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    This article analyzes the GABRB3 gene as a candidate for autism spectrum disorders. It finds that mutations on chromosome 15q11-q13, which contains the GABRB3 gene that regulates the inhibitory neurotransmitter GABA, are associated with autism. Single nucleotide polymorphisms in GABRB3 have been linked to autism symptoms. Sensory sensitivity, common in autism patients, has also been tied to genetic markers of the GABRB3 gene. The study helps introduce new vocabulary for researching DNA and autism.

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    This article analyzes the GABRB3 gene as a candidate for autism spectrum disorders. It finds that mutations on chromosome 15q11-q13, which contains the GABRB3 gene that regulates the inhibitory neurotransmitter GABA, are associated with autism. Single nucleotide polymorphisms in GABRB3 have been linked to autism symptoms. Sensory sensitivity, common in autism patients, has also been tied to genetic markers of the GABRB3 gene. The study helps introduce new vocabulary for researching DNA and autism.

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    194 views1 page

    Zakriya

    Uploaded by

    api-512107573
    This article analyzes the GABRB3 gene as a candidate for autism spectrum disorders. It finds that mutations on chromosome 15q11-q13, which contains the GABRB3 gene that regulates the inhibitory neurotransmitter GABA, are associated with autism. Single nucleotide polymorphisms in GABRB3 have been linked to autism symptoms. Sensory sensitivity, common in autism patients, has also been tied to genetic markers of the GABRB3 gene. The study helps introduce new vocabulary for researching DNA and autism.

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    of 1

    Ansa Zakriya

    IRI/10h/3
    11/3/19
    Citation:
    Chen, Chia-Hsiang, et al. "Genetic analysis of GABRB3 as a candidate gene of autism spectrum
    disorders." ​Molecular Autism​, vol. 5, no. 1, 2014. ​Gale Academic OneFile Select,​
    https://link.gale.com/apps/doc/A541245908/GPS?u=clar33415&sid=GPS&xid=9dc628f9
    . Accessed 3 Nov. 2019.
    Annotation:
    This article explains the effect of mutated genes on Autism patients. The male to female

    ratio of ASD is 4:1. Chromosome 15q11-q13 is an area where many mutations related to autism

    have been found. Gamma-aminobutyric acid (GAMA) is the main inhibitory neurotransmitter in

    the brain, and they are mapped in that region of DNA. There have been a few Single Nucleotide

    Polymorphisms(SNPs) found in GABRB3 that are related to ASD symptoms. Different SNPs

    found in ASD patients may delete or duplicate transcription factors. Sensory sensitivity is

    common in Autism patients, and according to these findings, there is an association with genetic

    markers of GABAB3 and sensitivity commonly found in autism.

    Overall this article was helpful to the researcher because she was introduced to new

    vocabulary that will be commonly used in upcoming DNA studies. Additionally, the article was

    directly related to her research, therefore all aspects of the article may be used. The main critique

    of the article is that the researcher is unable to understand what the article is saying without

    having to constantly search up terms. She hopes to talk to Mrs. Chamness about certain

    confusing parts of the article in order to clarify the meaning. Lastly, the article dates back to

    2014, which is not very old. Additionally, this source is reliable because it came from the gale

    database.

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