TABLE 7 JUMPS

OCM

Ms. V , 12 Y.O , ♀
E : Gene Mutation

RF: Heredity

CC: Fatigue

Lack of Nutrient Anemia Hypoglycemia

Eats enough Anemic

Looked Looked Hb ↓
portion with proper Conjuctiva
pale weak Eythrocyte ↓
composition

HT PE LE
Fatigue (last three Looked pale and weak Hemoglobin ↓
months) (worsen) Jaundice Skin Erythrocyte ↓
Looked Pale Anemic Conjunctiva Rituclocyte ↑
Relative (Her Uncle) Icteric Sclera Bilirubin ↑
suffered from the similar Hepatosplenomegaly SGOT -
symptoms Microcytosis ++
Polichromasia +
Poikilocytosis +
Crenation +++
Osmotic Fragility ↑

Prognosis:
Ad Vitam : Dubia Ad Bonam
Ad Fungsionam : Ad Malam BHP

PHOP
 FCM

Ms. V , 12 Y.O , ♀
E : Gene Mutation RF :
Heredity
Frameshift due to mutation on Chromosome 8

Protein not synthesized in RBC (Spectrin, Ankyrin , Band 3, Protein 4.2)

Membrane stability ↓

Membrane Loss

Spherical shape of RBC

RBC Deformability ↓

Splenic Trapping

RBC Phagocytosis by Macrophage

Hemolysis

Hemolytic Anemia Due to Heredity Spherocytosis

Osmotic Fragility ↑ Microcytosis ++

Breakdown Of
Crenation +++ RBC ↑ Poikilocytosis +

RBC ↓ Hb ↓ Heme ↑ Overwo

rk of
Erithropoesis↑ O2 ↓ Bilirubin Spleen
Anemic Overwork
Conjuct of hepar ↑
Reticulocyte ATP ↓ Pale
iva
↑
Fatigue Spleno
Hepatomegally Icteric Juandice megally
Polychro Reticulocyt
masia + e count ↑