Secondary intention Intramembranous bone healing
1. Granulation stage (immediate-5 days)
Hemostasis Inflammation Granulation tissue o Start from the base of the socket, extending cretally along the socket wall o Blood clot occupy central portion o Osteoclast accumulate along alveolar bone crest
2. Initial angiogenic stage (1st week)
Angiogenesis o Start at the base of socket + PDL at cribiform plate (lamina dura) Because of the thick and strong trabeculae and capillary plexus o New sinusoids fills up 2/3 of the socket Sinusoids = irregular trabecular space for passage of blood Active bone resorption o Mainly at crestal bone and cortical margin of alveolar socket
3. New bone formation (2nd week)
Osteoid trabeculae (from base and sides of socket) slowly extends into clot Anastomosing sinusoids new bone trabeculae (governed by expansion and location of the sinusoids) Woven bone formation (incompletely ossified)
4. Bone growth stage (4th-5th week)
Deposit additional trabeculae Thickened socket base and wall fill up 2/3 of original socket volume
5. Bone reorganization stage (6th week)
From primary spongiosa (spongy cancellous bone) secondary spongiosa (irregular and larger framework)
6. Remodelling (3rd week onwards)
A series of bone deposition and resorption 6th-8th week: apparent radiographic evidence of bone formation 4th-6th month: complete healing on radiograph