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  • DNAmPhenoAge Gen-1

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    Rupesh Yadav
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    This spreadsheet calculates a Mortality Score and Phenotypic Age from biomedical values using coefficients from epigenetic aging research. It contains conversions to standardize input units, weightings derived from published studies, and a linear combination calculation to estimate a person's Phenotypic Age, DNA methylation-based age, and mortality risk score based on their biomedical results when aged 84.

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    Age file

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    DNAmPhenoAge_gen-1

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    This spreadsheet calculates a Mortality Score and Phenotypic Age from biomedical values using coefficients from epigenetic aging research. It contains conversions to standardize input units, weightings derived from published studies, and a linear combination calculation to estimate a person's Phenotypic Age, DNA methylation-based age, and mortality risk score based on their biomedical results when aged 84.

    Copyright:

    © All Rights Reserved
    Download as XLS, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    221 views1 page

    DNAmPhenoAge Gen-1

    Uploaded by

    Rupesh Yadav
    This spreadsheet calculates a Mortality Score and Phenotypic Age from biomedical values using coefficients from epigenetic aging research. It contains conversions to standardize input units, weightings derived from published studies, and a linear combination calculation to estimate a person's Phenotypic Age, DNA methylation-based age, and mortality risk score based on their biomedical results when aged 84.

    Copyright:

    © All Rights Reserved
    Download as XLS, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    A spreadsheet to calculate Mortality Score and Phenotypic Age. Author: John G.

    Cramer
    Refs: "An epigenetic biomarker of aging for lifespan and healthspan", Aging (Albany NY) 10(4) 573-591 (2018 Apr 18).
    "A New Epigenetic Clock for Aging and Life Expectancy", Talk by Morgan Levine
    Mean Cell Red Cell Alkaline White Blood
    Def. Albumin Creatinine Glucose C-reac Protein Lympocyte Age
    Volume Dist Width Phosphatase Cells
    Input 4.6 1.03 117 0.68 24 97 13.2 86 5.9 84
    Units g/dL mg/dL mg/dL mg/L % fL % U/L 10^3 cells/mL years
    Conv 10 88.401 0.0555 0.1
    cInput 46.00 91.0530 6.4935 -2.6882 24.00 97.00 13.20 86.00 5.90 84.00
    cUnits g/L mmol/L mmol/L Ln(mg/dL) % fL % U/L 10^3 cells/mL years
    Wts -0.0336 0.0095 0.1953 0.0954 -0.012 0.0268 0.3306 0.0019 0.0554 0.0804
    Terms -1.5456 0.8650 1.2682 -0.2565 -0.2880 2.5996 4.3639 0.1634 0.3269 6.7536
    Calculation:
    t 10 years 120 months
    g 0.0076927
    b0 -19.9067
    LinComb MortScore Ptypic Age est. DNAm Age est. D MScore
    Results -5.66 0.498 79.73 76.86 0.413

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