per Chapter Molecular Basis of the genetic material The final proof for DNA came from the experiments of (a) Hershey and Chase (b)_ Avery, MacLeod and MeCarty (6) Hargobind Khorana (@), Griftth, ay Ifthere are 999 bases in an RNA that code for a protein with 333 amino acids, and the base at position 901 is deleted such that the length of the RNA becomes 998 bases, how many codons will be altered? 2012) @ b) 33 ©) 333 @t (NEET 2017) During DNA replication, Okazaki fragments are used to elongate (@) the lagging strand towards replication fork (b) the leading strand away from replication fork (©) the lagging strand away from the replication fork (@) the leading strand towards replication fork. (NEET 2017) Which of the following RNAs should be most abundant in animaal cell? (@) RNA (b) mRNA | (e) miRNA (d) “RNA (NEET 2017) Spliceosomes are not found in cells of (@) fungi (b) animals (©) bacteria (4) plants, (ELT 2017) The association of histone Hy, with, imate nucleosome 10. 2 b. Inheritance (b) Vicia faba (c) Drasophila melanogaster (d) & coll The equivalent of a structural gene is (@)_muton (b) cistron (c) operon (d) recon (NEE Which of the following /RNAS acts as structural RNA as well as ribozyme in bacteria (a) 5S/RNA (b) 18S *RNA (©) 238 RNA (a) 5.88 RNA (NEET- A molecule that can act as a genetic material must fulfill the traits given below, except (a) it should be able to expre: of ‘Mendelian characters” (b) it should be able to generate its replica (c) it should be unstable structurally and chemically (d) itshould provide the scope for slow changes that are required for evolution (NEEPIT. DNA-dependent RNA Polymerase catalyses transcription on one strand of the DNA which is called the (@) template strand (b) coding strand (©) alpha strand (@) antistrand. (NEET-11 2016) Which one of the following is the starter cod itselfin the form (@) UAA b) UAC © AuG (@) UGA Wiel (NEETI 2016) ich of the following is aie, ig i8 required as inducer eo Taos Presion of Lac operon? (0) Lactose 5; and © Glucose *lastose @) Galactose Scanned with CamScannerAcomplex of ribosomes a tached to 4 W frand Of RNA is known ag M40 a single _ (a) Polypeptide (6) Okazaki fray, c ), polysome (4) polymer. mene (NEET: 42016) eon Of the following is not Applicable {@) Heterocyclic nitrogenous bases (0) Chargaf?’s rule (@) Complementary base pairing {@ 5° phosphoryl and 3° hydroxyl ends * 2015) 6 Balbiani rings are sites of {@) polysaccharide synthesis (b) RNA and protein synthesis {@) lipid synthesis {d) nucleotide synthesis. (2015) Hy Mdentify the correct order of organisation of genetic material from largest to smallest, (@) Genome, chromosome, gene, nucleotide ©) Chromosome, genome, nucleotide, gene {€) Chromosome, gene, genome, nucleotide (@ Genome, chromosome, nucleotide, gene (2015) important because it ‘does not code for proteins and is same in | all members of the population for enzymes needed for DNA Proteins needed in cell cycle Ws high degree of polymorphism in and also the same degree of | in an individual, which is n parents (o children. (013) governing lactose operon of the Zac I gene product is epressible because repressor nts transcription aa The percentages of the other three bases expected fo be present in this DNA are (a) G17%,A33%, 733% (b) G8.5%, A 50%, T 24.5% (©) G34%, A 24.5%, T 24.5 (4) 617%, A16.5%, T 32, (2015 Cancelled) Whitt one of the following is wrongly matched? (a) Transcription - Writing information from DNA tofRNA (b) Translation - Using information in mRNA to make protein (c)_ Repressor protein Binds to operator to stop enzyme synthesis (4) Operon - Structural genes, operator and promoter. ory 22. Transformation was discovered by (a) Meselson and Staht (b) Hershey and Chase (c) Griffith (4) Watson and Crick. (ory 23. Select the correct option. Direction of Direction of reading RNA synthesis the template DNA strand (a) 3 x-5 (by 3 5" 3 (3 5-3 @ x5 ¥-5 por |. Which of the following statements is not true of two genes that show 50% frequency? (a) The gene show independent assortment. (b) If the. genes are present on the same chromosome, they undergo more than one Grossovers in every meiosis, (©) The genes may be on different (4). The genes are tightly linked, (NEET 2013) ‘The diagram shows.an important concept in the genetic implication of DNA. Fill in the Awe. QUA, A. 85 prin Po, (A - Transcription, B ~ i a [rascription, B -Translation, © (by Aj Trslation, B-Extension, C- Rosalind recombination Scanned with CamScannerChaptorwise NEE Mrurm' ~ 342 (@) A-Transcription, B Replication, C - James (a) VNTR (by sscr Watson (c) SCAR (d) AFLP. (@) A- Translation, B - Transcription, C - Ervin (Karnataka NEET 20/34 Chargatt (NBET 20/3) | 43. Removal of introns and joining of exons in a 26. Which enzyme will be produced in a cel! there defined order during transcription is called is a nonsense mutation in the /ac ¥ gene” (a) looping (>) induc (a) Transacetylase fc) slicing (d) splicing (b) Lactose permease and transacetylase 34, Ifone strand of DNA has the us ba (c) B-galactosidase sequence as ATCTG, what would be th (d) Lactose permease (NBET 201) peach sequence ' (a) TH (b) UAGAC Props ATCGI oe () AACTG (a) Ribosomal RNA is actively synthesized in (b) nucleolus n. (QQ Sy mRNA LS Protein ‘The figure gives an important concept in the | yg, genetic implication of DNA. Fill the Blanks | “"" (@) Iysosomes et (c) nucleoplasm (4) ribosomes, (a) A-Maurice Wilkins, B-Transeription, (C-Translation @) Acdanies Watspn, B-Replicajion, C> | 36. Which one of the folloning Is pot 8 Pan Extension transcription unit in DNA? (@ Actrwin Chargetl, BeTyanslation, | (1) The.inducer .()-A waranty C-Replication (c) Apromoter (@) The structural ger ae, (@ A-Francis Crick, B-Translation, -Transcription Removal of RNA polymerase III from nucleoplasm will affect the synthesis of (Karnataka NEET 2013) 28. Satellite RNAS are present in some (a) RNA (b) hnRNA (a) viroids (b) prions - (©), mRNA (6), RNA. 20. (¢) bacteriophages i meh Me soy 38. What are the structures called that give an es - appearance as ‘beads-on-string’ in the 2. oe is not a property of the chromosomes when viewed under electron - 2 microscope? (a) Non-overlapping (b) Ambiguous (a) Genes (b) Nucleotides (¢) Degeneracy @) Universal | (©) Nucleosomes (a) Base pairs (20/// (Karnataka NEET 2013) ‘90. Genes ofintrestcan be selected froma genomic | 39 THe unequivocal proof of DNA as the genctic material came from the studies on a library by using Gy chong (a) bacterium (b) fungus {b) DNA probe: (©) viroid (d) bacterial virus. & pm ewe (Main 2011) — oe, 40. Which one of the following does not follow wrnataka 2013) the central dogma of molecular biology? 31, In an inducible operon, the genes are (@) Pea (b) Afueor (©) Chlamydomonas (A) HIV Od @) wally ct expressed ules alge turns: () ually expesed unless signal tans them (©) never expressed ~ (d) always expresser, 41, Which one of the following palindromic base, (Karnataka NERY 2013) of the mes Heavenly used egniques | (gy S—— GatatG — y 3'—— CTACTA x Scanned with CamScanner—__ FF as pi a ic Bre Lac operon consi (9) Sar regulatory genes ©) ene regulatory pene 1 attached to 8 single mes allached 10 & strand of reticulum, 2008) Scanned with CamScanner3. Aer a mutation at a genetic locus the charac Scanned with CamScannerfy) TATOC jy VAvac when adenine i ress We be In cal ding one met pone | ee | (9) regulator gene) operator (©) stu seve (d) promoncr gene. 00) alam Scanned with CamScanner{INTE Cilia NEETAPHT SOLUTION 346 84. Out of 64 cod i jons, 61 codons code fo gone ‘acid. It ia called wr 20 types (a) dispersive (b) conservative ® degenercy toa {e) semi-conservative (4) Non conservat ee i (©), wobbling of codon 44. Which of the following is initiation cod 7 aa (a) UAG ow 2003 ie (2002) | (c) AUG (@) ECU ae (d) universility of codons Which cf hich of the following reunites he ex | gs, Ant jeodon ys, Anticodan occurs in (a) RNA (b) RNA (d) DNA 12000) 85. segments after RNA splicing? (a) RNA polymerase (b) SNA (e) RNA ligase (d) RNA scl (9 AY owpay) | 96 Length of one loop of B-DNA 86. Which ofthe following enzymes are used fo join ay saan (by 0:34 nm bits of DNA? | @ 20 nm (a) 10mm. — (2000) (a) Ligase (b) Primase: |% tn three dimensional view the molecule of AN () DNA polymerase (4) Endonuclease is . 200); L-shaped (by S-shaped 87. Exon part of @RNAS have ‘code for (©) Y-shaped (@) E-shaped. 2000) (a) protein (b) lipid ‘9g. Similarity in DNA and RNA is that (c) carbohydrate (d) phospholipid. (a) both are polymer of nucleotides (2002) (b) both have similar pyrimidine a. oe {e) both have similar Suet ie — sequence of nucleotide in DNA 's {a) both are genetic ‘material. 2000) (a) ‘mutagen (b) mutation 99. the Preiiniococus Exper proves that {o) recombination — translation (a) bacteria do not reproduce sexually oo0y,| 0) RNA a etime controls the prodverion A , DNA and proteins 89. peo’ coats DNA EE which | (@) DNA isthe menetic material ‘ pacteria undergo binary fissi° 1999) aan wor @ in undergo binary MSs) on. 9 (6) both (a) and (>? (d) any. co0)),| 90.19, oper concept, regulator gene funcsons & (a) inhibitor (b) repressor 90. In negative operon, i a (c) regulator (@)_ all of these @ ‘co-repressor binds with repressor 1999) Bingnor bind wit FePresscr | 101. fniiaticr codon in eukaryotes is (@) GAU. (b) AGU (@ VAG (991% (b) co-repressor hinds with inducer Jac operon (¢) AUG © have negative effect on (2000) | y02, DNA is mainly found in (b) nucleus only (a) camp “gh eid ten wes wo tons (a) nucleolus ymonymousy Oe (c) cytoplasm only (d) mone of these ‘enntains many genes 11998) sc vamtes, the genetic material is Scanned with CamScanner: pest Be of Ibetance os.The eukaryotic genome differs from the rokaryotic genome because | ft) the DNA is complexed with histone in / prokaryotes {@) the DNA is circular and single stranded in prokaryotes ) (© repetitive sequences are present in eukaryotes (4) genes in the former case are organized into | operons 71999) jas. What base is responsible for hot spots for spontaneens point mutations @ S-bromouracil _(b) S-methyleytosine (6) Guanine (@ Adenine (7998) 107, Genes that are involved in turning on or off the transcription of @ set of structural genes are called (a) redundant genes (b) regulatory genes | (c) polymorphic genes (4) operator genes. (1998) 108. DNA elements, which can switch their position are called (@) cistrons (b) transposons (c) exons (d) introns. (/998) 109. The codons causing chain termination are (8) AGT, TAG UGA (b) UAG, UGA, UAA | (o) TAG, TAA, TG | /@ GAT, AAT, AGT. (1997) | 10. DNA synthesis can be specifically measured by | estimating the incorporation of radio-labelled | (a) thymidine (b) deoxyribose sugar (a) adenine, (/997) = RNA that pick up specific amino acid from ing acid pool in the cytoplasm to ribosome protein synthesis is called (b) RNA (d) ANA. Which of the following step of translation does | sume a high energy phosphate bond? ptidyl transferase reaction ninoacy! ANA binding to A-site | nslocation Amino acid activation of the following serves as & terminal ‘ (b) AGA sieet (@) GCG 1997) | 1990) | 118, An environmental agent, which trig 1997) | o. 347 114, The maximum formation of mRNA occurs in (b) ueleoplasm (@) nucleolus. (1996) (a) ribosome (©) cytoplasm 115, Radio-tracer technique shows that DNA is in (a) muuilti-helix stage (b)_single-helix stage (c) doublehelix stage (d) none of these 1996) 116, The wild type Z:co/fcells are growing in normal medium with glucose. They are transferred to a medium containing only lactose as s of the following changes take place? (a) The /ac operon is induced. (b) E.coli cells stop dividing. (c) The /zc operon is repressed (a) All operons are induced. (1995) 117. The dac operon is an example of (a) repressible operon (b) overlapping genes (c) arabinose operon (d) inducible operon. transcription from. an operon, is @ (a) depressor (b) controlling element (c) regulator (d)_ inducer. (1995) 119, Ifthe sequence of bases in DNA is ATTCGATG, then the sequence of bases in its transeript will be (a) GUAGCUUA ——(b), AUUCGAUG (c) CAUCGAAU —(d), UAAGCUAC (1995) 120, If the DNA codons are ATG ATG ATG and a cytosine base is inserted at the beginning, then which of the following will result? (a) CAT GAT GATG (b) A non-sense mutation (©) C ATG ATG ATG (@) CA TGA TGA TG (1993) 121. In split genes, the coding sequences are called (>) cistros (d) operons (a) exons (©) introns (1995) ‘Anticodon is an unpaired triplet of bases in an exposed position of (a) RNA Oy sae (©) RNA (@) both (b) and (c), (1993) Scanned with CamScannerihut¢as Chapterwise NEET-AIPMT SOLUTIONS, 133. The process of translation is (a) ribosome synthesis (b) protein synthesis (c) DNA synthesis (d) RNA synthesis. (1993) 134. A DNA with unequal nitrogen bases would most probably be (a) single stranded — (b) double stranded (ce) triple stranded (d) four stranded. (1/993) 135. Nucleotide arrangement in DNA can be seen by (a) X-ray crystallography (b) electron microscope (c) ultracentrifuge (d) light microscope. (1993) 136. Experimental material in the study of DNA replication has been (a) Escherichia colt (b) Neurospora crassa (c) Preumococcus (d) Drosophila melanogaster. (1992) 137. Khorana first deciphered the triplet codons of (a) serine and isoleucine (b) cysteine and valine (c) tyrosine and tryptophan (d) phenylalanine and methinonine. (/992) 134k. Aecherichia coli fully labelled with '*N is Scanned with CamScanner- pect Doss of Ihortonce ute In the genetic dictionary, there are 64 codons as {a) 4 amino acids are to be coded {b) © types of RNAs are present {e) there are 44 nonsense codons and 20 sense codons (4) genetic code is triplet. {82.DNA replication is (a) conservative and discontinuous (1990) ffRpReERR EA PRR HR 349 (b) semi-conservative and semi-discontinuous (c) semi-conservative and discontinuous (d) conservative. 143, Genetic code consists of adenine and guanine cytosine and uracil cytosine and guanine all the above. (a) (b) (©) (d) 6. (b) (b) © @) (b) @ © @ @) @) 106. (c) 116. (a) 126. (d) 136. (a) RRRRARRRE Z: 17: a7 37. 47. ‘$7. 7. 7. 87. 97. 107. uy, 127. 137. ) @) @ @ (b) @) (b) (@) @) @ @) @ @ oe) 8. (b) (@ @ © @ @ (a) (@) ) @) ) (d) 128. () 138. (a) pESReaeR EEE 9 19. 29, 39, 49. 59. 69. 79. 89. 99. 109, 119. 129. © (d) (b) @ @) ©) @ (b) (a) © (b) @ (e) 139. (b) (1989) (1988) 10. (c) (a) () (@) @ © © © 90. (a) 100. ¢b) 110. (a) 120, (a) 130. (4) 140. (b) S23e22e8 7 Scanned with CamScanner —