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Differential diagnosis
syndrome.
5.Arthralgia
• Arthralgia (from Greek arthro-, joint + -
algos, pain) literally means joint pain. it is Malaria
a symptom Dengue
condition is inflammatory.
6.Diarrhea or diarrhoea
Diarrhea or diarrhoea is the condition of
Malaria
having at least three loose or liquid bowel
movements each day. Dengue-X
abnormalities by splenectomy .
Splenomegaly
DHF-x
leg pain happens when connective
tissues and muscles along the Chikungunya-x
Influenza-A-x
20.An eschar
Malaria
• An eschar ( Greek: eschara,
Dengue
"scab") is a slough[,or piece
DHF
of dead tissue that is cast off from
Chikungunya
the surface of the skin, particularly
Leptospirosis
after a burn injury, but also seen
Scrub typhus
in gangrene, ulcer, fungal
Typhoid
infections, necrotizing spider bite
Influenza-A
wounds,
Inoculation eschar on popliteal area and discrete
Maculopapular elements in patient with lymphangitis
infected with Rickettsia sibirica mongolitimonae,
21.Malaena
Malaria-x
DHF
stools composed largely of
Chikungunya-x
blood that has been acted
Leptospirosis-x
on by gastric juices,
Scrub typhus-x
indicative of bleeding in the Typhoid
upper digestive tract. Influenza-A-x
22.Upper respiratory tract infections
Malaria-x
Upper respiratory tract
Dengue-x
infections (URI or URTI) are the illnesses
DHF-x
caused by an acute infection which
involves the upper respiratory Chikungunya-x
Malaria 0 0 0 0 0 0 0 0 0 0 0
Dengue 0 0 0 0 0 0 0 0 0
DHF 0 0 0 0 0 0 0 0 0 0 0 0 0
Chikungunya 0 0 0 0 0 0
Leptospirosis 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Scrub typhus 0 0 0 0 0 0 0 0 0 0 0 0 0
Typhoid 0 0 0 0 0 0 0
Influenza-A 0 0 0 0 0 0 0
Fever 1 Diarrhea 6 Retroorbital pain 11 Conjunctival 16 Malaena 21
suffusion
Myalgias + + +++
Anemia ++ ++ +
Thrombocytopenia ++ ++ +++
*Mean frequency of symptoms from studies where the two diseases were directly compared among patient seeking care; +++ =
70-100% of patients; ++ = 40-69%; + = 10-39%; +/- = <10%; - = 0%.References: Nimmannitya S, et. al. Am J Trop Med Hyg
Differential Diagnosis of
Dengue, Chikungunya and
ZIKA
ZikaVirus Compared to Dengue and Chikungunya
Features Zika Dengue Chikungunya
Fever ++ +++ +++
Rash +++ + ++
Conjunctivitis ++ + +
Arthralgia ++ + +++
Myalgia + ++ +++
Head ache + ++ ++
Hemorrhage - ++ -
Shock - + -
Differential Diagnosis of
Dengue
Differential Diagnosis of Dengue
Infectious Etiologies
• Leptospirosis • Enterovirus
• Influenza • Meningococcemia
• Malaria • Bacterial sepsis
http://woodshedenvironmen
t.wordpress.com/2010/12/29
/dengue-fever-is-dangerous-
slideshow-v-1-3-is-here/
Dengue – Clinical Spectrum
• Dengue virus infections have a wide clinical
spectrum that includes asymptomatic infections
and symptomatic infections.
WHO/TDR 2009
• Any warning sign * Requiring strict observation and • CNS: Impaired consciousness
Laboratory confirmed dengue medical intervention • Heart and other organs
(important when no sign of plasma leakage)
So in November of 2009 WHO Proposed
Dengue Classification
Dengue case classification by severity
• Dengue with or without (less common – therefore small,
narrow arrow) warning signs.
Fever and 2 of the following criteria:
• Nausea, vomiting (NEW)
• Rash (old, 1997 case definition too)
• Aches and pains (NEW = headache + eye pain +
myalgia + arthralgia)
• Tourniquet test positive (old was in 1997 as
hemorrhagic manifestation)
• Leucopenia (old too)
• Any warning sign (NEW)
2009 New Dengue Classification
Dengue case classification by severity
Dengue ± warning signs Severe dengue
1. Severe plasma
With leakage
Without warning 2. Severe
signs hemorrhage
Criteria for dengue ± warning signs
3.Criteria
Severe organ
for severe dengue
Probable dengue Warning signs* impairment
1. Severe plasma leakage
Live in/travel to dengue endemic area. leading to:
• Abdominal pain or tenderness
Fever and 2 of following criteria: • Shock (DSS)
• Nausea, vomiting (New) • Persistent vomiting
• Fluid accumulation with
• Rash • Clinical fluid accumulation
respiratory distress
• Aches and pains (Combined) • Mucosal bleed
2. Severe bleeding
• Tourniquet test positive • Lethargy; restlessness
• Liver enlargement >2cm
as evaluated by clinician
• Leucopenia
• Increase in HCT with rapid 3. Severe organ involvement
• Any warning sign
• Liver: AST or ALT>=1000
WHO/TDR 2009
decrease in platelet count
Laboratory confirmed dengue • CNS: Impaired consciousness
(important when no sign of plasma leakage) * Requiring strict observation and
medical intervention • Heart and other organs
Probable dengue
• Live in/travel to dengue endemic area. Fever and 2
of following criteria:
• Nausea, vomiting (New)
• Rash
• Aches and pains (Combined)
• Tourniquet test positive
• Leucopenia
• Any warning sign
• Laboratory confirmed cases
• (important when no sign of plasma leakage
2009 New Dengue Classification
Dengue case classification by severity
Dengue ± warning signs Severe dengue
1. Severe
With plasma leakage
Without warning
2. Severe
signs hemorrhage
Criteria for dengue ± warning signs 3.Criteria
Severe for severe
organ dengue
1. Severe plasma leakage leading to:
Probable Warning signs* impairment
• Shock (DSS)
• Abdominal pain or tenderness
dengue • Persistent vomiting
• Fluid accumulation with respiratory
distress
Live in/travel to dengue endemic
• Clinical fluid accumulation
area. Fever and 2 of following
• Mucosal bleed 2. Severe bleeding
criteria:
• Lethargy; restlessness as evaluated by clinician
• Nausea, vomiting (New)
• Rash • Liver enlargement >2cm
3. Severe organ involvement
• Aches and pains (Combined) • Increase in HCT with rapid • Liver: AST or ALT>=1000
WHO/TDR 2009
• Tourniquet test positive decrease in platelet count • CNS: Impaired consciousness
• Leucopenia * Requiring strict observation and • Heart and other organs
• Any warning sign medical intervention
So in November of 2009 WHO Proposed
Dengue Classification
•Warning signs need strict observation
in hospital.
•Abdominal pain or tenderness
Persistent vomiting
•Clinical fluid accumulation
Mucosal bleed
•Lethargy; restlessness
Liver enlargement >2cm
•Laboratory: Increase in HCT concurrent
with rapid decrease in platelet count
2009 New Dengue Classification
Dengue case classification by severity
WHO/TDR 2009
decrease in platelet count
• Any warning sign • CNS: Impaired consciousness
* Requiring strict observation and
Laboratory confirmed dengue • Heart and other organs
medical intervention
(important when no sign of plasma leakage)
So in November of 2009 WHO Proposed
Dengue Classification
No more DHF or DSS. Focus on severe
manifestations. Patients may fit 1 or all 3
categories.
1. Severe plasma leakage leading to:
1.) Shock (DSS) and 2.) Fluid accumulation
with respiratory distress
2. Severe bleeding
as evaluated by clinician
3. Severe organ involvement
1.) Liver: AST or ALT>=1000, OR
2.) CNS: Impaired consciousness, OR
3.) Heart and other organs
Dengue Fever - Symptoms
http://woodshedenvironment.wordpres
s.com/2010/12/29/dengue-fever-is-
dangerous-slideshow-v-1-3-is-here/
Bleeding spots in skin
Normal
Dengue
Skin bleeds
Bleeding into the eye
Large bleed into skin
Without surveillance, control becomes a matter
of luck.