Scribd Logo
Upload

Welcome to Scribd!

  • Retrovirus-Like Gag Traffics Across Like Gag Protein Arc1 Binds RNA and Synaptic Boutons Protein Arc1 Binds RNA and

    Uploaded by

    carlos
    14 views2 pages
    1. The Drosophila Arc1 protein forms capsid-like structures that bind to darc1 mRNA in neurons. 2. Arc1 loads the darc1 mRNA into extracellular vesicles that are transferred from motor neurons to muscles. 3. This loading and transfer depends on the retrotransposon-like sequences in the 3' untranslated region of the darc1 mRNA. Disrupting this transfer blocks synaptic plasticity, suggesting it is required for this function.

    Original Description:

    Original Title

    virusyconsciencia

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    1. The Drosophila Arc1 protein forms capsid-like structures that bind to darc1 mRNA in neurons. 2. Arc1 loads the darc1 mRNA into extracellular vesicles that are transferred from motor neurons to muscles. 3. This loading and transfer depends on the retrotransposon-like sequences in the 3' untranslated region of the darc1 mRNA. Disrupting this transfer blocks synaptic plasticity, suggesting it is required for this function.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    14 views2 pages

    Retrovirus-Like Gag Traffics Across Like Gag Protein Arc1 Binds RNA and Synaptic Boutons Protein Arc1 Binds RNA and

    Uploaded by

    carlos
    1. The Drosophila Arc1 protein forms capsid-like structures that bind to darc1 mRNA in neurons. 2. Arc1 loads the darc1 mRNA into extracellular vesicles that are transferred from motor neurons to muscles. 3. This loading and transfer depends on the retrotransposon-like sequences in the 3' untranslated region of the darc1 mRNA. Disrupting this transfer blocks synaptic plasticity, suggesting it is required for this function.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    CellVolume 172, Issues 1-2

    1 , p262–274.e11,
    274.e11, 11 January 2018
    ARTICLE
    Switch to Standard View

    Retrovirus-like
    like Gag Protein Arc1 Binds RNA and
    Traffics across Synaptic Boutons
    James AshleyBenjamin Cordy2Diandra LuciaLee
    Lucia G. Fradkin
    Vivian Budnik3,4, Correspondenceinformationabouttheauthor Vivian Budnik Email theauthor Vivian
    Budnik
    Travis Thomson CorrespondenceinformationabouttheauthorTravis Thomson Email theauthorTravis
    Thomson
    2
    These authorscontributedequally
    3
    Senior author
    4
    Lead Contact

    Summary
    Arc/Arg3.1 isrequiredforsynapticplasticity and cognition, and mutations in this gene are linked
    to autism and schizophrenia. Arcbears a domainresembling retroviral/retrotransposon Gag-
    Gag
    likeproteins, whichmultimerizeinto a capsidthatpackages viral RNA. Thesignificance
    Thesignificance of such a
    domain in a plasticitymoleculeisuncertain. Here, wereportthatthe Drosophila Arc1
    proteinformscapsid-likestructuresthatbind
    likestructuresthatbind darc1 mRNA in neurons and
    is loadedintoextracellularvesiclesthat are transferredfrommotorneurons to muscles. Thisloading
    Thislo
    and transfer dependsonthe darc1-mRNA
    darc1 3′ untranslatedregion, whichcontainsretrotransposon-
    whichcontainsretrotransposon
    likesequences. Disrupting transfer blocks synapticplasticity, suggestingthat transfer of dArc1
    complexedwithitsmRNAisrequiredforthisfunction. Notably,
    culturedcellsalsoreleaseextracellularvesiclescontainingthe
    llsalsoreleaseextracellularvesiclescontainingthe Gag region of the Copia
    retrotransposoncomplexedwithitsownmRNA. Takentogether, ourresultspoint to a trans-
    synapticmRNAtransportmechanisminvolving retrovirus-likecapsids and extracellularvesicles.

    You might also like