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J Oral Maxillofac Surg

66:312-318, 2008

The Clinical Characteristics of Condylar


Hyperplasia: Experience With 61 Patients
Dorrit W. Nitzan, DMD,* Alex Katsnelson, DMD,†
Ido Bermanis, DMD,‡ Ilana Brin, DMD,§ and
Nardi Casap, DMD, MD储

Purpose: Much reported variation and discord exist regarding mandibular condylar hyperplasia (CH).
This study evaluated some of the characteristics of this disorder in a series of 61 patients with active CH.
Patients and Methods: A total of 61 patients with active temporomandibular CH who had been
evaluated in our departments were included. Demographic, clinical, radiologic, and bone scintiscan data
were collected and analyzed. Asymmetries were classified as transverse, vertical, or combined.
Results: CH was diagnosed during the growth period in 22 patients, and 39 patients were older than
20 years (range, 11 to 80 years). In 66% of the patients, the main complaint was progressive facial
asymmetry; and in the remainder, the main complaint was pain, dysfunction, or both. Transverse
asymmetry predominated (52%), and vertical or combined asymmetry occurred in 31% and 16% of
patients, respectively; asymmetry type was independent of age. The occlusal plane deviated in 48% of the
patients. Laterality was significantly gender-biased (females, 72% right; males, 64% left; P ⫽ .017). The
condylar head shape was normal in 15% of patients, deformed in 27%, and enlarged in 58%; the condylar
neck was elongated in 69% and enlarged in 19%. All of these changes were uncorrelated with the type
of asymmetry (vertical, transverse, or combined).
Conclusions: CH may occur at any age and is more prevalent in females. Clinicians should be aware
that only some patients complain primarily of facial asymmetry, and that symptoms of temporomandib-
ular disease also may be present. Because there is no correlation between the radiologic findings and the
clinical evaluation, classification should be simplified and based on clinical manifestation only—in other
words, the direction of asymmetry.
© 2008 American Association of Oral and Maxillofacial Surgeons
J Oral Maxillofac Surg 66:312-318, 2008

Temporomandibular joint (TMJ) condylar hyperplasia in which the pathology occurs at the head of the
(CH) is a rare pathology that was first described in condyle consequently affecting facial symmetry and
1836 as overgrowth of the mandibular condyle; com- occlusion and may be associated with pain and dys-
parable pathology has not been described in any function.1-4 The disorder is self-limiting, but as long as
other joint. CH is a distinct entity, a unilateral disorder it remains active, the asymmetry progresses together
with the associated occlusal changes.
Obewegeser and Makek5 classified the asymmetry
Received from the Hebrew University-Hadassah School of Dental
associated with CH into 3 categories: hemimandibular
Medicine, Jerusalem, Israel.
hyperplasia, causing asymmetry in the vertical plane;
*Professor, Department of Oral and Maxillofacial Surgery.
hemimandibular elongation, resulting in asymmetry
†Formerly, Resident, Department of Oral and Maxillofacial Sur-
in the transverse plane; and a combination of the 2
gery; and Currently, Resident, Oral and Maxillofacial Surgery De-
partment, University of Illinois at Chicago, Chicago, IL.
entities.5 The first type is caused by unilateral growth
‡General Practitioner, Department of Oral and Maxillofacial Sur-
in the vertical plane and is characterized by a sloping
gery. rima oris with almost no deviation of the chin and,
§Associate Professor, Department of Orthodontics. intraorally, by increased height of the maxillary alve-
储Senior Lecturer, Department of Oral and Maxillofacial Surgery. olar bone and downward deviation of the occlusal
Address correspondence and reprint requests to Dr Nitzan: Depart- plane in the ipsilateral side. If the maxillary plane fails
ment of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, to follow the mandibular plane, then an open bite
POB 12272, Jerusalem 91120, Israel; e-mail: Dorrit@cc.huji.ac.il may develop on the same side. Most commonly, the
© 2008 American Association of Oral and Maxillofacial Surgeons mandibular midline is straight, but it may shift ipsilat-
0278-2391/08/6602-0018$34.00/0 erally. Radiologically, Obewegeser and Makek5 re-
doi:10.1016/j.joms.2007.08.046 ported that the condyle appears enlarged and that its

312
NITZAN ET AL 313

head is usually irregular and deformed and its neck of 22 patients, has suggested that CH may represent
thickened and elongated, with coarse trabeculae fill- reactive growth in response to provocation by certain
ing the condyle. The mandibular angle is typically agents, and that genuine CH might be a process reac-
round, with the canal in low position. Joint pain was tive to joint arthrosis.18 The appearance of CH in 2
reported in 70% of the patients.6 siblings raised the possibility of a genetic cause, pos-
Hemimandibular elongation, the second type of sibly a Y-linked or autosomal dominant trait.19 In
CH,5 is associated with chin deviation toward the addition, condylar and ramus overgrowth, malocclu-
contralateral side with no vertical asymmetry. In- sion, and complementary maxillary deformity devel-
traorally, the mandibular midline deviates to the un- oping after severe facial injury suggested that trauma
affected side, while the contralateral mandibular molars may be contributive.20 Increased formation of condy-
deviate lingually in attempt to remain in occlusion; how- lar bone and cartilage was induced experimentally in
ever, cross-bite may develop in the contralateral side. rats by removal of the tibial marrow.21
The occlusal plane is maintained with no deviation. The The present study reports a series of 61 patients
condyle is of normal shape and size, but its neck can be with facial asymmetry due to active CH. From this
either slender or normal, with an elongated ascending relatively large series, we hoped to resolve these re-
ramus. The third type of CH is a combination of the ported disagreements and to gain further insight into
first 2 types.5 this evasive disorder.
Histopathologically, widening of the fibrocartilage
that covers the condyle, a wide richly vascularized
Patients and Methods
proliferation zone enriched with large cells near its
bony aspect, and osteoclasts in the lacunae between This retrospective study included 61 patients with
new trabeculae formed by the surrounding osteo- active TMJ CH who were evaluated in the Depart-
blasts can be observed.7 In active CH, the abnormal ments of Oral and Maxillofacial Surgery and Orth-
presence of large masses of hyaline cartilage sur- odontics at the Hebrew University Hadassah School of
rounding large cells and new cartilage formation also Dental Medicine between 1980 and 2004. Inclusion
have been reported,8 along with the constant pres- criteria were vertical, transverse, or vertical and trans-
ence of mesenchymal germinal cells and cartilage verse plane facial asymmetry with matching occlusal
islands in the bone under the fibrocartilage.9 The changes, as demonstrated clinically and by panoramic
growth center, however, is localized in the center of and cephalometric (posterior-anterior and lateral)
the condyle and not in the fibrocartilage.5 When ac- roentgenograms, and an active hyperplastic process
tive growth ceases, the histological appearance is of a confirmed by bone scan performed at the initial diag-
normal condyle with an irregular shape.1 In the ver- nosis and repeated at least 6 months later.
tical type of active CH, cartilage maturation layers and Patient evaluation included a patient questionnaire
increased growth are also noticeable, and inclusions detailing demographic information and a comprehen-
of cartilaginous tissue with glove fingers extending sive history that included primary complaints, initial
into the underlying cancellous bone have been de- symptoms, duration of symptoms, presence of joint
scribed.10 noise, limitation in mouth opening, and earlier treat-
Activity of CH is effectively demonstrated by bone ment. Each patient self-assessed his or her level of
scintography, is strongly correlated with the histolog- pain and extent of dysfunction using a visual analog
ical findings, and has become an efficient tool in the scale (VAS) and indicated its location on a facial dia-
differential diagnosis of facial asymmetry.7,9,11-16 Ac- gram. Two surgeons independently evaluated the se-
tivity associated with other pathologies of the joints verity of the facial asymmetry (VAS range, 0 to 5) and
must be differentiated, however.17 recorded its direction as transverse, vertical, or both.
Both types of CH have been reported to be equally Evaluation was based on clinical signs, including oc-
prevalent in males and females, with onset during or clusion, occlusal plane, deviation of mandibular mid-
after the period of growth.5 Others found hemiman- line, and others. The clinical examination included
dibular elongation mostly in younger patients and the determination of maximal mouth opening; range
hemimandibular hyperplasia in older patients.18 In of lateral and protrusive mandibular movements; char-
any case, early diagnosis in the active stage is impor- acteristics of the limitation in jaw movement, when
tant because of the progressive nature of CH, partic- present; determination of joint noise on palpation;
ularly when the patient is under orthodontic treat- and evaluation of pain on palpation of the head and
ment or when orthognathic surgery is planned.8 neck muscles and both TMJs. The severity of occlusal
The pathogenesis of CH that occurs only in the TMJ plane inclination was evaluated from the angle be-
remains obscure. It has been suggested that the stim- tween the occlusal plane and the interpupil line. In-
ulus for the abnormal growth originates from the traorally, deviation of dental midline, cross-bite, and
fibrocartilaginous layer.5 One study, based on a series open-bite were also recorded.
314 CLINICAL CHARACTERISTICS OF CONDYLAR HYPERPLASIA

Table 1. PREOPERATIVE DEMOGRAPHIC AND CLINICAL CHARACTERISTICS IN 62 PATIENTS WITH DIAGNOSED


ACTIVE CH

Characteristics

Females/males, n (%) 46 (75)/15 (25)


Age (years), mean ⫾ standard deviation (SD) (range) 27.85 ⫾ 14.7 (11–80)
Duration, months, mean ⫾ SD (range) 31; 18.03 ⫾ 12.81 (6–72)
Main complaint, n (%)
Asymmetry, n (%) 40 (65.6)
Pain and dysfunction, n (%) 17 (27.9)
Asymmetry, pain, and dysfunction 4 (6.6)
Affected joint (right/left bilateral), n (%) 39 (64)/21 (34)/1 (1.6)
Males (right/left), n (%) 5 (36)/9 (64)
Females (right/left/bilateral), n (%) 34 (72)/12 (26)/1 (2)
Maximal mouth opening (mm), mean ⫾ SD (range) 44.31 ⫾ 7.48 (10–65)
Asymmetry type: transverse/vertical/combined 32 (52)/19 (31)/10 (16.9)
Occlusal plane inclined, n (%) 29 (48%)
Severity of asymmetry (VAS 0 to 5), mean ⫾ SD (range) 3.24 ⫾ 1.04 (1–5)
Nitzan et al. Clinical Characteristics of Condylar Hyperplasia. J Oral Maxillofac Surg 2008.

Radiologic evaluation (n ⫽ 52) included preopera- 1 year after release of ankylosis, 1 in the affected joint
tive transpharyngeal and transcranial radiographs of and the other in the contralateral joint. Four patients
the TMJ in the closed-mouth and open-mouth posi- (6.6%) complained of both pain and asymmetry.
tions, along with panoramic and cephalometric x-rays In 32 patients (53%), the asymmetry was in the trans-
in anterior-posterior and lateral views. The condylar verse plane; in 19 patients (31%), it was vertical; and in
head was classified as normal, enlarged, deformed, or 10 (16%), the asymmetry was both transverse and ver-
enlarged and deformed, and the condylar neck was tical. The type of asymmetry was independent of age.
classified as normal, elongated, or enlarged. The right TMJ was affected in 39 patients (64%), a
Bone scintography using 99Tc was performed in all significantly higher rate than the left joint (P ⫽ .025);
patients before the surgical intervention. The proce- 1 female presented with bilateral CH. Females were
dure was repeated after at least 6 months, and was more affected in the right TMJ (72%); males, in the left
performed in 3 phases to ascertain that the activity TMJ (64%) (P ⫽ .017). The mean maximal mouth
originated from osteoblastic activity. In young pa- opening (not counting 1 patient with limited mouth
tients, corrections were made for activity due to nor- opening due to ankylosis) was 44.3 ⫾ 7.5 mm (range,
mal growth. 10 to 65 mm). Joint pain, dysfunction, or clicking was
The Mann-Whitney test was used for comparing found in 24 patients (38.7%).
continuous or ordinal variables, and the ␹2 test was
applied to determine association between the cate-
gorical variables. Pearson’s correlation examined the
relationship between the age and severity of CH.

Results
The demographic and clinical data of the study
group are detailed in Table 1. A total of 61 patients
(46 females [75%] and 15 males [25%]), with a mean
age of 27.8 ⫾ 14.7 years (range, 11 to 80 years) were
diagnosed as having active CH. As shown in Figure 1,
22 of the patients were diagnosed during the
growth period and 39 after age 20 years. The age
distribution was similar for both genders (mean age
of females, 28.51 ⫾ 15 years; of males, 25.87 ⫾
14.21 years).
In 40 patients (65.6%), the main complaint was
progressive facial asymmetry; 17 (27.9%) complained FIGURE 1. Age distribution of active CH.
of pain, dysfunction, or both. Among the latter, 1 Nitzan et al. Clinical Characteristics of Condylar Hyperplasia.
patient had ankylosis, and 2 patients were diagnosed J Oral Maxillofac Surg 2008.
NITZAN ET AL 315

dylar head have not been agreed on. Historically,


female predisposition has been noted, and indeed our
group of 61 patients had more females than males (at
a ratio of 3:1), in agreement with other reports of
ratios of 7:222 and 3:1 ratios.18 However, other stud-
ies found that CH afflicted males and females in equal
proportions.12,17,23 An Iranian study found CH in 12
males and only 1 female.24
Most studies have found that CH occurs between
ages 10 and 30 years,8,12,22,25 and it has been sug-
gested that the abnormal growth of the hyperplasia
ceases with that of general growth and that hemiman-
dibular hyperplasia occurs at a significantly younger
age.5 Active CH after the growth period was consid-
ered prolongation of growth. Other studies, however,
FIGURE 2. Severity of active CH and age (VAS scale 0 to 5).
presented a wider age range for CH: 19 to 37 years
(mean, 25.8 years),24 10 to 40 years (mean, 23.5
Nitzan et al. Clinical Characteristics of Condylar Hyperplasia.
J Oral Maxillofac Surg 2008. years),26 and 14 to 59 years.18 In our group, age varied
widely, ranging from 11 to 80 years. About one third
of the patients were referred during the growth pe-
The occlusal plane was tilted in 29 patients (48%). riod, with the rest diagnosed after age 20. We found
The mean severity of asymmetry (on a scale of 1 to 5) no association between age at onset and the type of or
was 3.24 ⫾ 1.04. Twenty-three patients (38%) had a severity of CH, and thus suggest that awareness of
severity score between 3 and 4, and 8 (16%) scored changes in facial symmetry as a result of CH is indi-
between 4 and 5. Indeed, the asymmetry was less cated for any patients of any age.
severe in the transverse type than in the vertical type Reports on preferential laterality, such as those
(respective means of 3.1 and 3.6, and medians of 3 on right CH in 12 of 13 patients24 and left CH in 8
and 4). The severity of asymmetry increased with age of 12 patients,26 are rather baffling. On the other
(r ⫽ 0.27; P ⫽ .034; Fig 2); gender had no effect on hand, an equal side distribution has been found by
the degree of severity. others.2 In the present study, 1 side was signifi-
The radiologic evaluations of the condylar head and cantly more affected. This affect was highly gender-
neck and the ramus are summarized in Table 2. In dependent, with the right side predominating in
most patients (73%), the shape of the condylar head females and the left side predominating in males.
was normal; in 27%, it was deformed. Condylar head Further study of this finding, which remains ambig-
deformity did not correlate with any type of hyper- uous to us, may shed some light on the pathogen-
plasia. Among the patients with transverse CH, 5 had esis of this disorder. The underlying cause of CH
deformed condyles (17.8%) and 23 had normal con- remains unclear; however, it is worth mentioning
dyles (82.2%), whereas in those with vertical CH, 7
patients had deformed condyles (39%) and 11 had
normal condyles (61%). The size of the affected con- Table 2. ASSESSMENT BY 2 SURGEONS OF THE
dyle was notably larger than the contralateral condyle MANDIBULAR DEFORMATION IN PATIENTS WITH
THE TRANSVERSE, VERTICAL, AND COMBINED TYPES
in 30 patients (58%). In the patients with transverse OF ACTIVE CH (N ⴝ 52)
CH, 13 had enlarged condyles (46%) and 15 had
normal condyles (54%), whereas in the patients with Asymmetry
vertical CH, 14 had large condyles (78%) and 4 had Transverse Vertical Combined
normal condyles (22%). These differences in these
Shape of condylar head
proportions were statistically significant. The condy- Deformed 5 (18%) 7 (39%) 2 (33%)
lar neck was elongated in 36 patients (69%) and en- Normal 23 (82%) 11 (61%) 4 (67%)
larged in 6 patients (12%), and its proportion was Size of condylar head
similar in all types of asymmetry. Large 13 (46%) 14 (78%) 3 (50%)
Normal 15 (54%) 4 (22%) 3 (50%)
Neck
Discussion Long 19 (68%) 13 (72%) 4 (67%)
Large 2 (7%) 4 (22%) 0
The clinical characteristics of CH are controversial, Normal 7 (25%) 1 (6%) 2 (33%)
because such issues as the effect of gender, age of Nitzan et al. Clinical Characteristics of Condylar Hyperplasia.
onset, type of asymmetry, and structure of the con- J Oral Maxillofac Surg 2008.
316 CLINICAL CHARACTERISTICS OF CONDYLAR HYPERPLASIA

that 3 of our patients had ankylosis, due to trauma, to hemimandibular hyperplasia), transverse (compa-
associated with the disease. rable to hemimandibular elongation), or combined,
Attention to the patient’s primary complaint is im- and found that about 52% of the patients had sole-
portant for the early diagnosis of CH, because the ly the transverse form of asymmetry, 31% had only
patient’s awareness of the exact nature of such a the vertical type, and the rest had the combined type.
slowly growing pathology may be low. Almost one The occlusal line, an indicator of the asymmetry in the
third of the patients complained not about asymme- vertical direction or combined, was inclined in 48% of
try, but rather about swelling on the contralateral the patients.
side, pain, and dysfunction; therefore, attention must The 3 types of asymmetry demonstrate typical clin-
be paid to facial symmetry even when it is not among ical signs and symptoms, whereas the radiologic ap-
the patient’s complaints. Pain, dysfunction, and click- pearance varies and fails to follow the classification
ing were common findings, indicating that the disease system of Obwegeser and Makek.5 In our group of
may be associated with various degrees of pain and/or patients, condylar deformity was present in all types
dysfunction, as as been reported by others.6,18 This of asymmetry, with no correlation with the vertical
persistent pain is most likely caused by changes in the type of hyperplasia as proposed by Obwegeser and
length, form, and size of the condyle and occasionally Makek.5 Normal-shaped condyles also were observed
unstable occlusion. among all types of asymmetry and in most of the
The classification of asymmetry in CH suggested by patients with vertical asymmetry (Table 2) and not as
Obwegeser and Makek5 was challenged by 3-dimen- suggested. Enlarged condyles were found in almost
sional reconstructions from computed tomography one half of the patients with transverse or combined
data showing that the mandibular morphology varied asymmetry and in approximately one quarter of the
from one case to another uncorrected with the clas- patients with vertical asymmetry. This random radio-
sification.27 We have classified the asymmetries by 3 logic appearance is demonstrated by the description
types according to the clinical criteria as vertical (akin of 2 patients in Figures 3 and 4.

FIGURE 3. A, Facial asymmetry in the vertical aspect in an 11-year-old girl with a marked inclined occlusal line. B, Marked open bite in the affected
side with deviation of the midline contralaterally. C, In the panoramic view, the left condyle is slim and long.
Nitzan et al. Clinical Characteristics of Condylar Hyperplasia. J Oral Maxillofac Surg 2008.
NITZAN ET AL 317

FIGURE 4. A, Facial asymmetry in the vertical aspect in a 56-year-old man. B, Marked deviation of the mandibular midline to the contralateral side,
with no inclination of an occlusal line or an ipsilateral open bite. C, In the panoramic view, the right condyle is large and deformed.
Nitzan et al. Clinical Characteristics of Condylar Hyperplasia. J Oral Maxillofac Surg 2008.

In conclusion, our findings indicate that CH may 2. Rushton MA: Unilateral hyperplasia of the mandibular condyle.
Proc R Soc Med 39:431, 1946
occur at any age, it does not stop at the end of the
3. Hovell JH: Condylar hyperplasia. Br J Oral Surg 47:105,
growth period, it is more prevalent in females, and its 1963
laterality is gender-dependent. Clinicians should be 4. Bruce RA, Hayward JR: Condylar hyperplasia and mandibular
aware that the primary complaint is facial asymmetry asymmetry: A review. J Oral Surg 26:281, 1968
5. Obwegeser HL, Makek MS: Hemimandibular hyperplasia– hemi-
in only some patients, and that signs and symptoms of mandibular elongation. J Maxillofac Surg 14:183, 1986
TMJ disease can be present. Purely transverse asym- 6. Hampf G, Tasanen A, Nordling S: Surgery in mandibular con-
metry, vertical asymmetry, and a combined type of dylar hyperplasia. J Maxillofac Surg 13:74, 1985
7. Luz JG, de Rezende JR, Jaeger RG, et al: Microanatomic features
asymmetry were seen in 32, 19, and 10 patients, of unilateral condylar hyperplasia. Bull Group Int Rech Sci
respectively. The shape and size of the condyle varied Stomatol Odontol 37:87, 1994
among the types of asymmetry, not correlated with 8. Eales E, Jones ML, Sugar AW: Condylar hyperplasia causing
CH as had been suggested previously. Therefore, clas- progressive facial asymmetry during orthodontic treatment: A
case report. Int J Paediatr Dent 3:145, 1993
sification of CH should be based on the clinical signs 9. Gray RJ, Horner K, Testa HJ, et al: Condylar hyperplasia: Cor-
and symptoms, namely the direction of asymmetry: relation of histological and scintigraphic features. Dentomaxil-
transverse, vertical, or combined (Table 2). lofac Radiol 23:103, 1994
10. Pantoja R: Vertical condylar hyperplasia: Clinical and histologic
aspects apropos of 2 cases. Rev Stomatol Chir Maxillofac 95:
285, 1994
References 11. Pogrel MA: Quantitative assessment of isotope activity in the
1. Norman JE, Painter DM: Hyperplasia of the mandibular condyle: A temporomandibular joint regions as a means of assessing uni-
historical review of important early cases with a presentation and lateral condylar hypertrophy. Oral Surg Oral Med Oral Pathol
analysis of twelve patients. J Maxillofac Surg 8:161, 1980 60:15, 1985
318 CLINICAL CHARACTERISTICS OF CONDYLAR HYPERPLASIA

12. Matteson SR, Proffit WR, Terry BC, et al: Bone scanning with 20. Lineaweaver W, Vargervik K, Tomer BS, et al: Posttraumatic
99m-technetium phosphate to assess condylar hyperplasia: Re- condylar hyperplasia. Ann Plast Surg 22:163, 1989
port of two cases. Oral Surg Oral Med Oral Pathol 60:356-67, 21. Bab I, Gazit D, Massarawa A, et al: Removal of tibial marrow
1985 induces increased formation of bone and cartilage in rat man-
13. Kaban LB, Cisneros GJ, Heyman S, et al: Assessment of man- dibular condyle. Calcif Tissue Int 37:551, 1985
dibular growth by skeletal scintigraphy. J Oral Maxillofac Surg 22. Hodder SC, Rees JI, Oliver TB, et al: SPECT bone scintigraphy
40:18, 1982 in the diagnosis and management of mandibular condylar hy-
14. Cisneros GJ, Kaban LB: Computerized skeletal scintigraphy for perplasia. Br J Oral Maxillofac Surg 38:87, 2000
assessment of mandibular asymmetry. J Oral Maxillofac Surg 23. Blomquist K, Hogeman KE: Benign unilateral hyperplasia of the
42:513, 1984 mandibular condyle: Report of eight cases. Acta Chir Scand
15. Beirne OR, Leake DL: Technetium-99m pyrophosphate uptake
126:414, 1963
in a case of unilateral condylar hyperplasia. J Oral Surg 38:385,
24. Motamedi MH: Treatment of condylar hyperplasia of the man-
1980
dible using unilateral ramus osteotomies. J Oral Maxillofac Surg
16. de Bont LG, van der Kuijl B, Stegenga B, et al: Computed
tomography in differential diagnosis of temporomandibular 54:1161, 1996
joint disorders. Int J Oral Maxillofac Surg 22:200, 1993 25. Murray IP, Ford JC: Tc-99m medronate scintigraphy in mandib-
17. Henderson MJ, Wastie ML, Bromige M, et al: Technetium-99m ular condylar hyperplasia. Clin Nucl Med 7:474, 1982
bone scintigraphy and mandibular condylar hyperplasia. Clin 26. Iannetti G, Cascone P, Belli E, et al: Condylar hyperplasia:
Radiol 41:411, 1990 Cephalometric study, treatment planning, and surgical correc-
18. Slootweg PJ, Muller H: Condylar hyperplasia: A clinico-patho- tion (our experience). Oral Surg Oral Med Oral Pathol 68:673,
logical analysis of 22 cases. J Maxillofac Surg 14:209, 1986 1989
19. Yang J, Lignelli JL, Ruprecht A: Mirror-image condylar hyper- 27. Mutoh Y, Ohashi Y, Uchiyama N, et al: Three-dimensional
plasia in two siblings. Oral Surg Oral Med Oral Pathol Oral analysis of condylar hyperplasia with computed tomography. J
Radiol Endod 97:281, 2004 Craniomaxillofac Surg 19:49, 1991

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