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    Jordan Malaggay Machanum
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    A study compared the effects of amlodipine versus other calcium channel blockers (CCBs) on blood pressure variability (BPV) in hypertensive patients in China. For both hypertensive patients overall and those with comorbidities, patients prescribed amlodipine showed significantly lower BPV than patients prescribed other CCBs. Amlodipine has the longest half-life and greatest bioavailability of CCBs, making it suitable for once-daily administration and resulting in lower BPV compared to other CCBs.

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    A study compared the effects of amlodipine versus other calcium channel blockers (CCBs) on blood pressure variability (BPV) in hypertensive patients in China. For both hypertensive patients overall and those with comorbidities, patients prescribed amlodipine showed significantly lower BPV than patients prescribed other CCBs. Amlodipine has the longest half-life and greatest bioavailability of CCBs, making it suitable for once-daily administration and resulting in lower BPV compared to other CCBs.

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    25 views1 page

    Theoretical

    Uploaded by

    Jordan Malaggay Machanum
    A study compared the effects of amlodipine versus other calcium channel blockers (CCBs) on blood pressure variability (BPV) in hypertensive patients in China. For both hypertensive patients overall and those with comorbidities, patients prescribed amlodipine showed significantly lower BPV than patients prescribed other CCBs. Amlodipine has the longest half-life and greatest bioavailability of CCBs, making it suitable for once-daily administration and resulting in lower BPV compared to other CCBs.

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    For the hypertensive patients (n = 1756, for each cohort), patients prescribed amlodipine showed lower

    BPV than patients prescribed other CCBs (12.90 vs 13.76 mmHg, p < 0.05 [SD] and 9.47 vs 10.06,
    p < 0.05 [CV]). For the hypertensive patients with comorbidity (n = 1080, for each cohort), patients
    prescribed amlodipine had lower BPV than patients prescribed other CCBs as well (13.24 vs
    14.23 mmHg, p < 0.05 [SD] and 9.66 vs 10.28, p < 0.05 [CV]).

    https://www.ncbi.nlm.nih.gov/pubmed/29888950

    J Comp Eff Res. 2018 Jul;7(7):651-660. doi: 10.2217/cer-2017-0063. Epub 2018 Jun 11.

    Comparison of amlodipine versus other calcium channel


    blockers on blood pressure variability in hypertensive
    patients in China: a retrospective propensity score-
    matched analysis.
    Zhang L1, Yang J1, Li L2, Liu D3, Xie X3, Dong P3, Lin Y2.

    *blood pressure variability

    The amlodipine has the longest half-life and the greatest bioavailability among all chemical abstract
    service for chemical information(CAs).This profile of amlodipine makes it suitable for convenient
    once-daily administration (NDA, 2007).

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