1

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Products of 5‐lipoxygenase: hydroperoxyeicosatetraenoic acid (HPETE), 
hydroxyeicosatetraenoic acid (HETE), and the leukotrienes (LTA4, LTB4, LTC4, LTD4, LTE4).

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 inflammation

Lipoxins (LXs) are nonclassic eicosanoids. LXs form during, and then act to resolve, 

inflammatory responses. 

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↳ was TXA instead of TXAZ
,

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 CoA needed to activate FA ( uses Bs )

LPL, Lipoprotein lipase

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LPL, Lipoprotein lipase

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Binding of a chylomicron to lipoprotein lipase on the inner surface of a capillary. The 
chylomicron is anchored by lipoprotein lipase, which is linked by a polysaccharide chain 
to the lumenal surface of the endothelial cell. When activated by apoprotein C‐II, the 
lipase hydrolyzes the triacylglycerols in the chylomicron, allowing uptake into the cell of 
the glycerol and the free fatty acids.

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26
 glycerol

Sand kinase

by Her
, kidney ,

intestine , mammary glands

other tissues :
use DHP
glucose
→

G 3 PDH f.

G3P

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Insulin signals storage
NE E
, signals use stores

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30
 § .

FA-fatty acid, TAG-Triacylglycerol, DAG-Diacylglycerol, MAG-Monoacylglycerol,

GPAT-Glycerophosphate-Acyltransferase, ATGL-Adipose Tryglycerid lipase, HSL-
Hormon-sensitive lipase

Atkins diet works !

↳ But fats I stored T FAS in blood

digest
:
ingested ...

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 in tissue =

always
activated

HSL (Hormone sensitive lipase)
Fatty acid are tranbsported across membranes by specific transporters, 
usually in a ATP‐dependent manner by ABC (ATP binding casstette)‐transporters
In the cell, the fatty acids are activated. Thus, they are bound to CoA in an ATP‐
dependent manner. 
This reaction is catalyzed by acyl‐CoA synthetase.  

in blood
albumin is transporter of FAS .

from
Long chain Fas come
adipwpes in blood by hydrolysis of stores

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33
34
thinking

35
Oxidation of fatty acids with even‐numbered double bonds require auxiliary reductase 
and isomerase,
Oxidation of fatty acids with odd‐numbered double bonds require an auxiliary
isomerase

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 instead of GA
acetyl

[ branch chain FA oxid .

When branch CoA formed

pnpiohyl
-

no branch
acetyl CoA formed
-

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[ problem WI Atkins diet .

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The three ketone bodies are acetoacetate, beta‐hydroxybutyrate and acetone

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The unripened or inedible portions of the Akee fruit contain the hypoglycin toxins. 
Hypoglycin A is a type of Trojan Horse Inhibitor, also known as a Suicide Inhibitor, that in 
itself does not inhibit any biochemical pathway. However, hypoglycin A is metabolizes 
into toxic inhibitors that inhibit the activity of acyl CoA dehydrogenase and some 
enzymes that are required for gluconeogenesis. The reduction in gluconeogenesis and 
the reduction in fatty acid oxidation are the cause of most of the symptoms of Jamaican 
vomiting sickness. The blocking of fatty acid metabolism causes cells to start using 
glycogen for energy. Once glycogen is depleted, the body is unable to produce more, 
which leads to a severe case of hypoglycemia. These biochemical effects are detected by 
an excess of medium chain fatty acids in urine and acidosis. Key treatments are aimed at 
circumventing or counteracting the biochemical changes, and include IV fluids and 
glucose, and hemodialysis in the case of renal failure.

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65
The unripened or inedible portions of the Akee fruit contain the hypoglycin toxins. 
Hypoglycin A is a type of Trojan Horse Inhibitor, also known as a Suicide Inhibitor, that in 
itself does not inhibit any biochemical pathway. However, hypoglycin A is metabolizes 
into toxic inhibitors that inhibit the activity of acyl CoA dehydrogenase and some 
enzymes that are required for gluconeogenesis. The reduction in gluconeogenesis and 
the reduction in fatty acid oxidation are the cause of most of the symptoms of Jamaican 
vomiting sickness. The blocking of fatty acid metabolism causes cells to start using 
glycogen for energy. Once glycogen is depleted, the body is unable to produce more, 
which leads to a severe case of hypoglycemia. These biochemical effects are detected by 
an excess of medium chain fatty acids in urine and acidosis. Key treatments are aimed at 
circumventing or counteracting the biochemical changes, and include IV fluids and 
glucose, and hemodialysis in the case of renal failure.

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CPTT def
:

-9 FA in blood

Hypoglycemia
-

-
Low levels of ketone

CPFZ dlf
:

3 ms .

myohysis , myalgia myoglobihnria

,

67