DRUG Drug MODE/ MECHANISM OF INDICATIONS CONTRA- ADVERSE DRUG INTERACTIONS NURSING Responsibilities

Name Classification ACTION INDICATIONS REACTIONS

Doxofylline Antiasthmatic Doxophylline is a
& COPD methylxanthine derivative
Preparations that possesses potent
bronchodilator activity by
inhibiting phosphodiesterase
enzymes followed by an
increase in cyclic-3’, 5’
adenosine monophosphate
(cAMP) resulting in smooth
muscle relaxation.
Bronchial asthma & Acute
pulmonary disease hypotension
w/ spastic bronchial
component.
MI, Cardiac Decreased xanthine 1. Assess lung sounds,
disorders: clearance with pulse and blood pressure
Tachycardia, cimetidine, allopurinol, before administration and
palpitation, propranolol, antibiotics during peak of
extrasystole. (e.g. erythromycin, medication. Not amount,
lincomycin, color, and character of
Metabolism and ciprofloxacin) and anti- sputum produced.
nutrition flu vaccine. Increased
disorders: xanthine clearance with 2. Monitor pulmonary
Hyperglycaemia anticonvulsants (e.g. function tests before
. phenytoin). May initiating therapy and
potentiate hypokalaemia periodically during therapy
 with β2- agonist. to determine effectiveness
Gastrointestinal of medication.
disorders:
Nausea, 3. Observe for paradoxical
vomiting, bronchospasm (wheezing).
abdominal pain, If conditions occur,
epigastric pain. withhold medication and
notify physician of other
General health care professional
disorders and immediately.
administration
site disorders:
Irritability.

Nervous system
disorders:
Headache,
nervousness,
dizziness.

Psychiatric
disorders:
Insomnia,
nervousness.

Renal and
urinary
disorders:
Albuminuria.