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Issue 37, 2015 Previous Article Next Article About Cited by Related

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RSC Advances
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Luciferase gene-loaded CS-Qdots as self-illuminating This article contains 10 page(s)
probes for specific hepatoma imaging
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Chenyan Yuan,a Ling Wang,†ab Yanli An,a Guoqiu Wua and Dongsheng Zhang*bc

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Chitosan encapsulated quantum dots (CS-Qdots) exhibit fascinating optical properties and can efficiently deliver
genes into cells in a visualized process. By using CS-Qdots as gene carriers, specific hepatocellular carcinoma (HCC)
expressed firefly luciferase genes (p[HRE]AFP-luc) were transfected into HCC cells for hepatoma bioluminescence
imaging. The results obtained in this study show that nanocarrier CS-Qdots can be excited by the luciferase coded in Article information
the genes delivered into the cells. The maximum emission wavelength of the bioluminescence red-shi ed from 560
https://doi.org/10.1039/C5RA01508A
nm to 630 nm. The excitation of CS-Qdots by bioluminescence occurs at the macroscopic scale and is independent of
covalent bond. The luciferase gene-loaded CS-Qdots can act as wavelength-tunable self-illuminating probes thus
holding potential for improved tumor optical molecular imaging. Submitted 26 Jan 2015

Accepted 16 Mar 2015

First published 17 Mar 2015

Citation RSC Adv., 2015, 5, 29048-29057

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Chenyan Yuan

Ling Wang

Yanli An
Guoqiu Wu

Dongsheng Zhang

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