Human Chromosomes

Authors
(view affiliations)

Orlando J. Miller
Eeva Therman

Textbook

34 Citations
10 Mentions
1.3m Downloads

Chapters
About

Table of contents
1. Front Matter
Pages i-xvi
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2. Origins and Directions of Human Cytogenetics
Orlando J. Miller, Eeva Therman
Pages 1-11
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3. The Mitotic Cell Cycle
Orlando J. Miller, Eeva Therman
Pages 13-27
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4. DNA Replication and Chromosome Reproduction
Orlando J. Miller, Eeva Therman
Pages 29-44
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5. General Features of Mitotic Chromosomes
Orlando J. Miller, Eeva Therman
Pages 45-59
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6. The Chemistry and Packaging of Chromosomes
Orlando J. Miller, Eeva Therman
Pages 61-77
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7. Chromosome Bands
Orlando J. Miller, Eeva Therman
Pages 79-94
 PDF
8. Molecular Correlates of Chromosome Bands
Orlando J. Miller, Eeva Therman
Pages 95-105
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9. In Situ Hybridization
Orlando J. Miller, Eeva Therman
Pages 107-124
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10. Main Features of Meiosis
Orlando J. Miller, Eeva Therman
Pages 125-140
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11. Details of Meiosis
Orlando J. Miller, Eeva Therman
Pages 141-155
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12. Meiotic Abnormalities: Abnormal Numbers of Chromosomes
Orlando J. Miller, Eeva Therman
Pages 157-174
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13. Abnormal Phenotypes Due to Autosomal Aneuploidy or Polyploidy
Orlando J. Miller, Eeva Therman
Pages 175-185
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14. Chromosome Structural Aberrations
Orlando J. Miller, Eeva Therman
Pages 187-205
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15. The Causes of Structural Aberrations
Orlando J. Miller, Eeva Therman
Pages 207-221
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16. Syndromes Due to Autosomal Deletions and Duplications
Orlando J. Miller, Eeva Therman
Pages 223-237
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17. Clinical Importance of Translocations, Inversions, and Insertions
Orlando J. Miller, Eeva Therman
Pages 239-254
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18. Sex Determination and the Y Chromosome
Orlando J. Miller, Eeva Therman
Pages 255-266
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19. The X Chromosome, Dosage Compensation, and X Inactivation
Orlando J. Miller, Eeva Therman
Pages 267-281
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20. Phenotypic Effects of Sex Chromosome Imbalance
Orlando J. Miller, Eeva Therman
Pages 283-294
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21. Fragile Sites, Trinucleotide Repeat Expansion, and the Fragile X Syndrome
 Orlando J. Miller, Eeva Therman
Pages 295-308
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22. Euploid Chromosome Aberrations, Uniparental Disomy, and Genomic Imprinting
Orlando J. Miller, Eeva Therman
Pages 309-322
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23. Chromosome Changes in Cell Differentiation
Orlando J. Miller, Eeva Therman
Pages 323-338
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24. Somatic Cell Hybridization in Cytogenetic Analysis
Orlando J. Miller, Eeva Therman
Pages 339-351
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25. Chromosome Instability Syndromes
Orlando J. Miller, Eeva Therman
Pages 353-367
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26. DNA and Gene Amplification
Orlando J. Miller, Eeva Therman
Pages 369-383
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27. Genome Destabilization and Multistep Progression to Cancer
Orlando J. Miller, Eeva Therman
Pages 385-403
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28. Chromosomes and Cancer: Activation of Oncogenes
Orlando J. Miller, Eeva Therman
Pages 405-414
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29. Chromosomes and Cancer: Inactivation of Tumor Suppressor Genes
Orlando J. Miller, Eeva Therman
Pages 415-430
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30. Mapping Human Chromosomes
Orlando J. Miller, Eeva Therman
Pages 431-446
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31. Genome Plasticity and Chromosome Evolution
Orlando J. Miller, Eeva Therman
Pages 447-461
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32. The Future of Human Cytogenetics
Orlando J. Miller, Eeva Therman
Pages 463-474
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33. Back Matter
Pages 475-501
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About this book

Introduction

This is the fourth edition of an acclaimed introductory textbook on the structure and
function of human chromosomes. The explosion of information on human genetic
diseases has meant that there is a greater need than ever for students, practising
physicians, laboratory technicians, and researchers to have a concise, up-to-date
summary of the normal and abnormal behavior of chromosomes. This book continues to
fulfill that need, and is strengthened by the complete revision of material on the
molecular genetics of chromosomes and chromosomal defects.

Keywords

Activation Chromosom DNA Termination biology genes genetics hybridization

Authors and affiliations

Orlando J. Miller (1)

Eeva Therman (2)

1. Center for Molecular Medicine and Genetics, Wayne State University School of
Medicine, , Detroit, USA
2. Laboratory of Genetics, University of Wisconsin, , Madison, USA

Bibliographic information

DOI https://doi.org/10.1007/978-1-4613-0139-4
Copyright Information Springer-Verlag New York, Inc. 2001
Publisher Name Springer, New York, NY
eBook Packages Springer Book Archive
Print ISBN 978-0-387-95046-4
Online ISBN 978-1-4613-0139-4
Buy this book on publisher's site

© 2019 Springer Nature Switzerland AG. Part of Springer Nature.

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