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JACC March 20, 2018

Volume 71, Issue 11

Arrhythmias and Clinical EP

FACTORS ASSOCIATED WITH IMPAIRED QUALITY OF LIFE AMONG ATRIAL FIBRILLATION
PATIENTS IN REAL-WORLD CLINICAL PRACTICE: INSIGHTS FROM THE PROSPECTIVE SPRINT-AF
REGISTRY
Poster Contributions
Poster Hall, Hall A/B
Monday, March 12, 2018, 9:45 a.m.-10:30 a.m.

Session Title: Atrial Fibrillation: Outcomes and Management

Abstract Category: 08. Arrhythmias and Clinical EP: Supraventricular/Ventricular Arrhythmias
Presentation Number: 1276-038

Authors: Andrew C. T. Ha, Christopher Labos, Mahesh Kajil, Michelle Tsigoulis, Jafna Cox, Paul Dorian, G. B. John Mancini, David
Gladstone, Evan Lockwood, Ashfaq Shuaib, William Chan, Narendra Singh, Milan Gupta, Canadian Collaborative Research Network,
Brampton, Canada
Background: Atrial fibrillation (AF) patients often have impaired quality of life (QoL). Hence, characterization of their QoL status is
important when tailoring therapies to improve it. We sought to identify factors associated with impaired QoL among AF patients in a
prospective registry.
Methods: The Stroke Prevention and Rhythm INTerventions in Atrial Fibrillation (SPRINT-AF) registry prospectively enrolled 2,498 patients
with non-valvular AF at 132 community-based practices in Canada (Nov 2013 to March 2016). We assessed the baseline QoL of patients
with a disease-specific AF QoL questionnaire, the Atrial Fibrillation Effect on Quality of Life (AFEQT). The AFEQT score ranged from
0 (worst QoL) to 100 (best QoL). Using multivariable linear regression, we examined factors associated with worse AF-related QoL as
reflected by lower AFEQT scores, respectively.
Results: Baseline AFEQT scores were available in 2,483 patients and the mean AFEQT score was 77.6±19.2 points. The mean age was
73±10 years and 63% of the cohort was male. On multivariable analysis, factors associated with lower baseline AFEQT scores (worse
baseline AF-related QoL) included: female sex (4.8 point decrease, 95% CI 2.9 to 6.7, p<0.001), anti-arrhythmic drug use (4.1 point
decrease, 95% CI 1.4 to 6.8, p=0.003), higher CHA2DS2-VASc score (1.7 point decrease per 1-point increase in CHA2DS2-VASc, 95% CI
0.7 to 2.6, p=0.001), higher BMI (0.3 point decrease per 1 unit increase in BMI, 95% CI 0.1 to 0.4, p=0.001), and younger age (0.3 point
decrease for each year increment in age, 95% CI 0.2 to 0.5, p<0.001). A history of diabetes or the use of oral anticoagulation were not
associated with lower baseline AFEQT scores (0.7 point increase if the patient was diabetic, 95% CI -1.3 to 2.7, p=0.51; 1.2 point increase
if the patient was treated with an oral anticoagulant, 95% CI -1.1 to 3.5, p=0.31).
Conclusion: Baseline AF-related QoL can be predicted with simple, readily available clinical factors. Female sex and use of anti-arrhythmic
drugs were the strongest factors associated with impaired baseline AF-related QoL.