUNE Muade no ezaizes uy 120g 8p as0u) YNWINOSNDINWGLINY VLLYSIGS NIIWaVoaud ‘LYWWuld0L 'Wvd3Z¥NOTD “NiaVOVIL ‘NILLVEVDIA ‘NUINZAVEVD ‘QINIXNSOL3 ITT “9 010 ‘2.euiticuto> ap euioy gns ezeansiuuipe as ‘stewlicuso> ap guso} ans jo1o ezeauisiujWipe 3s «| anedoeday eujwinap areod + wisiue8.0 gisisied soai20ap ‘sardjen imjnpppe ajinsgs 95350(0) 25 Londayda ngs pois, 3d 8 andayda nei ajaiew, ad ayze x53 DHowsTwA NAY“ kgjet0 aisuadsns ayewtduioa ap guiso qns javo ereansumupe 35 « YNIG3ZVNVEEVD “E g1IgeI>8fu) aifnjos ap euLiO} Gns jossyuasad nes. 010 ayeuuticusoa ap uo) qns euofeu essdojde ui ereanstuupe 95 @ WNIOLINGS *2 99 UASIEA e| inovaid aunduul as sAuoD ‘euofew aisdayida sifompur + jorazuasod 1820 alinjos nes atewnidisos ap gino) qns ‘ovo peeoussiujwipe 25+ TWuguvaonss _"t USTED auenuanucs S1e10urals ap ieredes vorap—Ds ‘easopes jesouad ws asienpo Hizo—s €9 ne Ininsipeui eteoyput a ezeansiujwipe as e2eunp gBunj ap arse vaweyen, rusian jmysas UL wopURNE eaveD|paidu forieNDx@ e aieDse>599 3p spluamay eavapees und eiaisane @ adede ap elusraay peas f erin drussui ao ONS aye tumizaye aye nes exBuluow 24 usjnauod ‘aysdoyd9 -aBojone ap yuaL9}/pul sOps;nAUOD Hoede op eluandaij ypers es 16 aisinaues gosezido ¢5 oligedeD sseqqueueaipaw ajuessqns suns ajaauenssinauos|ue nes ajsonday eae YoUdTIaaINY vilvoIGaW ACER re 1x03 1 Iq} AAA ede no eyed Ua-sjul enozIp 95 axe araqind ap guLiO} ns ‘ovo ezeaasiuiupe 25» (208550) WUWTENWY WNLINOMIS + BojouLs0pUa naipow ao auingets ‘aw04ps a29)p ul ‘eteUIUULOD ap eiLIO4 gné jo10 ezeasiunupe ss a (,j24019%) WROINOWANASI GoW wn ¢ ej guep F osazuauod nes (guni/dat) eyeuicwoo 2p euuios qns jolo gzesnciujuine as (,enstuog) WNDINOWGNVEIaDY + sueuiades od ewudwoy meunduc> 99 gu0}qrsjano EeeaRSINUpE aS 4 (,xowoso4) WNDINOXONSTY OY ‘REET TOU gas HURST {ue T nes tun} 9 2| quaweye:2 e| jnsundses 16 >ojoig-oo1UND enjena en as duse8 qUeWesUed un nd gunaidw ezea.astuIWipe 95 .q euqused}A.n9 yua}twoSUED exisIULUpE ayeod as au@wioysuapoaso und jazcuodoasso eaiesnsouaeIp dap fetunu eoiput as yZOUOdO31S0 NI SivDIGNI TINSWIVoIGAW ESSE TURE R eae hy EME e er3. BENSERAZID se prezinté sub forma de comprimate sau capsule, cu acininistrare oral, In combinatie cu LEVODOPA /Madopar’} SUBSTAN’ 1. BROMOCRIPTINA + este un agonist partial ‘are efect mai slab decét LEVODOPA © este mal putin folosits + de obicei, se recomandé ja inceputul tratamentului pentru a intérzia ‘aciministrares levodopei © altd indicatie - se foloseste in scderea sectetiel de prolactin administeazd oral, sub form’ de capsule sau drajeuti 2. SELEGILINA cereste cisponibilul de dopamin’, avand efect antiparkinsonian * se adminstreaz’ oral, sub form de comprimate 3. AMANTADINA (Viregye ~K") * favorizeazs sinteza presinaptica si craste eliberarea de dopamin’ © are siefect antiviral * se administreazs oral, sub forma de capsule 4. ALTE: PERGOUD ROPINIROL PRAMIPEXOL CARBEGOUN RASAGI ROTIGOTIN PIRIBEDIL vvvvyy BARBITURICE, SEDATIVE, HIPNOTICE ABARBITURIE SSS % au actiune anxiolitics, sedativs, hipnoticd sl anticon % se-controindicéia cel eu astm bronsi, is > determin’ somnolents, bradipnee, bradicardi arteriald > se administrear3 oral, sub forma de comprimate si parenteral, sub forma de solutie injectabila Reprezentant! 1. FENOBARBITAL 2. AMOBARBITAL 66 cICLOBARBITAL, BUTABARBITAL PENTOBARBITAL 5. SECOBARBITAL 8, SEDATIVE, HIPNOTICE © au actiune farmacodinamic3 sedativé-hipnotic’, anxi anticonvulsivant’ * se indicé: mai ales in insomnie anxioas& © sunt contraingicatetn sarcind $alaptare, © seadmi ie8, miorelaxanté suficients cardiacd, renall, hepaticé istreazé oral, sub forma de comprimate, solutie oral, parenteral, sub form’ de solutie injectabilé sl intrarectal sub form’ de supoaitoare Reprezentangi: DERIVAT! DE BENZODIAZEPINA 1. DIAZEPAM CLONAZEPAM OxazePam LORAZEPAM NITRAZEPAM FLUNITRAZEPAM MIDAZOLAM: INOLAZEPAM, Alt = ZOLPIDEM = ZOPICLONA © ALPRAZOLAM (Xonax*) ANXIOLITICE/TRANCHILIZANTE MINORE 4.Derivati de benrodiazeping: # se absoarb bine in intestin si se elimina renal . laxanta, anticonvulsivanté © seindic reanestezie © se adm 2 forma de 8) porenteral, sub forms de solu Reprerentan 1. DIAZEPAM 2. OKAZEPAM: 3. 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AYWVEONS < vNIZIXOWGIN < 4 aay wvdoswoL wvevaor) axoazzviayora vaazvows wwerzvas2. MIANSERINA, 1. ANTIDEPRESIVELE TRICICLICE Yaciune antidepres cu efect mai rani, ndicSnduse hn tulburiridepresive > sunt eficace in psihozele afective Y-_ seacminisreaci oral sub formé de comprimate lai > au tect antidepresty, sedativ, anxiolitic SARURILE DEUTIU > se administreaz’ orel, sub form’ de comprimate sav parenteral sub forma ° de solutie injectabil Reprezentanti AMIUTRIPTIUNA, OMIPRAMINA, MMIPRAMINA MAPROTILINA NORTRIPTILINA, DOXEPINA AMOXAPINA REBOXETINA, RAL MONOAMIN ‘8u actiune anticiepresivé - efect comparabil cu al antidepresivelor triciclice sunt psihostimulant in depresille cu inhiitie psinicd se administreazd initial doze mici care se cresc apoi progresiy (in 2 prize/zi) | indicatia medicul F au ca reactii adverse: hipotensiune ortastatic’, rise lipotimie, afectare hepatica si polinevrits 2 recidivelor la incigala), tratamentul curativ al acceselor maniacale, renle 1 2 3 a 5. 6 2 8. BI Reprezentar > CARBONAT DE LIT! > GLUCONAT DE UTI Repretentant ‘PSIHOSTIMULANTELE IPRONIAZIDA, NIALAMIDA MOCLOBEMIDA = 3. INMIBITORI SELECTIVI DE RECAPTARE SEROTONINERGICA (SSRI) 1. TRAZODONA + are efect sed m find indicat in depresii cu = + amelioreazs procesele de invitare s! memorare : Reprezentanth 2. FLUOXETINA 1 PIRACETAM (Luceter 3, SERTRALINA a 4. PAROXETINA 5. FLUVOXaMNA . 6 CITALOPRAM . 7. ESCITALOPRAM suferins&ceret 4. INH IBITORI DE RECAPTARE SEROTONINERGICA $I NORADRENERGICA (SIRI cerebrale acute (di 1. VENLAFAXINA 2. MILNACIPRAN 5. ANTAGONISTI Al RECEPTORILOR A2 (NASSI) . 1. 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(joaeuda2u3) YONI snyrbypaw exf>ipuie pezozuav0d ‘nes gjeu0 atinjos ‘ajnsdeo ‘arewuudwos ap guii0j qn j210 gzeasisiuipLIe as fiusan ‘enuwuosur arpueniyen> Nurofen stop gr > Pseudoefedrina (cor.) RSS as Ure eee en tae nui PREPARATE PENTRU ZONA ORO-FARIGIANA 1. Antiseptice oro-feringiene > ALCOOL DICLOR/BENZITIC ~ Strepsits” (comprimate supt) AMBAZONUM — Foringosept” (comprimste) > CLORHEXIDINUM ~ Hexoraletten’ (comprimate supt) 2. Antibiotice > FOSFOMICINA [Afos" ~ comprimate supt) > FUSAFUNGIN (Bioparox’- spray) J TIROTRICIN (Trachisan’ -solutie externa, pulbere, comprimate) 3. Plante > inhalant’ -sol.ext. > Proposest’ ~ cpr. % Sinupret’ ~ dj, sol. alcoolicd PRODUSE PENTRU CAVITATEA ORALA > Pedi-dent’ (cpr) 2. Antiinfectioase locale: > BENZYDAMINUM ~ Tantum Verde" cpr. CHLORHEXIDINUM ~ Corsady/ Combinarit: Bucosept” — comp > Degalinum’~ aerasat 76 AMEDICATIA DERMATOLOGICA 51 VENEROLOGICA. CHIMIOTERAPICE ANTIFUNGICE ao © Sunt substanfe medicamentoase indicate in infeciile fungice determinate cal mai freevent de Candida albicans, Trichomonas vaginal neoformans, Trichosporon ete. Criptococcus Reprezentantt: CLOTRIMAZOL se prezintl sub forma de spray 1%, crem& 2%, solutie pentru va extern 1%, unguent, pulbere, comprimate vaginaie are indicoti in cancidoza vaginal, candidoza tegumetar3, tricomoniar3 se contraindicd in alergie,sarcin& fu se acministreaza comprimatele vaginale in timpu KETOCONAZOL > comprimate 200 mg cu adiministrare oral si ovule 400 mg ~ intravaginal > se indica in infect micoticesistemice, candidoza cutaneo-mucoase, miceze ale tegumentult, parului si unghillor, candideza vaginal MICONAZOL > comprimate cu administrare orolé-250mg, comprimate vaginale-150me, capsule vaginale de 200mg si de 4oomg, gel 2%, unguent sau cram’ 2% > seindied in cancidoze orale, intestinale, vaginal, pitiriazis versicolor > se contraingicé fo copii sub 2 ani, prudent in timpul saci, alergie FLUCONAZOL > capsule gela oralé de Somg/Sml, 200mg/Sml > contraindicat > _se indicd in criptococcee, candidze, dermatomicaze NISTATIN > drajeuri de 500,000 u.i sat 100 mg, pulbere suspendabild de 400.000 ui ovule 150 000 ui, unguent sau crema de 200.000 i, comprimate v2 > se indicd in candidoze superifciale mucoase si cutanate, vulvite 31 vulv vaginite > se contraingicd tn ale v vvy lului menstrual 150, 200 mg, pulbere pentru suspensie olutie Injectabité de 2 mg/m! 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CEFADROXIL 2. CEFAZOLIN 3. CEFALEXIN 4, CEFALOTIN GENERATIA A I-A * au activitate superioaré pe Bacilii Gram negative © se absoarbe variabil in functie de preparat © 59 elimind renal siintr-o cantitate sedzuté biliar © se indicd fn infectii ORL, pulmonare, cutanate, ginecologice, urinare Reprezentanti; 1. CEFACLOR 2. CEFUROXIM, 3, CEFAMANDOL 4. CEFOTETAN 5. CEFOXITIN GENERATIA A ia © au spectru larg de actiune © pStrund fn LCR. * se indie’ in meningite, infectii de tract respirator si urinar, endocardite, cutanate, ORL, Boala Lyme, gonoree se administreaza in monoteragie sau impreund cu un aminoglicozid prin metabolizarea lor elibereazé produsi de metabolism activi ind renal si billar determing reactii alergle, tulburdri de coagulare, modificiri ale hemoleucogramet si transaminazelor Reprezentar CEFOPERAZONA CEFOTAXIM CEFTIBUEN CEFTAZIDIM CEFTRIAXONA GENERATIA A IV-A © se administreaza parenteral © seeliminarenal ‘© se indic® in infectii severe bacteriene, intrsebdomin 84 Reprezentangi: 4. CEFEPIMA 2. CEFPIROMA amuvogucozine + sunt medicamente bectericide ective pe bacterile Gram pezitive, der mal ales pe bacteriile Gram negative NU se absorb digestiv, dar au acfiune Ia acest nivel se elimina renal 2u c@ reocti! adverse: nefrotoxicitates, ototoxictatea, embriotexicitatea se contraindic le gravide, efectiuni renale cronice toate sunt cu administrare porenteralé, cu exceptie tobramicinel si Retilmicinel care se prezintd sub form’ de colir sau unguent pentru vz oitelmic si neornicinei su forms de comprimate *peperioade administrri se recomands urmarirea valori ereatininel serice # se administreaza la incicatia meciculul Reprezentanti > NETILMICINA > AMIKACINA > GENTAMICINA > TOBRAMICINA > KANAMICINA > NEOMICINA > STREPTOMICINA MACROUIDELE © Inhib§ sinteza proteinelor bacteriene © auefect bactericid mai ales pe pneuenocod si streptocod beta hemoltc de grup A Reprezentan: ERITROMICINA Y actioneazd pe coci Gram pozitivi si Gram negativi, Legionella, Mycoplasma, Chlami ¥ are ca reacpii cdverse in principa! simptome digestive Y se administreex’ ora! sub form’ de comprimate granule pentru suspensie orala s! parentero! sub form’ de Hofiizat pentru solutie pertuzabls ¥ doze maxitn pe 24 ore la adult este de 100mg AZITROMICINA Y- are actiune similard eritromicine’ dar are spectru si pe ba Gram negativi 853 yomxosiunns < vNizwiavsins_< ‘WRZOTSNTET IS SAIENOTINS wanzeviad < wanzeowaw < Wandin! < qUBUSTSTCTy feyds uw ninaypeus eni2>yput restslulupe no euqespafut arinjos nzquad asagind sp guuoy qns gquizasd as « pale aunisusiodiy ‘ayeu/aixoounay ‘arenpixoroyjau ‘so}/ujp eaered “annsadip laginginy) je28U93 a Juoyainus ways ‘egayocues ‘x}qey‘2ueonun “gle20j arfeanpuy ‘a12anp ‘wara) 31690) 4 uns as/apo ufsoas aqwarzay eu! af & igosseue ad anjize sue0, ‘sAneBsu wierg 1192 fizod wieis 09:4 4e wn B18] syeoy nuIzeds un ne 6 paypeg 19949 ne + SNSNESVERS peBou weg (90: NONVATVEva NONYAWLINO AA ay noypaus evjeoypus e| jends ui gzeanswuwipe as @ gygewalur atinjos nquad sez Wap euLc} ans gwuzadas @ ‘nev yf>9jul w YeaIpUI Ase —@ RINVIGOTEL eugeenyad/euqena atinjos nsiued we2jiyoy ap eusso) qns gruyeasd as « Injnoypow evfesiput 2} jovaquasod exeansiunwape as» Huaysizautiod 03. ‘onoignue sp gsnpur gseoueiquiswiopnasd e309 us sale eu! orDoypur s1s3 6 epoueneg sso ‘YNDINOINYA ‘FOdadOINS ‘WNNDDONIN + ‘wNNDIXod < 98 YATRIVULEL < laneeu wep 1$ yaneod weg pegs [09 ad, wens emuunue uy es ew speoipet wins aoueysouazeg eonoignuewuns + HTD g1iqerD3{u atinjos ap eusioy qns jasazuased es aiewiy srewudwiod ap PUUOJ Gns joo greansumWpeE Bs supnwoou) e0yeueUIasE B15 A eNIDAINWANITD pjo10 eiensjunupe no ajnsde> ap guuso) ans giuizaid as» ‘}22uo3Li0d nes ase0s0 ‘s2090 Yes ipuyas “a ‘seuanpe nna apoignue un aisa ‘YNIDINOONTT sfuequazaiday 1281 '3aNsaBip giNg|T assaqp0 19921 ¢ ne jaun Wy apjaueised 1S y 0d gsuy ‘anqneIso\sarzeq uns ‘ua|Jay2eq Jojaujatoud ezaiuis ezeowolg FOWSOONT aojanaje giyolep esuensay axe: axeypyKoxoyeday ‘ao1diaye ajepads jen pjo10 aiensjuyuipe no geo stsuadsns ty BiewUdwi09 ap ewuos gns eruizaid as jorowse|doxor muaueess us gerAN (2upeutenoy) NIINVES ge}9fu) 2/imos naauad yer 3p pluios qns jouaiuaod iS gies aisuadsns nnued ajnued ‘SieUy aIewsduiOD 9p guO} gns 10 grease 35 A 7 o}kd saneqooyaH ad #6 ounihe ove sep foupmonye guejuIs sunIive ae A YNIDINOWLINYTD nauad ainuesd é aie opines sqe}oo[uy eisuadsns nsqued azaqind ap W0$ gns /osaiua.od j$ elet0 ajsusdsns msqusit araqynd ‘ajnsde> ‘yew, ayewudwio ap gu} gns jo10 greanstulWpe as +> SULFADOXINA > SULFAIMETOXAZOL, TRIMETOPRIM+SULFAMETOXAZOL (Biseptol’, Sumetrolim’) Se prezinta sub forma de comprimate sau sirap, cu administrare oral’ ALTE ANTIBIOTICE > CLORAMFENICOL QUINUPRI DALFOPRISTIN, FOSFOMICINA TELITROMICINA UNEZOLID DAPTOMICINA, TIGECICUNA, RIFAMPICINA POLIMIXINA E (COLISTINUL) vvvvyy vvvy MEDICATIA ANTIVIRALA Mevicatia antivirald cuprinde substange medicamentoase care actioneazé asupra AND-ului, ARN-ului virusiior in dferitele etape ale repliiri Se clasifica 1. Antivirotice antivirusurl ARN 2. Antivirotice antivirusuri ADN 3, Antivirotice antiretrovirusuri Reprezentanti 1. ACICLOVIR 2. VALACICLOVIR, 3. GANCICLOVIR 4, PENCICLOVIR 8. 6 7 FAMCICLOVIR FOSCARNET RIBAVIRINA 8. LAMIVUDINA, 9. AMANTADINA 10. RIMANTADINA ‘LL INTERFERON ALFA, ‘TERAPIA ANTIHEPATITA 8 LAMIVUDINA Y InhibS sinteza ADN - VHB 88 se administreazd oral ¥ determing cit ADEFOVIR se administreazé la indicatia medic are mai pune react adverse ENTECAVIR este activ pe tul Indicatis medicul lizd hepatica si muscular&, tovicitate medular3 ini LAMIVUDIN rezistento ‘TERAPIA ANTINEPATITA C RIBAVIRINA + intr in schema de tratament pentru hepatitaviald C + se prezinta sub form’ de comprimate, capsule, solute oralé + se adminsitreazé orafin scheme stabilite de cBtce medic + se controindicd administrares le geavide INTERFERON ‘+ sunt glicoproteine biologice care au actiune antiviral + se administreazé in infectile cu virus hepatitic 8, C, dar are actiune si pe virusurile herpetice, zostetian, citomegal © deasemanea au efect antipraliferativ (antitumoral Reprezentanti Interferon alfa: INTRON A, ROFERON A Interferon beta: BETAFERCN Peginterferon alfa: PEGINTRON, PEGASYS imunomedulator TERAPIA ANTI ~ HlV (Bosls SIDA Cuprinde medicamente care inhiba fn special replicarea viruswiu! HIV se administreaz3 oral sub forma de capsule, comprimate, solusie oral se administreazé la indica i dupa scheme precis stabilite pot determina hiversensibilitate, motiv pentru care sunt contraindicate la acesti pacient! Reprezentanti ZIDOVUDINE (20V) STAVUDINE (D4T) LAMIVUDINE (3TC) DIDANOSINE (dai) ABACAVIR EMTRICITABINA Bs16 snzn02036429 seojuoyseja‘epicuey ad ouniize puere Sie) 32805 m9 anoDtwunue Un 3159» { )21021N)) 1OzWNOIOLAN yozwNoIwAAI yozvNooms romain TOzeNODIN 7ozWNODCIBY_< SMYOLISWD aydoy nes auasis easiunupe sodas ® anpueSnisep aes exisinisus puedoss Zep puudo sojfun; aieinjo> sisueiquiai greaiaje « AKAAKA soyiBuny ease rage nou usp gjeds 2s 2109 gap ainuus of exdearge ag 2x0jeds gdnp djeas ad jndes| njnsypa soyyfemypur woos aseowauienig 2p asfeurquio 0 auyfuoo a> aisjnuse 2p gusio; qns gweaid os wNTigzd © goidor svesisjunupe no aisjnusa if uoduies ap eos qns ewuizaudl as — NOMA 6 2idon guide 2s aye guuo1n ep guusoy ns ulzaid 25 (o}4H4aq) WZNAS 3G LVOZNE * ‘vodueé nes undgs ap guuo} ans quid yeusas ~ wefins e § 21 wyatd ae unisaye aye eua{va equips en egds en as ydsoo eieyeidns geo ad oyde as aigazs uy - supe a5 a1¢0 3wangun ap puusoy Qns BURA es— NAS SqEGE TEAC YaUIRVaVEENV YI 08: epjorewsi equLeyod uy as-npuenstwywpe guUE;MUNSoUNUIY auNds0 8 BF EL TTOSINWART 3]e2a)Joyuoyenr 2p Jojsuawexa ezeq ad auipmsa> 3p aasouseIp Un ednp en squad douis ‘21210 afinjos “ayewidutoy ap guusoy qns od greanisiMUUpe as « yosinwAn ‘vaIWSOIN yozvanaavu yozvanaa3w yozvanaaw AAAAA RamasTaraoy _Payjoarye unyneg nogrenoseasnu + edovedey ‘nedoysu ‘ajBsop2 “pune “aseadgre ‘puDIeS us pripujosUOD as « _NITEXe| UN no yuByIWIODUOD STEWISIUILIPE 9s Bs eptEUODA aS ‘saeuryno iiidrus easeaida ‘s9j2j89 ‘yalawie ‘ynfaud ‘sareip :asiaapo wisoay« fouas guia 2s 1 (ezgjornoyeday 2p Woipuis-sxeyoIKo}oVeday eulUuelap sje0d) aneday ezeszijoqeisU os + “uunijos e1U3e, ‘eeurSes e1u2e] ‘snsojnuest snaac20uNyp3 ‘aleveponp ewoysopouy ‘eUNKoNT sup ‘SueyMOIWUIaA snigossLUg “saploauquin| sipueasy winsaid Joyiuiusjay excise auniize ne yoznpjuyjzuaq ap uiongsap + epoisaa it ‘sporewart ‘spcreulsu uy edwi as $ nuuo gr233s94U 34¢9 YULIOIA JUS BIUIWIOH, LNIPTSHING VILWoIGaN “aquadoanay (.woszna) omswinans < ZNGUIAWER < aNiavanan < ‘SSVOINSTIVSIGEW SINVIsanS S11 lawned ‘MIAYNIGNI ainwnvzeoy MIAYNENTAN IAWNOLS ‘MIAYNINDYS aavnauaney MIAYNIGNI YIVILOWT IC TO LGN AKAAAAAA\dicat in infectii micotice sistemice si de organ, mai ales formele cronice cum ar fi candidoza cutaneo-mucaasé oral8, vaginal, cutanaté Y- se administreazd oral si extern (CLOTRIMAZOL VY este antimicotic cu spectru larg Y indicat in candisoza cutaneo mucoasé, stomatite angulard cu Candida ¥- se administreazd extern sau oral FLUCONAZOL (Diftucan’) este antimicotic cu spectru larg Y este indicat In criptococoze {meningita, infectii pulmonare, cutanate}, candidore sistemice, candidoze ale mucoaselor, candidoze genitale, dermatomicoze (onicomicore} se administreaza oral sau topic se poate utiliza sila pacientii cu imunadepreste (transplant, SIDA, etc} 2.Antibiotice macrolidice polienice: AMFOTERICINA B este antimicotic, activ pe Candida albicans, Blastomices, Histoplasma ¥- este indicat in infectii cutaneo-mucoase, infe se administreazs orol sau perfuzebil -.antlbiotice antifungice: NISTATIN este un antimicotic cu actiune pe Candida albicans, Criptonocus, Histoplasma se indica in candidoze oro-faringiene, gastro-intestinale, genitale Y. se administreazé: oral, topic Terai) ANTIANEMICE ANEMIA FERIPRIVA este anemia caracterizaté prin sciderea sericd a fierulu’ > fierul este indispensabil pentru organism, intrdnd in constitutia unor enzime ale oxido-reducerii celulare #1 a hemoglobinel (Hb) % fierul se absoarbe numai dacd este sub form’ de Fier feros, bivalent > cel mai frecvent se giseste in forma trivalenté, iar transformarea din Fier fericin Fier foros se face numai dacé pH-ul sternaculul este acid > la bolnavii cu deficit de KC! sau la cet gastrectomizatl, absorbtja este sobzuté ANEMIILE MEGALOBLASTICE v substangele care cresc aciditatea gastrics cum ar fi acidul ascorbic (Vitamina C}, cresc absorbtia de Fier absorbtia Fierului pe stomacul cu al au ca reoctii adverse: tulburari digestive, colorarea scaunului in brun-negru NU se administreazé pacientilor cu afectiuni digestive {ulcer, colite) se administreaz’ oral, sub forma de comprimate, drajeuri, solutle orala sirop sau parenteral sub form’ de solutie injectabila 5 se administreazd in cure stabitite de c&tre medic (3 luni, 6 luni, 12 luni} > se pot gasi siin combinatii cu vitamina C, acid folic, Vitamina By: Reprezentanti: 1. SULFAT FEROS 2. GLUCONAT FEROS 3, FUMARAT FEROS 4, GLUTAMAT FEROS (Glubifer") 5. COMPLEX HIDROXIO DE FIER POLIMALTOZAT (Ferrum Hausmann") 6 7 8 vy COMPLEX DE HIDROXID DE FIER SUCROZA (Venofer") FEROCHOUINAT SOMBINATIE > GLUCONAT FEROS+ACID ASCORBIC (Ascofer’, Sorbifer Duruies’) > SULFAT DE FIER+ACID FOLIC+VITAMINA B12 (Ferro-Folgamma’) 90 82") icarea si dervoltarea colulars cv proliferare intens’ sin sintezs acitilor grasi din neuroniisistemului nervos central ‘anemia megaloblastics (in combinatle cu acid fo ‘© se administreaz’ parenteral sub formé ¢e solujie injectabilé sau oral sub form de comprimate, capsule, solutie oral, sirop in combinatie cu alte ACIDUL FOLIC © este un factor de maturare a eritrocitelor tn anemia megaloblastics, dar alte ant ial gidin sarcin’ mai ales cea © se aciministreazé ora! sub form’ de comprimateaaneday upingyra nes aaSojo.eway vesngim ‘yBe.owey ouarsp od « ‘apsid as y2aja 45928 3g}e no ayfe. 95 ETOP I—9 no #8 JUBUIED|paUL op HLH Sz0p | JOP gIssHUEW 3s yUeHS.BenUE IMDaID < “9 ‘plelae sileygy ‘Jesqaz83 so\rasea quapore ’pjes0nad ‘aemped Baveuyigedaise pros BUVISHOVId J1SLNVORUSVLNY YNRUYZEYM “Z (,dossoquioss “wostuIs) YOUVINNIONEIY “TE siuequazoudoy \guugdes E-2) sIpouad greanjenaas djuown gzeauisuupe as 4 FVIO FEINVIND VOTING: ymuaped 2180019 8 21 yeuszna Aesds/i}os0158 ‘gleuenD atinjas “oH ‘eqeuen aisynue ep euuoy gns gwIzoid as < (gsevexs) yodou aVULsiNTivaY NO WNRuWaaH (,21403%) aviKioBY iid) YNIAIAS (,20§odheo4) yunaO¥GYN (,dayouu) WaNtdvaWZNiL jponubo.4) YNIWERENG "2 uDx2 9) YNIBVEWXONA“t iuewuazaidoy youosnogns eresnsiuwpe as 4 ppluye asianip upd (preuo2esjau) o1epLers eueday uIP UAlgoas (WW) yous yaWINDZTON aLwiNaYs NO TaNRvERH pifuaje yuaped e} gzeans lupe asm < aids uy'gro0n(8 nes [DEN =p guaroR| ainjos o-RULaIENfiod wy geesrsIUIWPE 2s < ojiq easenjena gdnp feunu greansiuiwpe as < auejnasen ~oypseo aje8unanyp oq jeueHse woquie If szequioan‘aigeyoquost uy Heap pues® gonoqwonue aundse mo jugindeoagUE UNIS < nieve “T spluewezaidey 2102 gpeipies efuapyns yLAsiRA “grosmO 08H "89/21P "BATA ufnesang ‘ayyyourzea ‘s1uadosnay ‘ayeamun ‘apadoe ‘anedoyau ‘ginaday ‘seuun |S ANSSAip mM aye eoWsY vasranpe: Sania TAT auanas suiskewnen ‘qejonuosay aunisusyiediy ‘oxiewe} “guisues “Hore ap giuauiw ‘sjeusy jeday junjfoaye ‘aniSesouray vuniSoaye “uawea|paus P| aLeyiq'suas ody syfeajpurenue3 Jojoquio eassuanaid naqued jeosSsnsiysasod ajouae eysqy nyuaueren ‘apunjosd aseouan sojazoqwost eneyyoud oypsezojus aueur sad oonwayss 6 szeuoUjnd sojyioquia easluanaid ageqput (Sere VTaIeA) FDIS TINVINSVORINY 2je10 $8 ajexazuaied syueineoonue ypauu jmaUEISIse injroypaw eenpus e] gzea.ysiuuape 9¢ runsioaje oun sjySipuod uy aBugs ap sojasen nes ynjnpuco jnjanws 21 JojIqw0.3 Ysewi03 easesipaiduul doos e9 ne aus ayuewerjpeus uns < < FEINVINSVODINY tweiZouo! qowered 16 ajerin a!founy ezuouuoUl 8A jea1paus jmuDisise geo,paui as2yBonescns grou gas ‘sojsteos010sd uuoju09 ynynaipaw erfeaiput e;jexids w ezeansiuuipe as ninneujog (ian yna)S1ess e} ued nes quejdsuesr 2] gugd ‘uo. suowejest Un a1Se YNLLROdOULIYI MD mUduEyess soynewoy yYOIUL jnjanIL ey esnposd 159 euRstOda.RUa uowuoy ap mers aie 2129 “YNLLSIOdOULINS 2159 aADO|NUELE nsqUAd Jo\}UOIO9 @ aze|rUNAS ap jnsor2e ‘2\nj39 ap und, 1oytunue eareinyew I$ easeyoAz—ap nu yuuiad aze> aiveysqns 1uns pnaiodoreway ssorsa.9 ap woe, easeyjonzep greajnus 16 IDL3OdO.LWW3H 38318349 30 HOLIWS> se contraindicé in accidentele vasculare cerebrale in faza acuté se yor administra la indicatia medicului se administreazé ora! sub formé de comprimate Reprezentant - 1. ACID ACETIL SALICILICUM (Aspirino') CLOPIDOGREL (Plavix’, Trombex’) DIPIRIDAMOL TICLOPIDINUM TRIFLUSAL SULODEXIDUM TIROFIBAN ABCIXIMAB ENZIME indicajia mediculul parenteral sub forma de soiutie injectabilé sau pulbere pentru solutie perfuzabils sunt indicate tn infarct miocardic gi prevenirea evenimentelar trombotice 1. ALTEPLAZE 2. RETEPLAZE ‘STREPTOKINAZA UROKINAZA DESIRUDINA, HEMOSTATICE HEMOSTAZA = oprirea spontand a sangerariln urrte lezBril veselor sanguine > mecanismele hemostazei implica trombogeneza, coagularea si fibrinoliza vascular si vasoconstrictie, ulterior aderénd plachetele sanguine care perc: membrana si formeazi o mass de consistent gelatinoasi (ca un dop) care opreste rapid hemoragia > ingeneral, medicamentale ou rol > unele dintre aceste medicamente favorizeaz’ procesale de coagulare, lar altele scad rezistenta capilara prin actiune asupra lor > se clasificd in hemostatice sistemice silocale HEMOSTATICELE SISTEMICE Utilzt verapeutice hemor = hemofi 96, cu anticoagulante Reprezentanti 1, VITAMINELE K > se folosesc pentru tratamentul hemoragilior prin deficit de vitamina K > exist 3 vitamine K: vitaming K, sau FTOMENADIONAvitaming K, sintetizaté de flora microbian& intestinalé si vitamina Ks obtinutS prin sintezi FITOMENADIONA (vitamina Ky) © este indicaté pentru prev etiologie sau prin exces de anticoagulante orale, disteze hemoragice, purpura trombocitopenics seu alte afectiani hemoragice ‘© se administreaxd parenteral a indicatia medicului sub forma de solutie injectabils 2, ETAMSILAT © are actiune antihemoragici th hemoragii copilare © se indieé profllactic si terapeuticin diverse afectiuni manifestate prin hemaragie rear’ p.o, sub forms de comprimate sau parenteral sub fom’ jectabils 3. CARBAZOCROM (Adirenostazin'} © actionesz’ prin cresterea ravistental capilare: este indicatd in hemoragt ¢ Se adminisireaz’ norenteral sub form’ de solut 28 Intotdeaune ia indicetia medi de congulare personalului medical (medic, asistent medical > pe perioada administrrii se vor ur simptomele Reprezentan 1. FACTORUL ANTIHEMOFILIC A (FACTORUL VI 2, FACTORUL IX {COMPLEXUL PROTROMBINIC) 3. CONCENTRATUL DE FACTOR 4. ALTE: SULFATULDE PROTAMINA, VENOSTAT’, ACIDUL AMINOCAPROIC, ACIDUL TRANEKAMIC levitate, sernnele siguioe ap ginse eifsasip 3yeuqese9 owns ‘squepanazue UL JeiMosen-ciqios29 EERIE sieuouay nganginy (8H www arte anyouselp wi ae ‘uoyea) opnadesor pyejosiuozeu ‘guBijew gjeuioHe sunisueuadiy ep auoKs| AAA uind-o1pien eayeyasnsay atusqewinesyjod /asenas owisaewnen {uew} y1q)sasdwoasu asen ap eazeuoriound uguigidgs z ap wuacau jew u280 ap eiscoig ‘32 OF arowiRIN Us aje>:8snaiyD rueneQU AAAAAAA STEPIPUTER Nianwisaa = QWNIELONd « wawidiisaNai vavidaizy BrWw't ojpaun exteryou! e| jexauased greanisIuIWpe os a1eucwind Woquia (Joyquos e aa8nsI8Ip sp-o1y 23948 un aie) jnze apievoi y21eju! wip sojiquuOs exdnse aze2Y9 BLED} asa & yeulqwiosa, yay eWojouya; ud snpo.d quawesipaw un aso . wana 7 Injnoqpaw exteaipuy e} qeznpied jeraquased ezeansjumuipe as 36 poaodasis sp 1d} J9Un ap preZRaTUIS PulsIoUd oso « WZWNDIOLEIULS sfueavereadey eo/8seye wives iBesowray wy a2ypurc.2u02 95° ‘nge 2yp2eD0Nw DAEAL sojiquion (eaisSninsip} ez sonpoud aie squawerpauiauns SQ1LNIONIUALd varxo wzointa> (@0lLWASOW3H HINNOds) NEOVIOD 3a LL3uNE ‘YNLSYIdOIWOSL %02-S 105 VIRAS VUNYOT AISWLod 1S RINIITTTW 30 TRLVFINS au 1 Yaung ap guioy gns2idor eaiée as « 238 gonseyd aiBsnuiys ‘ai@neyzonau Uy ajeoy8unanyp wjuoniau) gdnp sojBesoway easzide niquad eyeipur aya» wna glessiuared eavensiunuupe giozpuiouos asa « 2yeunsoiur-onses sojSeiouiay inzeo Uy sovo 1S esisiuluipe eteod as + ywor2elepBiwe gdnp uBeiowey “spersica uy s5e0ya puyy guUgy Uy InjRuaBOULGy eaeuossUEN BrESZUOAE, + jauagind nes ajinios ap guo} qns1do1 gzoansiumuipo 2s ‘wNigWwouL, uoyesado 1Sejd injonty eS eoyde ayeod as « se0uan jesoway aszenlp Ul 818iNg Sp rueG Bp RUDY ans arS2s0I0} 25 « N39 aypaus 22399 ap augers ienussuos asap ULJo20y greansiUMUpe as + WO B7ne> ap yBesowlsy aye eve Uap "Dee safes eautido niauad spersoway eo Bin2my ase «| golusaind sieotsiqsuo0sen aumij200 sie» wNnvNayay uewuezasdoy gupnd nes ayn: (S sseyideo ‘speeqsido wip soy jaStuis e=4eja¥e09 ereaz}ioNe} nes pieyeucins 3p ajaursioud gz29jne09 ay ‘aiiou1suo20seA ay pueanpoud aja spuRiaUES atajeudns ad vaveoyde und ‘elBesoway dsaido aie0 aywsweripau wns < AWOTSUVSOWEA18 1s, 20. 24. 2 SIBLIOGRAFIE SELECTIVA *** Cursutl Farmacologie ~ UME lagi, Timisoara, Targu Muses Agenda medical - 2013, Cristea Aurelia Nicoleta, Trotat de formacologie, editis |, Editure Medi 2007 Fulga, Formacologie, Ketaung €.G., Bosic®&Ctinical Pharmacology. 8th edition, Lange Medical Book, 2001 Lawrence M. Tierney, Stephen J. McPhee, Maxine A. Papadakis, Diagnostic 51 trotoment in proctica medicala, Eéisieintenagionali, 2020 Lupusoru Catalina flena, Farmacotogie Lupusoru Catilina Elena, Cristina Mihi athophysiological challenges and pharmacological approaches, Ed. Junimes, 2008 Lupusoru Cataling Elena, Cristina Mihaela Ghiciue. Farmacologia in “comprimote” Eéitura Alfa, 2008. Lupusoru Catélin Elena, Liliana Taryau (edita harmcologic active substances: from bench to beds! Lupusoru Catating Elena, Imunofarmacologie, Eo. Alfa Adverse effects of lon = Elemente de broform: 2008 Rang and Dale, Parmacoiogy, Sth edition, 2008 Roach Sally, Pharmacology for health professionals, Lippincott Willams and wilkins, 208 Stroescu V. Bazele farmacologice ale practic! medicole vot 1. Editure medicala 1988 Tica A. VoicuV.8, Fasmacolo Voleu V, Macovel M, Mi AMALTEER, 1999, ,, Editura Medicala » Grid de toricol iu C Meconisme farmacolo, ‘medicamente ~ terfefe membranare ~ , Ed.Academiei Roméne, \oicu V.A, Tonleolagie ic, Ed. Albatros, Bucuresti, 1999