Infection H.

pylori
Morphology of
H.Pylori
Micro-aerophilic

Gram Negative

Slow Growing

Spiral Shaped

Flagellated
Prevalance of
H.Pylori
Infection
Indication for treatment of H.Pylori
Past or present duodenal gastric ulcer

Dyspepsia

Atrophic gastritis

Low grade MALT lymphoma : Early stages (Lugano I/Ii)

Following resection of gastric cancer

First degree relatives with gastric cancer

Patient wish
H.Pylori and GERD
Epidemiological studies show negative association between prevalence of H Pylori and
severity of GERD and incidence of esophageal adenocarcinoma (GRADE A )

H Pylori eradication does not exacerbate pre existing GERD or affect treatment efficacy
(Grade A)
H.Pylori and long term treatment with PPI
Long term treatment with PPIs In HP positive patietns associated with development of
corpus predominant gastritis leading to atrophic gastritis (Grade A)

Eradication of HP in pts receiving long term PPIs heals gastritis and prevent progession to
atrophic gastritis but no evidence of reducing risk of gastric cancer (Grade A)
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