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Nano in Implant Dentistry
Copyright © 2014 Ryo Jimbo et al. This is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Nanolevel modification of biomaterials has significantly early healing periods. J. Löberg et al. have suggested that
improved their properties. With regard to implant dentistry, the nanostructure acts as a nucleation center for the early
the application of “nano” to implants, abutments, and bone formation of hydroxyapatites, which supports the in vivo
substitutes drastically changed the biologic response to them. reports. Contradictory to these studies, the in vivo animal
Numerous in vitro, in vivo, and clinical studies proved that study performed by L. M. Svanborg et al. has shown no
the submicron modification, normally impossible to detect effects in their histological and biomechanical study. They
with our eyes, has enhanced osteogenesis to the biomaterial. have speculated that “nano” may not exert significant effects
An interesting fact is that one of the authors in this special in sites with excellent bone quality. Furthermore, the presence
issue L. M. Svanborg has suggested in her thesis work that of microtopography, different implant macrogeometry, and
nanotopography in fact exists on most of the commercially coarse evaluation techniques could be one of the causes,
available implant surfaces. However, these structures are most which could be disguising the effect of “nano.” K. Breding
of the time the result of native titanium oxides formed due et al. have shown in their study that the effect of the nano-level
to the exposure to air; thus, these structures are regarded as modification could not be detected when removal torque tests
nonintended nanomodification. were performed; however, gene expression analysis of the
An important aspect for the application of “nano” to removed implants clearly pointed out that osteogenic gene
biomaterial surfaces is that the modification is “intended” or expression had been upregulated for some genes. Based on
“strategically” performed. Cell responses differ depending on these studies, the destructive removal torque method may not
the topography and chemistry, and controlling these param- be suitable to evaluate the effect of nano-level modification
eters could target specific biologic phenomena. Thus, studies and advanced techniques may be necessary for evaluation.
show that not only the successful enhancement of osseointe- Nano in implant dentistry restricts itself not only to
gration but also the enhancement of soft tissue responses to implant surface modifications but also to other biomaterials
abutment surfaces. used in this field. C. Marin et al. have shown that nano-
This special issue is a comprehensive compendium of the structured synthetic alloplasts fused with collagen promoted
state of the art research directed towards implants dentistry. bone ingrowth compared to other materials, which could
A. Alenezi et al. compared two different commercially avail- be a promising material to regenerate bone in severe bone
able implant surfaces, one with and one without nanostruc- defects due to atrophy after tooth/teeth loss. E. Bressan et al.
tures. It was suggested that the two different surfaces present have shown that the antibacterial properties of silver nano-
distinct bone healing kinetics, and the surfaces possessing particles are effective towards targeted pathogens, whereas no
nanostructures seemed to be effective in osteoconduction at cytotoxic effects were observed on human cells. This noble
2 International Journal of Dentistry
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