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International Journal of Universal Pharmacy and Bio Sciences 6(2): March-April 2017
KEYWORDS: ABSTRACT
Pyrazolone, Anti- This chapter tries to present an overview about (i) nutricosmetic
inflammatory, Analgesic, ingredients that may not only act on skin, hair, and nails but also have a
Antimicrobial,
more systemic effect resulting in improved health and fitness; (ii) the
Anticonvulsant,
Antidepressant Activities. possible working mechanisms of such health and fitness enhancing
For Correspondence: nutricosmetics, focusing on the carotenoid and phenolic ingredients; and
Dhanashri Mahale*
(iii) the concept of combined nutria cosmetical cosmeceutical
Address:
Department of applications (i.e., combined oral and topical applications) and combined
Pharmaceutics, R. G.
nutriacosmetical physiotherapeutical interventions (i.e., combined oral
Sapkal College of
and exercise or massage applications).
Pharmacy, Anjaneri,
Nashik-422213,
Maharashtra, India.
INTRODUCTION:
Nutricosmetics
The term "Nutricosmetics" is a result of the fusion of "Nutraceuticals" and "Cosmeceuticals."
They are ingestible natural health products that enhance the function and appearance of an
individual's skin, nails, and hair. They are a range of beauty supplements and functional foods and
beverages that claim to contain active ingredients and nutrients such as botanical actives, sterol
esters, lycopene, enzymes, proteins, minerals, and vitamins that enhance beauty and are
beneficial to health.
Nurturing Beauty through Nutrition examines the emerging market sector of nutricosmetics.
Anyone in the beauty, food, beverage or nutritional supplements industries will get value from this
report, to understand the developing global trends in the emerging market of nutricosmetics.
The nutricosmetics market it has been demonstrating growth of 10 to 12% annually.
The aging population spends billions of dollars each year on vitamins, minerals, botanical extracts,
and antioxidants in an effort to maintain a youthful appearance of the skin and promote overall
well-being. Hormonal imbalance, inflammation, smoking, exposure to UV radiation, and
environmental stressors contribute to the aging of the skin by production of reactive oxygen species
(ROS) that can potentially damage cell membranes, proteins, and DNA. This overload of oxidative
stress and a production of free radicals can eventually break down connective tissues and collagen,
and release chemicals that lead to cellular and molecular events that are evident as signs of aging,
such as the formation of wrinkles uneven skin tone, dyspigmentation, inflammation,
immunosuppression, photoaging photocarcinogenesis, and sagging skin. Nutricosmetics provide
nutritional antioxidant supplementation to support endogenous antioxidant enzymes that may help
to internally provide nutritional antioxidant supplementation to support endogenous antioxidant
enzymes that may help to internally.
Evolution of Nutricosmetics
Nutricosmetics is a combination of Nutritive and Cosmetic values, which promote the concept of
beauty through healthy food drinks. Nutricosmetics are Eco- friendly in nature and has wide
acceptance throughout the world. Nutricosmetics are products which when ingested have
preventive or reactive effects that offer beautification and/or personal hygiene benefits. They are
condition specific agents that enhance beauty internally. The ingestion of nutricosmetics is mainly
by supplements or by food fortification.
Current estimated $66 billion skin care Estimated current nutricosmetics market
market is$1 to $2 billion
Sales of cosmeceuticals have grown into a US market for oral beauty products grew at
$14 billion industry worldwide ~16%between 2001 and 2006
Nutricosmetic industries:
• Ranbaxy Lab, Gurgaon
• Samis lab, Hyderabad
• Dabur, Ghaziabad
•Wockhardt Limited, Mumbai
• Lupin Pharma, Mumbai
• Himalaya Herbal Health Care, Bangaluru
• Amway, Nestle, Revlon, Danones etc...
Product variation by Geography
Bottled water is by far the best-selling format in beauty-from-within foods and drinks. With
sales of $737 million globally in 2010, the category has increased its already sizeable lead
from $718 million in 2006.
The second largest beauty food and drink category is dairy, with global sales of $119
million in 2010. Of this figure, the vast majority is accounted for by yogurt.
Asia has the highest number of new products in the functional beauty benefits area where
drinks, yoghurt and soup are the primary categories.
In Europe drink categories such as tea and drinkable yoghurt, as well as fruit snacks are
seeing the most launches.
Popular Nutricosmetic brands
Borba has a wide range of Nutricosmetic products- beauty supplements, skin care water, skin
care drink mixes. Their water is enriched with Vitamins A, C and E, and other fruit extracts and is
available in six formulas- Age Defying, Clarifying, Replenishing, Firming, Anti-Aging and Skin
Calming. Borba products also include antioxidant packed gummy bears and jelly beans.
The dietary supplement has health benefits like toning, anti-ageing, anti-hair loss, sun tanning,
anticellulite and dry skin. Inneov plans to enter China by next year and may also expand markets to
Latin America.
IMEDEEN skincare supplements are recognized worldwide as the gold standard in skincare.
Imedeen categorizes products based on customers’ age groups and it provides specific products to
treat different conditions. It has products for women and men Products include Derma One, Time
Perfection, Prime Renewal, Management, Tan optimizer and products for Hair & Nails.
Glisodin (developed by Isocell laboratories, Paris specializing in antiaging medicine) is a non
GMO melon extract that is rich in superoxide dismutase supplement that promotes body’s natural
Anti-oxidant system. This whole line of nutricosmetic supplements cater to antiaging. It helps to
retain the moisture and fights signs of ageing.
Protein M+ (contains chondroitin sulfate and collagen) from Copalis is known for its synergistic
effect on skin and has been positioned for delayed aging process. Copalis is based in France and is
focused on marine bioactives Other products include Collactive, CollagenHM, and Prolastin for
skin elasticity.
Biocell Technology LLC is an exclusive supplier of patented biocell collagen II ( contains
chondrotin Sulphate, Hyaluranic acid and hydrolyzed collagen II) positioned for joint health and
skin health.
Nightly beauty is a beauty enhancing hot chocolate drink with collagen II-based dietary
supplement from biocell that has been positioned for skin health. It is available in three different
flavours–chocolate, chocolate chai, and vanilla. It also contains vitamins, natural oxidants, and
sleep enhancing extracts that result in vibrant skin
Future trends in Nutricosmetics
Historically, plant ingredients have been used in topical and oral applications for various
dermatological benefits. Topically used ingredients are directly applied to the skin and hair.
However, large molecules (vitamins, peptides) cannot penetrate to the lower skin layers without
additional transport systems. Orally ingesting bioactive nutrients avoids external oxidation and can
increase bioavailability. Additionally, efficient long term effects on deeper skin layers can be
continuously achieved through bloodstream supply. Because of these different delivery systems, the
most efficient way to fully exploit the natural potential seems to combine the benefits of
nutricosmetics and cosmetics; both from the inside and on the outside. The main purpose of
nutricosmetics is to slow down the ageing process through botanical ingredients with antioxidant
properties which fight against cell damaging free radicals. Nutricosmetics can also help to replenish
essential nutrients for healthy skin that decline with age.
Beauty drinks and beverages currently seem to be the strongest growing segment in beauty market.
They benefit from combining the natural hydration effect with bioactive fortification. The most
highly demanded products are herbal teas (red, green, black), followed by exotic fruit and
CONCLUSION
It is well known that a balanced diet is important for our health. Our skin, hair and nails are
sensitive indicators of nutritional deficiencies. As a consequence, food, drinks and dietary
supplements with anti ageing benefits are currently the most innovative products on the beauty
market. These so called ―nutricosmetics‖ promise to support healthy skin, hair and nails.
REFERENCES:
1. The drugs and cosmetics act 1940, published by government of india, ministry of health and
family welfare, department of health, India.
2. Dzanis, D.A. 1998. Nutraceuticals: Food or Drug? TNAVC Proceedings. p. 430-431.
3. Mohamed Amer, Mina Maged. Cosmeceuticals versus pharmaceuticalsClinics in
Dermatology (2009) 27, 428–430.
4. Madhere, S, Simpson, P. A Market Overview of Nutricosmetics. Cosmetic Dermatology. June
2010. 23 (6) 268-274.
5. Kline & Company, Nutricosmetics 2006: Japan, United States and Western Europe.
6. KalraEK. Nutraceutical - Definition and IntroductionAAPS PharmSci2003; 5 (3): 1-2.
7. Zeisel SH. Regulation of "Nutraceuticals." Science1999;285:185. -186.
8. Brower V. Nutraceuticals: poised for a healthy slice of the healthcare market? Nat Biotechnol.
1998;16:728-731.
9. Elizabeth AC. Over-the-counter products: nonprescription medications, nutraceuticals, and
herbal agents. ClinObstet Gynecol. 2002;45(1):89-98.
10. FDA/CFSAN resources page. Food and Drug Administration Web site.Dietary Supplement
Health and Education Act of 1994.
11. Dureja, H., Kaushik, D., Gupta, M., Kumar, V. and Lather, V. cosmeceuticals: An emerging
concept, Indian J. Pharmacol, 1995, 37, 155–159.
12. Grace R. Cosmeceuticals: Functional food for the skin. Natural Foods Merchandiser
2002;XXIII: 92‐9.
13. Draelos ZD. The cosmeceutical realm.ClinDermatol. Nov‐ Dec 2008;26(6):627‐32.
14. J. Padma Preetha*, K.Karthika1Cosmeceuticals – An Evolution Int.J.ChemTech
Res.2009,1(4).
15. SinghalMukul, KhannaSurabhi ,NasaAtul. Cosmeceuticals for the skin: an overviewasian j
pharm clin res, vol 4, issue 2, 2011, 16.
16. Nutricosmetics—health and beauty within and without! Frost & Sullivan.
17. Grammenou E. What’s next for cosmeceuticals and nutricosmetics?
GCIMagazine.April6,2009.
18. Prasobh G R Nutricosmetics.H.J.D.Med. 2011:3(1).
19. Liu S, Lu H, Zhao Q, et al. Theaflavin derivatives in black tea and catechin derivatives in
green tea inhibit HIV-1 entry by targeting 41.
20. Nakachi K, Eguchi H, Imai K. "Can teatime increase one's lifetime?" Ageing Res Rev. 2003
Jan;2(1):1-10.
21. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M, Chantre P, Vandermander J.
"Efficacy of a Green Tea extract rich in catechin polyphenols and caffeine in increasing 24-
h energy expenditure and fat oxidation in humans." Am J ClinNutr. 1999 Dec;70(6):1040-5.
22. Chung FL, Schwartz J, Herzog CR, Yang YM. "Tea and cancer prevention: studies in animals
and humans." J Nutr. 2003 Oct;133(10):3268S-74S.
23. Katiyar SK. "Skin photoprotection by green tea: antioxidant and immunomodulatory effects."
Curr Drug Targets Immune EndocrMetabolDisord. 2003 Sep;3(3):234-42.
24. Hakim IA, Harris RB, Brown S, Chow HH, Wiseman S, Agarwal S, Talbot W. "Effect of
Increased Tea Consumption on Oxidative DNA Damage among Smokers: A Randomized
Controlled Study." J Nutr. 2003 Oct;133(10):3303S-9S.
25. Bell SJ, Goodrick GK. "A functional food product for the management of weight."Crit Rev
Food SciNutr. 2002 Mar;42(2):163-78.
26. Katiyar SK, Ahmad N and Mukhtar H. Green tea and skin. Arch Dermatol. 2000
Aug;136(8):989-94.
27. Ferro-Luzzi, A., Cialfa, E., Leclercq, C., Toti, E., The Mediterranean diet revisited. Focus on
fruit and vegetables. International Journal of Food Sciences and Nutrition 1994, (45) pp
291-300.
28. Lampe, J. W., Health effects of vegetables and fruit: assessing mechanisms of action in
human experimental studies. The American Journal of Clinical Nutrition, 1999, Vol 70, No
3, pp 475-490.
29. Inserra, P., et al, Immune function improves during fruit and vegetable extract
supplementation. Molecular Biology of the Cell 1998, (9) p182.
30. Simin, L., et al, Intake of vegetables rich in carotenoids and risk of coronary heart disease in
men: The Physicians' Health Study. International Journal of Epidemiology, 2001, 30;
pp130-135.
31. Bone RA. Landrum JT. Distribution of macular pigment components, zeaxanthin and lutein,
in human retina.Methods Enzymol 1992:213:360–6.
32. Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene
and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996;334:1150–5.
33. Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation
with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N
Engl J Med 1996;334:1145–9.
34. Gerster H (1997). "The potential role of lycopene for human health".J Am CollNutr16 (2):
109–26.
35. Stahl W, Heinrich U, Wiseman S,Eichler O, Sies H, Tronnier H. SmithRN, et al. Dietary
tomato paste protectsagainst ultraviolet light-inducederythema in humans. J Nutr.
2001May;131(5):1449-51.
36. Rizwan M, Rodriguez-Blanco I, Harbottle A, Birch-Machin M, Watson REB,.Rhodes LE.
Lycopene protects against biomarkers of photodamage in human skin. Presented at the
British Society for Investigative Dermatology Annual Meeting, 8 April 2008, University of
Oxford.
37. Giovannucci E, Rimm EB, Liu Y, et al. A prospective study of tomato products, lycopene,
and prostate cancer risk. J Natl Cancer Inst 2002;94(5):391-398.
38. Bowen P, Chen L, Stacewicz-Sapuntzakis M, et al. Tomato sauce supplementation and
prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis.
ExpBiol Med (Maywood) 2002;227(10):886-893.
39. Gianetti J, Pedrinelli R, Petrucci R, et al. Inverse association between carotid intima-media
thickness and the antioxidant lycopene in atherosclerosis. Am Heart J 2002;143(3):467-474.
40. Singh M, Krishanappa R, Bagewadi A, et al. Efficacy of oral lycopene in the treatment of oral
leukoplakia. Oral Oncol 2004;40(6):591-596.
41. Giovannucci E. Tomatoes, tomato-based products, lycopene, and cancer: Review of the
epidemiologic literature. Journal of the National Cancer Institute 1999; 91(4): 317-331
1999.
42. Peter H. Langsjoen, "Introduction of Coezyme Q10.
43. Gaby AR, Mischley LK (2006). Coenzyme Q10. In JEPizzornoJr, MT Murray, eds., Textbook
of Natural Medicine, 3rd ed., pp. 859-869. Edinburgh: Churchill Livingstone.
44. Coenzyme Q10 (2006). Medical Letter on Drugs and Therapeutics, 48(1229): 19-20.
45. Tran UC, Clarke CF (June 2007). "Endogenous Synthesis of Coenzyme Q in
Eukaryotes".Mitochondrion7 (Suppl): S62–71.
46. Bentinger M, Tekle M, Dallner G (May 2010). "Coenzyme Q-biosynthesis and
functions".Biochem.Biophys. Res. Commun.396 (1): 74–9.
47. Rosenfeldt FL, et al. (2007). Coenzyme Q10 in the treatment of hypertension: A meta-
analysis of the clinical trials. Journal of Human Hypertension, 21(4): 297-306.
48. Bhagavan, Hemmi N.; Chopra, Raj K. (2006). "Coenzyme Q10: Absorption, tissue uptake,
metabolism and pharmacokinetics". Free Radical Research. 1991;40 (5): 445–53.
49. Muller, Werner E. G. (2003). "The Origin of Metazoan Complexity: Porifera as Integrated
Animals". Integrated Computational Biology43 (1): 3–10.
50. Di Lullo, Gloria A.; Sweeney, Shawn M.; Körkkö, Jarmo; Ala-Kokko, Leena& San Antonio,
James D. (2002). "Mapping the Ligand-binding Sites and Disease-associated Mutations on
the Most Abundant Protein in the Human, Type I Collagen".J. Biol. Chem.277 (6): 4223–
4231.
51. Sikorski, Zdzisław E. (2001). Chemical and Functional Properties of Food Proteins. Boca
Raton: CRC Press. p. 242.
52. Bornstein, P., and Sage, H.: Structurally Distinct Collagen Types ,Annu Rev Biochem 49, 957,
1980.
53. Bruckner, P., and van der Rest, M.: Structure and Function of Cartilage Collagens ,Microsc
Res Tech 28, 378, 1994.
54. Burgeson, R., and Nimni, M.: Collagen Types - Molecular Structure and Tissue Distribution
,ClinOrthop 282, 250, 1992.
55. Atkins, E., and Sheehan, J.: Structure of Hyaluronic Acid, Nature New Biol 235, 253, 1972.
56. Bettelheim, F.: Crystalline Sodium Hyaluronate ,Nature 182, 1301, 1958.
57. Taussig, A.: A Simple Method for the Preparation of Hyaluronic Acid ,Can J Biochem 43,
132, 1965.
58. Ammon, H. P. T. and Wahl, M. A. (1991) Pharmacology of Curcuma Longa. PlantaMedica.
57,1-7.
59. Balasubramanian K. Molecular Orbital Basis for Yellow Curry Spice Curcumin's Prevention
of Alzheimer's Disease. J. Agric. Food Chem., 54 (10), 3512 -3520, 2006.
60. Calabrese V, Butterfield DA, Stella AM. Nutritional antioxidants and the hemeoxygenase
pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease. Ital J
Biochem. 2003 Dec;52(4):177-81. 2003.
61. Arora, R. B., Basu, N., Kapoor, V. and Jain, A. (1971) Anti-inflammatory studies of Curcuma
longa. The Indian Journal of Medical Research. 59, 1289-1295.
62. Morton, J. Date. In: Fruits of warm climates. Julia F. Morton. Miami, FL. -Purdue University.
Center for New Crops and Plants Products.1987; 5–11.
63. Hanson, Wendy (2008-06-13). "Date palm seed from Masada is the oldest to germinate". Los
Angeles Times.
64. Walid Al-Shahib, Richard J. Marshall (2003). "The fruit of the date palm: its possible use as
the best food for the future?".International Journal of Food Sciences and Nutrition54 (4):
247–259.
65. Miller, C. J.; Dunn, E. V.; Hashim, I. B. (2002). "Glycemic index of 3 varieties of
dates".Saudi medical journal23 (5): 536–538.
66. Havsteen, B. H. The biochemistry and medical significance of the flavonoids, Pharmacology
& Therapeutics (2002) Vol 96 67-202.
67. Prior, R. L. and Cao, G. Flavonoids: Diet and Health Relationships Nutrition in Clinical Care
(2000) Vol 3 No 5: 279–288.
68. Michael Beam, James Duncan Davidson: Cocoa in a Nutshell, O'Reilly, 1st Edition 2003,
Paperback.
69. SimsonGarfinkel, Michael K. Mahoney: Building Cocoa Applications: A Step by Step Guide,
O'Reilly, 1st Edition 2002, Paperback.
70. Biesalski, H.K.: 5 am Tag [5 a day]: Obst-, Gemüse- und Kartoffelverarbeitung 85 (2000),
112 [Fruit, Vegetable and Potato processing]
71. Dittrich, K., Leitzmann, C.: BioaktiveSubstanzen [Bioactive substances], trias, Stuttgart 1996.
72. Krinsky, N. I.: Antioxidant functions of carotenoids, Free Radical biology & Medicine, 7
(1989617.
73. Janick, Jules; Robert E. Paull. The encyclopedia of fruit & nuts.CABI.2008; 610.
74. Pomegranates: An Exquisite Fruit. Exotic Fruit for Health. 19 August 2011.
75. Journal of Drugs in Dermatology"; Innovations in Natural Ingredients and Their Use in Skin
Care; J.F. Fowler Jr.; June 2010.
76. Schauss, A. G.; Wu, X.; Prior, R. L.; Ou, B.; Huang, D.; Owens, J.; Agarwal, A.; Jensen, G.
S.; Hart, A. N.; Shanbrom, E. Antioxidant capacity and other bioactivities of the freeze-
dried Amazonian palm berry, Euterpeoleraceae Mart. (acai) J. Agric. Food Chem. 2006.
77. Pilaczynska-Szczesniak, L.; Skarpanska-Steinborn, A.; Deskur, E.; Basta, P.; Horoszkiewicz-
Hassan, M. The influence of chokeberry juice supplementation on the reduction of oxidative
stress resulting from an incremental rowing ergometer exercise Int. J. Sport Nutr.
Exerc.Metab. 2005.
78. Bagchi D, Sen CK, Ray SD, et al. Molecular mechanisms of cardioprotection by a novel
grape seed proanthocyanidin extract. Mutat Res. 2003;523-524:87-97.
79. Khanna S, Venojarvi M, Roy S, et al. (October 2002). "Dermal wound healing properties of
redox-active grape seed proanthocyanidins". Free Radic Biol Med. 33 (8): 1089–96.
80. Yahara N, Tofani I, Maki K, Kojima K, Kojima Y, Kimura M (June 2005). "Mechanical
assessment of effects of grape seed proanthocyanidins extract on tibial bone diaphysis in
rats". J Musculoskelet Neuronal Interact. 5 (2): 162–9.
81. Bays HE. Safety considerations with omega-3 Fatty Acid therapy. Am J Cardiol.
2007;99(6A):S35-43.
82. Balk EM, Lichtenstein AH, Chung M et al. Effects of omega-3 fatty acids on serum markers
of cardiovascular disease risk: A systematic review. Atherosclerosis. 2006 Nov;189(1):19-
30.
83. Boelsma E, Hendriks HF. Roza L. Nutritional skin care: health effects of micronutrients and
fatty acids. Am J Clin Nutr. 2001;73(5):853-864.
84. Akhisa, T.; Kokke, W. (1991). "Naturally occurring sterols and related compounds from
plants". In Patterson, G. W.; Nes, W. D.. Physiology and Biochemistry of Sterols.
Champaign, IL: American Oil Chemists' Society. pp. 172–228.
85. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2010). "Scientific Opinion
on the substantiation of health claims related to plant sterols and plant stanols and
maintenance of normal blood cholesterol concentrations (ID 549, 550, 567, 713, 1234,
1235, 1466, 1634, 1984, 2909, 3140), and maintenance of normal prostate size and normal
urination (ID 714, 1467, 1635) pursuant to Article 13(1) of Regulation (EC) No 1924/2006".
EFSA Journal 8 (10): 1813.
86. Quideau, D. Deffieux, C. Douat-Casassus, & L. Pouységu, 2011.
87. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int
Ed Engl. 2011, 50(3):586–621.
88. Nichols JA and Katiyar SK. Skin photo-protection by natural polyphenols: anti-inflammatory,
antioxidant and DNA repair mechanisms. Arch Dermatol Res. 2010 Mar;302(2):71-83.
Epub 2009 Nov 7.
89. Ensminger AH, Ensminger, ME, Kondale JE, Robson JRK. Foods & Nutriton Encyclopedia.
Pegus Press, Clovis, California 1983.
90. Bermudez B, Lopez S, Ortega A et al. Oleic Acid in olive oil: from a metabolic framework
toward a clinical perspective. Curr Pharm Des. 2011;17(8):831-43. 2011.
91. Bondia-Pons I, Schroder H, Covas MI et al. Moderate consumption of olive oil by healthy
European men reduces systolic blood pressure in non-Mediterranean participants. J Nutr.
2007 Jan;137(1):84-87. 2007.
92. Bullo M, Lamuela-Raventos R and Salas-Salvado J. Mediterranean Diet and Oxidation: Nuts
and Olive Oil as Important Sources of Fat and Antioxidants. Curr Top Med Chem. 2011
Apr 21.
93. Lieberman, S, Bruning, N (1990). The Real Vitamin & Mineral Book. NY: Avery Group, 3.
94. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12,
Pantothenic Acid, Biotin, and Choline (1998) National Academy of Sciences. Institute of
Medicine. Food and Nutrition Board.
95. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000)
National Academy of Sciences. Institute of Medicine. Food and Nutrition Board.
96. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper,
Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001)
National Academy of Sciences. Institute of Medicine. Food and Nutrition Board.
97. Ernst E. (2000) Adverse effects of herbal drugs in dermatology. Br J Dermatol 143:923–929.
98. Marshall JM (2000) Aloe vera gel: what is the evidence? Pharm J 244:360–362.
99. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen
Pract. 1999 Oct;49(447):823-8.
100. Eshun, K., He, Q (2004) Aloe Vera: A Valuable Ingredient for the Food, Pharmaceutical
and Cosmetic Industries—A Review. Critical Reviews in Food Science and Nutrition,
44(2): 91-96.
101. Fortin, Francois, Editorial Director. The Visual Foods Encyclopedia. Macmillan, New York
1996.
102. Rakhimov MR. Pharmacological study of papain from the papaya plant cultivated in
Uzbekistan (Article in Russian). Eksp Klin Farmakol 2000 May-Jun;63(3):55-7 2000.
103. Cho E, Seddon JM, Rosner B, Willett WC, Hankinson SE. Prospective study of intake of
fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch
Ophthalmol. 2004 Jun;122(6):883-92. 2004.
104. Sebastian P, Schaefer H, Telford IR, et al. Cucumber (Cucumis sativus) and melon (C.
melo) have numerous wild relatives in Asia and Australia, and the sister species of melon is
from Australia. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14269-73. Epub 2010 Jul
23. 2010.
105. Ghebretinsae AG, Thulin M and Barber JC. Relationships of cucumbers and melons
unraveled: molecular phylogenetics of Cucumis and related genera (Benincaseae,
Cucurbitaceae). Am J Bot. 2007 Jul;94(7):1256-66. 2007.
106. Lee DH, Iwanski GB, and Thoennissen NH. Cucurbitacin: ancient compound shedding new
light on cancer treatment. Scientific World Journal. 2010 Mar 5;10:413-8. Review. 2010.
107. Nema NK, Maity N, Sarkar B et al. Cucumis sativus fruit-potential antioxidant, anti-
hyaluronidase, and anti-elastase agent. Arch Dermatol Res. 2011 May;303(4):247-52. Epub
2010 Dec 14. 2011.