This paper presents an extension of our recent work, in which we addressed
the simultaneous synthesis of heat-integrated water networks. The novelty
and goal of this work is the development of an extended superstructure and simultaneous optimization model of heat-integrated water networks now involving process-to-process streams, and other streams within the overall network, for heat integration. Those heat-integration opportunities have not yet been fully taken into account in most existing models of heat- integrated water networks. In this study, we presented two strategies for heat integration of process-to-process streams. The first one includes the placement of heat exchangers on each hot and cold process-to-process stream. The second allows for the cooling and splitting of hot streams, and heating and splitting of cold streams. This extended model was formulated as a non-convex mixed-integer non-linear programming (MINLP) problem. The objective was to minimize the total annual network cost. Two examples with single and multiple contaminants are used in order to demonstrate that involving process-to-process streams for heat integration, novel and improved solutions can be obtained compared to those reported in the literature.