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ACUTE PANCREATITIS IM 141

PATHO: Inflammation of the pancreas due to activation of pancreatic enzymes within the pancreas
Autodigestion
Proteolytic enzymes (e.g., trypsinogen, chymotrypsinogen, proelastase) are activated in the pancreas rather than in
the intestinal lumen

Common etiologies: alcohol, gallstones, idiopathic


Drugs: didanosine, asparaginase, azathioprine, valproic acid, pentavalent antimonials,pentamidine,
mercaptopurine, mesalamine, sulfamethoxazole, sulfasalazine, furosemide, sulindac opiates, tetracycline,
cytarabine, steriods
Endoscopic retrograde cholangiopancratography ERCP
Trauma
post op
Hyper tryglicerides, hyperlipedemia, hypercalcemia, heredetary pancreatitis,
infection
Malignant tumors, toxins, insectisides, scorpion venom

RISK FACTORS
Excessive alcohol consumption
Cigarette smoking
Obesity.
Family history of pancreatitis.

THEORIES
SECRETORY BLOCK THEORY
REFLUX THEORY
DIRECT DAMAGE TO PANCREAS

SYMPTOMS- RUQ PAIN, FEVER, TACHY, N/V, WEIGHT LOSS,

FOX SIGN- ECCHYMOSIS OF THE INGUINAL LIGAMENT


BRYANT SIGN- BLUISH DISCOLORATION OF THE SCROTUM

LABORATORY

DIFFERENTIAL DIAGNOSIS
COMPLICATIONS

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