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450 Key Words

Systematic review, adhesive


capsulitis, physical therapy

Physical Therapy for by Joshua Cleland


Christopher J Durall
Adhesive Capsulitis
Systematic review

Summary
Objective To review recent research on the efficacy of
Duplay is credited with publishing the
physical therapy for patients with adhesive capsulitis.
first case report of adhesive capsulitis, or
Design Search of Medline and CINAHL databases for studies ‘periarthrite-scapulo-humerale’, more than
published between January 1990 and December 2000. 125 years ago (Melzer et al, 1995). Iron-
ically, Duplay reported treating many
Inclusion criteria Non-operative experimental or descriptive patients successfully with manipulation
research-based outcomes studies of physical therapy. under anaesthesia, a procedure still
commonly performed for recalcitrant
Main outcome measures Methodological quality scoring cases of adhesive capsulitis. Codman
using 16 predetermined criteria with 100% (16/16) indicating labelled the pathology ‘frozen shoulder’
highest quality. in 1934, describing the presentation as a
‘slow onset of shoulder pain, an inability
Results Quality scores of the 12 studies that met inclusion to sleep on the affected side, restricted
criteria ranged from 38% to 69% (mean 54%). By design, glenohumeral elevation and external
scores were highest for the reviewed retrospective and rotation, and a normal radiological
randomised controlled studies. appearance’ (Pearsall and Speer, 1998).
Neviaser and Neviaser (1987) coined the
Conclusions How efficacious physical therapy is for patients term ‘adhesive capsulitis’, theorising that
with adhesive capsulitis is uncertain. Reviewed studies this pathology results from thickening
suggest that many patients treated with physical therapy and eventual contracture of the gleno-
benefited from reduced symptoms, increased mobility, humeral capsule. Hannafin and Chiaig
(2000) hypothesised that adhesive
and/or functional improvement. However, the lack of rigour
capsulitis stems from synovial inflam-
and poor standardisation of terminology, methodology, mation that progresses to a react-
and outcome measurements in these investigations ive capsular fibrosis. Bunker (1997)
undermines their validity and clinical application. identified via arthroscopy a fibrous
More rigorous investigations are needed to compare the contracture of the rotator interval and
effects and costs of individual physical therapy interventions. coracohumeral ligament, which markedly
limited motion, primarily external
rotation. Histological evaluation of the
Introduction fibrous tissue revealed a dense collagen
Adhesive capsulitis is a pathology of often matrix consisting of mainly type 3
unknown aetiology characterised by collagen, remarkably similar to tissue
painful and gradually progressive found in Dupuytren’s contracture.
restriction of active and passive gleno- Adhesive capsulitis has been sub-divided
humeral joint motion (Baslund et al, 1990; into primary (insidious) and secondary
Pearsall and Speer, 1998). Approximately (traumatic) syndromes, which have
2-3% of adults aged between 40 and 70 similar clinical presentations but distinct
years develop adhesive capsulitis with a precipitating factors (Stam, 1994).
greater occurrence in women (Anton, Primary adhesive capsulitis is char-
Cleland, J and Durall,
C J (2002). ‘Physical 1993; Connolly, 1998; Stam, 1994). Full or acterised by an insidious progressive pain-
therapy for adhesive partial restoration of motion may occur ful loss of active and passive glenohum-
capsulitis: Systematic over months or years with or without eral joint motion (Hannafin and Chiaia,
review’, Physiotherapy, medical intervention (Ogilvie-Harris et al, 2000). Secondary adhesive capsulitis has
88, 8, 450-457. 1995). an identical histopathological appearance

Physiotherapy August 2002/vol 88/no 8


Review 451

but stems from a known intrinsic or clinical trials comparing the outcomes of
extrinsic cause (Hannafin and Chiaia, various treatments for adhesive capsulitis
2000). With either sub-type the pre- are few and often involve small numbers
cipitating factor may be a chronic in- of patients (Murnaghan, 1988; Van der
flammatory process that results in Windt et al, 1998; Winters et al, 1997).
capsular adhesions (Grubbs, 1993). Despite being frequently involved in the
Diagnosis of adhesive capsulitis is often care of patients with adhesive capsulitis,
made through the history and physical physical therapists have failed to elucidate
examination. Individuals with adhesive the extent to which their interventions
capsulitis typically complain of poorly are effective in ameliorating this
localised shoulder pain with focal tender- condition. This literature review was
ness adjacent to the deltoid insertion and per formed to summarise findings of
occasional pain radiation to the elbow recent outcomes investigations of physical
and at times into the lateral forearm therapy in the treatment of patients with
(Grubbs, 1993; McClure and Flowers, adhesive capsulitis; and to examine
1992). This pain is usually aggravated by systematically the quality (or rigour) of
shoulder movement and alleviated by the investigations, since this affects the
limiting use of the arm (Hannafin and validity of the results.
Chiaia, 2000; Seigel et al, 1999).
Occasionally the pain is most intense at Methods
night and may disturb the patient’s sleep Literature Review
(Neviaser and Neviaser, 1987; Stam, A search of computerised Medline and
1994). Functional impairments include CINAHL databases was performed for
difficulty with dressing, particularly with articles published in English between
garments that require fastening behind January 1990 and December 2000. Key
the back (eg a brassière) (Connolly, 1998; words used for the database searches were
Murnaghan, 1988). ‘physical therapy in the treatment of’ …
A frequently reported finding during ‘adhesive capsulitis’, ‘frozen shoulder
physical examination is multi-directional syndrome’, ‘pericapsulitis’, ‘periarthritis’,
limitation of active and passive gleno- ‘periarticular adhesions’, and ‘humeral
humeral joint motion (Grubbs, 1993; scapular fibrositis’. Inclusion criteria
Pearsall and Speer, 1998). Losses of range consisted of experimental or descriptive
of motion over 50% have been reported research-based outcomes studies that
(Reeves, 1975). Compensatory increases included physical therapy in non-
in scapulothoracic joint movement are operative treatment of adhesive capsulitis
common (Roubal et al, 1996). Cyriax or a synonymous diagnostic label.
proposed that pathologies involving the Use of the key words in the combined
glenohumeral joint capsule result in a Medline and CINAHL database searches
predictable pattern of joint restriction yielded 117 articles published between
(capsular pattern) with lateral rotation January 1990 and December 2000.
most restricted, abduction next most Twenty-six articles that did not directly
restricted, and medial rotation third most involve the glenohumeral joint were
restricted (Cyriax and Cyriax, 1983). immediately excluded. A further 43
Classically, the natural history of frozen articles were omitted because they lacked
shoulder has been divided into three an experimental procedure. Thirty-four
stages: the painful, adhesive and thawing studies were excluded because surgery
phases. In stage 1 (21/2 to nine months) was involved. Two case studies were
there is a gradual onset of shoulder pain omitted because of the lack of gener-
at rest, with a sharp pain at the extremes alisability of single-case designs. The
of motion. During stage 2 (four to 12 remaining 12 articles underwent quality
months) the pain begins to subside but scoring by the primary author (JC).
there is a characteristic progressive loss of Quality scoring was performed in lieu
glenohumeral flexion, abduction, internal of meta-analysis since the articles that
and external rotation. The thawing stage were reviewed varied considerably in
(five to 26 months) is characterised by a experimental design, methodology and
progressive improvement in functional reported validity. In our opinion, this
range of motion (Pearsall and Speer, experimental heterogeneity precluded
1998). fair and meaningful comparison of
Prospective randomised controlled treatment and control group differences

Physiotherapy August 2002/vol 88/no 8


452

(effect sizes) between the reviewed were totalled, then converted to a per-
articles. Instead, to facilitate qualitative centage with 100% (16/16) indicating
assessment of the different experimental highest quality.
designs used to study the treatment of Criteria used to determine quality scores
adhesive capsulitis via physical therapy., for this review included explicit enrolment,
the articles were sub-divided into three subject randomisation, standardisation
categories: of interventions, outcome assessments,
blinding of the assessor, stratification
■ Prospective (N = 9) (Ekelund and
by pathology staging and classification,
Rydell, 1992; Griggs et al, 2000; Mao
follow-up duration, number of treatment
et al, 1997; Melzer et al, 1995; Placsek
sessions, cost-effectiveness, duration of
et al, 1998; Roubal et al, 1996; Sharma
symptoms, group size greater than 40,
et al, 1993; Vermeulen et al, 2000;
documentation of the reliability and
Waldberg et al, 1992).
validity of measurements and the presence
■ Retrospective (N = 1) (Shaffer et al, of treatment side effects (table 1).
1992). Criteria were chosen as indicators of
■ Randomised clinical trials (N = 2) sound scientific methodology and/or
(Van der Windt et al, 1998; Winters because of the unique nature of adhesive
et al, 1997). capsulitis. For instance, the length of
follow-up was assessed due to reports of
Methodological Quality gradual and spontaneous resolution of
Scoring Protocol adhesive capsulitis symptoms often
A 16-item scoring protocol, modified occurring within 12 to 42 months (Stam,
from a validity assessment protocol 1994), and a reported average duration of
designed by Van der Heijden et al (1997) symptoms of 30 months (Reeves, 1975).
was used to assess the methodological Treatment economics were considered
rigour of each of the reviewed articles. since interventions deemed efficacious via
One point was assigned to each of the 16 experimentation could not be used
quality criteria. Points for each article clinically if they were not cost-effective.
Adverse treatment side-effects were also
considered as they could outweigh
treatment benefits.
Table 1: Quality scoring criteria
Results
Criteria Points Percentage of Quality Scores
scored studies that Randomised Clinical Trials
satisfied criteria
The two randomised clinical trials
Explicit enrolment criteria 1 100 included in this review received quality
Randomisation 1 25 scores of 57% (Winters et al, 1997) and
Stage of pathology 1 25 69% (Van der Windt et al, 1998) (mean
Classified into primary/secondary 1 50 63%) (table 2). The authors of these
Duration of symptoms before investigations reported that patients
intervention 1 100 treated with corticosteroid injections had
Group size > 40 1 42 superior outcomes to patients treated with
Outcome assessment physical therapy. In the Van der Windt et
Pain 1 67 al (1998) investigation, 40 of 52 (77%)
ROM 1 83 patients treated with triamcinolone
Function 1 67 acetonide injections over seven weeks
Standardisation of interventions 1 92 achieved ‘treatment success’ while only 26
Blinded assessment of outcomes 1 42 of 56 (46%) of patients treated with 12
Realiability and validity of sessions of physical therapy (passive joint
measurements 1 42 mobilisation, moist heat, electrotherapy,
Number of treatments <10 1 0 extensibility-enhancing exercises, streng-
Adverse side effects 1 75 thening exercises) were considered
Length of follow-up >1 year 1 50 successfully treated. Treatment success
Economic evaluation 1 0 was defined as the patient’s perception
Total 16 of complete recovery or significant
improvement.
ROM = Range of motion Winters et al (1997) (quality score 57%)

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Review 453

Table 2: Details of trials reviewed and their quality scores

Study and Number of Duration of Interventions and Outcomes Follow-up Quality


date published shoulders symptoms number of measured score
treatments (%)

Randomised clinical trials

Van der Windt 108 5 months Physical therapy. Pain 52 weeks 69


et al (1998) 12 treatments vs ROM
3 corticosteroid Function
injections
Winters 114 18 months Physical therapy. pain 11 weeks 57
et al (1997) 20 treatments
(no mobilisation)
vs manipulation vs
corticosteroid injections
Retrospective studies

Shaffer et al (1992) 62 2 weeks- Physical therapy. ROM 7 years 69


48 months Number of Function
treatments not
available

Prospective studies

Griggs et al (2000) 77 9 months Physical therapy Pain 22 months 63


passive stretching. ROM
Number of visits Function
unknown
Placzek et al (1998) 31 7 months Manipulation and Pain 14 months 57
14 physical therapy ROM
treatments Function
Melzer et al (1995) 110 18 months Physical therapy versus Pain 4 months 57
manipulation ROM
Function
Sharma et al (1993) 32 9 months Hydraulic distension ROM 44 months 50
and manipulation
with 8 weeks of
physical therapy
Vermeulen et al 7 8 months Physical therapy with Pain 9 months 50
(2000) end-range mobilisation ROM
techniques 2 x per week Function
x 3 months
Waldberg 50 3 months Physical therapy Pain 6 months 50
et al (1992) 21 treatments versus Function
calcitonin injections
Ekelund and 23 15 months Distension ROM 48 months 44
Rydell (1992) arthrography and Pain
manipulation with
physical therapy.
Number of visits
unknown
Roubal et al (1996) 6 7 months Manipulation and ROM 4 weeks 44
physical therapy.
16 treatments
Mao et al (1997) 12 2-12 months Physical therapy. ROM 2 weeks 38
12-18 treatments

ROM = Range of motion

compared the outcomes of patients a 20% ‘cure rate’. The authors neglected
treated with physical therapy, manip- to indicate if ‘cure’ meant complete
ulation, or corticosteroid injections. symptom resolution, or merely satis-
Following five weeks of treatment the faction of some predetermined criteria.
injection group had a 75% ‘cure rate’; the Their physical therapy included ‘exercise
manipulation group had a 40% ‘cure therapy, massage and physical applic-
rate’, and the physical therapy group had ations’. Interestingly, the authors chose

Physiotherapy August 2002/vol 88/no 8


454

not to include joint mobilisation in their as good, and one (14%) rated it as
strategy, claiming that passive mobilisation moderate.
is a skill incompatible with everyday Melzer et al (1995) and Waldberg et al
practice. (1992) prospectively compared outcomes
of patients treated with a physical therapy
Retrospective Design regimen of moist heat, gentle stretching,
The retrospective study by Shaffer et al range of motion exercises, mobilisation,
(1992) received a quality score of 69% electro-analgesia (TENS) and cryotherapy
(table 2). Results of this study indicated to outcomes of patients treated with
that following a mean of six months’ either manipulation under anaesthesia
physical therapy (Codman’s exercises, (Melzer et al, 1995) or subcutaneous
ultrasound, transcutaneous electrical calcitonin injections (Waldberg et al,
nerve stimulation, passive joint mobil- 1992). Patients treated with physical
isation and strengthening exercises), therapy in the Melzer et al (1995)
statistically significant improvements in investigation gained an average active
active range of motion were achieved range of motion that exceeded that of the
(99% flexion, 101% abduction, 62% manipulation group, but the results were
external rotation). not reported as statistically significant.
Waldberg et al (1992) reported that
Prospective Design physical therapy, combined with sub-
The nine prospective studies included in cutaneous calcitonin injections per f-
this review received quality scores of ormed daily for 21 days, resulted in
38% (Mao et al, 1997), 44% (Ekelund significantly greater pain reduction
and Rydell, 1992), 44% (Roubal et al, compared to physical therapy alone
1996), 50% (Sharma et al, 1993), 50% (p < 0.02). Both groups received ident-
(Vermeulen et al, 2000), 50% (Waldberg ical physical therapy including active
et al, 1992), 57% (Melzer et al, 1995), 57% mobilisation with electro-analgesia and
(Placzek et al, 1998), and 63% (Griggs et cryotherapy. However, there was no
al, 2000), with a mean score of 50.3% significant difference in the time to
(table 2). functional recovery between the two
Mao et al (1997) reported statistically groups.
significant improvements in gleno- Four of the reviewed studies (Ekelund
humeral active range of motion, and and Rydell, 1992; Placzek et al, 1998;
reappearance of the axillary recess (via Roubal et al, 1996; Sharma et al, 1993)
arthrography) in subjects managed with prospectively compared outcomes of
12 to 18 sessions of physical therapy patients managed with a combination of
including moist heat, ultrasound, passive physical therapy and either hydraulic
joint mobilisations, and flexibility and distension or manipulation. Sharma et al
strengthening exercises. (1993) compared the effectiveness of
Griggs et al (2000) reported that manipulation and physical therapy to the
following a physical therapy programme effectiveness of hydraulic distension and
consisting of passive stretching exercises physical therapy (passive mobilisation and
(forward elevation, external rotation, active exercise). Patients treated with
horizontal adduction, and internal hydraulic distension gained significantly
rotation) at a mean follow-up of 22 greater active range of motion (mean
months, patients demonstrated a improvement 86.75°) than patients
reduction in pain score from 1.57 to 1.16 treated with manipulation (mean
in a range from one to five points, improvement 46.6°).
improvements in active range of motion, Ekelund and Rydell (1992) compared
and 64 patients (90%) reported a outcomes of patients treated with
‘satisfactory outcome’. distension arthrography, local anaes-
Vermeulen et al (2000) reported that thetics, and manipulation followed by
patients subjected to end-range mob- physical therapy (the details of which
ilisation techniques demonstrated were not indicated). At four to six weeks
significant increases in active range follow-up, 91% of the subjects who had
of motion. At a nine-month follow-up undergone this combination of treat-
appointment four patients (57%) rated ments reported complete or partial relief
their improvement in shoulder function of pain and 82% exhibited normal active
as excellent, while two (29%) rated it range of motion (defined as a sum of

Physiotherapy August 2002/vol 88/no 8


Review 455

flexion and abduction active range of investigators combined multiple mod- Authors
motion greater than 200°) or near normal alities, which precludes assessment of Joshua Cleland DPT
active range of motion. individual treatments. However, in two is a physical therapist
Placzek et al (1998) (quality score 60%) studies improvements in active range of at the Physical
reported that translation manipulation motion, pain, and function were reported Therapy Center of
performed with a brachial plexus block following passive stretching alone (Griggs Milford, NH. He was a
followed by physical therapy (cold packs, et al, 2000) and end-range joint mob- graduate student in
high volt galvanic stimulation, pulsed ilisation alone (Vermeulen et al, 2000). the transitional
Doctor of Physical
ultrasound, passive glenohumeral mob- The variability of outcomes measures
Therapy programme
ilisation, and strengthening exercises) between the reviewed studies is ex- at Creighton
resulted in significant pain reduction and emplified in the assessment of range of University when this
improvements in Wolfgang’s functional motion. This was assessed in the majority study was conducted.
assessment at a 14-month follow-up. of the studies reviewed, but some authors
Christopher J Durall
Roubal et al (1996) reported that chose to measure only active or passive
PT MS SCS ATC/L
manipulation followed by an average of range of motion, while other authors CSCS is assistant
16 treatments consisting of high volt measured both. It seems sensible to track professor in the
galvanic stimulation, glenohumeral and report changes in active and passive Department of
mobilisation, and strengthening exercises, range of motion in patients with adhesive Physical Therapy,
resulted in mean glenohumeral active capsulitis since these patients have been School of Pharmacy
range of motion increases of 76° flexion, reported to present with limitations of and Allied Health
82° abduction, 50° external rotation, and both (Connolly, 1998; Pearsall and Speer, Professions,
49° internal rotation. 1998; Seigel et al, 1999). Creighton University,
Only seven of the 12 articles reviewed Omaha, NE.
Discussion included functional outcomes assess-
The aim of this systematic literature ments. Shaffer et al (1992) reported that This article was
review was to present a summary of all but 11% treated with physical therapy received on May 4,
research findings, and to assess the returned to ‘full function’. Placzek et al 2001, and accepted
validity of these findings by examining (1998) reported that patients treated with on January 25, 2002.
the scientific rigour or quality of the manipulation followed by physical therapy
investigations relative to predetermined exhibited significant improvements in
Address for
criteria. Between studies on an identical Wolfgang functional scores while Van der
Correspondence
problem, the findings of a rigorously Windt et al (1998) reported that the mean
conducted study (ie higher quality) would shoulder disability rating was 42 with Joshua Cleland DPT,
The Physical Therapy
have greater validity than the findings of a patients treated with cortisone injections
Center of Milford,
study with a less stringent methodology. compared to 38 with patients treated with
17 Armory Road,
In evidence-based clinical practice, it is physical therapy. Patients treated with Milford, NH 03055,
sensible to incorporate the most valid mobilisation in the investigation by USA.
evaluative and treatment techniques. Melzer et al (1995) reported an average
Quality review of the articles revealed a functional improvement of 78 points,
trend in the omission of a number of the while patients treated with mobilisation e-mail:
quality criteria including evidence of under anaesthesia demonstrated a jcleland@mcttelecom.
reliability and validity of measurements 50-point mean improvement. Waldberg et com
of treatment efficacy, the stage of the al (1992) found no difference in the time
pathology, group size greater than 40 to ‘functional recovery’ between patients
subjects, and economic evaluation. In treated with physical therapy and patients
addition, the 12 studies reviewed varied treated with calcitonin injections. Griggs
considerably in intervention strategies, et al (2000) demonstrated that at an
duration of treatment, and outcome average of 22 months 90% of patients
measures. who received passive stretching exer-
Due to the significant differences cises achieved a ‘satisfactory’ outcome.
between the articles in quality and Vermeulen et al (2000) demonstrated
reported physical therapy efficacy, we can that 57% of patients rated their shoulder
merely conclude that physical therapy function improvement as excellent and
may be beneficial in the treatment of 29% rated it as good.
patients with adhesive capsulitis. It is It is plausible that the measured
impossible to determine the particular improvements in range of motion, pain
treatments or combinations of inter- and function reported in these invest-
ventions that are efficacious in treat- igations may have been partially due to
ing adhesive capsulitis as most of the spontaneous recovery (Anton, 1993;

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456

Stam, 1994). However, it has not been need for more prospective, randomised
firmly established that spontaneous controlled clinical trials using a stand-
resolution occurs in all cases of adhesive ardised outcomes assessment to judge
capsulitis (Shaffer et al, 1992; Sharma et al, the efficacy of various physical therapy
1993). Shaffer et al (1992) indicated that interventions on adhesive capsulitis.
one-half of the patients with ‘frozen Because physiotherapy is typically a
shoulder’ managed non-operatively mixture of treatments, it is impossible to
remained symptomatic an average of determine the components that are most
seven years later. efficacious by examining the reviewed
The evaluated literature suggests that studies. As direct comparison of clinical
physical therapy may be beneficial for studies is possible only when subject
patients with adhesive capsulitis, but at populations are homogeneous, patients
what cost to the consumer? The number need to be stratified according to their
of physical therapy visits within these 12 stage of disease progression. The incorp-
studies ranged from 12 to 29. With the oration of universally accepted valid and
emphasis on cost-containment in medical reliable outcome measures would sign-
care, it is increasingly important that ificantly enhance the comparison of
scientific investigators report intervention results between studies and allow for
costs. None of the reviewed studies meaningful meta-analyses.
included supporting data on the cost- Determining the biological trigger
efficiency of the techniques investig- responsible for the development of
ated. This is an apparent shortcoming synovitis and subsequent capsular
of many physical therapy outcomes adhesions would greatly facilitate
studies. Ultimately, the inter vention understanding of the pathogenesis of
that demonstrates effectiveness and cost- adhesive capsulitis and perhaps help
efficiency will be adopted as standard harmonise terminology. The lack of
clinical practice. The examination of the consistent terminology and standard
cost-efficiency of treatment for adhesive diagnostic criteria poses a threat to
capsulitis is especially important given determining the most effective and
that the natural history of adhesive economical treatments for adhesive
capsulitis may be eventual spontaneous capsulitis and confounds direct
symptomatic resolution (Grubbs, 1993). comparison of clinical trials.
A limitation of our study is that we
searched only two databases (Medline and Conclusion
CINAHL) and looked only at articles This review and synthesis of 12 studies
published in English. In addition, the published between 1990 and 2000
heterogeneity of the articles reviewed revealed many inconsistencies in
does not allow for direct comparison terminology, intervention strategy, and
between studies using the same outcome outcomes measurement between the
measurement. This does not allow for studies, making it difficult to compare
statistical pooling of the results. Also the relevant published research and det-
inclusion of article designs other than ermine the effectiveness or economic
randomised control trials prevents efficiency of treatments. Most of the
calculation of effects size for comparison. articles reviewed suggest that physical
The quality scoring of the articles was therapy alone, or as part of a combination
carried out by only one of the authors of modalities is beneficial for patients
(JC) who was not blinded to the origin of with adhesive capsulitis, but the extent of
the studies included, so that reviewer bias this benefit is not clear. Quality scores
cannot be excluded. of the 12 articles ranged from 38% to
69%. Until the effectiveness and econ-
Recommendations for Future Research omic efficiency of a single intervention
One of the objectives of systematic are firmly established, management of
literature reviews is to identify facets of adhesive capsulitis will remain a topic of
clinical practice in need of further debate.
research. This review has highlighted the

Physiotherapy August 2002/vol 88/no 8


Review 457

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Physiotherapy August 2002/vol 88/no 8

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