RERDS

Centre for Pharmaceutical Research (CPR) SOP No. RERDS/CPR/SOP

STANDARD OPERATING PROCEDURE PAGE No. 1 of 5 Pages

TITLE OPERATIONAL PROCEDURE OF DIFFERENTIAL SCANNING CALORIMETER

EFFECTIVE DATE REVIEW DATE

1.0 OBJECTIVE:
The objective of the SOP is to lay down the procedure for operation of Differential
scanning calorimeter.
Model No : 412105
Company Name : Venchal Scientific.
Date of installation : 21-08-2019
S/No : 219050377
Temperature range : RT 800 0C
2.0 SCOPE:
The scope of the procedure is applicable for the operation of Differential scanning
calorimeter.
3.0 RESPONSIBILITY:
3.1 Researchers:
Researchers of RERDS has to be responsible for the execution of the
SOP in the laboratory.
3.2 Research. Assoc. of the Department:
The Staff of the RERDS has to be responsible for the reviewing the “operational
procedure of Differential Scanning Calorimeter” records and also the execution of the
SOP properly.
3.3 HOD of the Department:
The HOD of the department has to be responsible to ensure that “operational Procedure
of Differential scanning calorimeter” is conducted properly as per the mentioned rules
and regulations.
4.0 ACCOUNTABILITY:
Head of the Department
5.0 PROCEDURE:
5.1. Check it out the surroundings if it is not clean, clean it properly

5.2. Switch on the main power supply, connect the power cord to the appropriate
specifications of the special socket. After turning on the power supply turn on the power
switch at the right bottom of the refrigerator. This medical freezer has been preset to
temperature (3-50C) do not need to set temperature. To set deep freezer from room
temperature to -40 0C, it takes 2 ½ hours from turning on the instrument.

5.3. Press the <mute> button to eliminate the alarm buzzing.

[RIPER Campus, Anantapur, Andhra Pradesh, 515721]

 RERDS
Centre for Pharmaceutical Research (CPR) SOP No. RERDS/CPR/SOP

STANDARD OPERATING PROCEDURE PAGE No. 2 of 5 Pages

TITLE OPERATIONAL PROCEDURE OF DIFFERENTIAL SCANNING CALORIMETER

EFFECTIVE DATE REVIEW DATE

5.4. Check the chamber temperature whether it has reached the required temperature or not,
observe the medical freezer whether running normally for more than 24 hours.

5.5. After refrigerator temperature is normal and stable, you can put a small number of items
placed in the medical freezer.
5.6. Please store the goods in batches, each time shall be less than 1/3 items of the refrigerator
capacity. Try not to open the door in the process of cooling, otherwise it will cause
temperature rise.

6.0 Temperature maintenance

6.1 In the normal running state, press and release the set button to display the temperature
setting value, and press the set button or wait for 15 seconds without operation to resume
normal temperature display.

7.0 Modify the temperature set value

7.1 Pressing the set button for 2 seconds.

The current temperature set value will be displayed and the set indicator will light.
Modify the set value by pressing the or button in 15 seconds.
Press the set button or wait for 15 seconds without operation to store the new set value.

8.0 Lock/Unlock the keyboard

8.1 Press and hold the < + > button combination for more than 3 seconds. The panel
displays the <OFF> character and the keyboard is locked.
8.2 When the keyboard is locked, parameter adjustment cannot be performed by button
operation. Press and hold the + button combination for more than 3 seconds.
8.3 The panel displays the <ON> character and the keyboard is unlocked.

9.0 Alarm code display

Alarm code Fault description

P1 Sensor failure
HA High temperature alarm
LA Low temperature alarm
dA Door open alarm

9.1 After the alarm sound is artificially eliminated in the fault state, the fault delay alarm will
not start if a new fault occurs, the digital tube will flash to display the fault code, and the
buzzer will no longer alarm.
9.2 The fault delay alarm will not be effective until all faults have been eliminated and the
[RIPER Campus, Anantapur, Andhra Pradesh, 515721]
 RERDS
Centre for Pharmaceutical Research (CPR) SOP No. RERDS/CPR/SOP

STANDARD OPERATING PROCEDURE PAGE No. 3 of 5 Pages

TITLE OPERATIONAL PROCEDURE OF DIFFERENTIAL SCANNING CALORIMETER

EFFECTIVE DATE REVIEW DATE

buzzer can re-alarm.

10.0 Defrost
The blood refrigerator will automatically defrost in the working process, which is
convenient to use. If the unit is not used for long time, please disconnect power supply
and maintain as the following procedures.
10.1 Ensure there is not any water around the liners to avoid the seal of door is frozen.

11.0 Cleaning of units

Clean the unit with diluted neutral detergent. Brushes, acids, gasoline, soap powder,
polishes or hot water should not be used to clean medical freezers, as the above materials
may damage the painted surface and plastic rubber parts. Be careful not to use volatile
solvents such as gasoline to wipe plastic rubber parts.

12.0 REFERENCE DOCUMENTS

Instruction manual: Venchal Scientific, Deep Freezer 2462-270.

13.0 ABBREVIATIONS
RIPER Raghavendra Institute of Pharmaceutical SOP Standard operating
Education and Research procedure
PQA Pharmaceutical Quality Assurance HOD Head of the
Department
UG Under graduates PG Post graduates
Asst. Assistant Professor Assoc. Associate
Prof. Professor No. Number

14.0 ANNEXURES (Current Revision)

S.No. Annexure Title
1 Annexure-1 Deep Freezer 2462-270.

15.0 SAFETY PRECAUTIONS

15.1 Do not ground the blood refrigerator through gas pipe, water pipe, telephone line or
lighting rod, which may easily cause electric shock.
15.2 After installation the power plug must be accessible easily to convenient to unplug the
power cord in case of emergency.
15.3 Do not cover the vents of the blood refrigerator.
[RIPER Campus, Anantapur, Andhra Pradesh, 515721]
 RERDS
Centre for Pharmaceutical Research (CPR) SOP No. RERDS/CPR/SOP

STANDARD OPERATING PROCEDURE PAGE No. 4 of 5 Pages

TITLE OPERATIONAL PROCEDURE OF DIFFERENTIAL SCANNING CALORIMETER

EFFECTIVE DATE REVIEW DATE

15.4 The product should be responsible by a special person, check the running state and record
every day (every 2-4 hours record and check) in case of failure or shutdown, the
temperature in the blood refrigerator will raise. If it cannot be repaired within a short
period of time, please take out the stored items and transfer them to a place that meets
their temperature requirements to avoid damage.
15.5 Before putting the samples into the blood refrigerator, the temperature required by the
samples should be confirmed in advance in accordance with the temperature range of the
blood refrigerator so as to avoid damage to the stored goods because the temperature of
the blood refrigerator does not reach the temperature required by the samples.
15.6 It is not allowed to use unauthorised electric appliances inside of the refrigerator.
15.7 Please make sure that there is a certain air circulation space around the chamber when
putting in the items, especially do not block the temperature sensor located inside of the
refrigerator otherwise it will affect the stability accurate display and control of the
chamber temperature.
15.8 Keep machines slides back at least 30 cm away from the wall.
15.9 Keep no obstacle at the machine ventilator.
15.10 Do not touch interior of freezer without proper hand protection while the freezer is
operating.

16.0 CHANGE HISTORY

CHANGE HISTORY
Supersede CCD No. Revision No. Changes Made
Nil NA 00 New SOP

END OF DOCUMENT

Sign: Sign: Sign: Sign:

Date: Date: Date: Date:
Prepared by Checked by Approved by Authorised by
M.Kavya Nainita Dr.K. Vinod Kumar Dr.P. Ramalingam Dr.Y. Padmanabha
Reddy

[RIPER Campus, Anantapur, Andhra Pradesh, 515721]

 RERDS
Centre for Pharmaceutical Research (CPR) SOP No. RERDS/CPR/SOP

STANDARD OPERATING PROCEDURE PAGE No. 5 of 5 Pages

TITLE OPERATIONAL PROCEDURE OF DIFFERENTIAL SCANNING CALORIMETER

EFFECTIVE DATE REVIEW DATE

Head of the department Director CEO

Pharmaceutical Analysis RERDS-CPR RERDS-CPR

[RIPER Campus, Anantapur, Andhra Pradesh, 515721]